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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIAA0907 Gene

protein-coding   GIFtS: 41
GCID: GC01M155882

KIAA0907

  Search for KIAA0907
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
KIAA09071 2
BLOM72 3
RP11-336K24.12
UPF0469 Protein KIAA09072

External Ids:    HGNC: 291451   Entrez Gene: 228892   Ensembl: ENSG000001326807   UniProtKB: Q7Z7F03   

Export aliases for KIAA0907 gene to outside databases

Previous GC identifers: GC01M153746 GC01M151642 GC01M152660 GC01M153099 GC01M152695 GC01M154149 GC01M127243


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KIAA0907 Gene: 
KIAA0907 (KIAA0907) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIAA0907 gene promoter:
         NF-1   NF-1/L   POU3F1   AP-4   C/EBPalpha   CREB   deltaCREB   Sox9   c-Myb   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIAA0907 promoter sequence
   Search SABiosciences Chromatin IP Primers for KIAA0907

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA0907


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

KIAA0907 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA0907 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M155882:  view genomic region     (about GC identifiers)

Start:
155,882,834 bp from pter      End:
155,904,191 bp from pter
Size:
21,358 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: K0907_HUMAN, Q7Z7F0 (See protein sequence)
Recommended Name: UPF0469 protein KIAA0907  
Size: 614 amino acids; 64845 Da
Sequence caution: Sequence=BAA74930.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for KIAA0907:
2YQR (3D)    
Secondary accessions: O94981 Q7L7Q2 Q7Z7E9 Q8TBQ0
Alternative splicing: 4 isoforms:  Q7Z7F0-1   Q7Z7F0-2   Q7Z7F0-3   Q7Z7F0-4   

Explore the universe of human proteins at neXtProt for KIAA0907: NX_Q7Z7F0

Explore proteomics data for KIAA0907 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z7F0

  • KIAA0907 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KIAA0907 Protein Expression
    REFSEQ proteins: NP_055764.2  
    ENSEMBL proteins: 
     ENSP00000357304   ENSP00000357303   ENSP00000357302  

    Human Recombinant Protein Products for KIAA0907: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q7Z7F0

    UniProtKB/Swiss-Prot: K0907_HUMAN, Q7Z7F0
    Similarity: Belongs to the UPF0469 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KIAA0907 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KIAA0907

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KIAA0907 
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    SwitchGear 3'UTR luciferase reporter plasmidKIAA0907 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA0907

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for KIAA0907 (Q7Z7F03 ENSP000003573044) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    U2AF2P263683, ENSP000003078634I2D: score=4 STRING: ENSP00000307863
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIAA0907 (K0907)

    Search CenterWatch for drugs/clinical trials and news about KIAA0907 / K0907

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIAA0907 gene: 
    NM_014949.2  

    Unigene Cluster for KIAA0907:

    KIAA0907
    Hs.24656  [show with all ESTs]
    Unigene Representative Sequence: AB020714
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368321(uc001fmi.1 uc009wrl.1 uc001fml.1 uc001fmm.3)
    ENST00000368320(uc001fmj.1) ENST00000478002 ENST00000466520 ENST00000465953
    ENST00000483237 ENST00000368319 ENST00000482337 ENST00000466713(uc001fmo.3)
    ENST00000491599
    miRNA
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    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate KIAA0907 (see all 35):
    hsa-miR-596 hsa-miR-4291 hsa-miR-3194-5p hsa-miR-607 hsa-miR-374a hsa-miR-371-5p hsa-miR-105 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidKIAA0907 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KIAA0907
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIAA0907
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    OriGene clones in human, mouse for KIAA0907 (see all 8)
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    GenScript: all cDNA clones in your preferred vector: KIAA0907 (NM_014949)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA0907
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIAA0907
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIAA0907

    Additional mRNA sequence: 

    AB020714.1 AK225714.1 AK289902.1 AY112680.1 AY112681.1 AY112682.1 BC027182.1 BC062637.1 

    19 DOTS entries:

    DT.97789541  DT.316458  DT.307984  DT.91753461  DT.121443609  DT.97838465  DT.121443608  DT.91753458 
    DT.95302690  DT.97768601  DT.100684956  DT.121443574  DT.121443589  DT.95302698  DT.95360066  DT.100701816 
    DT.121443573  DT.121443601  DT.91900261 

    24/244 AceView cDNA sequences (see all 244):

