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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIAA1143 Gene

protein-coding   GIFtS: 39
GCID: GC03M044769

KIAA1143

  Search for KIAA1143
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
KIAA11431 2
Uncharacterized Protein KIAA11432

External Ids:    HGNC: 291981   Entrez Gene: 574562   Ensembl: ENSG000001638077   UniProtKB: Q96AT13   

Export aliases for KIAA1143 gene to outside databases

Previous GC identifers: GC03M043746 GC03M043970 GC03M044609 GC03M044755 GC03M044750


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KIAA1143 Gene: 
KIAA1143 (KIAA1143) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIAA1143 gene promoter:
         STAT1   IRF-1   STAT5A   E4BP4   YY1   Ik-2   FOXJ2 (long isoform)   FOXO1a   FOXJ2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIAA1143 promoter sequence
   Search SABiosciences Chromatin IP Primers for KIAA1143

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA1143


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

KIAA1143 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA1143 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M044769:  view genomic region     (about GC identifiers)

Start:
44,779,153 bp from pter      End:
44,803,173 bp from pter
Size:
24,021 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: K1143_HUMAN, Q96AT1 (See protein sequence)
Recommended Name: Uncharacterized protein KIAA1143  
Size: 154 amino acids; 17465 Da
Secondary accessions: A8K0I4 Q96HJ8 Q9ULS7

Explore the universe of human proteins at neXtProt for KIAA1143: NX_Q96AT1

Explore proteomics data for KIAA1143 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96AT1

  • KIAA1143 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KIAA1143 Protein Expression
    REFSEQ proteins: NP_065747.1  
    ENSEMBL proteins: 
     ENSP00000296121  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q96AT1


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for KIAA1143:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KIAA1143 
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    SwitchGear 3'UTR luciferase reporter plasmidKIAA1143 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA1143

    1 Interacting protein for KIAA1143 (Q96AT13) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP76Q8TAP63I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIAA1143 (K1143)

    Search CenterWatch for drugs/clinical trials and news about KIAA1143 / K1143

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIAA1143 gene: 
    NM_020696.3  

    Unigene Cluster for KIAA1143:

    KIAA1143
    Hs.744955  [show with all ESTs]
    Unigene Representative Sequence: NM_020696
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000484437 ENST00000296121(uc011bac.2)
    miRNA
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    hsa-miR-607 hsa-miR-631 hsa-miR-4297 hsa-miR-374b hsa-miR-3617 hsa-miR-374a hsa-miR-3661 hsa-miR-3137
    SwitchGear 3'UTR luciferase reporter plasmidKIAA1143 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of KIAA1143 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIAA1143
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIAA1143

    Additional mRNA sequence: 

    AB032969.1 AK289549.1 BC008468.1 BC016790.1 BC070360.1 

    10 DOTS entries:

    DT.412339  DT.100001508  DT.92430600  DT.95212391  DT.86835999  DT.95075869  DT.97861188  DT.120892337 
    DT.97864129  DT.97794407 

    24/191 AceView cDNA sequences (see all 191):

    AA346922 CA441808 BU741967 AI220879 AA312341 BC070360 AI028667 H99280 
    AI383011 BE550939 BM544645 CR591210 BU521189 BQ071694 CB268898 AI866482 
    AI632470 BQ718264 BM767412 BF939434 CB140061 CA421236 AW627790 CR613386 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIAA1143 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTTTGTGT
    KIAA1143 Expression
    About this image


    See KIAA1143 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIAA1143

    SOURCE GeneReport for Unigene cluster: Hs.744955
        SABiosciences Custom PCR Arrays for KIAA1143
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1143

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KIAA1143 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1110059G10Rik1 , 5 RIKEN cDNA 1110059G10 gene1, 5 88.1(n)1
    88.31(a)1
      9 (73.30 cM)5
    662021  NM_025419.41  NP_079695.21 
     1229450895 
    chicken
    (Gallus gallus)
    Aves KIAA11431 KIAA1143 62.12(n)
    59.09(a)
      420709  NM_001006369.1  NP_001006369.1 
    lizard
    (Anolis carolinensis)
    Reptilia KIAA11436
    Uncharacterized protein
    64(a)
    1 ↔ 1
    GL343224.1(295572-324405)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.73402 Xenopus laevis transcribed sequence with weak similarity more 73.02(n)    BJ094972.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa20b032 Transcribed sequence with weak similarity to protein more 70.02(n)    CF549715.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG422451 CG42245 53.19(n)
    46.81(a)
      7354428  NM_001144404.1  NP_001137876.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T25G3.16
    Protein T25G3.1
    32(a)
    1 ↔ 1
    I(7552975-7554553)


    ENSEMBL Gene Tree for KIAA1143 (if available)
    TreeFam Gene Tree for KIAA1143 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIAA1143 gene

    KIAA1143 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KIAA1143
    PGOHUM00000237563


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/181 SNPs in KIAA1143 are shown (see all 181)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0272724
    ----see VAR_0272722 I M mis40--------
    rs1888078211,2
    --44789738(+) CAAAAC/TCACAT 1 -- int10--------
    rs1807836391,2
    --44789783(+) TGTTCC/TATTTT 1 -- int10--------
    rs1480055801,2
    --44789856(+) CTACTA/GTATTA 1 -- int10--------
    rs1853977641,2
    --44789910(+) AGGTAA/TGTACA 1 -- int10--------
    rs779526881,2
    C,F--44789931(+) AACATA/GCTACA 1 -- int11Minor allele frequency- G:0.03NA 120
    rs1126126311,2
    C,F--44789983(+) AGGTCC/TTGGAA 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1893068421,2
    --44790077(+) GGCATC/GTTACA 1 -- int10--------
    rs1824097931,2
    --44790078(+) GCATGG/TTACAG 1 -- int10--------
    rs1874143591,2
    --44790188(+) CTACAC/GATGAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for KIAA1143 (44779153 - 44803173 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KIAA1143: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KIAA1143
    DNA2.0 Custom Variant and Variant Library Synthesis for KIAA1143

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIAA1143 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with KIAA1143)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2, 3 Hirosawa M.... Ohara O. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    5. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    6. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    7. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    8. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57456 HGNC: 29198 AceView: KIAA1143 Ensembl:ENSG00000163807 euGenes: HUgn57456
    ECgene: KIAA1143 H-InvDB: KIAA1143

    (According to HUGE)
    About This Section
    HUGE: KIAA1143

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIAA1143 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIAA1143 gene:
    Search GeneIP for patents involving KIAA1143

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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