Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KIAA0922 Gene

Aliases for KIAA0922 Gene

  • KIAA0922 2 3
  • TMEM131L 3 4
  • Transmembrane Protein 131-Like 3

External Ids for KIAA0922 Gene

Previous GeneCards Identifiers for KIAA0922 Gene

  • GC04P155355
  • GC04P154894
  • GC04P155055
  • GC04P154965
  • GC04P154745
  • GC04P154607
  • GC04P154387
  • GC04P150118

Summaries for KIAA0922 Gene

GeneCards Summary for KIAA0922 Gene

KIAA0922 (KIAA0922) is a Protein Coding gene. An important paralog of this gene is TMEM131.

UniProtKB/Swiss-Prot for KIAA0922 Gene

  • Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA0922 Gene

Genomics for KIAA0922 Gene

Regulatory Elements for KIAA0922 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KIAA0922 Gene

153,466,346 bp from pter
153,636,856 bp from pter
170,511 bases
Plus strand

Genomic View for KIAA0922 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIAA0922 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA0922 Gene

Proteins for KIAA0922 Gene

  • Protein details for KIAA0922 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 131-like
    Protein Accession:
    Secondary Accessions:
    • B3KRV3
    • D3DP10
    • Q7LGA7
    • Q86Y92
    • Q8WU56
    • Q9H065
    • Q9Y2D7

    Protein attributes for KIAA0922 Gene

    1609 amino acids
    Molecular mass:
    179339 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIAA0922 Gene


neXtProt entry for KIAA0922 Gene

Proteomics data for KIAA0922 Gene at MOPED

Post-translational modifications for KIAA0922 Gene

  • Ubiquitination at Lys199, Lys246, Lys572, Lys686, and Lys699
  • Glycosylation at Asn343, Asn439, Asn522, Asn593, Asn709, and Asn846
  • Modification sites at PhosphoSitePlus

Other Protein References for KIAA0922 Gene

No data available for DME Specific Peptides for KIAA0922 Gene

Domains for KIAA0922 Gene

Protein Domains for KIAA0922 Gene


Suggested Antigen Peptide Sequences for KIAA0922 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM131 family.
  • Belongs to the TMEM131 family.
genes like me logo Genes that share domains with KIAA0922: view

No data available for Gene Families for KIAA0922 Gene

Function for KIAA0922 Gene

Molecular function for KIAA0922 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.

Animal Model Products

CRISPR Products

miRNA for KIAA0922 Gene

miRTarBase miRNAs that target KIAA0922

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA0922 Gene

Localization for KIAA0922 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA0922 Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=During intrathymic development, resides in punctate cytoplasmic structures in DN1 and DN2 cells. In DN3 cells, found in large crescent-shaped membrane structures, which preferentially localize in cell-to-cell contact zones. {ECO:0000269 PubMed:23690469}.
Isoform 1: Endoplasmic reticulum. Note=Transmembrane localization is essential for Wnt signaling inhibition. {ECO:0000269 PubMed:23690469}.
Isoform 5: Cytoplasm. Note=Scattered throughout the cytoplasm in small-sized punctate structures. {ECO:0000269 PubMed:23690469}.

Subcellular locations from

Jensen Localization Image for KIAA0922 Gene COMPARTMENTS Subcellular localization image for KIAA0922 gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KIAA0922 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 23690469
GO:0005886 plasma membrane IDA 23690469
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KIAA0922: view

Pathways for KIAA0922 Gene

SuperPathways for KIAA0922 Gene

No Data Available

Interacting Proteins for KIAA0922 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000386787 A2VDJ0-T131L_HUMAN for KIAA0922 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for KIAA0922 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033088 negative regulation of immature T cell proliferation in thymus IMP 23690469
GO:0090090 negative regulation of canonical Wnt signaling pathway IDA 23690469
genes like me logo Genes that share ontologies with KIAA0922: view

No data available for Pathways by source for KIAA0922 Gene

Transcripts for KIAA0922 Gene

Unigene Clusters for KIAA0922 Gene

Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIAA0922

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0922 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1: - - -
SP2: - -

ExUns: 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35 ^ 36 ^ 37
SP1: - -

Relevant External Links for KIAA0922 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KIAA0922 Gene

mRNA expression in normal human tissues for KIAA0922 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIAA0922 Gene

This gene is overexpressed in Whole Blood (5.5).

