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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIAA0922 Gene

protein-coding   GIFtS: 46
GCID: GC04P154387

KIAA0922

  Search for KIAA0922
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
KIAA09221 2
TMEM131L2 3
Transmembrane Protein 131-Like2

External Ids:    HGNC: 291461   Entrez Gene: 232402   Ensembl: ENSG000001212107   UniProtKB: A2VDJ03   

Export aliases for KIAA0922 gene to outside databases

Previous GC identifers: GC04P155355 GC04P154894 GC04P155055 GC04P154965 GC04P154745 GC04P154607 GC04P150118


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KIAA0922 Gene: 
KIAA0922 (KIAA0922) is a protein-coding gene. An important paralog of this gene is TMEM131.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIAA0922 gene promoter:
         TBP   Pax-5   E47   GATA-1   c-Ets-1   POU2F1   POU2F1a   TFIID   HFH-1   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KIAA0922

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA0922


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.3   Ensembl cytogenetic band:  4q31.3   HGNC cytogenetic band: 4q31.3

KIAA0922 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA0922 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P154387:  view genomic region     (about GC identifiers)

Start:
154,387,498 bp from pter      End:
154,557,863 bp from pter
Size:
170,366 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: T131L_HUMAN, A2VDJ0 (See protein sequence)
Recommended Name: Transmembrane protein 131-like precursor  
Size: 1609 amino acids; 179339 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: B3KRV3 Q7LGA7 Q86Y92 Q8WU56 Q9H065 Q9Y2D7
Alternative splicing: 4 isoforms:  A2VDJ0-1   A2VDJ0-2   A2VDJ0-3   A2VDJ0-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KIAA0922: NX_A2VDJ0

Explore proteomics data for KIAA0922 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A2VDJ0

  • KIAA0922 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KIAA0922 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001124479.1  NP_056011.3  

    ENSEMBL proteins: 
     ENSP00000386574   ENSP00000413054   ENSP00000386787   ENSP00000240487   ENSP00000409663  

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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    KIAA0922 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR022113 DUF3651_TMEM131

    Graphical View of Domain Structure for InterPro Entry A2VDJ0

    ProtoNet protein and cluster: A2VDJ0

    UniProtKB/Swiss-Prot: T131L_HUMAN, A2VDJ0
    Similarity: Belongs to the TMEM131 family


    KIAA0922 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KIAA0922 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KIAA0922 
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    SwitchGear 3'UTR luciferase reporter plasmidKIAA0922 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA0922

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for KIAA0922 (A2VDJ03 ENSP000003867874) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIAA0922 (T131L)

    Search CenterWatch for drugs/clinical trials and news about KIAA0922 / T131L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIAA0922 gene (2 alternative transcripts): 
    NM_001131007.1  NM_015196.3  

    Unigene Cluster for KIAA0922:

    KIAA0922
    Hs.732450  [show with all ESTs]
    Unigene Representative Sequence: NM_001131007
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409663(uc010ipp.3 uc003inm.4) ENST00000445960 ENST00000409959(uc010ipq.3)
    ENST00000462540 ENST00000240487(uc010ips.1) ENST00000509565 ENST00000497247
    ENST00000478919 ENST00000440693
    miRNA
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    hsa-miR-20a hsa-miR-519d hsa-miR-130a* hsa-miR-106a hsa-miR-106b hsa-miR-23c hsa-miR-4282 hsa-miR-548t
    SwitchGear 3'UTR luciferase reporter plasmidKIAA0922 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB023139.1 AK001454.1 AK092270.1 AK096538.1 AK308448.1 BC044932.1 BC131505.1 

    11 DOTS entries:

    DT.113268  DT.100763815  DT.95269968  DT.92046368  DT.97855222  DT.99972444  DT.95186518  DT.97766379 
    DT.121252328  DT.91695655  DT.91887563 

    24/149 AceView cDNA sequences (see all 149):

    AW452654 BM970288 CA426543 AA598429 BU618854 AW572663 AW504212 AA126528 
    BE646203 BE855727 BQ181324 AI624173 CA487192 CK431153 AW575157 BM681941 
    AK128028 AW169266 AW501402 BM680569 AW444733 AA456498 BC044932 BQ007940 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0922    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:                                                  -                                                           -     -                                       
    SP2:                          -                       -                                                                                                         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35 ^ 36 ^ 37
    SP1:                                                        -           -                     
    SP2:                                                                                          
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for KIAA0922

