Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KIAA0408 Gene

Aliases for KIAA0408 Gene

  • KIAA0408 2 3

External Ids for KIAA0408 Gene

Previous GeneCards Identifiers for KIAA0408 Gene

  • GC06M127608
  • GC06M127742
  • GC06M127745
  • GC06M127803
  • GC06M127761

Summaries for KIAA0408 Gene

GeneCards Summary for KIAA0408 Gene

KIAA0408 (KIAA0408) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA0408 Gene

Genomics for KIAA0408 Gene

Regulatory Elements for KIAA0408 Gene

Enhancers for KIAA0408 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G127514 1.2 Ensembl ENCODE 22.3 -56.4 -56410 2.8 PKNOX1 SIN3A ZNF2 ZNF48 SLC30A9 GLIS2 ZNF143 KLF7 ZNF202 SP3 KIAA0408 SOGA3 PIR32248
GH06G127518 0.9 ENCODE 20.9 -59.7 -59664 1.4 ZNF76 KLF17 SIN3A ZNF2 ZSCAN5C EGR2 ZNF263 SP3 REST ZNF843 KIAA0408 SOGA3 PIR32248
GH06G127340 1.7 Ensembl ENCODE dbSUPER 10.8 +116.7 116663 4.7 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ECHDC1 KIAA0408 C6orf58 GC06P127344 RNA5SP217
GH06G127481 1.4 Ensembl ENCODE dbSUPER 12.7 -23.9 -23924 4.0 TBP FOXA2 TBL1XR1 ZEB1 GATA2 ZNF366 FOS RELB USF2 CEBPB C6orf58 KIAA0408 SOGA3 ECHDC1 PIR32248
GH06G127419 1.5 FANTOM5 Ensembl ENCODE 11.7 +38.7 38660 1.5 ELF3 CBX3 FOXA2 TBL1XR1 WRNIP1 RAD21 ZBTB40 ZNF143 FOS RELB ECHDC1 KIAA0408 RNF146 LOC100287856 RPL17P23
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIAA0408 on UCSC Golden Path with GeneCards custom track

Genomic Location for KIAA0408 Gene

Chromosome:
6
Start:
127,438,406 bp from pter
End:
127,459,391 bp from pter
Size:
20,986 bases
Orientation:
Minus strand

Genomic View for KIAA0408 Gene

Genes around KIAA0408 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA0408 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA0408 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA0408 Gene

Proteins for KIAA0408 Gene

  • Protein details for KIAA0408 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZU52-K0408_HUMAN
    Recommended name:
    Uncharacterized protein KIAA0408
    Protein Accession:
    Q6ZU52
    Secondary Accessions:
    • B3KRE5
    • E1P573
    • O43158
    • Q5TF20
    • Q7L2M2

    Protein attributes for KIAA0408 Gene

    Size:
    694 amino acids
    Molecular mass:
    79163 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA23704.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA0408 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA0408 Gene

Post-translational modifications for KIAA0408 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIAA0408 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIAA0408 Gene

Domains & Families for KIAA0408 Gene

Protein Domains for KIAA0408 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA0408: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for KIAA0408 Gene

Function for KIAA0408 Gene

Gene Ontology (GO) - Molecular Function for KIAA0408 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with KIAA0408: view

Phenotypes for KIAA0408 Gene

GenomeRNAi human phenotypes for KIAA0408:
genes like me logo Genes that share phenotypes with KIAA0408: view

Animal Model Products

CRISPR Products

miRNA for KIAA0408 Gene

miRTarBase miRNAs that target KIAA0408

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA0408 Gene

Localization for KIAA0408 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA0408 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KIAA0408 Gene

Pathways & Interactions for KIAA0408 Gene

SuperPathways for KIAA0408 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA0408 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA0408 Gene

Transcripts for KIAA0408 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0408 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12 ^ 13a · 13b · 13c · 13d ^
SP1: - - - -
SP2: - - - -
SP3: -
SP4: - - - -
SP5: - -
SP6: -
SP7: -
SP8: -
SP9: -
SP10:
SP11:

ExUns: 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:

Relevant External Links for KIAA0408 Gene

GeneLoc Exon Structure for
KIAA0408
ECgene alternative splicing isoforms for
KIAA0408

Expression for KIAA0408 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIAA0408 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIAA0408 Gene

This gene is overexpressed in Muscle - Skeletal (x9.4), Esophagus - Muscularis (x5.2), and Esophagus - Gastroesophageal Junction (x4.8).

Protein differential expression in normal tissues from HIPED for KIAA0408 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (61.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KIAA0408 Gene



NURSA nuclear receptor signaling pathways regulating expression of KIAA0408 Gene:

KIAA0408
genes like me logo Genes that share expression patterns with KIAA0408: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA0408 Gene

Orthologs for KIAA0408 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA0408 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOGA3 34
  • 99.38 (n)
KIAA0408 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA0408 34 35
  • 83.2 (n)
mouse
(Mus musculus)
Mammalia 9330159F19Rik 34 16 35
  • 76.46 (n)
rat
(Rattus norvegicus)
Mammalia Rgd1310049 34
  • 74.78 (n)
dog
(Canis familiaris)
Mammalia KIAA0408 35
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA0408 35
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA0408 35
  • 37 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA0408 34 35
  • 59.97 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA0408 35
  • 38 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii soga3a 34 35 35
  • 45.05 (n)
Species where no ortholog for KIAA0408 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA0408 Gene

ENSEMBL:
Gene Tree for KIAA0408 (if available)
TreeFam:
Gene Tree for KIAA0408 (if available)

Paralogs for KIAA0408 Gene

(3) SIMAP similar genes for KIAA0408 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with KIAA0408: view

No data available for Paralogs for KIAA0408 Gene

Variants for KIAA0408 Gene

Sequence variations from dbSNP and Humsavar for KIAA0408 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000300917 -- 127,457,735(+) AACAC(A/C)CAAGT intron-variant
rs1000364243 -- 127,451,817(+) GGTGA(A/G)GTATG intron-variant
rs1000703910 -- 127,451,822(+) GGTAT(A/G)AATCA intron-variant
rs1000754311 -- 127,451,539(+) CTTGG(C/T)GACAC intron-variant
rs1000798788 -- 127,451,501(+) GGAAC(A/C)CTAAA intron-variant

Variation tolerance for KIAA0408 Gene

Residual Variation Intolerance Score: 27.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.87; 83.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA0408 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA0408

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KIAA0408 Gene

Disorders for KIAA0408 Gene

Relevant External Links for KIAA0408

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA0408

No disorders were found for KIAA0408 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA0408 Gene

Publications for KIAA0408 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  4. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 3 4 64
  5. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3 64

Products for KIAA0408 Gene

Sources for KIAA0408 Gene

Content
Loading form....