Protein differential expression in normal tissues for KIAA0922 Gene

This gene is overexpressed in Heart (68.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIAA0922 Gene

SOURCE GeneReport for Unigene cluster for KIAA0922 Gene Hs.732450

mRNA Expression by UniProt/SwissProt for KIAA0922 Gene

Tissue specificity: Expressed in thymocytes.
genes like me logo Genes that share expressions with KIAA0922: view

Expression partners for KIAA0922 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for KIAA0922 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIAA0922 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KIAA0922 35
  • 84.78 (n)
  • 81.97 (a)
KIAA0922 36
  • 81 (a)
(Canis familiaris)
Mammalia KIAA0922 35
  • 89.74 (n)
  • 87.98 (a)
KIAA0922 36
  • 88 (a)
(Mus musculus)
Mammalia D930015E06Rik 35
  • 81.86 (n)
  • 77.34 (a)
D930015E06Rik 16
D930015E06Rik 36
  • 77 (a)
(Pan troglodytes)
Mammalia KIAA0922 35
  • 99.52 (n)
  • 99.11 (a)
KIAA0922 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC679811 35
  • 82.1 (n)
  • 77.89 (a)
(Monodelphis domestica)
Mammalia KIAA0922 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia KIAA0922 36
  • 70 (a)
(Gallus gallus)
Aves KIAA0922 35
  • 71.18 (n)
  • 64.08 (a)
KIAA0922 36
  • 61 (a)
(Anolis carolinensis)
Reptilia KIAA0922 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa0922 35
  • 59.67 (n)
  • 50.06 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9794 35
(Danio rerio)
Actinopterygii Dr.26860 35
si:ch211-208h7.4 35
  • 50.9 (n)
  • 38.95 (a)
si:ch211-208h7.4 36
  • 32 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8370 36
  • 14 (a)
(Caenorhabditis elegans)
Secernentea C27F2.8 36
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for KIAA0922:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIAA0922 Gene

Gene Tree for KIAA0922 (if available)
Gene Tree for KIAA0922 (if available)

Paralogs for KIAA0922 Gene

Paralogs for KIAA0922 Gene

genes like me logo Genes that share paralogs with KIAA0922: view

Variants for KIAA0922 Gene

Sequence variations from dbSNP and Humsavar for KIAA0922 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs713247 -- 153,487,208(-) CATTA(G/T)TTAAT intron-variant
rs713248 -- 153,487,302(-) TAAAA(C/T)CCTGG intron-variant
rs731442 -- 153,544,209(+) GGAAT(A/G)TGGAA intron-variant
rs754196 -- 153,555,347(-) ACAAA(C/T)GAAAA intron-variant
rs755078 - 153,604,344(+) GACCT(A/C)CAAGA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for KIAA0922 Gene

Variant ID Type Subtype PubMed ID
nsv830118 CNV Loss 17160897
esv2678129 CNV Deletion 23128226
esv2661180 CNV Deletion 23128226
esv2728553 CNV Deletion 23290073
nsv482972 CNV Gain 15286789

Relevant External Links for KIAA0922 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA0922 Gene

Disorders for KIAA0922 Gene

Relevant External Links for KIAA0922

Genetic Association Database (GAD)

No disorders were found for KIAA0922 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for KIAA0922 Gene

Publications for KIAA0922 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Identification of TMEM131L as a novel regulator of thymocyte proliferation in humans. (PMID: 23690469) Maharzi N. … Canque B. (J. Immunol. 2013) 3 4
  5. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PMID: 17903295) Lunetta K.L. … Murabito J.M. (BMC Med. Genet. 2007) 48

Products for KIAA0922 Gene

Sources for KIAA0922 Gene

Back to Top