KIAA0753 Gene
protein-coding GIFtS: 41
GCID: GC17M006422
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KIAA0753
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Aliases
for KIAA0753 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| KIAA07531 2 | | Uncharacterized Protein KIAA07532 |
Export aliases for KIAA0753 gene to outside databasesPrevious GC identifers: GC17M006870 GC17M007212 GC17M006426 GC17M006682 |
Summaries
for KIAA0753 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for KIAA0753 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KIAA0753 gene promoter:
Max1 USF1 Pax-5 AP-4 N-Myc HSF2 USF-1 Msx-1 Pax-4a c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for KIAA0753
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA0753 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1KIAA0753 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M006422: view genomic region
(about GC identifiers)
Start:
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6,481,468 bp from pter |
End:
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6,544,247 bp from pter |
Size:
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62,780 bases |
Orientation:
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minus strand |
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Proteins
for KIAA0753 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: K0753_HUMAN, Q2KHM9 (See
protein sequence)Recommended Name: Uncharacterized protein KIAA0753 Size: 967 amino acids; 109407 Da
Sequence caution: Sequence=BAA34473.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8KA11 B7Z479 O94853 Q05D97 Q2KHN0 Q9UG45Alternative splicing: 2 isoforms: Q2KHM9-1 Q2KHM9-2 Explore the universe of human proteins at neXtProt for KIAA0753: NX_Q2KHM9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q2KHM9
KIAA0753 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055619.2
ENSEMBL proteins: ENSP00000460156 ENSP00000355250 ENSP00000460816 ENSP00000460050 ENSP00000444946 ENSP00000459530 ENSP00000458983 ENSP00000458247 ENSP00000444634 ENSP00000467318
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
KIAA0753 for ontologies About GeneDecksing
KIAA0753 Antibody Products:
Assay Products for KIAA0753: |
Protein
Domains /
Families
for KIAA0753 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q2KHM9 |
Function
for KIAA0753 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA0753 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA0753
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KIAA0753 (NM_014804) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIAA0753 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA0753 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA0753 |
1 GenomeRNAi human phenotype for KIAA0753:
|
Pathways & Interactions
for KIAA0753 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA0753
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for KIAA0753 (ENSP000003552504) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for KIAA0753 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KIAA0753
Search CenterWatch for drugs/clinical trials and news about KIAA0753 / K0753
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Transcripts
for KIAA0753 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KIAA0753 gene: NM_014804.2 Unigene Cluster for KIAA0753: KIAA0753 Hs.28070 [show with all ESTs]Unigene Representative Sequence: NM_01480413 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000576281 ENST00000361413(uc010vtd.2 uc010clo.3 uc002gde.4 uc010vte.2)
ENST00000570790 ENST00000572370 ENST00000542826 ENST00000575027 ENST00000572235
ENST00000576823 ENST00000571642 ENST00000573033 ENST00000570455 ENST00000542606
ENST00000589033
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA0753 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA0753
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KIAA0753 (NM_014804) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIAA0753 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA0753 |
Additional cDNA sequence: AB018296.1 AK292876.1 AK296971.1 AK300547.1 AL080108.1 BC113016.1 BC113017.1 10 DOTS entries: DT.97820955 DT.455374 DT.97796333 DT.120964695 DT.100748547 DT.120964608 DT.120964623 DT.422168 DT.95365747 DT.92424531 24/85 AceView cDNA sequences (see all 85): F11470 CR597760 AI935979 F09132 AW366768 BG152633 CB130644 AI206760 BG111641 CA441574 AB018296 AI031989 BX103147 CD674565 BM988811 AA482035 AL080108 AW243778 AA369864 AW189123 AI611058 AA417574 AA805370 BG121022
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0753 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ |
|---|
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| SP1: | | | - | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 22 |
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| SP1: | | | |
| SP2: | | | |
| SP3: | | | |
| SP4: | | | |
| SP5: | | |
ECgene alternative splicing isoforms for KIAA0753
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Expression
for KIAA0753 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KIAA0753 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGAAAGAAT
About this image
See KIAA0753 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIAA0753
SOURCE GeneReport for Unigene cluster: Hs.28070
SABiosciences Custom PCR Arrays for KIAA0753
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIAA0753
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIAA0753 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIAA0753 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIAA0753 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA0753 |
Orthologs
for KIAA0753 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KIAA0753 gene from 3/11 species (see all 11) About this table
ENSEMBL Gene Tree for KIAA0753 (if available)
TreeFam Gene Tree for KIAA0753 (if available) |
Paralogs
for KIAA0753 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for KIAA0753 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KIAA0753 (6481468 - 6544247 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KIAA0753
1 CNV: 67124 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIAA0753 |
|
Disorders
/ Diseases
for KIAA0753 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for KIAA0753 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KIAA0753 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KIAA0753) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (1998)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for KIAA0753 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KIAA0753 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KIAA0753 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing KIAA0753 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KIAA0753 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for KIAA0753 gene:
Search GeneIP for patents involving KIAA0753
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KIAA0753 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIAA0753 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIAA0753 | | | OriGene Protein Over-expression Lysate for KIAA0753 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KIAA0753 | | OriGene 3'-UTR Clone for KIAA0753 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA0753 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA0753 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KIAA0753 | | OriGene Custom Protein Services for KIAA0753 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KIAA0753 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIAA0753 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA0753 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIAA0753 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIAA0753 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIAA0753 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA0753 |
|  |  |  | | | | Search ThermoFisher Antibodies for KIAA0753 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA0753 |
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