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KIAA0825 Gene

protein-coding   GIFtS: 38
GCID: GC05M093514

KIAA0825

(Previous name: chromosome 5 open reading frame 36)
(Previous symbol: C5orf36)
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disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
KIAA08251 2
C5orf361 2 3
Chromosome 5 Open Reading Frame 361
Uncharacterized Protein KIAA08252

External Ids:    HGNC: 285321   Entrez Gene: 2856002   Ensembl: ENSG000001852617   UniProtKB: Q8IV333   

Export aliases for KIAA0825 gene to outside databases

Previous GC identifers: GC05M092772 GC05M094184 GC05M093777 GC05U900474 GC05M093562


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KIAA0825 Gene:
KIAA0825 (KIAA0825) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for KIAA0825
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for KIAA0825

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIAA0825


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q15   Ensembl cytogenetic band:  5q15   HGNC cytogenetic band: 5q15

KIAA0825 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA0825 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M093514:  view genomic region     (about GC identifiers)

Start:
93,486,556 bp from pter      End:
93,954,309 bp from pter
Size:
467,754 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: K0825_HUMAN, Q8IV33 (See protein sequence)
Recommended Name: Uncharacterized protein KIAA0825  
Size: 1275 amino acids; 147763 Da
Sequence caution: Sequence=BAC85469.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BF514032; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the
N-terminal part;
Secondary accessions: O94914 Q6ZNN2
Alternative splicing: 3 isoforms:  Q8IV33-1   Q8IV33-2   Q8IV33-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KIAA0825: NX_Q8IV33

Explore proteomics data for KIAA0825 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KIAA0825 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001139150.1  NP_775936.1  

    ENSEMBL proteins: 
     ENSP00000424618   ENSP00000331385   ENSP00000400288   ENSP00000312205  

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    antibodies-online proteins for KIAA0825 (2 products) 

     
    antibodies-online peptides for KIAA0825

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR027993 DUF4495

    Graphical View of Domain Structure for InterPro Entry Q8IV33

    ProtoNet protein and cluster: Q8IV33


    Find genes that share domains with KIAA0825           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for KIAA0825

    miRNA
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    miRTarBase miRNAs that target KIAA0825:
    hsa-mir-335-5p (MIRT018655)

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    hsa-miR-3163 hsa-miR-320a hsa-miR-193a-3p hsa-miR-376b hsa-miR-320d hsa-miR-376a hsa-miR-511 hsa-miR-320b
    SwitchGear 3'UTR luciferase reporter plasmidKIAA0825 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIAA0825
    Interactions:

        Search GeneGlobe Interaction Network for KIAA0825

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIAA0825 (K0825)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KIAA0825 gene (2 alternative transcripts): 
    NM_001145678.1  NM_173665.2  

    Unigene Cluster for KIAA0825:

    KIAA0825
    Hs.425123  [show with all ESTs]
    Unigene Representative Sequence: NM_001145678
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000513200(uc003kkn.3 uc011cuk.2) ENST00000504117 ENST00000329378(uc003kkp.2)
    ENST00000427991 ENST00000312498
    miRNA
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    hsa-miR-3163 hsa-miR-320a hsa-miR-193a-3p hsa-miR-376b hsa-miR-320d hsa-miR-376a hsa-miR-511 hsa-miR-320b
    SwitchGear 3'UTR luciferase reporter plasmidKIAA0825 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat KIAA0825
      QuantiFast Probe-based Assays in human, mouse, rat KIAA0825

    Additional mRNA sequence: 

    AB020632.1 AK130941.1 AK308195.1 BC035515.1 BX648338.1 

    5 DOTS entries:

    DT.95196191  DT.92066162  DT.91670807  DT.86847136  DT.92060010 

    11 AceView cDNA sequences:

    CK429901 NM_173665 BC035515 CR621527 BI523973 BX490732 AI283303 BX370075 
    BX648338 BX399185 BU656943 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIAA0825 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTTTTTC
    KIAA0825 Expression
    About this image

