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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KIAA1024 Gene

protein-coding GIFtS: 43
GCID: GC15P079724

KIAA1024

Explore 1 disease affiliated with
KIAA1024 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
KIAA1024¹ ²
UPF0258 Protein KIAA1024²

External Ids:	HGNC: 29172¹	Entrez Gene: 23251²	Ensembl: ENSG00000169330⁷	UniProtKB: Q9UPX6³

Export aliases for KIAA1024 gene to outside databases

Previous GC identifers: GC15P075709 GC15P072905 GC15P077300 GC15P077440 GC15P077511 GC15P056483

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KIAA1024 gene promoter:
HOXA9 HOXA9B AML1a Olf-1 Meis-1b Arnt FOXO1 Meis-1 Ik-1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA1024

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.1 Ensembl cytogenetic band: 15q25.1 HGNC cytogenetic band: 15q25.1

KIAA1024 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA1024 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P079724: view genomic region (about GC identifiers)

Start:	79,724,858 bp from pter	End:	79,764,642 bp from pter
Size:	39,785 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
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About This Section

UniProtKB/Swiss-Prot: K1024_HUMAN, Q9UPX6 (See protein sequence)

Recommended Name: UPF0258 protein KIAA1024

Size: 916 amino acids; 102993 Da

Subcellular location: Membrane; Single-pass membrane protein (Potential)

Sequence caution: Sequence=BAA82976.2; Type=Erroneous initiation;

Secondary accessions: A7MD43

Explore the universe of human proteins at neXtProt for KIAA1024: NX_Q9UPX6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UPX6

KIAA1024 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_056021.1

ENSEMBL proteins:

ENSP00000307461 ENSP00000454088

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

KIAA1024 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KIAA1024 for domains About GeneDecksing

1 InterPro domain/family:

IPR009626 UPF0258

Graphical View of Domain Structure for InterPro Entry Q9UPX6

ProtoNet protein and cluster: Q9UPX6

UniProtKB/Swiss-Prot: K1024_HUMAN, Q9UPX6

Similarity: Belongs to the UPF0258 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KIAA1024

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for KIAA1024 gene:

NM_015206.2

Unigene Cluster for KIAA1024:

KIAA1024

Hs.301654 [show with all ESTs]

Unigene Representative Sequence: BC152466

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000305428(uc002bew.1 uc010unk.1) ENST00000559272

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Additional cDNA sequence:

AB028947.2 AF035294.1 AL110095.1 BC144700.1 BC152466.1

1 DOTS entry:

DT.410930

24/25 AceView cDNA sequences (see all 25):

BX485466 F13302 BX485465 AB028947 BM129225 AF035294 BX509345 BM129714

CK819641 F10900 BM129425 BQ787772 N54776 AI425065 BX099669 BM453711

H29603 BM713723 BQ434216 AL110095 AA310244 N45328 R18551 H29691

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KIAA1024 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAAATTGGC

About this image

KIAA1024 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KIAA1024 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIAA1024

SOURCE GeneReport for Unigene cluster: Hs.301654

SABiosciences Custom PCR Arrays for KIAA1024

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for KIAA1024 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KIAA1024¹	KIAA1024	75.39(n) 81.6(a)		415485 NM_001007827.1 NP_001007828.1
lizard (Anolis carolinensis)	Reptilia	KIAA1024⁶	--	76(a)	1 ↔ 1	GL343332.1(351349-367233)
zebrafish (Danio rerio)	Actinopterygii	LOC100331504¹	UPF0258 protein KIAA1024-like	63.42(n) 62.22(a)		100331504 XM_002667392.1 XP_002667438.1

ENSEMBL Gene Tree for KIAA1024 (if available)
TreeFam Gene Tree for KIAA1024 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KIAA1024 gene

KIAA1024L²

KIAA1024 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs34250647^1,2	C,F,	--	56509728(+)	`GCACTC/-CAGCC`	1	--	int¹		4		NA	8
rs151129385^1,2		--	79722996(+)	`GCAAGA/GTACAG`	1	--	us2k¹		0	--	--	--	--
rs140118669^1,2		--	79723155(+)	`CAACAC/TGTATC`	1	--	us2k¹		0	--	--	--	--
rs141125264^1,2	C,	--	79723230(+)	`TTTTT-/AAAAAA`	1	--	us2k¹		0	--	--	--	--
rs78361721^1,2	C,F,	--	79723242(+)	`CTTTTT/CATTAG`	1	--	us2k¹		1		EA	120
rs116858502^1,2	F,	--	79723364(+)	`CTGAGA/GCTGAG`	1	--	us2k¹		1		EA	120
rs190744304^1,2		--	79723382(+)	`TCCCCC/GCAGGG`	1	--	us2k¹		0	--	--	--	--
rs80242461^1,2	C,F,	--	79723400(+)	`TCCGAT/CCACAG`	1	--	us2k¹		1		WA	118
rs114326959^1,2	F,	--	79723585(+)	`CCCCGA/GAACTA`	1	--	us2k¹		1		WA	118
rs77758229^1,2	C,F,	--	79723669(+)	`CCCCAG/ACCACA`	1	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for KIAA1024 (79724858 - 79764642 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for KIAA1024
1 CNV: 72297
1 Indel: 72296

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KIAA1024 for disorders About GeneDecksing

1 disease for KIAA1024: About MalaCards

keratoconus

1 disease from the University of Copenhagen DISEASES database for KIAA1024:

Keratoconus

Export disorders for KIAA1024 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KIAA1024 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KIAA1024)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)^{1, 2, 3} Kikuno R....Ohara O. (1999)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Large-scale concatenation cDNA sequencing. (PubMed id 9110174)¹ Yu W.... Gibbs R.A. (1997)
A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)¹ Andersson B.... Gibbs R.A. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23251	HGNC: 29172	AceView: KIAA1024	Ensembl:ENSG00000169330	euGenes: HUgn23251
ECgene: KIAA1024	H-InvDB: KIAA1024

(According to HUGE)
About This Section

HUGE: KIAA1024

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KIAA1024	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KIAA1024 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for KIAA1024 gene:
Search GeneIP for patents involving KIAA1024

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1024

	SwitchGear 3'UTR luciferase reporter plasmids for KIAA1024
	Browse SwitchGear Promoter luciferase reporter plasmids for KIAA1024

Search ThermoFisher Antibodies for KIAA1024

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA1024

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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KIAA1024 Gene

KIAA1024

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KIAA1024 Gene

KIAA1024

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