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KIAA0907 Gene

protein-coding   GIFtS: 44
GCID: GC01M155882

KIAA0907

  Search for KIAA0907
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
KIAA09071 2
BLOM72 3
UPF0469 Protein KIAA09072

External Ids:    HGNC: 291451   Entrez Gene: 228892   Ensembl: ENSG000001326807   UniProtKB: Q7Z7F03   

Export aliases for KIAA0907 gene to outside databases

Previous GC identifers: GC01M153746 GC01M151642 GC01M152660 GC01M153099 GC01M152695 GC01M154149 GC01M127243


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KIAA0907 Gene:
KIAA0907 (KIAA0907) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIAA0907 gene promoter:
         NF-1   NF-1/L   POU3F1   AP-4   C/EBPalpha   CREB   deltaCREB   Sox9   c-Myb   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIAA0907 promoter sequence
   Search Chromatin IP Primers for KIAA0907

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIAA0907


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

KIAA0907 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA0907 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M155882:  view genomic region     (about GC identifiers)

Start:
155,882,834 bp from pter      End:
155,904,191 bp from pter
Size:
21,358 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: K0907_HUMAN, Q7Z7F0 (See protein sequence)
Recommended Name: UPF0469 protein KIAA0907  
Size: 614 amino acids; 64845 Da
Sequence caution: Sequence=BAA74930.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for KIAA0907:
2YQR (3D)    
Secondary accessions: O94981 Q7L7Q2 Q7Z7E9 Q8TBQ0
Alternative splicing: 4 isoforms:  Q7Z7F0-1   Q7Z7F0-2   Q7Z7F0-3   Q7Z7F0-4   

Explore the universe of human proteins at neXtProt for KIAA0907: NX_Q7Z7F0

Explore proteomics data for KIAA0907 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KIAA0907 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055764.2  
    ENSEMBL proteins: 
     ENSP00000357304   ENSP00000357303   ENSP00000357302  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q7Z7F0

    UniProtKB/Swiss-Prot: K0907_HUMAN, Q7Z7F0
    Similarity: Belongs to the UPF0469 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
         
    KIAA0907 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KIAA0907
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    miRNA
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    miRTarBase miRNAs that target KIAA0907:
    hsa-mir-324-5p (MIRT043019), hsa-mir-18a-5p (MIRT031327)

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    Selected qRT-PCR Assays for microRNAs that regulate KIAA0907 (see all 35):
    hsa-miR-596 hsa-miR-4291 hsa-miR-3194-5p hsa-miR-607 hsa-miR-374a hsa-miR-371-5p hsa-miR-105 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidKIAA0907 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1
    peroxisome1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIAA0907
    Interactions:

        Search GeneGlobe Interaction Network for KIAA0907

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for KIAA0907 (Q7Z7F03 ENSP000003573044) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    U2AF2P263683, ENSP000003078634I2D: score=4 STRING: ENSP00000307863
    CDC5LENSP000003605324STRING: ENSP00000360532
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIAA0907 (K0907)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KIAA0907 gene: 
    NM_014949.2  

    Unigene Cluster for KIAA0907:

    KIAA0907
    Hs.24656  [show with all ESTs]
    Unigene Representative Sequence: AB020714
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368321(uc001fmi.1 uc009wrl.1 uc001fml.1 uc001fmm.3)
    ENST00000368320(uc001fmj.1) ENST00000478002 ENST00000466520 ENST00000465953
    ENST00000483237 ENST00000368319 ENST00000482337 ENST00000466713(uc001fmo.3)
    ENST00000491599
    miRNA
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    Block miRNA regulation of human, mouse, rat KIAA0907 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KIAA0907 (see all 35):
    hsa-miR-596 hsa-miR-4291 hsa-miR-3194-5p hsa-miR-607 hsa-miR-374a hsa-miR-371-5p hsa-miR-105 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidKIAA0907 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KIAA0907
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA0907
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    OriGene qPCR primer pairs and template standards for KIAA0907
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KIAA0907
      QuantiTect SYBR Green Assays in human, mouse, rat KIAA0907
      QuantiFast Probe-based Assays in human, mouse, rat KIAA0907

    Additional mRNA sequence: 

    AB020714.1 AK225714.1 AK289902.1 AY112680.1 AY112681.1 AY112682.1 BC027182.1 BC062637.1 

    19 DOTS entries:

    DT.97789541  DT.316458  DT.307984  DT.91753461  DT.121443609  DT.97838465  DT.121443608  DT.91753458 
    DT.95302690  DT.97768601  DT.100684956  DT.121443574  DT.121443589  DT.95302698  DT.95360066  DT.100701816 
    DT.121443573  DT.121443601  DT.91900261 

