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Aliases for KIAA0753 Gene

Aliases for KIAA0753 Gene

  • KIAA0753 2 3
  • Moonraker 2 3
  • MNR 3 4
  • OFIP 3

External Ids for KIAA0753 Gene

Previous GeneCards Identifiers for KIAA0753 Gene

  • GC17M006870
  • GC17M007212
  • GC17M006426
  • GC17M006682
  • GC17M006422

Summaries for KIAA0753 Gene

GeneCards Summary for KIAA0753 Gene

KIAA0753 (KIAA0753) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KIAA0753 Gene

  • Involved in centriole duplication. Positively regulates CEP63 centrosomal localization. Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:24613305, PubMed:26297806).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA0753 Gene

Genomics for KIAA0753 Gene

Regulatory Elements for KIAA0753 Gene

Enhancers for KIAA0753 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KIAA0753 on UCSC Golden Path with GeneCards custom track

Promoters for KIAA0753 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KIAA0753 on UCSC Golden Path with GeneCards custom track

Genomic Location for KIAA0753 Gene

Chromosome:
17
Start:
6,578,148 bp from pter
End:
6,641,744 bp from pter
Size:
63,597 bases
Orientation:
Minus strand

Genomic View for KIAA0753 Gene

Genes around KIAA0753 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA0753 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA0753 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA0753 Gene

Proteins for KIAA0753 Gene

  • Protein details for KIAA0753 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2KHM9-MOONR_HUMAN
    Recommended name:
    Protein moonraker
    Protein Accession:
    Q2KHM9
    Secondary Accessions:
    • A8KA11
    • B7Z479
    • O94853
    • Q05D97
    • Q2KHN0
    • Q9UG45

    Protein attributes for KIAA0753 Gene

    Size:
    967 amino acids
    Molecular mass:
    109407 Da
    Quaternary structure:
    • Interacts with CEP63, PCM1 and WDR62.
    SequenceCaution:
    • Sequence=BAA34473.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA0753 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA0753 Gene

Proteomics data for KIAA0753 Gene at MOPED

Post-translational modifications for KIAA0753 Gene

  • Ubiquitination at Lys 26
  • Modification sites at PhosphoSitePlus

Other Protein References for KIAA0753 Gene

No data available for DME Specific Peptides for KIAA0753 Gene

Domains & Families for KIAA0753 Gene

Protein Domains for KIAA0753 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA0753 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA0753: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KIAA0753 Gene

Function for KIAA0753 Gene

Molecular function for KIAA0753 Gene

UniProtKB/Swiss-Prot Function:
Involved in centriole duplication. Positively regulates CEP63 centrosomal localization. Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:24613305, PubMed:26297806).
genes like me logo Genes that share phenotypes with KIAA0753: view

Animal Models for KIAA0753 Gene

MGI Knock Outs for KIAA0753:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for KIAA0753 Gene

Localization for KIAA0753 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA0753 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA0753 Gene COMPARTMENTS Subcellular localization image for KIAA0753 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for KIAA0753 Gene

Pathways & Interactions for KIAA0753 Gene

SuperPathways for KIAA0753 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA0753 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA0753 Gene

Drugs & Compounds for KIAA0753 Gene

No Compound Related Data Available

Transcripts for KIAA0753 Gene

Unigene Clusters for KIAA0753 Gene

KIAA0753:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0753 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^
SP1: - - -
SP2: -
SP3:
SP4: - -
SP5:

ExUns: 22
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for KIAA0753 Gene

GeneLoc Exon Structure for
KIAA0753
ECgene alternative splicing isoforms for
KIAA0753

Expression for KIAA0753 Gene

mRNA expression in normal human tissues for KIAA0753 Gene

Protein differential expression in normal tissues from HIPED for KIAA0753 Gene

This gene is overexpressed in Colon (23.6), Fetal Liver (10.5), Tonsil (9.1), and Kidney (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIAA0753 Gene



SOURCE GeneReport for Unigene cluster for KIAA0753 Gene Hs.28070

genes like me logo Genes that share expression patterns with KIAA0753: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KIAA0753 Gene

Orthologs for KIAA0753 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA0753 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIAA0753 35
  • 83.73 (n)
  • 77.66 (a)
KIAA0753 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4933427D14Rik 35
  • 81.54 (n)
  • 76.65 (a)
4933427D14Rik 16
4933427D14Rik 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIAA0753 35
  • 99 (n)
  • 98.61 (a)
KIAA0753 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1304728 35
  • 81.17 (n)
  • 77.04 (a)
dog
(Canis familiaris)
Mammalia KIAA0753 36
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA0753 36
  • 36 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA0753 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA0753 35
  • 59.48 (n)
  • 47.89 (a)
KIAA0753 36
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkey-243i1.1 36
  • 35 (a)
OneToOne
Species with no ortholog for KIAA0753:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA0753 Gene

ENSEMBL:
Gene Tree for KIAA0753 (if available)
TreeFam:
Gene Tree for KIAA0753 (if available)

Paralogs for KIAA0753 Gene

No data available for Paralogs for KIAA0753 Gene

Variants for KIAA0753 Gene

Sequence variations from dbSNP and Humsavar for KIAA0753 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs16955985 - 6,628,232(+) CTGGG(A/C/T)TGAGG nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs9889363 - 6,620,978(+) TTCTT(A/T)TCCAG nc-transcript-variant, reference, missense
rs17794522 - 6,620,979(+) TCTTT(C/T)CCAGG nc-transcript-variant, reference, missense
rs2289643 - 6,612,134(+) CGTAT(C/T)GGGCT nc-transcript-variant, reference, missense
rs2289642 - 6,612,067(+) CTTCC(A/G)GAACT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KIAA0753 Gene

Variant ID Type Subtype PubMed ID
esv26106 CNV Loss 19812545
esv273047 CNV Insertion 20981092
esv267669 CNV Insertion 20981092

Variation tolerance for KIAA0753 Gene

Residual Variation Intolerance Score: 87.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.40; 98.55% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KIAA0753 Gene

Disorders for KIAA0753 Gene

Relevant External Links for KIAA0753

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA0753

No disorders were found for KIAA0753 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA0753 Gene

Publications for KIAA0753 Gene

  1. Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication. (PMID: 26297806) Kodani A. … Reiter J.F. (Elife 2015) 2 3 4 67
  2. OFIP/KIAA0753 forms a complex with OFD1 and FOR20 at pericentriolar satellites and centrosomes and is mutated in one individual with oral-facial-digital syndrome. (PMID: 26643951) Chevrier V. … Thauvin-Robinet C. (Hum. Mol. Genet. 2016) 2 3
  3. Proximity Interactions among Centrosome Components Identify Regulators of Centriole Duplication. (PMID: 24613305) Firat-Karalar E.N. … Stearns T. (Curr. Biol. 2014) 2 3
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for KIAA0753 Gene

Sources for KIAA0753 Gene

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