Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KIAA0754 Gene

Aliases for KIAA0754 Gene

  • KIAA0754 2 3
  • Microtubule-Actin Crosslinking Factor 1 5
  • MACF1 5

External Ids for KIAA0754 Gene

Previous GeneCards Identifiers for KIAA0754 Gene

  • GC01U990245
  • GC01P039648
  • GC01P039875

Summaries for KIAA0754 Gene

GeneCards Summary for KIAA0754 Gene

KIAA0754 (KIAA0754) is a Protein Coding gene. Among its related pathways are Oncogenic MAPK signaling and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and calcium ion binding. An important paralog of this gene is DST.

Additional gene information for KIAA0754 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA0754 Gene

Genomics for KIAA0754 Gene

GeneHancer (GH) Regulatory Elements for KIAA0754 Gene

Promoters and enhancers for KIAA0754 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I039080 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 550.8 +0.1 77 1.6 MEIS2 MXI1 KLF1 ZNF792 RB1 SUZ12 SIN3A ZNF335 ZFHX2 CTBP1 KIAA0754 MACF1 RNU6-608P GC01M039121
GH01I039082 Enhancer 0.6 FANTOM5 dbSUPER 550.8 +1.0 1028 0.2 EZH2 MACF1 KIAA0754 ENSG00000226438 GJA9 MYCBP BMP8A RNU6-608P GC01M039121
GH01I039182 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14.2 +109.2 109186 15.7 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF143 FOS MACF1 KIAA0754 ENSG00000226438 PPIEL RNU6-608P OXCT2P1 TRIT1 PPIE PABPC4 BMP8B
GH01I039102 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 11.6 +24.4 24415 7.1 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF213 MACF1 KIAA0754 ENSG00000226438 OXCT2P1 ENSG00000182109 GJA9 MYCBP PABPC4 BMP8A OXCT2
GH01I039391 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +314.9 314922 10.2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A YY1 ZNF766 FOS DEK PPIEL PPIE LOC101929516 SNORA55 PABPC4 OXCT2P1 KIAA0754 MACF1 TRIT1 BMP8A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KIAA0754 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KIAA0754 gene promoter:

Genomic Locations for KIAA0754 Gene

Genomic Locations for KIAA0754 Gene
chr1:39,081,316-39,487,177
(GRCh38/hg38)
Size:
405,862 bases
Orientation:
Plus strand
chr1:39,875,176-39,882,154
(GRCh37/hg19)

Genomic View for KIAA0754 Gene

Genes around KIAA0754 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA0754 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA0754 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA0754 Gene

Proteins for KIAA0754 Gene

  • Protein details for KIAA0754 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94854-K0754_HUMAN
    Recommended name:
    Uncharacterized protein KIAA0754
    Protein Accession:
    O94854
    Secondary Accessions:
    • E9PMC2
    • Q6ZSB2

    Protein attributes for KIAA0754 Gene

    Size:
    1291 amino acids
    Molecular mass:
    135148 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIAA0754 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA0754 Gene

Post-translational modifications for KIAA0754 Gene

No Post-translational modifications

No data available for DME Specific Peptides for KIAA0754 Gene

Domains & Families for KIAA0754 Gene

Protein Domains for KIAA0754 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA0754: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for KIAA0754 Gene

Function for KIAA0754 Gene

Phenotypes From GWAS Catalog for KIAA0754 Gene

Gene Ontology (GO) - Molecular Function for KIAA0754 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI --
GO:0008017 microtubule binding IEA --
GO:0016887 ATPase activity ISS --
genes like me logo Genes that share ontologies with KIAA0754: view

Phenotypes for KIAA0754 Gene

GenomeRNAi human phenotypes for KIAA0754:
genes like me logo Genes that share phenotypes with KIAA0754: view

Animal Model Products

CRISPR Products

miRNA for KIAA0754 Gene

miRTarBase miRNAs that target KIAA0754

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA0754 Gene

Localization for KIAA0754 Gene

Gene Ontology (GO) - Cellular Components for KIAA0754 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005794 Golgi apparatus IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with KIAA0754: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for KIAA0754 Gene

Pathways & Interactions for KIAA0754 Gene

genes like me logo Genes that share pathways with KIAA0754: view

Pathways by source for KIAA0754 Gene

1 BioSystems pathway for KIAA0754 Gene

Gene Ontology (GO) - Biological Process for KIAA0754 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010632 regulation of epithelial cell migration ISS --
GO:0016055 Wnt signaling pathway IEA --
GO:0030177 positive regulation of Wnt signaling pathway ISS --
GO:0030334 regulation of cell migration IDA --
GO:0032886 regulation of microtubule-based process IMP --
genes like me logo Genes that share ontologies with KIAA0754: view