    BC062637 BM476408 AA383676 AW772432 BU156386 AA550964 AA748670 H98689 
    BF919013 AL558433 AA594446 AI690212 BX107254 N51003 AW008418 AY112681 
    CA418411 AA401270 AW572365 AA742982 BM724115 AI953333 BU632683 AI610204 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0907 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a ·
    SP1:                                                                          -                       -           -                                             
    SP2:                                                  -     -     -     -     -     -     -           -                                                         
    SP3:                                                                                                                                                            
    SP4:                          -     -                                                                                                                           
    SP5:                                                                          -                       -                                                         

    ExUns: 14b · 14c ^ 15 ^ 16
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for KIAA0907

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIAA0907 expression in normal human tissues (normalized intensities)      KIAA0907 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTGATTT
    KIAA0907 Expression
    About this image


    KIAA0907 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Breast (Uncategorized)
             breast epithelium   
     
     Umbilical Cord (Extraembryonic Tissues)
             stem cells (umbilical cord cd34+)   
     
     Bone (Muscoskeletal System)
             Mandibular Condyle
     
     Blood (Extraembryonic Tissues)
             stem cells (umbilical cord cd34+)   
     
     Epithelium
             breast epithelium   

    See KIAA0907 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIAA0907

    SOURCE GeneReport for Unigene cluster: Hs.24656
        SABiosciences Custom PCR Arrays for KIAA0907
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KIAA0907 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2810403A07Rik1 , 5 RIKEN cDNA 2810403A07 gene1, 5 91.15(n)1
    96.23(a)1
      3 (38.93 cM)5
    742001  NM_028814.31  NP_083090.21 
     886857945 
    chicken
    (Gallus gallus)
    Aves KIAA09071 KIAA0907 81.05(n)
    88.63(a)
      425070  NM_001031328.1  NP_001026499.1 
    lizard
    (Anolis carolinensis)
    Reptilia KIAA09076
    Uncharacterized protein
    82(a)
    1 ↔ 1
    GL343519.1(470048-495921)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.141942 Xenopus laevis transcribed sequence with moderate similarity more 77.52(n)    BX851301.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.16182 Danio rerio mRNA similar to KIAA0907 protein (cDNA more 79.26(n)    BC045375.1 


    ENSEMBL Gene Tree for KIAA0907 (if available)
    TreeFam Gene Tree for KIAA0907 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/417 SNPs in KIAA0907 are shown (see all 417)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1426025181,2
    C--155898385(+) AAGAC-/AAAAAAAA 1 -- int10--------
    rs2002901931,2
    C--155905007(+) GGTTTC/TTTTTT 1 -- us2k10--------
    rs7086141,2
    C,F,A,H--162382965(+) TGCCTG/ATAATC 1 -- int17Minor allele frequency- A:0.33NA WA 18
    rs766449931,2
    F--162382986(+) AGGAGA/GCTGAG 1 -- int11Minor allele frequency- G:0.00NA 2
    rs1821582181,2
    --162383069(+) AGAGCA/GAGACT 1 -- int10--------
    rs716286971,2
    C,F--162383131(+) AAACCC/TGCTTC 1 -- int14Minor allele frequency- T:0.10NA 126
    rs1865416841,2
    --162383132(+) AACCCA/GCTTCA 1 -- int10--------
    rs578108441,2
    C--162383329(+) TTGCAT/CTGTGC 1 -- int12Minor allele frequency- C:0.04WA 120
    rs412649851,2
    F--162383667(+) CCAAAA/GTCCTA 1 -- ut310--------
    rs1925948951,2
    --162383879(+) CCCCAA/GTTAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KIAA0907 (155882834 - 155904191 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KIAA0907:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509513CNV Insertion20534489
    esv33869CNV Loss17666407

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KIAA0907
    DNA2.0 Custom Variant and Variant Library Synthesis for KIAA0907

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIAA0907 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with KIAA0907)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T....Ohara O. (1998)
    2. Inhibition of pre-mRNA splicing by a synthetic Blom7a- interacting small RNA. (PubMed id 23144703)1 Loscher M....Grillari J. (2012)
    3. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    4. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    5. Blom7alpha is a novel heterogeneous nuclear ribonucle oprotein K homology domain protein involved in pre-mRNA splicing that interacts with SNEVPrp19-Pso4. (PubMed id 19641227)1 Grillari J....Grillari-Voglauer R. (2009)
    6. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22889 HGNC: 29145 AceView: KIAA0907 Ensembl:ENSG00000132680 euGenes: HUgn22889
    ECgene: KIAA0907 H-InvDB: KIAA0907

    (According to HUGE)
    About This Section
    HUGE: KIAA0907

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIAA0907 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIAA0907 gene:
    Search GeneIP for patents involving KIAA0907

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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