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Aliases for KIAA0922 Gene

Aliases for KIAA0922 Gene

  • KIAA0922 2 3
  • TMEM131L 3 4

External Ids for KIAA0922 Gene

Previous GeneCards Identifiers for KIAA0922 Gene

  • GC04P155355
  • GC04P154894
  • GC04P155055
  • GC04P154965
  • GC04P154745
  • GC04P154607
  • GC04P154387
  • GC04P150118

Summaries for KIAA0922 Gene

GeneCards Summary for KIAA0922 Gene

KIAA0922 (KIAA0922) is a Protein Coding gene. An important paralog of this gene is TMEM131.

UniProtKB/Swiss-Prot for KIAA0922 Gene

  • Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA0922 Gene

Genomics for KIAA0922 Gene

Regulatory Elements for KIAA0922 Gene

Promoters for KIAA0922 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KIAA0922 on UCSC Golden Path with GeneCards custom track

Genomic Location for KIAA0922 Gene

Chromosome:
4
Start:
153,466,346 bp from pter
End:
153,637,608 bp from pter
Size:
171,263 bases
Orientation:
Plus strand

Genomic View for KIAA0922 Gene

Genes around KIAA0922 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA0922 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA0922 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA0922 Gene

Proteins for KIAA0922 Gene

  • Protein details for KIAA0922 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2VDJ0-T131L_HUMAN
    Recommended name:
    Transmembrane protein 131-like
    Protein Accession:
    A2VDJ0
    Secondary Accessions:
    • B3KRV3
    • D3DP10
    • Q7LGA7
    • Q86Y92
    • Q8WU56
    • Q9H065
    • Q9Y2D7

    Protein attributes for KIAA0922 Gene

    Size:
    1609 amino acids
    Molecular mass:
    179339 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIAA0922 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA0922 Gene

Proteomics data for KIAA0922 Gene at MOPED

Post-translational modifications for KIAA0922 Gene

  • Ubiquitination at Lys 199, Lys 246, Lys 572, Lys 686, and Lys 699
  • Glycosylation at Asn 343, Asn 439, Asn 522, Asn 593, Asn 709, and Asn 846
  • Modification sites at PhosphoSitePlus

Other Protein References for KIAA0922 Gene

No data available for DME Specific Peptides for KIAA0922 Gene

Domains & Families for KIAA0922 Gene

Protein Domains for KIAA0922 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA0922 Gene

Graphical View of Domain Structure for InterPro Entry

A2VDJ0

UniProtKB/Swiss-Prot:

T131L_HUMAN :
  • Belongs to the TMEM131 family.
Family:
  • Belongs to the TMEM131 family.
genes like me logo Genes that share domains with KIAA0922: view

No data available for Gene Families for KIAA0922 Gene

Function for KIAA0922 Gene

Molecular function for KIAA0922 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.
genes like me logo Genes that share phenotypes with KIAA0922: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA0922 Gene

Localization for KIAA0922 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA0922 Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=During intrathymic development, resides in punctate cytoplasmic structures in DN1 and DN2 cells. In DN3 cells, found in large crescent-shaped membrane structures, which preferentially localize in cell-to-cell contact zones. {ECO:0000269 PubMed:23690469}.
Isoform 1: Endoplasmic reticulum. Note=Transmembrane localization is essential for Wnt signaling inhibition. {ECO:0000269 PubMed:23690469}.
Isoform 5: Cytoplasm. Note=Scattered throughout the cytoplasm in small-sized punctate structures. {ECO:0000269 PubMed:23690469}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA0922 Gene COMPARTMENTS Subcellular localization image for KIAA0922 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 3
extracellular 2
nucleus 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for KIAA0922 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 23690469
genes like me logo Genes that share ontologies with KIAA0922: view

Pathways & Interactions for KIAA0922 Gene

SuperPathways for KIAA0922 Gene

No Data Available

Interacting Proteins for KIAA0922 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000386787%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000264018%0d%0a9606.ENSP00000367207%0d%0a
Selected Interacting proteins: A2VDJ0-T131L_HUMAN ENSP00000386787 for KIAA0922 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for KIAA0922 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090090 negative regulation of canonical Wnt signaling pathway IDA 23690469
genes like me logo Genes that share ontologies with KIAA0922: view

No data available for Pathways by source and SIGNOR curated interactions for KIAA0922 Gene

