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KIAA1107 Gene

protein-coding   GIFtS: 43
GCID: GC01P092632

KIAA1107

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
KIAA11071 2
Uncharacterized Protein KIAA11072

External Ids:    HGNC: 291921   Entrez Gene: 232852   Ensembl: ENSG000000697127   UniProtKB: Q9UPP53   

Export aliases for KIAA1107 gene to outside databases

Previous GC identifers: GC01M093020 GC01P091832 GC01P091972 GC01P092104 GC01P092344 GC01P092407 GC01P090752


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KIAA1107 Gene:
KIAA1107 (KIAA1107) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIAA1107 gene promoter:
         TBP   GR   GR-beta   POU2F1   POU2F1b   POU2F1a   IRF-7A   STAT3   GR-alpha   POU2F1c   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for KIAA1107

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIAA1107


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.1   Ensembl cytogenetic band:  1p22.1   HGNC cytogenetic band: 1p22.1

KIAA1107 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA1107 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P092632:  view genomic region     (about GC identifiers)

Start:
92,632,542 bp from pter      End:
92,650,280 bp from pter
Size:
17,739 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: K1107_HUMAN, Q9UPP5 (See protein sequence)
Recommended Name: Uncharacterized protein KIAA1107  
Size: 1409 amino acids; 155681 Da
Sequence caution: Sequence=AAC28132.1; Type=Erroneous initiation;
Secondary accessions: O14767 Q8N3X7
Alternative splicing: 2 isoforms:  Q9UPP5-1   Q9UPP5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KIAA1107: NX_Q9UPP5

Explore proteomics data for KIAA1107 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KIAA1107 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056052.2  
    ENSEMBL proteins: 
     ENSP00000359404   ENSP00000386957  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR027907 DUF4596

    Graphical View of Domain Structure for InterPro Entry Q9UPP5

    ProtoNet protein and cluster: Q9UPP5


    Find genes that share domains with KIAA1107           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for KIAA1107:
     Decreased viability with pacli 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for KIAA1107

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytoskeleton1
    cytosol1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIAA1107
    Interactions:

        Search GeneGlobe Interaction Network for KIAA1107

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for KIAA1107 (Q9UPP52, 3 ENSP000003594044) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2D3P610772, 3, ENSP000003497224MINT-8276086 I2D: score=2 STRING: ENSP00000349722
    SNUPNO951493, ENSP000003098314I2D: score=2 STRING: ENSP00000309831
    UBE2D2ENSP000003817174STRING: ENSP00000381717
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIAA1107 (K1107)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KIAA1107 gene: 
    NM_015237.2  

    Unigene Cluster for KIAA1107:

    KIAA1107
    Hs.21554  [show with all ESTs]
    Unigene Representative Sequence: NM_015237
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370378(uc010otd.2 uc001dop.3) ENST00000409154
    miRNA
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    hsa-miR-7-2* hsa-miR-130a* hsa-miR-23c hsa-miR-570 hsa-miR-23b hsa-miR-3613-3p hsa-miR-7-1* hsa-miR-23a
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      QuantiFast Probe-based Assays in human, mouse, rat KIAA1107

    Additional mRNA sequence: 

    AB029030.1 AF017090.1 AK302496.1 BC037317.2 BC047628.1 

    2 DOTS entries:

    DT.99983293  DT.311940 

    Selected AceView cDNA sequences (see all 41):

    AI887456 AI391664 CD722488 Z40242 BM993072 Z45836 AA253236 Z44283 
    AI202013 AB029030 BC037317 BC047628 BI915577 BX476546 AA206903 R55696 
    BX488432 R45515 AW962887 AA863471 AA206775 F04696 BG150446 BI545590 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIAA1107 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTCTCTAA
    KIAA1107 Expression
    About this image


    KIAA1107 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Eye (Sensory Organs)
             Retina
    KIAA1107 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIAA1107 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.21554
        Custom PCR Arrays for KIAA1107
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1107

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KIAA1107 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia A830010M20Rik1 , 5 RIKEN cDNA A830010M20 gene1, 5 73.09(n)1
    60.33(a)1
      5 (52.23 cM)5
    2315701  NM_001007574.21  NP_001007575.21 
     1074973785 
    chicken
    (Gallus gallus)
    Aves KIAA11071 KIAA1107 67.39(n)
    54.49(a)
      424504  XM_004936602.1  XP_004936659.1 
    lizard
    (Anolis carolinensis)
    Reptilia KIAA11076
    KIAA1107
    49(a)
    1 ↔ 1
    4(93890512-93910962)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.171692 Transcribed sequences 75.09(n)    AL859391.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-389b16.26
    si:ch73-389b16.2
    26(a)
    1 ↔ 1
    6(20364750-20416246) ENSDARG00000075907


    ENSEMBL Gene Tree for KIAA1107 (if available)
    TreeFam Gene Tree for KIAA1107 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIAA1107 (see all 368)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs800668851,2
    C,F--92630690(+) AAAAAA/TAAGAA 1 -- us2k13Minor allele frequency- T:0.06WA NA 240
    rs2005022871,2
    --92630690(+) AAAAA-/TAAGAA 1 -- us2k10--------
    rs801825781,2
    C,F--92630722(+) TTTTAG/TTTTTG 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs2021162971,2
    --92631078(+) AAAAC-/AGAGGCT 1 -- us2k10--------
    rs798360701,2
    --92631106(+) ATGCTG/TTCCAT 1 -- us2k10--------
    rs785758891,2
    F--92631119(+) TAGGTA/GTTTCA 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs5331241,2
    C,H--92631362(+) cttgaG/Agccta 1 -- us2k17Minor allele frequency- A:0.00NS EA NA WA 542
    rs1865347341,2
    --92631432(+) AGATTC/GAAGAC 1 -- us2k10--------
    rs1431448401,2
    --92631483(+) GCCATA/GTTTTT 1 -- us2k10--------
    rs1474768861,2
    --92631654(+) CCATAG/TAGATC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KIAA1107 (92632542 - 92650280 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KIAA1107:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714684CNV Deletion23290073
    nsv871508CNV Gain21882294
    dgv264n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIAA1107 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with KIAA1107)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2, 3 Kikuno R.... Ohara O. (DNA Res. 1999)
    2. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    3. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (Science 2007)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23285 HGNC: 29192 AceView: KIAA1107 Ensembl:ENSG00000069712 euGenes: HUgn23285
    ECgene: KIAA1107 H-InvDB: KIAA1107

    (According to HUGE)
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    HUGE: KIAA1107

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KIAA1107 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KIAA1107 gene:
    Search GeneIP for patents involving KIAA1107

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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