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Aliases for KIAA1143 Gene

Aliases for KIAA1143 Gene

  • KIAA1143 2 3

External Ids for KIAA1143 Gene

Previous GeneCards Identifiers for KIAA1143 Gene

  • GC03M043746
  • GC03M043970
  • GC03M044609
  • GC03M044755
  • GC03M044750

Summaries for KIAA1143 Gene

GeneCards Summary for KIAA1143 Gene

KIAA1143 (KIAA1143) is a Protein Coding gene.

Additional gene information for KIAA1143 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1143 Gene

Genomics for KIAA1143 Gene

Regulatory Elements for KIAA1143 Gene

Enhancers for KIAA1143 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H044760 1.1 ENCODE 22.5 -0.4 -390 2.4 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 CBX5 KIAA1143 ZNF852 KIF15 HNRNPA1P77
GH03H044729 1.1 ENCODE 20.8 +32.1 32079 1.2 MLX ARNT ZFP64 ARID4B DMAP1 YY1 ZNF143 SP3 ZHX2 MXD4 KIAA1143 ZNF852 ZNF35 ZNF502 ZDHHC3 ZNF501 PIR43736
GH03H044624 1.1 ENCODE 14.1 +136.4 136364 2.1 PKNOX1 ARNT SIN3A ARID4B YY1 ZNF766 CBX5 ZNF143 SP3 ZHX2 ZNF197 ZNF35 ZNF852 KIAA1143 ZNF660 ZDHHC3 ZNF502 ZNF445 ZNF197-AS1
GH03H044882 1.7 FANTOM5 Ensembl ENCODE dbSUPER 8.7 -123.6 -123634 5.2 INSM2 KLF17 RFX5 GLIS2 ZNF366 RCOR1 FOS CEBPB TSHZ1 ZEB2 ZNF660 ZKSCAN7 KIAA1143 TGM4 ZNF501 ZNF197 ENSG00000235845
GH03H044974 1.3 ENCODE dbSUPER 9.3 -214.1 -214126 3.6 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 SP3 SP5 ZHX2 MXD4 ZNF445 EXOSC7 RN7SL145P CLEC3B ZNF502 ZKSCAN7 ZNF852 RNU5B-3P KIAA1143 ZNF197
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIAA1143 on UCSC Golden Path with GeneCards custom track

Promoters for KIAA1143 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000151599 -103 2001 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 CBX5

Genomic Locations for KIAA1143 Gene

Genomic Locations for KIAA1143 Gene
chr3:44,737,661-44,761,697
(GRCh38/hg38)
Size:
24,037 bases
Orientation:
Minus strand
chr3:44,779,153-44,803,173
(GRCh37/hg19)

Genomic View for KIAA1143 Gene

Genes around KIAA1143 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1143 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1143 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1143 Gene

Proteins for KIAA1143 Gene

  • Protein details for KIAA1143 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AT1-K1143_HUMAN
    Recommended name:
    Uncharacterized protein KIAA1143
    Protein Accession:
    Q96AT1
    Secondary Accessions:
    • A8K0I4
    • Q96HJ8
    • Q9ULS7

    Protein attributes for KIAA1143 Gene

    Size:
    154 amino acids
    Molecular mass:
    17465 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KIAA1143 Gene

Post-translational modifications for KIAA1143 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIAA1143 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIAA1143 Gene

Domains & Families for KIAA1143 Gene

Gene Families for KIAA1143 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KIAA1143 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA1143: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for KIAA1143 Gene

Function for KIAA1143 Gene

Gene Ontology (GO) - Molecular Function for KIAA1143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with KIAA1143: view

Phenotypes for KIAA1143 Gene

genes like me logo Genes that share phenotypes with KIAA1143: view

Animal Models for KIAA1143 Gene

MGI Knock Outs for KIAA1143:

Animal Model Products

CRISPR Products

miRNA for KIAA1143 Gene

miRTarBase miRNAs that target KIAA1143

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIAA1143 Gene

Localization for KIAA1143 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA1143 gene
Compartment Confidence
nucleus 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KIAA1143 Gene

Pathways & Interactions for KIAA1143 Gene

SuperPathways for KIAA1143 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA1143 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA1143 Gene

Drugs & Compounds for KIAA1143 Gene

No Compound Related Data Available

Transcripts for KIAA1143 Gene

mRNA/cDNA for KIAA1143 Gene

Unigene Clusters for KIAA1143 Gene

KIAA1143:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1143 Gene

No ASD Table

Relevant External Links for KIAA1143 Gene

GeneLoc Exon Structure for
KIAA1143
ECgene alternative splicing isoforms for
KIAA1143

Expression for KIAA1143 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIAA1143 Gene

Protein differential expression in normal tissues from HIPED for KIAA1143 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.7), Ovary (11.7), and Lymph node (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIAA1143 Gene



Protein tissue co-expression partners for KIAA1143 Gene

NURSA nuclear receptor signaling pathways regulating expression of KIAA1143 Gene:

KIAA1143

SOURCE GeneReport for Unigene cluster for KIAA1143 Gene:

Hs.744955

Evidence on tissue expression from TISSUES for KIAA1143 Gene

  • Nervous system(3)
genes like me logo Genes that share expression patterns with KIAA1143: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA1143 Gene

Orthologs for KIAA1143 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIAA1143 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1143 34
  • 100 (a)
OneToOne
LOC739627 33
  • 99.78 (n)
cow
(Bos Taurus)
Mammalia KIAA1143 33 34
  • 91.77 (n)
dog
(Canis familiaris)
Mammalia KIAA1143 33 34
  • 91.23 (n)
mouse
(Mus musculus)
Mammalia 1110059G10Rik 33 16 34
  • 88.1 (n)
rat
(Rattus norvegicus)
Mammalia RGD1311745 33
  • 86.8 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA1143 34
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1143 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1143 33 34
  • 62.12 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA1143 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1143 33
  • 65.8 (n)
Str.3626 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7340 33
zebrafish
(Danio rerio)
Actinopterygii zgc:77056 33 34
  • 63.51 (n)
wufa20b03 33
fruit fly
(Drosophila melanogaster)
Insecta CG42245 33 34
  • 53.19 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1575 34
  • 35 (a)
OneToOne
Species where no ortholog for KIAA1143 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA1143 Gene

ENSEMBL:
Gene Tree for KIAA1143 (if available)
TreeFam:
Gene Tree for KIAA1143 (if available)

Paralogs for KIAA1143 Gene

Pseudogenes.org Pseudogenes for KIAA1143 Gene

genes like me logo Genes that share paralogs with KIAA1143: view

No data available for Paralogs for KIAA1143 Gene

Variants for KIAA1143 Gene

Sequence variations from dbSNP and Humsavar for KIAA1143 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000020192 -- 44,758,701(+) TTCCA(A/G)ATTCC intron-variant
rs1000039206 -- 44,759,624(+) ATGGC(C/T)CAGGC intron-variant
rs1000198333 -- 44,759,058(+) GGGGT(C/T)TCACC intron-variant
rs1000327665 -- 44,751,461(+) TGGTC(A/G)CTTTG utr-variant-3-prime
rs1000380300 -- 44,751,863(+) AGGGT(A/G)AGAGT utr-variant-3-prime

Variation tolerance for KIAA1143 Gene

Residual Variation Intolerance Score: 85.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.02; 50.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1143 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1143

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KIAA1143 Gene

Disorders for KIAA1143 Gene

Relevant External Links for KIAA1143

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA1143

No disorders were found for KIAA1143 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1143 Gene

Publications for KIAA1143 Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for KIAA1143 Gene

Sources for KIAA1143 Gene

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