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Aliases for KIAA0586 Gene

Aliases for KIAA0586 Gene

  • KIAA0586 2 3
  • Talpid3 3 4 6
  • Ortholog Of Chicken Talpid{3} 3
  • Protein TALPID3 3

External Ids for KIAA0586 Gene

Summaries for KIAA0586 Gene

GeneCards Summary for KIAA0586 Gene

KIAA0586 (KIAA0586) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KIAA0586 Gene

  • Required for ciliogenesis and sonic hedgehog/SHH signaling.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA0586 Gene

Genomics for KIAA0586 Gene

Genomic Location for KIAA0586 Gene

Start:
58,427,385 bp from pter
End:
58,551,289 bp from pter
Size:
123,905 bases
Orientation:
Plus strand

Genomic View for KIAA0586 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIAA0586 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA0586 Gene

Regulatory Elements for KIAA0586 Gene

Proteins for KIAA0586 Gene

  • Protein details for KIAA0586 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVV6-TALD3_HUMAN
    Recommended name:
    Protein TALPID3
    Protein Accession:
    Q9BVV6
    Secondary Accessions:
    • B4DZB6
    • E7EWM8
    • J3KQH9
    • O60328
    • Q6NYC6
    • Q6UV20

    Protein attributes for KIAA0586 Gene

    Size:
    1533 amino acids
    Molecular mass:
    169307 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA25512.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA0586 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA0586 Gene

Proteomics data for KIAA0586 Gene at MOPED

Post-translational modifications for KIAA0586 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys380 and Lys688

No data available for DME Specific Peptides for KIAA0586 Gene

Domains for KIAA0586 Gene

Protein Domains for KIAA0586 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TALD3_HUMAN
Family:
  • Belongs to the TALPID3 family.:
    • Q9BVV6
genes like me logo Genes that share domains with KIAA0586: view

No data available for Gene Families for KIAA0586 Gene

Function for KIAA0586 Gene

Molecular function for KIAA0586 Gene

UniProtKB/Swiss-Prot Function: Required for ciliogenesis and sonic hedgehog/SHH signaling.

Gene Ontology (GO) - Molecular Function for KIAA0586 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KIAA0586: view
genes like me logo Genes that share phenotypes with KIAA0586: view

Animal Models for KIAA0586 Gene

MGI Knock Outs for KIAA0586:

miRNA for KIAA0586 Gene

miRTarBase miRNAs that target KIAA0586

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KIAA0586 Gene

Localization for KIAA0586 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA0586 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA0586 Gene COMPARTMENTS Subcellular localization image for KIAA0586 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for KIAA0586 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 19144723
GO:0036064 ciliary basal body IDA 24421332
genes like me logo Genes that share ontologies with KIAA0586: view

Pathways for KIAA0586 Gene

SuperPathways for KIAA0586 Gene

No Data Available

Interacting Proteins for KIAA0586 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000261244%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000260983%0d%0a
Selected Interacting proteins: ENSP00000261244 for KIAA0586 Gene via STRING

Gene Ontology (GO) - Biological Process for KIAA0586 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007224 smoothened signaling pathway ISS --
GO:0042384 cilium assembly IMP 24421332
GO:0060271 cilium morphogenesis ISS --
GO:0070201 regulation of establishment of protein localization IMP 24421332
genes like me logo Genes that share ontologies with KIAA0586: view

No data available for Pathways by source for KIAA0586 Gene

Transcripts for KIAA0586 Gene

Unigene Clusters for KIAA0586 Gene

KIAA0586:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0586 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2: - -
SP3:

Relevant External Links for KIAA0586 Gene

GeneLoc Exon Structure for
KIAA0586
ECgene alternative splicing isoforms for
KIAA0586

Expression for KIAA0586 Gene

mRNA expression in normal human tissues for KIAA0586 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KIAA0586 Gene

SOURCE GeneReport for Unigene cluster for KIAA0586 Gene Hs.232532

genes like me logo Genes that share expressions with KIAA0586: view

Orthologs for KIAA0586 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA0586 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA0586 36
  • 99.48 (n)
  • 99.09 (a)
KIAA0586 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA0586 36
  • 86.23 (n)
  • 80.79 (a)
KIAA0586 37
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA0586 36
  • 86.36 (n)
  • 80.17 (a)
KIAA0586 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2700049A03Rik 36
  • 78.86 (n)
  • 70.46 (a)
2700049A03Rik 16
2700049A03Rik 37
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA0586 37
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA0586 37
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC690035 36
  • 78.54 (n)
  • 71.1 (a)
chicken
(Gallus gallus)
Aves KIAA0586 36
  • 60.99 (n)
  • 48.44 (a)
TALPID3 37
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA0586 37
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa0586 36
  • 54.22 (n)
  • 44.88 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100537345 36
  • 48.98 (n)
  • 38.73 (a)
si:ch211-185a18.2 37
  • 39 (a)
OneToMany
si:ch211-185a18.2 37
  • 29 (a)
OneToMany
Species with no ortholog for KIAA0586:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA0586 Gene

ENSEMBL:
Gene Tree for KIAA0586 (if available)
TreeFam:
Gene Tree for KIAA0586 (if available)

Paralogs for KIAA0586 Gene

Selected SIMAP similar genes for KIAA0586 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with KIAA0586: view

No data available for Paralogs for KIAA0586 Gene

Variants for KIAA0586 Gene

Sequence variations from dbSNP and Humsavar for KIAA0586 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs6763 -- 58,427,095(-) CAACC(C/G)CCAGC upstream-variant-2KB
rs6764 -- 58,427,073(+) TCGCA(G/T)CCGAC upstream-variant-2KB
rs11611 -- 58,540,102(+) CAAAT(C/T)GAGCT synonymous-codon, reference, intron-variant
rs178389 -- 58,518,548(+) TTTTT(A/T)ACTGG intron-variant
rs178390 -- 58,525,428(+) ggtgg(G/T)gcgtt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA0586 Gene

Variant ID Type Subtype PubMed ID
nsv901985 CNV Loss 21882294
nsv826960 CNV Loss 20364138

Relevant External Links for KIAA0586 Gene

HapMap Linkage Disequilibrium report
KIAA0586

Disorders for KIAA0586 Gene

(1) University of Copenhagen DISEASES for KIAA0586 Gene

Relevant External Links for KIAA0586

Genetic Association Database (GAD)
KIAA0586
genes like me logo Genes that share disorders with KIAA0586: view

No data available for UniProtKB/Swiss-Prot for KIAA0586 Gene

Publications for KIAA0586 Gene

  1. The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation. (PMID: 19144723) Yin Y. … Tickle C. (Development 2009) 3 4
  2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The chicken talpid3 gene encodes a novel protein essential for Hedgehog signaling. (PMID: 16702409) Davey M.G. … Burt D.W. (Genes Dev. 2006) 2 3
  5. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PMID: 17370265) Denis N.J. … Figeys D. (Proteomics 2007) 3 4

Products for KIAA0586 Gene

Sources for KIAA0586 Gene

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