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Aliases for KIAA1024 Gene

Aliases for KIAA1024 Gene

  • KIAA1024 2 3

External Ids for KIAA1024 Gene

Previous GeneCards Identifiers for KIAA1024 Gene

  • GC15P075709
  • GC15P072905
  • GC15P077300
  • GC15P077440
  • GC15P077511
  • GC15P079724
  • GC15P056483
  • GC15P079432
  • GC15P079415
  • GC15P079416
  • GC15P079417

Summaries for KIAA1024 Gene

GeneCards Summary for KIAA1024 Gene

KIAA1024 (KIAA1024) is a Protein Coding gene. An important paralog of this gene is KIAA1024L.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1024 Gene

Genomics for KIAA1024 Gene

Regulatory Elements for KIAA1024 Gene

Enhancers for KIAA1024 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F079328 1 Ensembl ENCODE 10 -84.3 -84301 1.4 SOX13 ZNF687 NFIA HLF MAFG BACH1 ZNF592 MEF2D ZNF316 NFE2L1 KIAA1024 TMED3 GC15P079414
GH15F079853 0.9 ENCODE 9.7 +440.2 440248 1.0 HDAC1 CBX3 PKNOX1 TBL1XR1 SIN3A FEZF1 ZNF2 RAD21 SCRT2 ZNF143 MTHFS RNU6-667P BCL2A1 KIAA1024 GC15P079856 ENSG00000261229
GH15F079381 0.8 ENCODE 10.7 -32.3 -32261 0.2 GTF2F1 CTCF PKNOX1 BMI1 RAD21 TEAD3 EED ZNF143 SMC3 ETV6 KIAA1024 GC15P079414 TMED3
GH15F079370 0.4 ENCODE 17.7 -42.6 -42561 0.2 ARID1B HMBOX1 KIAA1024 RNU6-667P TMED3 GC15P079414
GH15F079364 0.6 ENCODE 10.5 -47.9 -47878 2.3 CTCF ATF3 MAFG NFE2 ZBTB33 ZBTB40 RAD21 YY1 KIAA1024 RNU6-667P TMED3 GC15P079414
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIAA1024 on UCSC Golden Path with GeneCards custom track

Genomic Location for KIAA1024 Gene

Chromosome:
15
Start:
79,413,494 bp from pter
End:
79,472,304 bp from pter
Size:
58,811 bases
Orientation:
Plus strand

Genomic View for KIAA1024 Gene

Genes around KIAA1024 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1024 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1024 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1024 Gene

Proteins for KIAA1024 Gene

  • Protein details for KIAA1024 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPX6-K1024_HUMAN
    Recommended name:
    UPF0258 protein KIAA1024
    Protein Accession:
    Q9UPX6
    Secondary Accessions:
    • A7MD43

    Protein attributes for KIAA1024 Gene

    Size:
    916 amino acids
    Molecular mass:
    102993 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA82976.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for KIAA1024 Gene

Post-translational modifications for KIAA1024 Gene

  • Glycosylation at Asn 222, Asn 234, Asn 301, Asn 397, Asn 461, Asn 543, and Asn 563
  • Modification sites at PhosphoSitePlus

Other Protein References for KIAA1024 Gene

No data available for DME Specific Peptides for KIAA1024 Gene

Domains & Families for KIAA1024 Gene

Protein Domains for KIAA1024 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA1024 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UPX6

UniProtKB/Swiss-Prot:

K1024_HUMAN :
  • Belongs to the UPF0258 family.
Family:
  • Belongs to the UPF0258 family.
genes like me logo Genes that share domains with KIAA1024: view

No data available for Gene Families for KIAA1024 Gene

Function for KIAA1024 Gene

genes like me logo Genes that share phenotypes with KIAA1024: view

Animal Model Products

miRNA for KIAA1024 Gene

miRTarBase miRNAs that target KIAA1024

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1024 Gene

Localization for KIAA1024 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA1024 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA1024 gene
Compartment Confidence
golgi apparatus 3
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KIAA1024 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KIAA1024: view

Pathways & Interactions for KIAA1024 Gene

SuperPathways for KIAA1024 Gene

No Data Available

Interacting Proteins for KIAA1024 Gene

Gene Ontology (GO) - Biological Process for KIAA1024 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA1024 Gene

Transcripts for KIAA1024 Gene

Unigene Clusters for KIAA1024 Gene

KIAA1024:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1024 Gene

No ASD Table

Relevant External Links for KIAA1024 Gene

GeneLoc Exon Structure for
KIAA1024
ECgene alternative splicing isoforms for
KIAA1024

Expression for KIAA1024 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIAA1024 Gene

mRNA differential expression in normal tissues according to GTEx for KIAA1024 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x10.3), Adrenal Gland (x10.0), and Brain - Cerebellum (x8.9).

