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Aliases for KIAA0922 Gene

Aliases for KIAA0922 Gene

  • KIAA0922 2 3
  • TMEM131L 3 4
  • Transmembrane Protein 131-Like 3

External Ids for KIAA0922 Gene

Previous GeneCards Identifiers for KIAA0922 Gene

  • GC04P155355
  • GC04P154894
  • GC04P155055
  • GC04P154965
  • GC04P154745
  • GC04P154607
  • GC04P154387
  • GC04P150118

Summaries for KIAA0922 Gene

GeneCards Summary for KIAA0922 Gene

KIAA0922 (KIAA0922) is a Protein Coding gene. An important paralog of this gene is TMEM131.

UniProtKB/Swiss-Prot for KIAA0922 Gene

  • Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA0922 Gene

Genomics for KIAA0922 Gene

Regulatory Elements for KIAA0922 Gene

Enhancers for KIAA0922 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F153438 1.2 FANTOM5 Ensembl ENCODE 28.8 -27.0 -26987 2.5 HDGF TBL1XR1 MTA2 ZBED1 YBX1 EBF1 TBX21 ZBTB40 IKZF1 NBN KIAA0922 MND1 GC04P153424
GH04F153485 1.3 Ensembl ENCODE 18.1 +26.5 26539 15.1 HDGF PKNOX1 WRNIP1 SIN3A FEZF1 ZNF2 YY1 FOS ZNF263 JUNB KIAA0922 MND1 PIR44013
GH04F153425 1.2 FANTOM5 Ensembl ENCODE 17.5 -38.6 -38615 4.5 CTCF CBX3 ZNF740 HLF PTRF RAD21 CREB3 IRF1 ZNF584 KIAA0922 RNF175 GC04P153424
GH04F153432 1.6 FANTOM5 Ensembl ENCODE 13 -32.8 -32802 2.7 HDGF PKNOX1 ARNT SIN3A ARID4B YBX1 ZNF48 YY1 GTF3C2 ELK1 MND1 KIAA0922 TLR2 GC04P153424
GH04F153512 1 Ensembl ENCODE 15.7 +47.7 47692 2.9 PKNOX1 JUN INSM2 FEZF1 ZNF2 HIC1 ZNF664 ZNF316 ZNF366 ZNF391 KIAA0922 MND1 RNF175 PIR44013 PIR33610
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIAA0922 on UCSC Golden Path with GeneCards custom track

Promoters for KIAA0922 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001436471 1254 4001 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 GLIS2

Genomic Location for KIAA0922 Gene

Chromosome:
4
Start:
153,466,346 bp from pter
End:
153,637,608 bp from pter
Size:
171,263 bases
Orientation:
Plus strand

Genomic View for KIAA0922 Gene

Genes around KIAA0922 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA0922 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA0922 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA0922 Gene

Proteins for KIAA0922 Gene

  • Protein details for KIAA0922 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2VDJ0-T131L_HUMAN
    Recommended name:
    Transmembrane protein 131-like
    Protein Accession:
    A2VDJ0
    Secondary Accessions:
    • B3KRV3
    • D3DP10
    • Q7LGA7
    • Q86Y92
    • Q8WU56
    • Q9H065
    • Q9Y2D7

    Protein attributes for KIAA0922 Gene

    Size:
    1609 amino acids
    Molecular mass:
    179339 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIAA0922 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA0922 Gene

Post-translational modifications for KIAA0922 Gene

  • Ubiquitination at Lys 199, Lys 246, Lys 572, Lys 686, and Lys 699
  • Glycosylation at Asn 343, Asn 439, Asn 522, Asn 593, Asn 709, and Asn 846
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KIAA0922 Gene

Domains & Families for KIAA0922 Gene

Protein Domains for KIAA0922 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA0922 Gene

Graphical View of Domain Structure for InterPro Entry

A2VDJ0

UniProtKB/Swiss-Prot:

T131L_HUMAN :
  • Belongs to the TMEM131 family.
Family:
  • Belongs to the TMEM131 family.
genes like me logo Genes that share domains with KIAA0922: view

No data available for Gene Families for KIAA0922 Gene

Function for KIAA0922 Gene

Molecular function for KIAA0922 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.
genes like me logo Genes that share phenotypes with KIAA0922: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA0922 Gene

Localization for KIAA0922 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA0922 Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=During intrathymic development, resides in punctate cytoplasmic structures in DN1 and DN2 cells. In DN3 cells, found in large crescent-shaped membrane structures, which preferentially localize in cell-to-cell contact zones. {ECO:0000269 PubMed:23690469}.
Isoform 1: Endoplasmic reticulum. Note=Transmembrane localization is essential for Wnt signaling inhibition. {ECO:0000269 PubMed:23690469}.
Isoform 5: Cytoplasm. Note=Scattered throughout the cytoplasm in small-sized punctate structures. {ECO:0000269 PubMed:23690469}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA0922 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 3
extracellular 2
nucleus 2
lysosome 1

