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KIAA1045 Gene

protein-coding   GIFtS: 42
GCID: GC09P034957

KIAA1045

  Search for KIAA1045
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
KIAA10451 2
Protein KIAA10452
DNAJB55
HSC405

External Ids:    HGNC: 291801   Entrez Gene: 233492   Ensembl: ENSG000001227337   OMIM: 6113285   UniProtKB: Q9UPV73   

Export aliases for KIAA1045 gene to outside databases

Previous GC identifers: GC09P035270 GC09P035127 GC09P034948 GC09P034947 GC09P034913


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KIAA1045 Gene:
KIAA1045 (KIAA1045) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIAA1045 gene promoter:
         GR   SRF   SRF (504 AA)   LUN-1   LCR-F1   NF-E2 p45   Ik-2   GR-alpha   NF-E2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIAA1045 promoter sequence
   Search Chromatin IP Primers for KIAA1045

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIAA1045


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13.2

KIAA1045 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA1045 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P034957:  view genomic region     (about GC identifiers)

Start:
34,957,484 bp from pter      End:
34,982,541 bp from pter
Size:
25,058 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: K1045_HUMAN, Q9UPV7 (See protein sequence)
Recommended Name: Protein KIAA1045  
Size: 400 amino acids; 45192 Da
Sequence caution: Sequence=BAA82997.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for KIAA1045:
1WIL (3D)    
Secondary accessions: B7Z253 Q58FE9 Q5T662

Explore the universe of human proteins at neXtProt for KIAA1045: NX_Q9UPV7

Explore proteomics data for KIAA1045 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KIAA1045 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056112.1  
    ENSEMBL proteins: 
     ENSP00000242315   ENSP00000444138  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR019786 Zinc_finger_PHD-type_CS
     IPR013083 Znf_RING/FYVE/PHD
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q9UPV7

    ProtoNet protein and cluster: Q9UPV7

    1 Blocks protein domain: IPB001965 Zn-finger-like

    UniProtKB/Swiss-Prot: K1045_HUMAN, Q9UPV7
    Similarity: Contains 1 PHD-type zinc finger


    KIAA1045 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
         
    KIAA1045 for ontologies           About GeneDecksing


    Animal Models:
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    hsa-miR-219-1-3p hsa-miR-3607-3p hsa-miR-330-5p hsa-miR-128 hsa-miR-218 hsa-miR-449a hsa-miR-1184 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidKIAA1045 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1
    extracellular1
    mitochondrion1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIAA1045
    Interactions:

        Search GeneGlobe Interaction Network for KIAA1045

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIAA1045 (K1045)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KIAA1045 gene: 
    NM_015297.1  

    Unigene Cluster for KIAA1045:

    KIAA1045
    Hs.7989  [show with all ESTs]
    Unigene Representative Sequence: NM_015297
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486477 ENST00000476115 ENST00000242315(uc003zvq.3 uc003zvr.3)
    ENST00000440503 ENST00000544237
    miRNA
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    hsa-miR-219-1-3p hsa-miR-3607-3p hsa-miR-330-5p hsa-miR-128 hsa-miR-218 hsa-miR-449a hsa-miR-1184 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidKIAA1045 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat KIAA1045

    Additional mRNA sequence: 

    AB028968.1 AK294342.1 AL137621.1 AY956806.1 AY956807.1 AY956808.1 BC041169.1 

    4 DOTS entries:

    DT.315326  DT.91758838  DT.315327  DT.70101922 

    Selected AceView cDNA sequences (see all 91):

    BG059571 BM702452 BM712542 BM666752 AL137621 F01546 BM720593 BU743017 
    Z39555 BM019904 AI373023 BM020181 Z43477 BC041169 AL134024 BM673825 
    BQ640075 AB028968 BM724625 Z42030 BI913353 CA411620 AA626183 AA805510 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIAA1045 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCTCTGCG
    KIAA1045 Expression
    About this image

    KIAA1045 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIAA1045 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.7989
        Custom PCR Arrays for KIAA1045
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1045

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KIAA1045 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia N281781 , 5 expressed sequence N281781, 5 88.15(n)1
    90.36(a)1
      4 (22.91 cM)5
    2300851  NM_172690.21  NP_766278.11 
     429166605 
    chicken
    (Gallus gallus)
    Aves KIAA10451 KIAA1045 73.45(n)
    72.77(a)
      427408  XM_424982.4  XP_424982.3 
    lizard
    (Anolis carolinensis)
    Reptilia KIAA10456
    KIAA1045
    55(a)
    1 ↔ 1
    GL343552.1(43175-83082)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia kiaa10451 KIAA1045 67.34(n)
    65.66(a)
      779945  NM_001079022.1  NP_001072490.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5589431 protein KIAA1045-like 60.93(n)
    54.43(a)
      558943  XM_005155643.1  XP_005155700.1 


    ENSEMBL Gene Tree for KIAA1045 (if available)
    TreeFam Gene Tree for KIAA1045 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIAA1045 (see all 481)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1856965791,2
    --34956204(+) CTTATC/TTGCAC 1 -- us2k10--------
    rs1418375401,2
    --34956280(+) GTGACA/GGAGTT 1 -- us2k10--------
    rs1904980601,2
    --34956399(+) CCACAA/GGCGCG 1 -- us2k10--------
    rs70317331,2
    C,F,A--34957215(+) ATATCG/CCACCA 1 -- us2k112Minor allele frequency- C:0.48NA WA CSA EA 375
    rs1151772061,2
    F--34957254(+) CTAGAC/TGCTCA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1462861211,2
    --34957277(+) GCATTA/GTATTT 1 -- us2k10--------
    rs132971511,2
    C,F--34957540(+) GGTTGC/GTGCAG 1 -- us2k14Minor allele frequency- G:0.22NA 126
    rs1380050921,2
    --34957572(+) GCACAA/GCCTCG 1 -- us2k10--------
    rs1426013511,2
    --34957603(+) ATAATA/CCCAGA 1 -- us2k10--------
    rs70319621,2
    C,F,A,H--34957613(+) AAAACA/GGCGCA 1 -- us2k119Minor allele frequency- G:0.35NS EA NA WA CSA 2338

    HapMap Linkage Disequilibrium report for KIAA1045 (34957484 - 34982541 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KIAA1045:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv21645CNV Loss19812545
    nsv824912CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KIAA1045
    DNA2.0 Custom Variant and Variant Library Synthesis for KIAA1045

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611328    OMIM disorders: --


    KIAA1045 for disorders           About GeneDecksing


    Export disorders for KIAA1045 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIAA1045 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with KIAA1045)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2, 3 Kikuno R.... Ohara O. (DNA Res. 1999)
    2. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    3. Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system. (PubMed id 20213681)2 Suzuki T.... Utsumi T. (Proteomics 2010)
    4. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23349 HGNC: 29180 AceView: KIAA1045 Ensembl:ENSG00000122733 euGenes: HUgn23349
    ECgene: KIAA1045 H-InvDB: KIAA1045

    (According to HUGE)
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    HUGE: KIAA1045

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KIAA1045 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KIAA1045 gene:
    Search GeneIP for patents involving KIAA1045

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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