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KIAA1143 Gene

protein-coding   GIFtS: 39
GCID: GC03M044769

KIAA1143

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
KIAA11431 2
Uncharacterized Protein KIAA11432

External Ids:    HGNC: 291981   Entrez Gene: 574562   Ensembl: ENSG000001638077   UniProtKB: Q96AT13   

Export aliases for KIAA1143 gene to outside databases

Previous GC identifers: GC03M043746 GC03M043970 GC03M044609 GC03M044755 GC03M044750


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KIAA1143 Gene:
KIAA1143 (KIAA1143) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the KIAA1143 gene promoter:
         STAT1   IRF-1   STAT5A   E4BP4   YY1   Ik-2   FOXJ2 (long isoform)   FOXO1a   FOXJ2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIAA1143 promoter sequence
   Search Chromatin IP Primers for KIAA1143

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIAA1143


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

KIAA1143 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA1143 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M044769:  view genomic region     (about GC identifiers)

Start:
44,779,153 bp from pter      End:
44,803,173 bp from pter
Size:
24,021 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: K1143_HUMAN, Q96AT1 (See protein sequence)
Recommended Name: Uncharacterized protein KIAA1143  
Size: 154 amino acids; 17465 Da
Secondary accessions: A8K0I4 Q96HJ8 Q9ULS7

Explore the universe of human proteins at neXtProt for KIAA1143: NX_Q96AT1

Explore proteomics data for KIAA1143 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KIAA1143 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065747.1  
    ENSEMBL proteins: 
     ENSP00000296121  

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    antibodies-online proteins for KIAA1143 (3 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR027911 DUF4604

    Graphical View of Domain Structure for InterPro Entry Q96AT1

    ProtoNet protein and cluster: Q96AT1


    Find genes that share domains with KIAA1143           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for KIAA1143:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KIAA1143
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    hsa-mir-192-5p (MIRT026588)

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    hsa-miR-607 hsa-miR-631 hsa-miR-4297 hsa-miR-374b hsa-miR-3617 hsa-miR-374a hsa-miR-3661 hsa-miR-3137
    SwitchGear 3'UTR luciferase reporter plasmidKIAA1143 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIAA1143
    Interactions:

        Search GeneGlobe Interaction Network for KIAA1143

    1 Interacting protein for KIAA1143 (Q96AT13) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP76Q8TAP63I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIAA1143 (K1143)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KIAA1143 gene: 
    NM_020696.3  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000484437 ENST00000296121(uc011bac.2)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate KIAA1143 (see all 14):
    hsa-miR-607 hsa-miR-631 hsa-miR-4297 hsa-miR-374b hsa-miR-3617 hsa-miR-374a hsa-miR-3661 hsa-miR-3137
    SwitchGear 3'UTR luciferase reporter plasmidKIAA1143 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KIAA1143
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      QuantiTect SYBR Green Assays in human, mouse, rat KIAA1143
      QuantiFast Probe-based Assays in human, mouse, rat KIAA1143

    Selected AceView cDNA sequences (see all 191):

    BF939434 AA312341 BM723999 BM544645 BU428664 BM767412 BC070360 BU741967 
    CA421236 CB140061 AA346922 CA441808 BE550939 BQ071694 H99280 AI866482 
    CB268898 AI632470 AI028667 BU521189 AI220879 BQ718264 CR591210 AA443720 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIAA1143 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTTTGTGT
    KIAA1143 Expression
    About this image

    KIAA1143 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIAA1143 Protein Expression
        Custom PCR Arrays for KIAA1143
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1143

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KIAA1143 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1110059G10Rik1 , 5 RIKEN cDNA 1110059G10 gene1, 5 88.1(n)1
    88.31(a)1
      9 (73.30 cM)5
    662021  NM_025419.41  NP_079695.21 
     1229450895 
    chicken
    (Gallus gallus)
    Aves KIAA11431 KIAA1143 62.12(n)
    59.09(a)
      420709  NM_001006369.1  NP_001006369.1 
    lizard
    (Anolis carolinensis)
    Reptilia KIAA11436
    KIAA1143
    64(a)
    1 ↔ 1
    GL343224.1(295572-324405)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.73402 Xenopus laevis transcribed sequence with weak similarity more 73.02(n)    BJ094972.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa20b032 Transcribed sequence with weak similarity to protein more 70.02(n)    CF549715.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG422451 CG42245 53.19(n)
    46.81(a)
      7354428  NM_001144404.2  NP_001137876.1 


    ENSEMBL Gene Tree for KIAA1143 (if available)
    TreeFam Gene Tree for KIAA1143 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KIAA1143 gene

    Find genes that share paralogs with KIAA1143           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for KIAA1143
    PGOHUM00000237563


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIAA1143 (see all 181)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1888078211,2
    --44789738(+) CAAAAC/TCACAT 1 -- int10--------
    rs1807836391,2
    --44789783(+) TGTTCC/TATTTT 1 -- int10--------
    rs1480055801,2
    --44789856(+) CTACTA/GTATTA 1 -- int10--------
    rs1853977641,2
    --44789910(+) AGGTAA/TGTACA 1 -- int10--------
    rs779526881,2
    C,F--44789931(+) AACATA/GCTACA 1 -- int11Minor allele frequency- G:0.03NA 120
    rs1126126311,2
    C,F--44789983(+) AGGTCC/TTGGAA 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1893068421,2
    --44790077(+) GGCATC/GTTACA 1 -- int10--------
    rs1824097931,2
    --44790078(+) GCATGG/TTACAG 1 -- int10--------
    rs1874143591,2
    --44790188(+) CTACAC/GATGAG 1 -- int10--------
    rs1918070191,2
    --44790204(+) CTCATC/GTATAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for KIAA1143 (44779153 - 44803173 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KIAA1143: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KIAA1143
    DNA2.0 Custom Variant and Variant Library Synthesis for KIAA1143

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIAA1143 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with KIAA1143)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2, 3 Hirosawa M.... Ohara O. (DNA Res. 1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    6. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    7. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    8. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57456 HGNC: 29198 AceView: KIAA1143 Ensembl:ENSG00000163807 euGenes: HUgn57456
    ECgene: KIAA1143 H-InvDB: KIAA1143

    (According to HUGE)
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    HUGE: KIAA1143

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KIAA1143 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KIAA1143 gene:
    Search GeneIP for patents involving KIAA1143

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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