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KIAA0895L Gene

protein-coding   GIFtS: 37
GCID: GC16M067209

KIAA0895-Like

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disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
KIAA0895-like1 2
Uncharacterized Protein KIAA0895-Like2

External Ids:    HGNC: 344081   Entrez Gene: 6533192   Ensembl: ENSG000001961237   UniProtKB: Q68EN53   

Export aliases for KIAA0895L gene to outside databases

Previous GC identifers: GC16M065774 GC16M065776 GC16M053082


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KIAA0895L Gene:
KIAA0895L (KIAA0895-like) is a protein-coding gene. An important paralog of this gene is KIAA0895.

Gene Wiki entry for KIAA0895L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIAA0895L gene promoter:
         p53   AP-1   NRSF form 1   MyoD   NRSF form 2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for KIAA0895L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIAA0895L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

KIAA0895L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA0895L gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M067209:  view genomic region     (about GC identifiers)

Start:
67,209,505 bp from pter      End:
67,217,943 bp from pter
Size:
8,439 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: K895L_HUMAN, Q68EN5 (See protein sequence)
Recommended Name: Uncharacterized protein KIAA0895-like  
Size: 471 amino acids; 53446 Da
Sequence caution: Sequence=AAI28540.1; Type=Erroneous initiation; Sequence=CAD38862.1; Type=Erroneous translation;
Note=Erroneous translation incorporating non-existent frameshift;
Secondary accessions: A2VCS8 Q8N3H9 Q8NAQ5 Q96IE5
Alternative splicing: 3 isoforms:  Q68EN5-1   Q68EN5-2   Q68EN5-3   

Explore the universe of human proteins at neXtProt for KIAA0895L: NX_Q68EN5

Explore proteomics data for KIAA0895L at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KIAA0895L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001035805.1  
    ENSEMBL proteins: 
     ENSP00000459322   ENSP00000456694   ENSP00000457099   ENSP00000290881   ENSP00000456838  

    KIAA0895L Human Recombinant Protein Products:

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    antibodies-online proteins for KIAA0895L (2 products) 

     
    antibodies-online peptides for KIAA0895L

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    antibodies-online kits for KIAA0895L (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR012548 DUF1704

    Graphical View of Domain Structure for InterPro Entry Q68EN5

    ProtoNet protein and cluster: Q68EN5


    Find genes that share domains with KIAA0895L           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for KIAA0895L

    miRNA
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    miRTarBase miRNAs that target KIAA0895L:
    hsa-mir-503-5p (MIRT041118)

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    hsa-miR-3130-5p hsa-let-7d hsa-miR-29a hsa-let-7g hsa-let-7a hsa-miR-98 hsa-miR-1231 hsa-miR-4300
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIAA0895L
    Interactions:

        Search GeneGlobe Interaction Network for KIAA0895L

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIAA0895L (K895L)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KIAA0895L gene: 
    NM_001040715.1  

    Unigene Cluster for KIAA0895L:

    KIAA0895-like
    Hs.651201  [show with all ESTs]
    Unigene Representative Sequence: AL834156
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000562514 ENST00000561679(uc002ers.3) ENST00000568563(uc002err.3)
    ENST00000569349 ENST00000561621 ENST00000290881(uc002ert.3 uc002eru.3)
    ENST00000563918 ENST00000563902 ENST00000563831 ENST00000570009 ENST00000564835
    ENST00000564423 ENST00000568165
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate KIAA0895L (see all 34):
    hsa-miR-3130-5p hsa-let-7d hsa-miR-29a hsa-let-7g hsa-let-7a hsa-miR-98 hsa-miR-1231 hsa-miR-4300
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat KIAA0895L
      QuantiFast Probe-based Assays in human, mouse, rat KIAA0895L

    Additional mRNA sequence: 