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIAA0922 expression in normal human tissues (normalized intensities)      KIAA0922 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAACCAAG
    KIAA0922 Expression
    About this image


    KIAA0922 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
             ganglion/cranial   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             Double Negative 3 Thymocytes Thymus
             Thymus
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             LYMPH NODE   

    See KIAA0922 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIAA0922

    SOURCE GeneReport for Unigene cluster: Hs.732450
        SABiosciences Custom PCR Arrays for KIAA0922
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA0922

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KIAA0922 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia D930015E06Rik1 , 5 RIKEN cDNA D930015E06 gene1, 5 82.13(n)1
    77.9(a)1
      3 (37.42 cM)5
    2294731  NM_172681.41  NP_766269.31 
     838982875 
    chicken
    (Gallus gallus)
    Aves KIAA09221 KIAA0922 71.21(n)
    63.96(a)
      422400  XM_420366.3  XP_420366.3 
    lizard
    (Anolis carolinensis)
    Reptilia KIAA09226
    KIAA0922
    60(a)
    1 ↔ 1
    5(130992603-131027274)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.97942 Xenopus laevis transcribed sequence with weak similarity more 76.16(n)    BM192572.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.268602 Transcribed sequence with weak similarity to protein more 74.31(n)    AL719886.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG83706
    --
    11(a)
    1 → many
    2R(11888628-11894413)
    worm
    (Caenorhabditis elegans)
    Secernentea C27F2.86
    Protein C27F2.8
    12(a)
    1 → many
    III(4991427-4998161)


    ENSEMBL Gene Tree for KIAA0922 (if available)
    TreeFam Gene Tree for KIAA0922 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIAA0922 gene
    TMEM1312  

    KIAA0922 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3775 SNPs in KIAA0922 are shown (see all 3775)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1932830501,2
    --154385567(+) AAAAGC/TTATAG 2 -- us2k10--------
    rs110998851,2
    C,F,A,H--154385570(+) AGCTAT/CAGCAG 2 -- us2k19Minor allele frequency- C:0.31NA CSA WA EA 370
    rs126447341,2
    C,F,A,H--154385594(+) TCCATA/GGCAAT 2 -- us2k110Minor allele frequency- G:0.31NA CSA WA EA 372
    rs76875591,2
    C,F,A,H--154385925(+) TAACTG/CCGTGG 2 -- us2k118Minor allele frequency- C:0.50NS EA NA WA CSA 797
    rs605636191,2
    C,F--154385935(+) GGGGAC/ACTTCA 2 -- us2k12Minor allele frequency- A:0.10WA 120
    rs107144631,2
    C,F--154386110(+) GTCCC-/TTTTTT 2 -- us2k1 trp33Minor allele frequency- T:0.33NA CSA 6
    rs2009543541,2
    C--154386110(+) GTCCCC/TTTTTT 2 -- us2k10--------
    rs1837446931,2
    --154386177(+) AAGCAA/GTTAGA 2 -- us2k10--------
    rs105934081,2
    C--154386216(+) AGACA-/GTGTGTG 2 -- us2k10--------
    rs600722981,2
    C,F--154386295(+) AGGATT/AGTGTC 2 -- us2k12Minor allele frequency- A:0.12WA 120

    HapMap Linkage Disequilibrium report for KIAA0922 (154387498 - 154557863 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for KIAA0922:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2728553CNV Deletion23290073
    esv2678129CNV Deletion23128226
    esv2661180CNV Deletion23128226
    nsv830118CNV Loss17160897
    nsv482972CNV Gain15286789

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KIAA0922 for disorders           About MalaCards

    KIAA0922 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KIAA0922

    Export disorders for KIAA0922 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIAA0922 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with KIAA0922)
        Utopia: connect your pdf to the dynamic
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    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (1999)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Identification of TMEM131L as a novel regulator of thy mocyte proliferation in humans. (PubMed id 23690469)1 Maharzi N....Canque B. (2013)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PubMed id 17903295)4 Lunetta K.L....Murabito J.M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23240 HGNC: 29146 AceView: KIAA0922 Ensembl:ENSG00000121210 euGenes: HUgn23240
    ECgene: KIAA0922 H-InvDB: KIAA0922

    (According to HUGE)
    About This Section
    HUGE: KIAA0922

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIAA0922 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIAA0922 gene:
    Search GeneIP for patents involving KIAA0922

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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