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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KIAA0895L Gene

protein-coding GIFtS: 39
GCID: GC16M067209

KIAA0895-like

Explore 1 disease affiliated with
KIAA0895L via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
KIAA0895-Like¹
LOC653319¹
Uncharacterized Protein KIAA0895-Like²

External Ids:	HGNC: 34408¹	Entrez Gene: 653319²	Ensembl: ENSG00000196123⁷	UniProtKB: Q68EN5³

Export aliases for KIAA0895L gene to outside databases

Previous GC identifers: GC16M065774 GC16M065776 GC16M053082

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for KIAA0895L

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KIAA0895L gene promoter:
p53 AP-1 NRSF form 1 MyoD NRSF form 2
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for KIAA0895L

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA0895L

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22.1

KIAA0895L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA0895L gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M067209: view genomic region (about GC identifiers)

Start:	67,209,505 bp from pter	End:	67,217,943 bp from pter
Size:	8,439 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: K895L_HUMAN, Q68EN5 (See protein sequence)

Recommended Name: Uncharacterized protein KIAA0895-like

Size: 471 amino acids; 53446 Da

Sequence caution: Sequence=AAI28540.1; Type=Erroneous initiation; Sequence=CAD38862.1; Type=Erroneous translation;

Note=Erroneous translation incorporating non-existent frameshift;

Secondary accessions: A2VCS8 Q8N3H9 Q8NAQ5 Q96IE5

Alternative splicing: 3 isoforms: Q68EN5-1 Q68EN5-2 Q68EN5-3

Explore the universe of human proteins at neXtProt for KIAA0895L: NX_Q68EN5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q68EN5

KIAA0895L Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001035805.1

ENSEMBL proteins:

ENSP00000455498 ENSP00000459322 ENSP00000456694 ENSP00000457099 ENSP00000290881

ENSP00000456838 ENSP00000462059

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KIAA0895L for domains About GeneDecksing

1 InterPro domain/family:

IPR012548 DUF1704

Graphical View of Domain Structure for InterPro Entry Q68EN5

ProtoNet protein and cluster: Q68EN5

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KIAA0895L

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for KIAA0895L gene:

NM_001040715.1

Unigene Cluster for KIAA0895L:

KIAA0895-like

Hs.651201 [show with all ESTs]

Unigene Representative Sequence: AL834156

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000562514 ENST00000561679(uc002ers.3) ENST00000568563(uc002err.3)

ENST00000569349 ENST00000561621 ENST00000290881(uc002ert.3 uc002eru.3)

ENST00000563918 ENST00000563902 ENST00000563831 ENST00000570009 ENST00000564835

ENST00000564423 ENST00000568165

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Additional cDNA sequence:

AK092303.1 AK094787.1 AK096855.1 AL834156.1 BC007594.1 BC080183.1 BC128539.1

16 DOTS entries:

DT.40122961 DT.100044760 DT.100044759 DT.100044757 DT.100828924 DT.120721780 DT.100044754 DT.100044761

DT.120721960 DT.86855029 DT.97778588 DT.100757463 DT.120721982 DT.86855028 DT.91744573 DT.215991

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0895L (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	·	8c
SP1:																	-		-		-		-
SP2:																			-		-		-
SP3:																							-
SP4:							-		-		-		-		-		-		-		-		-						-
SP5:

ECgene alternative splicing isoforms for KIAA0895L

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KIAA0895L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTTATTCC

About this image

KIAA0895L expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KIAA0895L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIAA0895L

SOURCE GeneReport for Unigene cluster: Hs.651201

SABiosciences Custom PCR Arrays for KIAA0895L

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for KIAA0895L gene from 4/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	4931428F04Rik^{1 , 5}	RIKEN cDNA 4931428F04 gene^{1, 5}	84.73(n)¹ 83.94(a)¹		8 (53.04 cM)⁵ 74356¹ NM_001166394.1¹ NP_001159866.1¹ 105280410⁵
chicken (Gallus gallus)	Aves	KIAA0895L¹	KIAA0895-like	79.24(n) 80.78(a)		415660 XM_414026.3 XP_414026.3
lizard (Anolis carolinensis)	Reptilia	KIAA0895L⁶	--	78(a)	1 ↔ 1	GL344557.1(22787-29237)
zebrafish (Danio rerio)	Actinopterygii	LOC562097¹	uncharacterized protein KIAA0895-like	61.81(n) 64.82(a)		562097 XM_680865.4 XP_685957.1

ENSEMBL Gene Tree for KIAA0895L (if available)
TreeFam Gene Tree for KIAA0895L (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KIAA0895L gene

KIAA0895²

1 SIMAP similar gene for KIAA0895L using alignment to 4 protein entries: K895L_HUMAN (see all proteins):

KIAA0895

KIAA0895L for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for KIAA0895L
PGOHUM00000234989 PGOHUM00000234990

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs55898607^1,2	C	--	67210520(+)	`GCAGGC/TCCCCA`	1	--	ut3¹		0	--	--	--	--
rs148681386^1,2		--	67210627(+)	`AGGCCA/GTGGAC`	1	--	ut3¹		0	--	--	--	--
rs141755260^1,2		--	67210659(+)	`GTTCTA/GGGGGC`	1	--	ut3¹		0	--	--	--	--
rs146229206^1,2		--	67210720(+)	`CAGTCA/GGGTAG`	2	P	syn¹		0	--	--	--	--
rs199684727^1,2	C,	--	67210754(+)	`CCAGCC/TGGTTG`	2	Q R	mis¹		0	--	--	--	--
rs61733789^1,2	C,F,	--	67210855(+)	`CGCAGC/GTGGTC`	2	H Q	mis¹		3		NS CSA	79
rs144066300^1,2	C,F,	--	67210903(+)	`ATCAGG/ACATAG`	1	--	int¹		1		EU	953
rs189018091^1,2		--	67210947(+)	`AGCCCA/GCTGCT`	1	--	int¹		0	--	--	--	--
rs115123305^1,2	C,F,	--	67211044(+)	`TCCTTC/TATCTT`	1	--	int¹		1		WA	118
rs76109504^1,2	F,	--	67211208(+)	`CCAAAA/CGTCAA`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for KIAA0895L (67209505 - 67217943 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KIAA0895L
1 CNV: 77385

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KIAA0895L for disorders About GeneDecksing

1 disease for KIAA0895L: About MalaCards

malaria

Export disorders for KIAA0895L gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KIAA0895L gene integrated from 9 sources:
(articles sorted by number of sources associating them with KIAA0895L)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 653319	HGNC: 34408	Ensembl:ENSG00000196123	euGenes: HUgn653319	ECgene: KIAA0895L
H-InvDB: KIAA0895L

(According to HUGE)
About This Section

HUGE: KIAA0895L

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KIAA0895L	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KIAA0895L gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for KIAA0895L gene:
Search GeneIP for patents involving KIAA0895L

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes KIAA0895L gene at Home site.

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KIAA0895L Gene

KIAA0895-like

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KIAA0895L Gene

KIAA0895-like

Aliasesfor KIAA0895L gene

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for KIAA0895L gene

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