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Aliases for KIAA0754 Gene

Aliases for KIAA0754 Gene

  • KIAA0754 2 3
  • Microtubule-Actin Crosslinking Factor 1 5
  • MACF1 5

External Ids for KIAA0754 Gene

Previous GeneCards Identifiers for KIAA0754 Gene

  • GC01U990245
  • GC01P039648
  • GC01P039875

Summaries for KIAA0754 Gene

GeneCards Summary for KIAA0754 Gene

KIAA0754 (KIAA0754) is a Protein Coding gene. Among its related pathways are Mesodermal Commitment Pathway and HIV Life Cycle. GO annotations related to this gene include nucleic acid binding and calcium ion binding. An important paralog of this gene is DST.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA0754 Gene

Genomics for KIAA0754 Gene

Regulatory Elements for KIAA0754 Gene

Enhancers for KIAA0754 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G039182 2 FANTOM5 Ensembl ENCODE dbSUPER 14.2 +109.2 109186 15.7 HDGF PKNOX1 ARNT WRNIP1 SIN3A FEZF1 ZNF2 YY1 ZNF766 CBX5 PPIEL MACF1 KIAA0754 ENSG00000226438 RNU6-608P OXCT2P1 RLF PABPC4 BMP8B ENSG00000270040
GH01G039391 2 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +314.9 314923 10.2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A YY1 ZNF766 FOS DEK PABPC4 ENSG00000259943 LOC101929516 PPIEL SNORA55 OXCT2P1 MYCBP KIAA0754 MACF1 BMP8A
GH01G039126 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.2 +49.6 49560 8.5 HDGF PKNOX1 ARNT ARID4B ZNF48 ZNF121 GATA2 ZNF143 FOS ZHX2 MACF1 ENSG00000226438 KIAA0754 OXCT2P1 GC01M039121 RNU6-608P RNA5SP44
GH01G039167 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +87.4 87366 2.2 HDGF PKNOX1 MLX ARNT ARID4B ZNF766 REST SMARCB1 ZNF592 KAT8 ENSG00000182109 RNU6-608P ENSG00000226438 KIAA0754 MACF1 BMP8A RNA5SP44 ENSG00000270040
GH01G039176 1.5 Ensembl ENCODE dbSUPER 10.6 +97.6 97594 5.5 PKNOX1 ARNT SIN3A YY1 TCF12 ZNF766 GATA2 FOS ZNF263 MEF2D MACF1 ENSG00000182109 ENSG00000226438 RNU6-608P KIAA0754 OXCT2P1 PABPC4 RNA5SP44 ENSG00000270040
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIAA0754 on UCSC Golden Path with GeneCards custom track

Promoters for KIAA0754 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000005003 184 1401 HDAC1 RB1 CREB3L1 RARA ZNF121 GLIS2 EGR2 SP3 ZNF24 ZBTB26

Genomic Location for KIAA0754 Gene

Chromosome:
1
Start:
39,081,316 bp from pter
End:
39,487,177 bp from pter
Size:
405,862 bases
Orientation:
Plus strand

Genomic View for KIAA0754 Gene

Genes around KIAA0754 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA0754 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA0754 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA0754 Gene

Proteins for KIAA0754 Gene

  • Protein details for KIAA0754 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94854-K0754_HUMAN
    Recommended name:
    Uncharacterized protein KIAA0754
    Protein Accession:
    O94854
    Secondary Accessions:
    • E9PMC2
    • Q6ZSB2

    Protein attributes for KIAA0754 Gene

    Size:
    1291 amino acids
    Molecular mass:
    135148 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIAA0754 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA0754 Gene

Post-translational modifications for KIAA0754 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIAA0754 Gene

Domains & Families for KIAA0754 Gene

Protein Domains for KIAA0754 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA0754: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for KIAA0754 Gene

Function for KIAA0754 Gene

Gene Ontology (GO) - Molecular Function for KIAA0754 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI --
GO:0008017 microtubule binding IEA --
GO:0016887 ATPase activity IEA --
genes like me logo Genes that share ontologies with KIAA0754: view

Phenotypes for KIAA0754 Gene

GenomeRNAi human phenotypes for KIAA0754:
genes like me logo Genes that share phenotypes with KIAA0754: view

Animal Model Products

CRISPR Products

miRNA for KIAA0754 Gene

miRTarBase miRNAs that target KIAA0754

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA0754 Gene

Localization for KIAA0754 Gene

Gene Ontology (GO) - Cellular Components for KIAA0754 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005794 Golgi apparatus IEA --
GO:0005856 cytoskeleton NAS --
GO:0005874 microtubule IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with KIAA0754: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for KIAA0754 Gene

