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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KIAA0907 Gene

protein-coding GIFtS: 41
GCID: GC01M155882

KIAA0907

Search for KIAA0907
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
KIAA0907¹ ²
BLOM7¹ ² ³
RP11-336K24.1²
UPF0469 Protein KIAA0907²

External Ids:	HGNC: 29145¹	Entrez Gene: 22889²	Ensembl: ENSG00000132680⁷	UniProtKB: Q7Z7F0³

Export aliases for KIAA0907 gene to outside databases

Previous GC identifers: GC01M153746 GC01M151642 GC01M152660 GC01M153099 GC01M152695 GC01M154149 GC01M127243

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KIAA0907 gene promoter:
NF-1 NF-1/L POU3F1 AP-4 C/EBPalpha CREB deltaCREB Sox9 c-Myb ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KIAA0907 promoter sequence

Search SABiosciences Chromatin IP Primers for KIAA0907

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA0907

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22 Ensembl cytogenetic band: 1q22 HGNC cytogenetic band: 1q22

KIAA0907 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA0907 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M155882: view genomic region (about GC identifiers)

Start:	155,882,834 bp from pter	End:	155,904,191 bp from pter
Size:	21,358 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: K0907_HUMAN, Q7Z7F0 (See protein sequence)

Recommended Name: UPF0469 protein KIAA0907

Size: 614 amino acids; 64845 Da

Sequence caution: Sequence=BAA74930.2; Type=Erroneous initiation;

1 PDB 3D structure from and Proteopedia for KIAA0907:

2YQR (3D)

Secondary accessions: O94981 Q7L7Q2 Q7Z7E9 Q8TBQ0

Alternative splicing: 4 isoforms: Q7Z7F0-1 Q7Z7F0-2 Q7Z7F0-3 Q7Z7F0-4

Explore the universe of human proteins at neXtProt for KIAA0907: NX_Q7Z7F0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q7Z7F0

KIAA0907 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055764.2

ENSEMBL proteins:

ENSP00000357304 ENSP00000357303 ENSP00000357302

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q7Z7F0

UniProtKB/Swiss-Prot: K0907_HUMAN, Q7Z7F0

Similarity: Belongs to the UPF0469 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KIAA0907

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for KIAA0907 (Q7Z7F0³ ENSP00000357304⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
U2AF2	P26368³, ENSP00000307863⁴	I2D: score=4 STRING: ENSP00000307863

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for KIAA0907
Search CenterWatch for drugs/clinical trials and news about KIAA0907 / K0907

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KIAA0907 gene:

NM_014949.2

Unigene Cluster for KIAA0907:

KIAA0907

Hs.728984 [show with all ESTs]

Unigene Representative Sequence: AB020714

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000368321(uc001fmi.1 uc009wrl.1 uc001fml.1 uc001fmm.3)

ENST00000368320(uc001fmj.1) ENST00000478002 ENST00000466520 ENST00000465953

ENST00000483237 ENST00000368319 ENST00000482337 ENST00000466713(uc001fmo.3)

ENST00000491599

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		hsa-miR-596 hsa-miR-4291 hsa-miR-3194-5p hsa-miR-607 hsa-miR-374a hsa-miR-371-5p hsa-miR-105 hsa-miR-298

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Additional cDNA sequence:

AB020714.1 AK225714.1 AK289902.1 AY112680.1 AY112681.1 AY112682.1 BC027182.1 BC062637.1

19 DOTS entries:

DT.97789541 DT.316458 DT.307984 DT.91753461 DT.121443609 DT.97838465 DT.121443608 DT.91753458

DT.95302690 DT.97768601 DT.100684956 DT.121443574 DT.121443589 DT.95302698 DT.95360066 DT.100701816

DT.121443573 DT.121443601 DT.91900261

24/244 AceView cDNA sequences (see all 244):

AL558433 BF433376 BF508843 AA401270 BU682408 AA742670 AY112681 BF431355

BM680294 AA550964 AI350097 AI127846 AA779343 BU156386 AA398955 AI964026

AI801677 AA748670 CA312770 BM476408 BC062637 BX107254 AI458500 AW591992

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0907 (see all 11) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b	^	14a	·
SP1:																									-								-				-
SP2:																	-		-		-		-		-		-		-				-
SP3:
SP4:									-		-
SP5:																									-								-

