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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIAA1045 Gene

protein-coding   GIFtS: 39
GCID: GC09P034957

KIAA1045

  Search for KIAA1045
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
KIAA10451 2
RP11-392A14.42
Protein KIAA10452

External Ids:    HGNC: 291801   Entrez Gene: 233492   Ensembl: ENSG000001227337   UniProtKB: Q9UPV73   

Export aliases for KIAA1045 gene to outside databases

Previous GC identifers: GC09P035270 GC09P035127 GC09P034948 GC09P034947 GC09P034913


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KIAA1045 Gene: 
KIAA1045 (KIAA1045) is a protein-coding gene. GO annotations related to this gene include metal ion binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008413.18  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIAA1045 gene promoter:
         GR   SRF   SRF (504 AA)   LUN-1   LCR-F1   NF-E2 p45   Ik-2   GR-alpha   NF-E2   Hlf   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KIAA1045

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA1045


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13.2

KIAA1045 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA1045 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P034957:  view genomic region     (about GC identifiers)

Start:
34,957,484 bp from pter      End:
34,982,541 bp from pter
Size:
25,058 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: K1045_HUMAN, Q9UPV7 (See protein sequence)
Recommended Name: Protein KIAA1045  
Size: 400 amino acids; 45192 Da
Sequence caution: Sequence=BAA82997.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for KIAA1045:
1WIL (3D)    
Secondary accessions: B7Z253 Q58FE9 Q5T662

Explore the universe of human proteins at neXtProt for KIAA1045: NX_Q9UPV7

Explore proteomics data for KIAA1045 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UPV7

  • KIAA1045 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KIAA1045 Protein Expression
    REFSEQ proteins: NP_056112.1  
    ENSEMBL proteins: 
     ENSP00000242315   ENSP00000444138  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR019786 Zinc_finger_PHD-type_CS
     IPR013083 Znf_RING/FYVE/PHD
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q9UPV7

    ProtoNet protein and cluster: Q9UPV7

    1 Blocks protein domain: IPB001965 Zn-finger-like

    UniProtKB/Swiss-Prot: K1045_HUMAN, Q9UPV7
    Similarity: Contains 1 PHD-type zinc finger


    KIAA1045 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
         
    KIAA1045 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA1045

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIAA1045 (K1045)

    Search CenterWatch for drugs/clinical trials and news about KIAA1045 / K1045

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for KIAA1045 gene: 
    NM_015297.1  

    Unigene Cluster for KIAA1045:

    KIAA1045
    Hs.7989  [show with all ESTs]
    Unigene Representative Sequence: NM_015297
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486477 ENST00000476115 ENST00000242315(uc003zvq.3 uc003zvr.3)
    ENST00000440503 ENST00000544237
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AB028968.1 AK294342.1 AL137621.1 AY956806.1 AY956807.1 AY956808.1 BC041169.1 

    4 DOTS entries:

    DT.315326  DT.91758838  DT.315327  DT.70101922 

    24/91 AceView cDNA sequences (see all 91):

    BM720593 AL137621 Z39555 BM712542 BM666752 BG059571 BM702452 F01546 
    BU743017 BC041169 BI913353 AL134024 BM019904 BX092374 BI488713 BI755378 
    BM673825 T09296 T33227 Z42030 Z43477 BM724625 BM679309 BQ640075 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIAA1045 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCTCTGCG
    KIAA1045 Expression
    About this image


    See KIAA1045 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIAA1045

    SOURCE GeneReport for Unigene cluster: Hs.7989
        SABiosciences Custom PCR Arrays for KIAA1045
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1045

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KIAA1045 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia N281781 , 5 expressed sequence N281781, 5 88.15(n)1
    90.36(a)1
      4 (22.91 cM)5
    2300851  NM_172690.21  NP_766278.11 
     429166605 
    chicken
    (Gallus gallus)
    Aves KIAA10451 KIAA1045 73.88(n)
    73.54(a)
      427408  XM_424982.3  XP_424982.3 
    lizard
    (Anolis carolinensis)
    Reptilia KIAA10456
    Uncharacterized protein
    55(a)
    1 ↔ 1
    GL343552.1(43175-83082)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5589431 protein KIAA1045-like 61.6(n)
    55.44(a)
      558943  XM_682234.4  XP_687326.2 


    ENSEMBL Gene Tree for KIAA1045 (if available)
    TreeFam Gene Tree for KIAA1045 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/481 SNPs in KIAA1045 are shown (see all 481)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1856965791,2
    --34956204(+) CTTATC/TTGCAC 1 -- us2k10--------
    rs1418375401,2
    --34956280(+) GTGACA/GGAGTT 1 -- us2k10--------
    rs1904980601,2
    --34956399(+) CCACAA/GGCGCG 1 -- us2k10--------
    rs70317331,2
    C,F,A--34957215(+) ATATCG/CCACCA 1 -- us2k112Minor allele frequency- C:0.48NA WA CSA EA 375
    rs1151772061,2
    F--34957254(+) CTAGAC/TGCTCA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1462861211,2
    --34957277(+) GCATTA/GTATTT 1 -- us2k10--------
    rs132971511,2
    C,F--34957540(+) GGTTGC/GTGCAG 1 -- us2k14Minor allele frequency- G:0.22NA 126
    rs1380050921,2
    --34957572(+) GCACAA/GCCTCG 1 -- us2k10--------
    rs1426013511,2
    --34957603(+) ATAATA/CCCAGA 1 -- us2k10--------
    rs70319621,2
    C,F,A,H--34957613(+) AAAACA/GGCGCA 1 -- us2k119Minor allele frequency- G:0.35NS EA NA WA CSA 2338

    HapMap Linkage Disequilibrium report for KIAA1045 (34957484 - 34982541 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KIAA1045:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv21645CNV Loss19812545
    nsv824912CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIAA1045 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KIAA1045)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2, 3 Kikuno R....Ohara O. (1999)
    2. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    3. Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system. (PubMed id 20213681)2 Suzuki T.... Utsumi T. (2010)
    4. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23349 HGNC: 29180 AceView: KIAA1045 Ensembl:ENSG00000122733 euGenes: HUgn23349
    ECgene: KIAA1045 H-InvDB: KIAA1045

    (According to HUGE)
    About This Section
    HUGE: KIAA1045

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIAA1045 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIAA1045 gene:
    Search GeneIP for patents involving KIAA1045

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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