KIAA1009 Gene
protein-coding GIFtS: 44
GCID: GC06M084891
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KIAA1009(Previous name: chromosome 6 open reading frame 84 )
(Previous symbol: C6orf84)
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Aliases
for KIAA1009 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| KIAA10091 2 | | C6orf841 2 3 | | QN11 2 3 | | Chromosome 6 Open Reading Frame 841 | | Protein QN1 Homolog2 |
Export aliases for KIAA1009 gene to outside databasesPrevious GC identifers: GC06M084780 GC06M082063 |
Summaries
for KIAA1009 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: QN1_HUMAN, Q5TB80Function: Functions in cell division regulating chromosome segregation and mitotic spindle assembly
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Genomic Views
for KIAA1009 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007299.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KIAA1009 gene promoter:
AML1a FOXD1 LCR-F1 C/EBPalpha MEF-2A POU2F1 FOXJ2 (long isoform) POU2F1a aMEF-2 FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for KIAA1009
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA1009 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q14.3 Ensembl cytogenetic band: 6q14.3 HGNC cytogenetic band: 6q14.3KIAA1009 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M084891: view genomic region
(about GC identifiers)
Start:
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84,833,960 bp from pter |
End:
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84,937,353 bp from pter |
Size:
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103,394 bases |
Orientation:
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minus strand |
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Proteins
for KIAA1009 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: QN1_HUMAN, Q5TB80 (See
protein sequence)Recommended Name: Protein QN1 homolog Size: 1403 amino acids; 161943 Da
Subunit: Interacts with alpha-tubulin (By similarity)
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Nucleus. Note=May alsolocalize to the cytoplasm (By similarity)
Miscellaneous: Depletion of KIAA1009 leads to abnormal mitosis leading to apoptosis
Sequence caution: Sequence=BAA76853.2; Type=Erroneous initiation;
Secondary accessions: A6PVL7 A6PVL8 Q6P475 Q9Y2L2Alternative splicing: 2 isoforms: Q5TB80-1 Q5TB80-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KIAA1009: NX_Q5TB80
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5TB80
KIAA1009 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055710.2
ENSEMBL proteins: ENSP00000257766 ENSP00000385215 ENSP00000410813
Human Recombinant Protein Products for KIAA1009:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
KIAA1009 for ontologies About GeneDecksing
KIAA1009 Antibody Products:
Assay Products for KIAA1009: |
Protein
Domains /
Families
for KIAA1009 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q5TB80 |
Function
for KIAA1009 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: QN1_HUMAN, Q5TB80Function: Functions in cell division regulating chromosome segregation and mitotic spindle assembly Genatlas biochemistry entry for KIAA1009:related to quail neuronal cell cycle withdrawal protein
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005515 | protein binding |
-- | -- |
KIAA1009 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1009 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1009 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for KIAA1009 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA1009 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1009 |
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Pathways & Interactions
for KIAA1009 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA1009
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for KIAA1009 (Q5TB803 ENSP000003852154) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
KIAA1009 for ontologies About GeneDecksing
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Drugs & Compounds
for KIAA1009 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KIAA1009
Search CenterWatch for drugs/clinical trials and news about KIAA1009 / QN1
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Transcripts
for KIAA1009 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KIAA1009 gene: NM_014895.2 Unigene Cluster for KIAA1009: KIAA1009 Hs.485865 [show with all ESTs]Unigene Representative Sequence: NM_0148956 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000257766(uc003pki.4 uc003pkj.4) ENST00000461137 ENST00000403245(uc010kbp.3 uc003pkk.2)
ENST00000487999 ENST00000497936 ENST00000435955
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1009 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1009 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KIAA1009 (NM_014895) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIAA1009 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA1009 |
Additional cDNA sequence: AB023226.1 AK023613.1 AK308190.1 BC127206.1 BC127207.1 6 DOTS entries: DT.452599 DT.99967385 DT.121334581 DT.99977045 DT.40202924 DT.101978881 24/69 AceView cDNA sequences (see all 69): BU622745 BG571270 BC063632 AA938917 BX483150 Z43299 CB215854 AA431701 BX280084 BQ773838 BX480748 BP377633 AB023226 Z39374 AA988550 CA428990 CA429366 AA953896 BG620341 BU677375 AI147106 AI474053 AK023613 BI825870
GeneLoc Exon Structure
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Expression
for KIAA1009 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KIAA1009 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACAAAGAGA
About this image
See KIAA1009 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIAA1009
SOURCE GeneReport for Unigene cluster: Hs.485865
SABiosciences Custom PCR Arrays for KIAA1009
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIAA1009
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIAA1009 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIAA1009 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIAA1009 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1009 |
Orthologs
for KIAA1009 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for KIAA1009 gene from 6/16 species (see all 16) About this table
ENSEMBL Gene Tree for KIAA1009 (if available)
TreeFam Gene Tree for KIAA1009 (if available) |
Paralogs
for KIAA1009 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for KIAA1009 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KIAA1009 (84833960 - 84937353 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KIAA1009: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIAA1009 |
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Disorders
/ Diseases
for KIAA1009 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KIAA1009 for disorders About GeneDecksing
OMIM gene information: 610201
OMIM disorders: --
3  diseases for KIAA1009: About MalaCardsinfective endocarditis endocarditis neuronitis
Export disorders for KIAA1009 gene to outside databases
|
Publications
for KIAA1009 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KIAA1009 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with KIAA1009) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- QN1/KIAA1009: a new essential protein for chromosome segregation and mitotic spindle assembly. (PubMed id 16302001)1, 2 Leon A.... Crisanti P. (2006)
- Expression, cellular distribution and protein binding of the glioma amplified sequence (GAS41), a highly conserved putative transcription factor. (PubMed id 11521196)1, 2 Munnia A.... Meese E. (2001)
- Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (1999)
- A yeast two-hybrid screen reveals that osteopontin ass ociates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PubMed id 22779921)1 Long P....Rose S. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)2 Denis N.J.... Figeys D. (2007)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
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External Searches for KIAA1009 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing KIAA1009 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing KIAA1009 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing KIAA1009 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KIAA1009 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for KIAA1009 gene:
Search GeneIP for patents involving KIAA1009
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KIAA1009 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KIAA1009 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIAA1009 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIAA1009 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for KIAA1009 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1009 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1009 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KIAA1009 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIAA1009 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA1009 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIAA1009 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIAA1009 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIAA1009 |
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 | | | KIAA1009 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1009 |
|  |  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA1009 |
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