Gene Ontology (GO) - Cellular Components for KIAA0922 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 23690469
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane IEA,IDA 23690469
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KIAA0922: view

Pathways & Interactions for KIAA0922 Gene

SuperPathways for KIAA0922 Gene

No Data Available

Interacting Proteins for KIAA0922 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000386787%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000264018%0d%0a9606.ENSP00000367207%0d%0a
Selected Interacting proteins: ENSP00000386787 A2VDJ0-T131L_HUMAN for KIAA0922 Gene via STRING IID

Gene Ontology (GO) - Biological Process for KIAA0922 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016055 Wnt signaling pathway IEA --
GO:0033088 negative regulation of immature T cell proliferation in thymus IMP 23690469
GO:0090090 negative regulation of canonical Wnt signaling pathway IDA 23690469
genes like me logo Genes that share ontologies with KIAA0922: view

No data available for Pathways by source and SIGNOR curated interactions for KIAA0922 Gene

Transcripts for KIAA0922 Gene

Unigene Clusters for KIAA0922 Gene

KIAA0922:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0922 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1: - - -
SP2: - -
SP3:
SP4:
SP5:

ExUns: 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35 ^ 36 ^ 37
SP1: - -
SP2:
SP3:
SP4:
SP5:

Relevant External Links for KIAA0922 Gene

GeneLoc Exon Structure for
KIAA0922
ECgene alternative splicing isoforms for
KIAA0922

Expression for KIAA0922 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIAA0922 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIAA0922 Gene

This gene is overexpressed in Whole Blood (x5.5).

Protein differential expression in normal tissues from HIPED for KIAA0922 Gene

This gene is overexpressed in Heart (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIAA0922 Gene



Protein tissue co-expression partners for KIAA0922 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KIAA0922 Gene:

KIAA0922

SOURCE GeneReport for Unigene cluster for KIAA0922 Gene:

Hs.732450

mRNA Expression by UniProt/SwissProt for KIAA0922 Gene:

A2VDJ0-T131L_HUMAN
Tissue specificity: Expressed in thymocytes.
genes like me logo Genes that share expression patterns with KIAA0922: view

Primer Products

Orthologs for KIAA0922 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIAA0922 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA0922 34 35
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia KIAA0922 34 35
  • 89.74 (n)
cow
(Bos Taurus)
Mammalia KIAA0922 34 35
  • 84.78 (n)
rat
(Rattus norvegicus)
Mammalia LOC679811 34
  • 82.1 (n)
mouse
(Mus musculus)
Mammalia D930015E06Rik 34 16 35
  • 81.86 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA0922 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA0922 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA0922 34 35
  • 71.18 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA0922 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa0922 34
  • 59.67 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9794 34
zebrafish
(Danio rerio)
Actinopterygii si:ch211-208h7.4 34 35
  • 50.9 (n)
Dr.26860 34
fruit fly
(Drosophila melanogaster)
Insecta CG8370 35
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C27F2.8 35
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToOne
Species where no ortholog for KIAA0922 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIAA0922 Gene

ENSEMBL:
Gene Tree for KIAA0922 (if available)
TreeFam:
Gene Tree for KIAA0922 (if available)

Paralogs for KIAA0922 Gene

Paralogs for KIAA0922 Gene

genes like me logo Genes that share paralogs with KIAA0922: view

Variants for KIAA0922 Gene

Sequence variations from dbSNP and Humsavar for KIAA0922 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10000932 -- 153,599,409(+) aaacc(A/G)tatca intron-variant
rs10001174 -- 153,553,113(+) ATTTC(A/T)GATTT intron-variant
rs10001304 -- 153,539,656(+) GCAGG(A/G)GGCTC intron-variant
rs10001845 -- 153,557,070(+) GGAGT(C/T)CTTTC reference, synonymous-codon
rs10003974 -- 153,570,226(+) TTCAC(A/G)TCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA0922 Gene

Variant ID Type Subtype PubMed ID
nsv949833 CNV duplication 24416366
nsv830118 CNV loss 17160897
nsv595749 CNV gain 21841781
nsv1022081 CNV gain 25217958
esv3602727 CNV loss 21293372
esv3602726 CNV loss 21293372
esv3602725 CNV loss 21293372
esv3432324 CNV duplication 20981092
esv2728553 CNV deletion 23290073
esv2678129 CNV deletion 23128226
esv2661180 CNV deletion 23128226

Variation tolerance for KIAA0922 Gene

Residual Variation Intolerance Score: 17.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.61; 86.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA0922 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA0922

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA0922 Gene

Disorders for KIAA0922 Gene

Relevant External Links for KIAA0922

Genetic Association Database (GAD)
KIAA0922
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA0922

No disorders were found for KIAA0922 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA0922 Gene

Publications for KIAA0922 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 64
  3. Identification of TMEM131L as a novel regulator of thymocyte proliferation in humans. (PMID: 23690469) Maharzi N. … Canque B. (J. Immunol. 2013) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for KIAA0922 Gene

Sources for KIAA0922 Gene

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