    Selected AceView cDNA sequences (see all 244):

    AI953333 BE549592 AW008418 AA506700 AA742670 AW591992 BQ888738 AI964026 
    BF919013 AA902459 AW572365 AW591641 AI690212 AA550964 BM680294 AI801677 
    H98689 AI127846 BU625425 AA923650 AI610204 BM724115 AY112682 AA398955 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0907 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a ·
    SP1:                                                                          -                       -           -                                             
    SP2:                                                  -     -     -     -     -     -     -           -                                                         
    SP3:                                                                                                                                                            
    SP4:                          -     -                                                                                                                           
    SP5:                                                                          -                       -                                                         

    ExUns: 14b · 14c ^ 15 ^ 16
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for KIAA0907

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIAA0907 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTGATTT
    KIAA0907 Expression
    About this image


    KIAA0907 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Mandibular Condyle
    KIAA0907 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIAA0907 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.24656
        Custom PCR Arrays for KIAA0907
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KIAA0907 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2810403A07Rik1 , 5 RIKEN cDNA 2810403A07 gene1, 5 90.66(n)1
    95.57(a)1
      3 (38.93 cM)5
    742001  NM_028814.31  NP_083090.21 
     886857945 
    chicken
    (Gallus gallus)
    Aves KIAA09071 KIAA0907 80.49(n)
    87.46(a)
      425070  NM_001031328.1  NP_001026499.1 
    lizard
    (Anolis carolinensis)
    Reptilia KIAA09076
    KIAA0907
    82(a)
    1 ↔ 1
    GL343519.1(470048-495921)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.141942 Xenopus laevis transcribed sequence with moderate similarity more 77.52(n)    BX851301.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.16182 Danio rerio mRNA similar to KIAA0907 protein (cDNA more 79.26(n)    BC045375.1 


    ENSEMBL Gene Tree for KIAA0907 (if available)
    TreeFam Gene Tree for KIAA0907 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIAA0907 (see all 417)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1426025181,2
    C--155898385(+) AAGAC-/AAAAAAAA 1 -- int10--------
    rs2002901931,2
    C--155905007(+) GGTTTC/TTTTTT 1 -- us2k10--------
    rs7086141,2
    C,F,A,H--162382965(+) TGCCTG/ATAATC 1 -- int17Minor allele frequency- A:0.33NA WA 18
    rs766449931,2
    F--162382986(+) AGGAGA/GCTGAG 1 -- int11Minor allele frequency- G:0.00NA 2
    rs1821582181,2
    --162383069(+) AGAGCA/GAGACT 1 -- int10--------
    rs716286971,2
    C,F--162383131(+) AAACCC/TGCTTC 1 -- int14Minor allele frequency- T:0.10NA 126
    rs1865416841,2
    --162383132(+) AACCCA/GCTTCA 1 -- int10--------
    rs578108441,2
    C--162383329(+) TTGCAT/CTGTGC 1 -- int12Minor allele frequency- C:0.04WA 120
    rs412649851,2
    F--162383667(+) CCAAAA/GTCCTA 1 -- ut310--------
    rs1925948951,2
    --162383879(+) CCCCAA/GTTAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KIAA0907 (155882834 - 155904191 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KIAA0907:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509513CNV Insertion20534489
    esv33869CNV Loss17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KIAA0907
    DNA2.0 Custom Variant and Variant Library Synthesis for KIAA0907

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIAA0907 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with KIAA0907)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    2. Inhibition of pre-mRNA splicing by a synthetic Blom7I+-interacting small RNA. (PubMed id 23144703)1 LAPscher M....Grillari J. (PLoS ONE 2012)
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    4. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    5. Blom7alpha is a novel heterogeneous nuclear ribonucleoprotein K homology domain protein involved in pre-mRNA splicing that interacts with SNEVPrp19-Pso4. (PubMed id 19641227)1 Grillari J....Grillari-Voglauer R. (J. Biol. Chem. 2009)
    6. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22889 HGNC: 29145 AceView: KIAA0907 Ensembl:ENSG00000132680 euGenes: HUgn22889
    ECgene: KIAA0907 H-InvDB: KIAA0907

    (According to HUGE)
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    HUGE: KIAA0907

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KIAA0907 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KIAA0907 gene:
    Search GeneIP for patents involving KIAA0907

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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