Pathways & Interactions for KIAA0754 Gene

genes like me logo Genes that share pathways with KIAA0754: view

Pathways by source for KIAA0754 Gene

1 BioSystems pathway for KIAA0754 Gene

Gene Ontology (GO) - Biological Process for KIAA0754 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010632 regulation of epithelial cell migration ISS --
GO:0016055 Wnt signaling pathway IEA --
GO:0030177 positive regulation of Wnt signaling pathway ISS --
GO:0032886 regulation of microtubule-based process IMP --
GO:0042060 wound healing ISS --
genes like me logo Genes that share ontologies with KIAA0754: view

No data available for SIGNOR curated interactions for KIAA0754 Gene

Transcripts for KIAA0754 Gene

mRNA/cDNA for KIAA0754 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(34) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIAA0754 Gene

KIAA0754:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0754 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^
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ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43a · 43b ^ 44 ^ 45 ^
SP1: - - -
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ExUns: 46 ^ 47 ^ 48 ^ 49 ^ 50 ^ 51 ^ 52 ^ 53 ^ 54 ^ 55 ^ 56 ^ 57 ^ 58 ^ 59 ^ 60 ^ 61 ^ 62a · 62b ^ 63 ^ 64 ^ 65 ^ 66 ^ 67 ^ 68 ^ 69 ^ 70 ^
SP1: -
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ExUns: 71 ^ 72 ^ 73 ^ 74 ^ 75 ^ 76 ^ 77 ^ 78a · 78b ^ 79 ^ 80a · 80b ^ 81 ^ 82 ^ 83 ^ 84 ^ 85 ^ 86 ^ 87a · 87b ^ 88 ^ 89a · 89b ^ 90 ^ 91a · 91b ^
SP1: -
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ExUns: 92a · 92b ^ 93a · 93b ^ 94 ^ 95 ^ 96a · 96b ^ 97 ^ 98a · 98b · 98c · 98d ^ 99a · 99b · 99c ^ 100 ^ 101a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - -
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SP9: -
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SP14: - - -
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Relevant External Links for KIAA0754 Gene

GeneLoc Exon Structure for
KIAA0754
ECgene alternative splicing isoforms for
KIAA0754

Expression for KIAA0754 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIAA0754 Gene

Protein differential expression in normal tissues from HIPED for KIAA0754 Gene

This gene is overexpressed in Heart (41.1), Breast (13.3), and Plasma (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIAA0754 Gene



Protein tissue co-expression partners for KIAA0754 Gene

NURSA nuclear receptor signaling pathways regulating expression of KIAA0754 Gene:

KIAA0754

SOURCE GeneReport for Unigene cluster for KIAA0754 Gene:

Hs.658760
genes like me logo Genes that share expression patterns with KIAA0754: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA0754 Gene

Orthologs for KIAA0754 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIAA0754 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia MACF1 35
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA0754 34
  • 80.99 (n)
MACF1 35
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia D830031N03Rik 34 16
  • 78.68 (n)
Macf1 35
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MACF1 35
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MACF1 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 84 (a)
OneToMany
-- 35
  • 83 (a)
OneToMany
-- 35
  • 79 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia MACF1 35
  • 86 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii macf1 35
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta shot 35
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vab-10 35
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 73 (a)
OneToMany
Species where no ortholog for KIAA0754 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KIAA0754 Gene

ENSEMBL:
Gene Tree for KIAA0754 (if available)
TreeFam:
Gene Tree for KIAA0754 (if available)

Paralogs for KIAA0754 Gene

Paralogs for KIAA0754 Gene

Pseudogenes.org Pseudogenes for KIAA0754 Gene

genes like me logo Genes that share paralogs with KIAA0754: view

Variants for KIAA0754 Gene

Sequence variations from dbSNP and Humsavar for KIAA0754 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1001002543 -- 39,415,384(+) GTGCT(A/G)GAGTG intron-variant, utr-variant-3-prime
rs1001261548 -- 39,408,690(+) TTGTC(A/G)GGGGA intron-variant, upstream-variant-2KB
rs1001476153 -- 39,415,115(+) AAAGC(C/T)AAATG intron-variant, utr-variant-3-prime
rs1001607657 -- 39,410,046(+) TGTCA(A/G)CCATG intron-variant, utr-variant-5-prime
rs1001638483 -- 39,409,724(+) AAACA(A/C)CCCAG intron-variant, utr-variant-5-prime

Variation tolerance for KIAA0754 Gene

Gene Damage Index Score: 4.67; 65.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA0754 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA0754

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KIAA0754 Gene

Disorders for KIAA0754 Gene

Relevant External Links for KIAA0754

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA0754

No disorders were found for KIAA0754 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA0754 Gene

Publications for KIAA0754 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  5. An investigation into the human serum "interactome". (PMID: 15174051) Zhou M. … Conrads T.P. (Electrophoresis 2004) 3 64

Products for KIAA0754 Gene

Sources for KIAA0754 Gene

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