NURSA nuclear receptor signaling pathways regulating expression of KIAA1024 Gene:

KIAA1024

SOURCE GeneReport for Unigene cluster for KIAA1024 Gene:

Hs.301654
genes like me logo Genes that share expression patterns with KIAA1024: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for KIAA1024 Gene

Orthologs for KIAA1024 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA1024 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1024 34 35
  • 99.42 (n)
mouse
(Mus musculus)
Mammalia AF529169 34 16 35
  • 86.35 (n)
rat
(Rattus norvegicus)
Mammalia LOC501033 34
  • 85.92 (n)
dog
(Canis familiaris)
Mammalia KIAA1024 34 35
  • 85.76 (n)
cow
(Bos Taurus)
Mammalia KIAA1024 34 35
  • 85.55 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA1024 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1024 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves DD1 35
  • 81 (a)
OneToOne
KIAA1024 34
  • 75.36 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA1024 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1024 34
  • 61.93 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100331504 34
  • 63.9 (n)
CU184872.1 35
  • 61 (a)
OneToOne
Species where no ortholog for KIAA1024 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA1024 Gene

ENSEMBL:
Gene Tree for KIAA1024 (if available)
TreeFam:
Gene Tree for KIAA1024 (if available)

Paralogs for KIAA1024 Gene

Paralogs for KIAA1024 Gene

genes like me logo Genes that share paralogs with KIAA1024: view

Variants for KIAA1024 Gene

Sequence variations from dbSNP and Humsavar for KIAA1024 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1004724 -- 79,457,965(+) GAAAT(C/T)GAACG nc-transcript-variant, reference, synonymous-codon
rs10438382 -- 79,471,588(+) ATAGA(C/T)GTGCT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs10444864 -- 79,425,142(+) tcaag(C/T)tattc intron-variant
rs1046582 -- 79,471,205(+) TTTAT(A/G)TAAAG intron-variant, nc-transcript-variant, utr-variant-3-prime
rs10519241 -- 79,462,945(-) TCCAG(C/G)CAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1024 Gene

Variant ID Type Subtype PubMed ID
dgv1250n106 CNV deletion 24896259
dgv1451e59 CNV duplication 20981092
dgv309e201 CNV deletion 23290073
dgv4673n54 CNV loss 21841781
dgv4674n54 CNV gain+loss 21841781
dgv4675n54 CNV loss 21841781
dgv4676n54 CNV gain 21841781
dgv4677n54 CNV loss 21841781
esv27073 CNV gain+loss 19812545
esv2749926 CNV deletion 23290073
esv2749928 CNV deletion 23290073
esv3559729 CNV deletion 23714750
nsv952006 CNV deletion 24416366
nsv570219 CNV loss 21841781
nsv570217 CNV loss 21841781
nsv570215 CNV gain 21841781
nsv570214 CNV loss 21841781
nsv1630 CNV insertion 18451855
nsv1071222 CNV deletion 25765185
esv3636999 CNV gain 21293372

Variation tolerance for KIAA1024 Gene

Residual Variation Intolerance Score: 73.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.65; 78.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1024 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1024

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1024 Gene

Disorders for KIAA1024 Gene

Relevant External Links for KIAA1024

Genetic Association Database (GAD)
KIAA1024
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA1024

No disorders were found for KIAA1024 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1024 Gene

Publications for KIAA1024 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4 64
  3. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PMID: 19875614) Paterson A.D. … Bull S.B. (Diabetes 2010) 46 64
  4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S. … Cupples L.A. (BMC Med. Genet. 2007) 46 64
  5. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PMID: 17903302) Levy D. … Mitchell G.F. (BMC Med. Genet. 2007) 46 64

Products for KIAA1024 Gene

Sources for KIAA1024 Gene

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