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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIAA0895 Gene

protein-coding   GIFtS: 46
GCID: GC07M036330

KIAA0895
 Explore 1 disease affiliated with
KIAA0895 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KIAA0895    

Aliases
for KIAA0895 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
KIAA08951 2
Uncharacterized Protein KIAA08952

External Ids:    HGNC: 222061   Entrez Gene: 233662   Ensembl: ENSG000001645427   UniProtKB: Q8NCT33   

Export aliases for KIAA0895 gene to outside databases

Previous GC identifers: GC07M036010 GC07M036104 GC07M036137 GC07M036244


Summaries
for KIAA0895 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Gene Wiki entry for KIAA0895


Genomic Views
for KIAA0895 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIAA0895 gene promoter:
         AhR   Pbx1a   AML1a   ATF-2   Cart-1   MIF-1   Nkx2-5   POU3F2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KIAA0895 promoter sequence
   Search SABiosciences Chromatin IP Primers for KIAA0895

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA0895


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.2   Ensembl cytogenetic band:  7p14.2   HGNC cytogenetic band: 7p14.2

KIAA0895 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA0895 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M036330:  view genomic region     (about GC identifiers)

Start:
 36,363,759 bp from pter      End:
 36,429,734 bp from pter
Size:
 65,976 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 36,401,769-36,467,734     

Proteins
for KIAA0895 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: K0895_HUMAN, Q8NCT3 (See protein sequence)
Recommended Name: Uncharacterized protein KIAA0895  
Size: 520 amino acids; 60525 Da
Sequence caution: Sequence=BAA74918.1; Type=Erroneous initiation;
Secondary accessions: B4DF35 B7ZLT4 B9EGB9 O94969 Q0VGC1 Q7Z4L2
Alternative splicing: 6 isoforms:  Q8NCT3-1   Q8NCT3-2   Q8NCT3-3   Q8NCT3-4   Q8NCT3-5   Q8NCT3-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KIAA0895: NX_Q8NCT3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NCT3

    • KIAA0895 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001093895.1  NP_001186635.1  NP_001186636.1  NP_001186637.1  NP_056129.2  

    ENSEMBL proteins: 
     ENSP00000297063   ENSP00000344805   ENSP00000319251   ENSP00000390837   ENSP00000389985  
     ENSP00000390183   ENSP00000399935   ENSP00000400749   ENSP00000390527  

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    Protein Domains /
    Families
    for KIAA0895 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KIAA0895 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR012548 DUF1704

    Graphical View of Domain Structure for InterPro Entry Q8NCT3

    ProtoNet protein and cluster: Q8NCT3


    Function
    for KIAA0895 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): KIAA0895
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KIAA0895
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    hsa-miR-520d-5p hsa-miR-429 hsa-miR-513a-5p hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-548a-3p hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmid: KIAA0895 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for KIAA0895

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA0895

    4 GenomeRNAi human phenotypes for KIAA0895:
     Cell division defect  Increased S DNA content  Increased cell number in G2M,   Increased cell size 


    Pathways & Interactions
    for KIAA0895 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA0895

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for KIAA0895 (ENSP000002970634) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Drugs & Compounds
    for KIAA0895 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIAA0895
    Search CenterWatch for drugs/clinical trials and news about KIAA0895 / K0895 

    Transcripts
    for KIAA0895 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KIAA0895 gene (5 alternative transcripts): 
    NM_001100425.1  NM_001199706.1  NM_001199707.1  NM_001199708.1  NM_015314.2  

    Unigene Cluster for KIAA0895:

    KIAA0895
    Hs.6224  [show with all ESTs]
    Unigene Representative Sequence: NM_001199707
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000297063(uc003tfd.2) ENST00000338533 ENST00000317020(uc003tfc.2 uc011kax.1 uc003tfb.2 uc011kaw.2)
    ENST00000440378 ENST00000436884 ENST00000453212 ENST00000483360 ENST00000480192
    ENST00000483526 ENST00000431396 ENST00000415803(uc003tfe.3 uc011kay.2)
    ENST00000493327 ENST00000429651

    miRNA
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    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate KIAA0895 (see all 18):
    hsa-miR-520d-5p hsa-miR-429 hsa-miR-513a-5p hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-548a-3p hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmid: KIAA0895 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIAA0895 (see all 4)
    OriGene shRNA RFP: KIAA0895
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIAA0895
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    Additional cDNA sequence: 

