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Aliases for KIAA0825 Gene

Aliases for KIAA0825 Gene

  • KIAA0825 2 3
  • C5orf36 3 4
  • Chromosome 5 Open Reading Frame 36 2
  • Uncharacterized Protein KIAA0825 3

External Ids for KIAA0825 Gene

Previous HGNC Symbols for KIAA0825 Gene

  • C5orf36

Previous GeneCards Identifiers for KIAA0825 Gene

  • GC05M092772
  • GC05M093777
  • GC05U900474
  • GC05M093562
  • GC05M093514

Summaries for KIAA0825 Gene

GeneCards Summary for KIAA0825 Gene

KIAA0825 (KIAA0825) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA0825 Gene

Genomics for KIAA0825 Gene

Regulatory Elements for KIAA0825 Gene

Enhancers for KIAA0825 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F094698 0.8 FANTOM5 12.4 -79.8 -79812 0.6 TBP MXI1 PKNOX1 JUN MAX FEZF1 RAD21 BRCA1 RFX5 POLR2A SLF1 KIAA0825 GC05P094754
GH05F094693 0.8 ENCODE 11.2 -75.0 -74959 0.2 JUN MAX FEZF1 BCL11B BRCA1 ZEB1 RFX5 ZNF366 RCOR1 FOS KIAA0825 SLF1 GC05P094754
GH05F094616 1.1 ENCODE 7.4 +0.1 77 3.5 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 NPM1P27 TTC37 KIAA0825 RPL7P18 ENSG00000270133
GH05F094694 0.6 Ensembl 11.2 -74.7 -74697 0.2 CTCF ZNF654 SMC3 TRIM22 REST RAD21 TCF7L2 KIAA0825 SLF1 GC05P094754
GH05F094569 0.6 Ensembl 10.7 +49.2 49204 0.4 CEBPA HLF CEBPB CEBPG CREM KIAA0825 SLF1 RPL7P18 MTND5P12 MTND6P3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIAA0825 on UCSC Golden Path with GeneCards custom track

Promoters for KIAA0825 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001285530 104 3001 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF263

Genomic Location for KIAA0825 Gene

Chromosome:
5
Start:
94,150,851 bp from pter
End:
94,618,604 bp from pter
Size:
467,754 bases
Orientation:
Minus strand

Genomic View for KIAA0825 Gene

Genes around KIAA0825 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA0825 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA0825 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA0825 Gene

Proteins for KIAA0825 Gene

  • Protein details for KIAA0825 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV33-K0825_HUMAN
    Recommended name:
    Uncharacterized protein KIAA0825
    Protein Accession:
    Q8IV33
    Secondary Accessions:
    • O94914
    • Q6ZNN2

    Protein attributes for KIAA0825 Gene

    Size:
    1275 amino acids
    Molecular mass:
    147763 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85469.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BF514032; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA0825 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA0825 Gene

Post-translational modifications for KIAA0825 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIAA0825 Gene

Domains & Families for KIAA0825 Gene

Protein Domains for KIAA0825 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA0825: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for KIAA0825 Gene

Function for KIAA0825 Gene

Phenotypes for KIAA0825 Gene

genes like me logo Genes that share phenotypes with KIAA0825: view

Animal Model Products

miRNA for KIAA0825 Gene

miRTarBase miRNAs that target KIAA0825

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA0825 Gene

Localization for KIAA0825 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA0825 gene
Compartment Confidence
cytosol 3
extracellular 2
cytoskeleton 2
mitochondrion 1
nucleus 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KIAA0825 Gene

Pathways & Interactions for KIAA0825 Gene

SuperPathways for KIAA0825 Gene

No Data Available

Interacting Proteins for KIAA0825 Gene

Selected Interacting proteins: Q8IV33-K0825_HUMAN for KIAA0825 Gene via IID

Symbol External ID(s) Details
APP
ILF3

Gene Ontology (GO) - Biological Process for KIAA0825 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA0825 Gene

Transcripts for KIAA0825 Gene

mRNA/cDNA for KIAA0825 Gene

(19) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIAA0825 Gene

KIAA0825:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0825 Gene

No ASD Table

Relevant External Links for KIAA0825 Gene

GeneLoc Exon Structure for
KIAA0825
ECgene alternative splicing isoforms for
KIAA0825

Expression for KIAA0825 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIAA0825 Gene

mRNA differential expression in normal tissues according to GTEx for KIAA0825 Gene

This gene is overexpressed in Whole Blood (x5.5).