    KIAA0825 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIAA0825 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.425123
        Custom PCR Arrays for KIAA0825
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KIAA0825 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2210408I21Rik1 , 5 RIKEN cDNA 2210408I21 gene1, 5 80.9(n)1
    72.09(a)1
      13 (40.98 cM)5
    723711  NM_001145676.11  NP_001139148.11 
     771355405 
    chicken
    (Gallus gallus)
    Aves KIAA08251 KIAA0825 72.4(n)
    61.66(a)
      427110  XM_003643061.2  XP_003643109.2 
    lizard
    (Anolis carolinensis)
    Reptilia KIAA08256
    KIAA0825
    14(a)
    1 ↔ 1
    2(25181992-25443625)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia kiaa08251 KIAA0825 ortholog 58.41(n)
    44.58(a)
      100498255  XM_002933436.2  XP_002933482.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7987411 uncharacterized LOC798741 52.44(n)
    39.33(a)
      798741  XM_001339137.5  XP_001339173.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG140856
    --
    1(a)
    1 ↔ 1
    3L(19262451-19267268)


    ENSEMBL Gene Tree for KIAA0825 (if available)
    TreeFam Gene Tree for KIAA0825 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIAA0825 (see all 7022)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1931696841,2
    --93486116(+) TCCCCC/TACCCC 1 -- ds50010--------
    rs1997418371,2
    C--93486121(+) CACCCC/GCTGGT 1 -- ds50010--------
    rs1430364501,2
    C--93486123(+) CCCCC-/TGGTAA
            
    CCGCC
    1 -- ds50010--------
    rs1833162191,2
    --93486322(+) CCATGA/GAACAT 1 -- ds50010--------
    rs1882705051,2
    --93486577(+) CTTTAC/TAATTT 1 -- ut310--------
    rs1916385071,2
    --93486657(+) ATAATC/TACATA 1 -- ut310--------
    rs1839329041,2
    --93486844(+) ATGGCC/TGGGCG 1 -- ut310--------
    rs343846741,2
    C,F--93486950(+) ACCCCG/ATCTCT 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs113631321,2
    C--93487129(+) AAAAA-/AAAAAA 1 -- ut311Minor allele frequency- A:0.00NA 2
    rs1493700721,2
    --93487425(+) TACAGA/GAATAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KIAA0825 (93486556 - 93736556 bp, first 250kb of KIAA0825)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KIAA0825 (see all 32):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv5260CNV Deletion18987735
    esv2382280CNV Deletion18987734
    esv2730470CNV Deletion23290073
    esv2667701CNV Deletion23128226
    esv2730474CNV Deletion23290073
    esv2730471CNV Deletion23290073
    esv2138679CNV Deletion18987734
    esv2534212CNV Deletion19546169
    nsv820630CNV Duplication20802225
    nsv823140CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIAA0825 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with KIAA0825)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (Nature 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    6. Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress. (PubMed id 22751105)1 Chu L....Tomasson M.H. (J. Clin. Invest. 2012)
    7. A genome-wide association study identifies SNP in DCC is associated with gallbladder cancer in the Japanese population. (PubMed id 22318345)1 Cha P.C....Nakamura Y. (J. Hum. Genet. 2012)
    8. Genome-wide association study of diabetic retinopathy in a Taiwanese population. (PubMed id 21310492)1 Huang Y.C....Tsai F.J. (Ophthalmology 2011)
    9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 285600 HGNC: 28532 AceView: MGC34713 Ensembl:ENSG00000185261 euGenes: HUgn285600
    ECgene: KIAA0825 H-InvDB: KIAA0825

    (According to HUGE)
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    HUGE: KIAA0825

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KIAA0825 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KIAA0825 gene:
    Search GeneIP for patents involving KIAA0825

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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