Drugs & Compounds for KIAA0922 Gene

No Compound Related Data Available

Transcripts for KIAA0922 Gene

Unigene Clusters for KIAA0922 Gene

KIAA0922:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0922 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1: - - -
SP2: - -
SP3:
SP4:
SP5:

ExUns: 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35 ^ 36 ^ 37
SP1: - -
SP2:
SP3:
SP4:
SP5:

Relevant External Links for KIAA0922 Gene

GeneLoc Exon Structure for
KIAA0922
ECgene alternative splicing isoforms for
KIAA0922

Expression for KIAA0922 Gene

mRNA expression in normal human tissues for KIAA0922 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIAA0922 Gene

This gene is overexpressed in Whole Blood (x5.5).

Protein differential expression in normal tissues from HIPED for KIAA0922 Gene

This gene is overexpressed in Heart (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for KIAA0922 Gene



SOURCE GeneReport for Unigene cluster for KIAA0922 Gene Hs.732450

mRNA Expression by UniProt/SwissProt for KIAA0922 Gene

A2VDJ0-T131L_HUMAN
Tissue specificity: Expressed in thymocytes.
genes like me logo Genes that share expression patterns with KIAA0922: view

Protein tissue co-expression partners for KIAA0922 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for KIAA0922 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIAA0922 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIAA0922 35
  • 84.78 (n)
  • 81.97 (a)
KIAA0922 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA0922 35
  • 89.74 (n)
  • 87.98 (a)
KIAA0922 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia D930015E06Rik 35
  • 81.86 (n)
  • 77.34 (a)
D930015E06Rik 16
D930015E06Rik 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIAA0922 35
  • 99.52 (n)
  • 99.11 (a)
KIAA0922 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC679811 35
  • 82.1 (n)
  • 77.89 (a)
oppossum
(Monodelphis domestica)
Mammalia KIAA0922 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA0922 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA0922 35
  • 71.18 (n)
  • 64.08 (a)
KIAA0922 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA0922 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa0922 35
  • 59.67 (n)
  • 50.06 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9794 35
zebrafish
(Danio rerio)
Actinopterygii Dr.26860 35
si:ch211-208h7.4 35
  • 50.9 (n)
  • 38.95 (a)
si:ch211-208h7.4 36
  • 32 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8370 36
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C27F2.8 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToOne
Species with no ortholog for KIAA0922:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIAA0922 Gene

ENSEMBL:
Gene Tree for KIAA0922 (if available)
TreeFam:
Gene Tree for KIAA0922 (if available)

Paralogs for KIAA0922 Gene

Paralogs for KIAA0922 Gene

genes like me logo Genes that share paralogs with KIAA0922: view

Variants for KIAA0922 Gene

Sequence variations from dbSNP and Humsavar for KIAA0922 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs7669418 - 153,592,475(+) CCTAG(A/G)TCAAG intron-variant, reference, missense
rs17370297 - 153,593,813(+) TGATA(C/T)GCAGA reference, missense
rs755078 - 153,604,344(+) GACCT(A/C/G/T)CAAGA reference, missense
rs35018723 - 153,621,754(-) TTACA(C/T)TGATG reference, missense
rs35543386 - 153,627,657(-) CCCGG(C/G)AGGAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KIAA0922 Gene

Variant ID Type Subtype PubMed ID
nsv830118 CNV Loss 17160897
esv2678129 CNV Deletion 23128226
esv2661180 CNV Deletion 23128226
esv2728553 CNV Deletion 23290073
nsv482972 CNV Gain 15286789

Variation tolerance for KIAA0922 Gene

Residual Variation Intolerance Score: 17.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.61; 86.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA0922 Gene

HapMap Linkage Disequilibrium report
KIAA0922

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA0922 Gene

Disorders for KIAA0922 Gene

Relevant External Links for KIAA0922

Genetic Association Database (GAD)
KIAA0922
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA0922

No disorders were found for KIAA0922 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA0922 Gene

Publications for KIAA0922 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PMID: 23648065) Low S.K. … Nakamura Y. (Cancer Sci. 2013) 3
  5. Identification of TMEM131L as a novel regulator of thymocyte proliferation in humans. (PMID: 23690469) Maharzi N. … Canque B. (J. Immunol. 2013) 3

Products for KIAA0922 Gene

Sources for KIAA0922 Gene

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