Protein differential expression in normal tissues from HIPED for KIAA0825 Gene

This gene is overexpressed in Urinary Bladder (38.3) and Rectum (19.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KIAA0825 Gene



NURSA nuclear receptor signaling pathways regulating expression of KIAA0825 Gene:

KIAA0825

SOURCE GeneReport for Unigene cluster for KIAA0825 Gene:

Hs.425123
genes like me logo Genes that share expression patterns with KIAA0825: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for KIAA0825 Gene

Orthologs for KIAA0825 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIAA0825 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC461751 34
  • 99.23 (n)
KIAA0825 35
  • 25 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA0825 34 35
  • 89.96 (n)
cow
(Bos Taurus)
Mammalia KIAA0825 34 35
  • 88.01 (n)
mouse
(Mus musculus)
Mammalia 2210408I21Rik 34 16 35
  • 80.9 (n)
rat
(Rattus norvegicus)
Mammalia RGD1560883 34
  • 79.89 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA0825 35
  • 18 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA0825 35
  • 15 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA0825 34 35
  • 72.4 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA0825 35
  • 14 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa0825 34
  • 58.41 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC798741 34
  • 52.44 (n)
KIAA0825 35
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14085 35
  • 1 (a)
OneToOne
Species where no ortholog for KIAA0825 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA0825 Gene

ENSEMBL:
Gene Tree for KIAA0825 (if available)
TreeFam:
Gene Tree for KIAA0825 (if available)

Paralogs for KIAA0825 Gene

No data available for Paralogs for KIAA0825 Gene

Variants for KIAA0825 Gene

Sequence variations from dbSNP and Humsavar for KIAA0825 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10035340 -- 94,154,760(+) CTCAA(C/T)CTACA intron-variant
rs10035650 -- 94,600,780(+) GCACC(A/G)CATAG intron-variant
rs10036091 -- 94,495,550(+) TACAG(A/G)GTCAG intron-variant
rs10037816 -- 94,602,741(+) gtttg(C/T)ttcac intron-variant, upstream-variant-2KB
rs10039118 -- 94,186,339(+) TATAG(A/G)TGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA0825 Gene

Variant ID Type Subtype PubMed ID
nsv964906 CNV duplication 23825009
nsv956458 CNV deletion 24416366
nsv830406 CNV gain 17160897
nsv823141 CNV loss 20364138
nsv823140 CNV loss 20364138
nsv823135 CNV gain 20364138
nsv823134 CNV loss 20364138
nsv820630 CNV duplication 20802225
nsv819118 CNV loss 19587683
nsv598952 CNV loss 21841781
nsv598951 CNV loss 21841781
nsv598950 CNV loss 21841781
nsv518269 CNV loss 19592680
nsv513248 CNV loss 21212237
nsv4919 CNV deletion 18451855
nsv327963 CNV deletion 16902084
nsv327822 CNV deletion 16902084
nsv1140558 CNV deletion 24896259
nsv1140557 CNV deletion 24896259
nsv1073906 CNV deletion 25765185
nsv10715 CNV loss 18304495
nsv1033608 CNV loss 25217958
esv5853 CNV loss 19470904
esv5260 CNV loss 18987735
esv3605821 CNV loss 21293372
esv3605820 CNV loss 21293372
esv3605819 CNV loss 21293372
esv3605816 CNV loss 21293372
esv3570253 CNV loss 25503493
esv3566287 CNV deletion 23714750
esv32708 CNV gain 17666407
esv29725 CNV loss 19812545
esv2759354 CNV loss 17122850
esv2730474 CNV deletion 23290073
esv2730471 CNV deletion 23290073
esv2730470 CNV deletion 23290073
esv2667701 CNV deletion 23128226
esv2534212 CNV deletion 19546169
esv2382280 CNV deletion 18987734
esv2138679 CNV deletion 18987734
esv1713122 OTHER inversion 17803354
dgv956n67 CNV loss 20364138
dgv955n67 CNV loss 20364138
dgv347n21 CNV loss 19592680
dgv3129n106 CNV deletion 24896259

Variation tolerance for KIAA0825 Gene

Residual Variation Intolerance Score: 58.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.34; 90.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA0825 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA0825

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA0825 Gene

Disorders for KIAA0825 Gene

Relevant External Links for KIAA0825

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA0825

No disorders were found for KIAA0825 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA0825 Gene

Publications for KIAA0825 Gene

  1. Estrogen-related receptor gamma implicated in a phenotype including hearing loss and mild developmental delay. (PMID: 27381092) Schilit S.L. … Morton C.C. (Eur. J. Hum. Genet. 2016) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 3 4 64

Products for KIAA0825 Gene

Sources for KIAA0825 Gene

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