    AB020702.1 AK293912.1 AK294686.1 AK302559.1 AK302632.1 BC028678.2 BC056191.1 BC063658.1 
    BC110422.1 BC136362.1 BC144032.1 

    7 DOTS entries:

    DT.95135788  DT.91751593  DT.100748847  DT.214246  DT.92420536  DT.121063987  DT.91754174 

    24/80 AceView cDNA sequences (see all 80):

    BU621995 AA384453 AA406321 AW389463 AA136428 AB020702 CK903341 AV708737 
    BC063658 AI373620 AA344245 Z40247 CA776581 R39328 F08979 BU507941 
    BE888262 CA776345 BC056191 AI374607 CB138971 AV708213 BF592150 F11318 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0895 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c
    SP1:              -     -     -     -     -     -           -                                             
    SP2:                                      -     -     -                                                   
    SP3:                                            -           -                                             
    SP4:                                                        -                                             
    SP5:                                            -     -     -                                             


    ECgene alternative splicing isoforms for KIAA0895

    Expression
    for KIAA0895 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIAA0895 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCACTCTGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KIAA0895 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KIAA0895 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIAA0895

    SOURCE GeneReport for Unigene cluster: Hs.6224
        SABiosciences Custom PCR Arrays for KIAA0895
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    In Situ
    Assay Products:     
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    Orthologs
    for KIAA0895 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for KIAA0895 gene from 3/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KIAA08951 KIAA0895 74.19(n)
    77.24(a)    		   420739  XM_003640726.1  XP_003640774.1 
    lizard
    (Anolis carolinensis)    		 Reptilia KIAA08956
    		 --
    		 63(a)
    		 1 ↔ 1
    		 6(46919167-46934114)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:dkey-222b8.41 si:dkey-222b8.4 62.19(n)
    64.43(a)    		   568013  XM_691325.4  XP_696417.4 


    ENSEMBL Gene Tree for KIAA0895 (if available)
    TreeFam Gene Tree for KIAA0895 (if available) 

    Paralogs
    for KIAA0895 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIAA0895 gene
    KIAA0895L2  
    1 SIMAP similar gene for KIAA0895 using alignment to 4 protein entries:     K0895_HUMAN (see all proteins):
    KIAA0895L

    KIAA0895 for paralogs           About GeneDecksing



    Genomic Variants
    for KIAA0895 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1032 NCBI SNPs in KIAA0895 are shown (see all 1032)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1869952921,2
    		--36363292(+) TCCCAC/TGTGTC 5 -- int10--------
    rs1501565231,2
    		--36363435(+) CCTGCC/TGCCAT 5 -- int10--------
    rs1381763371,2
    		--36363524(+) TTAAAC/TCTCTT 5 -- int10--------
    rs1495618481,2
    		--36363525(+) TAAACC/GTCTTT 5 -- int10--------
    rs624452601,2
    		C,F,--36363577(+) GCATGA/GGAATA 5 -- int14Minor allele frequency- G:0.15NA EA 244
    rs1921426921,2
    		--36363698(+) TAACGA/GCACTA 5 -- int10--------
    rs1842261481,2
    		--36363847(+) GGCACA/CGTTTC 5 -- ut310--------
    rs1904855481,2
    		--36363916(+) TTAAAA/CACTTT 5 -- ut310--------
    rs1825064921,2
    		--36363963(+) ATTTAC/TGTTTG 5 -- ut310--------
    rs1433048621,2
    		--36364063(+) AGTGGA/GCAAAA 5 -- ut310--------

    HapMap Linkage Disequilibrium report for KIAA0895 (36363759 - 36429734 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for KIAA0895
         1 CNV: 6541
         1 Indel: 12922

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    Disorders / Diseases
    for KIAA0895 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KIAA0895 for disorders           About GeneDecksing

    1 disease for KIAA0895:    About MalaCards
    malaria


    Export disorders for KIAA0895 gene to outside databases

    Publications
    for KIAA0895 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIAA0895 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KIAA0895)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T....Ohara O. (1998)
    2. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for KIAA0895 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KIAA0895 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23366 HGNC: 22206 AceView: KIAA0895 Ensembl:ENSG00000164542 euGenes: HUgn23366
    ECgene: KIAA0895 H-InvDB: KIAA0895

    Other Databases showing KIAA0895 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0895

    Specialized Databases showing KIAA0895 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIAA0895 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KIAA0895 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KIAA0895 gene:
    Search GeneIP for patents involving KIAA0895

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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