    AK092303.1 AK094787.1 AK096855.1 AL834156.1 BC007594.1 BC080183.1 BC128539.1 

    16 DOTS entries:

    DT.40122961  DT.100044759  DT.100044760  DT.100044757  DT.100828924  DT.120721780  DT.100044754  DT.100044761 
    DT.120721960  DT.86855029  DT.97778588  DT.100757463  DT.120721982  DT.86855028  DT.91744573  DT.215991 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0895L (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c
    SP1:                                                  -     -     -     -                                       
    SP2:                                                        -     -     -                                       
    SP3:                                                                    -                                       
    SP4:                    -     -     -     -     -     -     -     -     -                 -                     
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for KIAA0895L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIAA0895L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTATTCC
    KIAA0895L Expression
    About this image

    KIAA0895L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIAA0895L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.651201
        Custom PCR Arrays for KIAA0895L
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA0895L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KIAA0895L gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 4931428F04Rik1 , 5 RIKEN cDNA 4931428F04 gene1, 5 83.44(n)1
    82.44(a)1
      8 (53.04 cM)5
    743561  NM_028888.21  NP_083164.11 
     1052804105 
    chicken
    (Gallus gallus)
    Aves KIAA0895L1 KIAA0895-like 79.31(n)
    80.85(a)
      415660  XM_414026.4  XP_414026.4 
    lizard
    (Anolis carolinensis)
    Reptilia KIAA0895L6
    KIAA0895-like
    79(a)
    1 ↔ 1
    GL344557.1(22778-29258)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia kiaa0895l1 KIAA0895-like ortholog 65.66(n)
    67.17(a)
      100490287  XM_002931649.2  XP_002931695.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5620971 uncharacterized LOC562097 61.86(n)
    65.32(a)
      562097  XM_680865.5  XP_685957.1 


    ENSEMBL Gene Tree for KIAA0895L (if available)
    TreeFam Gene Tree for KIAA0895L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KIAA0895L gene
    KIAA08952  
    1 SIMAP similar gene for KIAA0895L using alignment to 3 protein entries:     K895L_HUMAN (see all proteins):
    KIAA0895

    Find genes that share paralogs with KIAA0895L           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for KIAA0895L
    PGOHUM00000234989 PGOHUM00000234990


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIAA0895L (see all 124)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs558986071,2
    C--67210520(+) GCAGGC/TCCCCA 1 -- ut310--------
    rs1486813861,2
    C--67210627(+) AGGCCA/GTGGAC 1 -- ut310--------
    rs1417552601,2
    --67210659(+) GTTCTA/GGGGGC 1 -- ut310--------
    rs1462292061,2
    C--67210720(+) CAGTCA/GGGTAG 2 P syn10--------
    rs1996847271,2
    C--67210754(+) CCAGCC/TGGTTG 2 Q R mis10--------
    rs2017182881,2
    C--67210788(+) CTGCCG/AGTAGC 2 /R /W mis11Minor allele frequency- A:0.00EU 1253
    rs2021582071,2
    C--67210794(+) GTAGCA/GTGCCA 2 R C mis10--------
    rs2004964231,2
    C--67210851(+) GGGCCA/GCAGGT 2 R W mis10--------
    rs617337891,2
    C,F--67210855(+) CGCAGC/GTGGTC 2 H Q mis13Minor allele frequency- G:0.09NS CSA 79
    rs1440663001,2
    C,F--67210903(+) ATCAGG/ACATAG 1 -- int11Minor allele frequency- A:0.02EU 953

    HapMap Linkage Disequilibrium report for KIAA0895L (67209505 - 67217943 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KIAA0895L (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2887n71CNV Loss21882294
    dgv2888n71CNV Loss21882294
    nsv906794CNV Loss21882294
    nsv906803CNV Loss21882294
    dgv2886n71CNV Loss21882294
    nsv524492CNV Loss19592680
    nsv827707CNV Loss20364138
    nsv457513CNV Loss19166990
    dgv2885n71CNV Loss21882294
    nsv524363CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIAA0895L gene integrated from 10 sources:
    (articles sorted by number of sources associating them with KIAA0895L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 653319 HGNC: 34408 Ensembl:ENSG00000196123 euGenes: HUgn653319 ECgene: KIAA0895L
    H-InvDB: KIAA0895L

    (According to HUGE)
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    HUGE: KIAA0895L

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KIAA0895L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KIAA0895L gene:
    Search GeneIP for patents involving KIAA0895L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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