No data available for SIGNOR curated interactions for KIAA0754 Gene

Drugs & Compounds for KIAA0754 Gene

No Compound Related Data Available

Transcripts for KIAA0754 Gene

mRNA/cDNA for KIAA0754 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(35) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIAA0754 Gene

KIAA0754:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0754 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^
SP1: - - - - - - -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7: - - - - -
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43a · 43b ^ 44 ^ 45 ^
SP1: - - -
SP2: - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

ExUns: 46 ^ 47 ^ 48 ^ 49 ^ 50 ^ 51 ^ 52 ^ 53 ^ 54 ^ 55 ^ 56 ^ 57 ^ 58 ^ 59 ^ 60 ^ 61 ^ 62a · 62b ^ 63 ^ 64 ^ 65 ^ 66 ^ 67 ^ 68 ^ 69 ^ 70 ^
SP1: -
SP2: - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

ExUns: 71 ^ 72 ^ 73 ^ 74 ^ 75 ^ 76 ^ 77 ^ 78a · 78b ^ 79 ^ 80a · 80b ^ 81 ^ 82 ^ 83 ^ 84 ^ 85 ^ 86 ^ 87a · 87b ^ 88 ^ 89a · 89b ^ 90 ^ 91a · 91b ^
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

ExUns: 92a · 92b ^ 93a · 93b ^ 94 ^ 95 ^ 96a · 96b ^ 97 ^ 98a · 98b · 98c · 98d ^ 99a · 99b · 99c ^ 100 ^ 101a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14: - - -
SP15: -
SP16: - -
SP17:
SP18:
SP19:
SP20:

Relevant External Links for KIAA0754 Gene

GeneLoc Exon Structure for
KIAA0754
ECgene alternative splicing isoforms for
KIAA0754

Expression for KIAA0754 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIAA0754 Gene

Protein differential expression in normal tissues from HIPED for KIAA0754 Gene

This gene is overexpressed in Heart (41.1), Breast (13.3), and Plasma (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIAA0754 Gene



Protein tissue co-expression partners for KIAA0754 Gene

NURSA nuclear receptor signaling pathways regulating expression of KIAA0754 Gene:

KIAA0754

SOURCE GeneReport for Unigene cluster for KIAA0754 Gene:

Hs.658760
genes like me logo Genes that share expression patterns with KIAA0754: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA0754 Gene

Orthologs for KIAA0754 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIAA0754 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia MACF1 34
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA0754 33
  • 80.99 (n)
MACF1 34
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia D830031N03Rik 33 16
  • 78.68 (n)
Macf1 34
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MACF1 34
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MACF1 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 84 (a)
OneToMany
-- 34
  • 83 (a)
OneToMany
-- 34
  • 79 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia MACF1 34
  • 86 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii macf1 34
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta shot 34
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vab-10 34
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 73 (a)
OneToMany
Species where no ortholog for KIAA0754 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KIAA0754 Gene

ENSEMBL:
Gene Tree for KIAA0754 (if available)
TreeFam:
Gene Tree for KIAA0754 (if available)

Paralogs for KIAA0754 Gene

Paralogs for KIAA0754 Gene

Pseudogenes.org Pseudogenes for KIAA0754 Gene

genes like me logo Genes that share paralogs with KIAA0754: view

Variants for KIAA0754 Gene

Sequence variations from dbSNP and Humsavar for KIAA0754 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1001002543 -- 39,415,384(+) A/G 3_prime_UTR_variant
rs1001261548 -- 39,408,690(+) A/G upstream_transcript_variant
rs1001476153 -- 39,415,115(+) T/C 3_prime_UTR_variant
rs1001607657 -- 39,410,046(+) A/G 5_prime_UTR_variant
rs1001638483 -- 39,409,724(+) C/A 5_prime_UTR_variant

Variation tolerance for KIAA0754 Gene

Gene Damage Index Score: 4.67; 65.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIAA0754 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA0754

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KIAA0754 Gene

Disorders for KIAA0754 Gene

Additional Disease Information for KIAA0754

No disorders were found for KIAA0754 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA0754 Gene

Publications for KIAA0754 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
  5. An investigation into the human serum "interactome". (PMID: 15174051) Zhou M … Conrads TP (Electrophoresis 2004) 3 58

Products for KIAA0754 Gene

Sources for KIAA0754 Gene

Content
Loading form....