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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIAA1107 Gene

protein-coding   GIFtS: 39
GCID: GC01P092632

KIAA1107

  Search for KIAA1107
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
KIAA11071 2
Uncharacterized Protein KIAA11072

External Ids:    HGNC: 291921   Entrez Gene: 232852   Ensembl: ENSG000000697127   UniProtKB: Q9UPP53   

Export aliases for KIAA1107 gene to outside databases

Previous GC identifers: GC01M093020 GC01P091832 GC01P091972 GC01P092104 GC01P092344 GC01P092407 GC01P090752


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KIAA1107 Gene: 
KIAA1107 (KIAA1107) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIAA1107 gene promoter:
         TBP   GR   GR-beta   POU2F1   POU2F1b   POU2F1a   IRF-7A   STAT3   GR-alpha   POU2F1c   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KIAA1107

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA1107


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.1   Ensembl cytogenetic band:  1p22.1   HGNC cytogenetic band: 1p22.1

KIAA1107 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA1107 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P092632:  view genomic region     (about GC identifiers)

Start:
92,632,542 bp from pter      End:
92,650,280 bp from pter
Size:
17,739 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: K1107_HUMAN, Q9UPP5 (See protein sequence)
Recommended Name: Uncharacterized protein KIAA1107  
Size: 1409 amino acids; 155681 Da
Sequence caution: Sequence=AAC28132.1; Type=Erroneous initiation;
Secondary accessions: O14767 Q8N3X7
Alternative splicing: 2 isoforms:  Q9UPP5-1   Q9UPP5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KIAA1107: NX_Q9UPP5

Explore proteomics data for KIAA1107 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UPP5

  • KIAA1107 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KIAA1107 Protein Expression
    REFSEQ proteins: NP_056052.2  
    ENSEMBL proteins: 
     ENSP00000359404   ENSP00000386957  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9UPP5


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for KIAA1107:
     Decreased viability with pacli 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA1107

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for KIAA1107 (Q9UPP52, 3 ENSP000003594044) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2D3P610772, 3, ENSP000003497224MINT-8276086 I2D: score=2 STRING: ENSP00000349722
    SNUPNO951493, ENSP000003098314I2D: score=2 STRING: ENSP00000309831
    UBE2D2ENSP000003817174STRING: ENSP00000381717
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIAA1107 (K1107)

    Search CenterWatch for drugs/clinical trials and news about KIAA1107 / K1107

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIAA1107 gene: 
    NM_015237.2  

    Unigene Cluster for KIAA1107:

    KIAA1107
    Hs.21554  [show with all ESTs]
    Unigene Representative Sequence: NM_015237
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370378(uc010otd.2 uc001dop.3) ENST00000409154
    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIAA1107
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIAA1107
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    Additional mRNA sequence: 

    AB029030.1 AF017090.1 AK302496.1 BC037317.2 BC047628.1 

    2 DOTS entries:

    DT.99983293  DT.311940 

    24/41 AceView cDNA sequences (see all 41):

    Z44283 Z45836 BM993072 AI887456 CD722488 AI202013 AA253236 AB029030 
    Z40242 AI391664 R45515 BX476546 AA863471 AA206903 R55696 BC037317 
    BI915577 BC047628 F04696 BG150446 AW962887 BX488432 AA206775 BG708660 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIAA1107 expression in normal human tissues (normalized intensities)      KIAA1107 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTCTCTAA
    KIAA1107 Expression
    About this image


    KIAA1107 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Thalamus
             Olfactory Bulb   
     
     Eye (Sensory Organs)
             Retina

    See KIAA1107 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIAA1107

    SOURCE GeneReport for Unigene cluster: Hs.21554
        SABiosciences Custom PCR Arrays for KIAA1107
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1107

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KIAA1107 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia A830010M20Rik1 , 5 RIKEN cDNA A830010M20 gene1, 5 72.97(n)1
    60.24(a)1
      5 (52.23 cM)5
    2315701  NM_001007574.21  NP_001007575.21 
     1074973785 
    chicken
    (Gallus gallus)
    Aves KIAA11071 KIAA1107 67.41(n)
    54.37(a)
      424504  XM_422344.3  XP_422344.3 
    lizard
    (Anolis carolinensis)
    Reptilia KIAA11076
    Uncharacterized protein
    48(a)
    1 ↔ 1
    4(93890512-93910962)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.171692 Transcribed sequences 75.09(n)    AL859391.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-389b16.21 si:ch73-389b16.2 47.5(n)
    38.07(a)
      550304  XM_002662430.2  XP_002662476.2 


    ENSEMBL Gene Tree for KIAA1107 (if available)
    TreeFam Gene Tree for KIAA1107 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/368 SNPs in KIAA1107 are shown (see all 368)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs800668851,2
    C,F--92630690(+) AAAAAA/TAAGAA 1 -- us2k13Minor allele frequency- T:0.06WA NA 240
    rs2005022871,2
    --92630690(+) AAAAA-/TAAGAA 1 -- us2k10--------
    rs801825781,2
    C,F--92630722(+) TTTTAG/TTTTTG 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs2021162971,2
    --92631078(+) AAAAC-/AGAGGCT 1 -- us2k10--------
    rs798360701,2
    --92631106(+) ATGCTG/TTCCAT 1 -- us2k10--------
    rs785758891,2
    F--92631119(+) TAGGTA/GTTTCA 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs5331241,2
    C,H--92631362(+) cttgaG/Agccta 1 -- us2k17Minor allele frequency- A:0.00NS EA NA WA 542
    rs1865347341,2
    --92631432(+) AGATTC/GAAGAC 1 -- us2k10--------
    rs1431448401,2
    --92631483(+) GCCATA/GTTTTT 1 -- us2k10--------
    rs1474768861,2
    --92631654(+) CCATAG/TAGATC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KIAA1107 (92632542 - 92650280 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KIAA1107:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2714684CNV Deletion23290073
    nsv871508CNV Gain21882294
    dgv264n71CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIAA1107 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KIAA1107)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2, 3 Kikuno R....Ohara O. (1999)
    2. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    3. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (2007)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23285 HGNC: 29192 AceView: KIAA1107 Ensembl:ENSG00000069712 euGenes: HUgn23285
    ECgene: KIAA1107 H-InvDB: KIAA1107

    (According to HUGE)
    About This Section
    HUGE: KIAA1107

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIAA1107 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIAA1107 gene:
    Search GeneIP for patents involving KIAA1107

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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