Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KIAA0754 Gene

Aliases for KIAA0754 Gene

  • KIAA0754 2 3
  • Microtubule-Actin Crosslinking Factor 1 5
  • MACF1 5

External Ids for KIAA0754 Gene

Previous GeneCards Identifiers for KIAA0754 Gene

  • GC01U990245
  • GC01P039648
  • GC01P039875

Summaries for KIAA0754 Gene

GeneCards Summary for KIAA0754 Gene

KIAA0754 (KIAA0754) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and calcium ion binding. An important paralog of this gene is DST.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA0754 Gene

Genomics for KIAA0754 Gene

Regulatory Elements for KIAA0754 Gene

Promoters for KIAA0754 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KIAA0754 on UCSC Golden Path with GeneCards custom track

Genomic Location for KIAA0754 Gene

Chromosome:
1
Start:
39,081,316 bp from pter
End:
39,487,177 bp from pter
Size:
405,862 bases
Orientation:
Plus strand

Genomic View for KIAA0754 Gene

Genes around KIAA0754 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA0754 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA0754 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA0754 Gene

Proteins for KIAA0754 Gene

  • Protein details for KIAA0754 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94854-K0754_HUMAN
    Recommended name:
    Uncharacterized protein KIAA0754
    Protein Accession:
    O94854
    Secondary Accessions:
    • E9PMC2
    • Q6ZSB2

    Protein attributes for KIAA0754 Gene

    Size:
    1291 amino acids
    Molecular mass:
    135148 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIAA0754 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA0754 Gene

Proteomics data for KIAA0754 Gene at MOPED

Post-translational modifications for KIAA0754 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIAA0754 Gene

Domains & Families for KIAA0754 Gene

Protein Domains for KIAA0754 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA0754: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for KIAA0754 Gene

Function for KIAA0754 Gene

Gene Ontology (GO) - Molecular Function for KIAA0754 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0044822 poly(A) RNA binding IDA --
GO:0051015 actin filament binding NAS --
genes like me logo Genes that share ontologies with KIAA0754: view

Phenotypes for KIAA0754 Gene

GenomeRNAi human phenotypes for KIAA0754:
genes like me logo Genes that share phenotypes with KIAA0754: view

Animal Model Products

CRISPR Products

miRNA for KIAA0754 Gene

miRTarBase miRNAs that target KIAA0754

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA0754 Gene

Localization for KIAA0754 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA0754 Gene COMPARTMENTS Subcellular localization image for KIAA0754 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for KIAA0754 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032587 ruffle membrane IDA --
genes like me logo Genes that share ontologies with KIAA0754: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KIAA0754 Gene

Pathways & Interactions for KIAA0754 Gene

SuperPathways for KIAA0754 Gene

No Data Available

Interacting Proteins for KIAA0754 Gene

Gene Ontology (GO) - Biological Process for KIAA0754 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest IEA --
GO:0010632 regulation of epithelial cell migration ISS --
GO:0016055 Wnt signaling pathway IEA --
GO:0043001 Golgi to plasma membrane protein transport IDA --
genes like me logo Genes that share ontologies with KIAA0754: view

No data available for Pathways by source and SIGNOR curated interactions for KIAA0754 Gene

Drugs & Compounds for KIAA0754 Gene

No Compound Related Data Available

Transcripts for KIAA0754 Gene

mRNA/cDNA for KIAA0754 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(34) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIAA0754 Gene

KIAA0754:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0754 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^
SP1: - - - - - - -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7: - - - - -
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43a · 43b ^ 44 ^ 45 ^
SP1: - - -
SP2: - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

ExUns: 46 ^ 47 ^ 48 ^ 49 ^ 50 ^ 51 ^ 52 ^ 53 ^ 54 ^ 55 ^ 56 ^ 57 ^ 58 ^ 59 ^ 60 ^ 61 ^ 62a · 62b ^ 63 ^ 64 ^ 65 ^ 66 ^ 67 ^ 68 ^ 69 ^ 70 ^
SP1: -
SP2: - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

ExUns: 71 ^ 72 ^ 73 ^ 74 ^ 75 ^ 76 ^ 77 ^ 78a · 78b ^ 79 ^ 80a · 80b ^ 81 ^ 82 ^ 83 ^ 84 ^ 85 ^ 86 ^ 87a · 87b ^ 88 ^ 89a · 89b ^ 90 ^ 91a · 91b ^
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

ExUns: 92a · 92b ^ 93a · 93b ^ 94 ^ 95 ^ 96a · 96b ^ 97 ^ 98a · 98b · 98c · 98d ^ 99a · 99b · 99c ^ 100 ^ 101a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14: - - -
SP15: -
SP16: - -
SP17:
SP18:
SP19:
SP20:

Relevant External Links for KIAA0754 Gene

GeneLoc Exon Structure for
KIAA0754
ECgene alternative splicing isoforms for
KIAA0754

Expression for KIAA0754 Gene

mRNA expression in normal human tissues for KIAA0754 Gene

Protein differential expression in normal tissues from HIPED for KIAA0754 Gene

This gene is overexpressed in Heart (41.1), Breast (13.3), and Plasma (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIAA0754 Gene



SOURCE GeneReport for Unigene cluster for KIAA0754 Gene Hs.658760

genes like me logo Genes that share expression patterns with KIAA0754: view

Protein tissue co-expression partners for KIAA0754 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIAA0754 Gene

Orthologs for KIAA0754 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIAA0754 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MACF1 36
  • 68 (a)
OneToOne
KIAA0754 35
  • 80.99 (n)
  • 70.61 (a)
dog
(Canis familiaris)
Mammalia MACF1 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Macf1 36
  • 67 (a)
OneToOne
D830031N03Rik 35
  • 78.68 (n)
  • 69.28 (a)
D830031N03Rik 16
oppossum
(Monodelphis domestica)
Mammalia MACF1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MACF1 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 79 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia MACF1 36
  • 86 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii macf1 36
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta shot 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vab-10 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 73 (a)
OneToMany
Species with no ortholog for KIAA0754:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KIAA0754 Gene

ENSEMBL:
Gene Tree for KIAA0754 (if available)
TreeFam:
Gene Tree for KIAA0754 (if available)

Paralogs for KIAA0754 Gene

Paralogs for KIAA0754 Gene

Pseudogenes.org Pseudogenes for KIAA0754 Gene

genes like me logo Genes that share paralogs with KIAA0754: view

Variants for KIAA0754 Gene

Sequence variations from dbSNP and Humsavar for KIAA0754 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_033338 -
VAR_033339 -
VAR_033340 -

Structural Variations from Database of Genomic Variants (DGV) for KIAA0754 Gene

Variant ID Type Subtype PubMed ID
nsv870829 CNV Gain 21882294

Variation tolerance for KIAA0754 Gene

Gene Damage Index Score: 4.67; 65.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA0754 Gene

HapMap Linkage Disequilibrium report
KIAA0754

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA0754 Gene

Disorders for KIAA0754 Gene

Relevant External Links for KIAA0754

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA0754

No disorders were found for KIAA0754 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA0754 Gene

Publications for KIAA0754 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  3. An investigation into the human serum "interactome". (PMID: 15174051) Zhou M. … Conrads T.P. (Electrophoresis 2004) 3

Products for KIAA0754 Gene

Sources for KIAA0754 Gene

Back to Top

Content