ExUns:	14b	·	14c	^	15	^	16
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for KIAA0907

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KIAA0907 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATTTGATTT

About this image

KIAA0907 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KIAA0907 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIAA0907

SOURCE GeneReport for Unigene cluster: Hs.728984

SABiosciences Custom PCR Arrays for KIAA0907

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIAA0907 gene from 8/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	2810403A07Rik^{1 , 5}	RIKEN cDNA 2810403A07 gene^{1, 5}	91.15(n)¹ 96.23(a)¹		3 (38.93 cM)⁵ 74200¹ NM_028814.3¹ NP_083090.2¹ 88685794⁵
chicken (Gallus gallus)	Aves	KIAA0907¹	KIAA0907	81.05(n) 88.63(a)		425070 NM_001031328.1 NP_001026499.1
lizard (Anolis carolinensis)	Reptilia	KIAA0907⁶	--	83(a)	1 ↔ 1	GL343519.1(471863-495315)
African clawed frog (Xenopus laevis)	Amphibia	Xl.14194²	Xenopus laevis transcribed sequence with moderate similarity more	77.52(n)		BX851301.1
zebrafish (Danio rerio)	Actinopterygii	Dr.1618²	Danio rerio mRNA similar to KIAA0907 protein (cDNA more	79.26(n)		BC045375.1
honey bee (Apis mellifera)	Insecta	--	--	20(a)	1 ↔ 1	Group6.16(854-6165)
thale cress (Arabidopsis thaliana)	eudicotyledons	RIK⁶	protein RIK	20(a)	1 ↔ 1	3(11289613-11294774)
rice (Oryza sativa)	Liliopsida	--	expressed protein	20(a)	1 ↔ 1	3(5966188-5972722)

ENSEMBL Gene Tree for KIAA0907 (if available)
TreeFam Gene Tree for KIAA0907 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192594895^1,2		--	155883310(+)	`CCCCAA/GTTAAA`	1	--	ut3¹		0	--	--	--	--
rs185382748^1,2		--	155883479(+)	`TTTCCC/TCACTA`	1	--	ut3¹		0	--	--	--	--
rs143700648^1,2		--	155883539(+)	`AACAGC/TAGTAA`	1	--	ut3¹		0	--	--	--	--
rs188703027^1,2		--	155883834(+)	`AGGCCC/TCAGAG`	1	--	ut3¹		0	--	--	--	--
rs200082502^1,2	C,	--	155884120(+)	`GAATAG/AAGAAA`	1	--	int¹		1		EU	1119
rs202168680^1,2		--	155884148(+)	`TCCCCA/GCCAAG`	1	--	int¹		0	--	--	--	--
rs147222585^1,2		--	155884274(+)	`TCACAC/GGAAAA`	1	--	int¹		0	--	--	--	--
rs724596^1,2	C,H	--	155884659(-)	`GATACG/AGACTT`	1	--	int¹ ese³		14		NA EA MN NS	994
rs139244454^1,2		--	155884681(+)	`TGGTAG/TTCACA`	1	--	int¹		0	--	--	--	--
rs143213703^1,2	C,	--	155884833(+)	`TATTT-/TCTCTCT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KIAA0907 (155882834 - 155904191 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KIAA0907
1 CNV: 6789

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIAA0907

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KIAA0907 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with KIAA0907)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)^{1, 2, 3} Nagase T....Ohara O. (1998)
Inhibition of pre-mRNA splicing by a synthetic Blom7a- interacting small RNA. (PubMed id 23144703)¹ Loscher M....Grillari J. (2012)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)
Blom7alpha is a novel heterogeneous nuclear ribonucle oprotein K homology domain protein involved in pre-mRNA splicing that interacts with SNEVPrp19-Pso4. (PubMed id 19641227)¹ Grillari J....Grillari-Voglauer R. (2009)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 22889	HGNC: 29145	AceView: KIAA0907	Ensembl:ENSG00000132680	euGenes: HUgn22889
ECgene: KIAA0907	H-InvDB: KIAA0907

(According to HUGE)
About This Section

HUGE: KIAA0907

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KIAA0907	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KIAA0907 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for KIAA0907 gene:
Search GeneIP for patents involving KIAA0907

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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KIAA0907 Gene

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KIAA0907 Gene

KIAA0907

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