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Aliases for KIAA0753 Gene

Aliases for KIAA0753 Gene

  • KIAA0753 2 3

External Ids for KIAA0753 Gene

Summaries for KIAA0753 Gene

GeneCards Summary for KIAA0753 Gene

KIAA0753 (KIAA0753) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA0753 Gene

Genomics for KIAA0753 Gene

Genomic Location for KIAA0753 Gene

Start:
6,578,148 bp from pter
End:
6,641,746 bp from pter
Size:
63,599 bases
Orientation:
Minus strand

Genomic View for KIAA0753 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIAA0753 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA0753 Gene

Regulatory Elements for KIAA0753 Gene

Proteins for KIAA0753 Gene

  • Protein details for KIAA0753 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2KHM9-K0753_HUMAN
    Recommended name:
    Uncharacterized protein KIAA0753
    Protein Accession:
    Q2KHM9
    Secondary Accessions:
    • A8KA11
    • B7Z479
    • O94853
    • Q05D97
    • Q2KHN0
    • Q9UG45

    Protein attributes for KIAA0753 Gene

    Size:
    967 amino acids
    Molecular mass:
    109407 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA34473.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA0753 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA0753 Gene

Proteomics data for KIAA0753 Gene at MOPED

Post-translational modifications for KIAA0753 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys26

Other Protein References for KIAA0753 Gene

No data available for DME Specific Peptides for KIAA0753 Gene

Domains for KIAA0753 Gene

Protein Domains for KIAA0753 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for KIAA0753 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA0753: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KIAA0753 Gene

Function for KIAA0753 Gene

Gene Ontology (GO) - Molecular Function for KIAA0753 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KIAA0753: view

Phenotypes for KIAA0753 Gene

GenomeRNAi human phenotypes for KIAA0753:
genes like me logo Genes that share phenotypes with KIAA0753: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KIAA0753 Gene

Localization for KIAA0753 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA0753 Gene COMPARTMENTS Subcellular localization image for KIAA0753 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for KIAA0753 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with KIAA0753: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KIAA0753 Gene

Pathways for KIAA0753 Gene

SuperPathways for KIAA0753 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA0753 Gene

None

No data available for Pathways by source for KIAA0753 Gene

Transcripts for KIAA0753 Gene

Unigene Clusters for KIAA0753 Gene

KIAA0753:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0753 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^
SP1: - - -
SP2: -
SP3:
SP4: - -
SP5:

ExUns: 22
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for KIAA0753 Gene

GeneLoc Exon Structure for
KIAA0753
ECgene alternative splicing isoforms for
KIAA0753

Expression for KIAA0753 Gene

mRNA expression in normal human tissues for KIAA0753 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIAA0753 Gene

SOURCE GeneReport for Unigene cluster for KIAA0753 Gene Hs.28070

genes like me logo Genes that share expressions with KIAA0753: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIAA0753 Gene

Orthologs for KIAA0753 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA0753 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA0753 35
  • 99 (n)
  • 98.61 (a)
KIAA0753 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA0753 35
  • 83.73 (n)
  • 77.66 (a)
KIAA0753 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA0753 36
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4933427D14Rik 35
  • 81.54 (n)
  • 76.65 (a)
4933427D14Rik 16
4933427D14Rik 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA0753 36
  • 36 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA0753 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1304728 35
  • 81.17 (n)
  • 77.04 (a)
chicken
(Gallus gallus)
Aves KIAA0753 35
  • 59.48 (n)
  • 47.89 (a)
KIAA0753 36
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkey-243i1.1 36
  • 35 (a)
OneToOne
Species with no ortholog for KIAA0753:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA0753 Gene

ENSEMBL:
Gene Tree for KIAA0753 (if available)
TreeFam:
Gene Tree for KIAA0753 (if available)

Paralogs for KIAA0753 Gene

No data available for Paralogs for KIAA0753 Gene

Variants for KIAA0753 Gene

Sequence variations from dbSNP and Humsavar for KIAA0753 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2009 -- 6,578,456(-) TTACA(A/G)GGTGT utr-variant-3-prime, intron-variant
rs9751 -- 6,578,613(-) AGTGC(C/T)GTCAT utr-variant-3-prime, nc-transcript-variant
rs356034 -- 6,615,540(+) aaccc(A/G/T)cgagg intron-variant
rs356035 -- 6,603,515(+) agagg(C/T)tgaaa intron-variant
rs367918 -- 6,589,736(+) AATTT(C/T)GCAAT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for KIAA0753 Gene

Variant ID Type Subtype PubMed ID
esv26106 CNV Loss 19812545
esv273047 CNV Insertion 20981092
esv267669 CNV Insertion 20981092

Relevant External Links for KIAA0753 Gene

HapMap Linkage Disequilibrium report
KIAA0753

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA0753 Gene

Disorders for KIAA0753 Gene

No disorders were found for KIAA0753 Gene.

No data available for UniProtKB/Swiss-Prot for KIAA0753 Gene

Publications for KIAA0753 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  2. Proximity Interactions among Centrosome Components Identify Regulators of Centriole Duplication. (PMID: 24613305) Firat-Karalar E.N. … Stearns T. (Curr. Biol. 2014) 2 3
  3. Quantitative Lys-I/-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. (PMID: 25147182) Thompson J.W. … Luchansky S.J. (J. Biol. Chem. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for KIAA0753 Gene

Sources for KIAA0753 Gene

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