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TTC37 Gene

protein-coding GIFtS: 43

GC05M094826

tetratricopeptide repeat domain 37
(Previous name: KIAA0372 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: KIAA0372)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
KIAA0372 ^¹, ², ³
MGC32587 ^²

Descriptions
TPR repeat protein 37 ^³
tetratricopeptide repeat domain 37 ^²

External Ids
HGNC: 23639¹
Entrez Gene: 9652²
UniProtKB: Q6PGP7³
Ensembl: ENSG00000198677⁷

Search outside databases for aliases for TTC37 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q15 Ensembl cytogenetic band: 5q15 HGNC cytogenetic band: 5q15

TTC37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M094826: (about GC identifiers)

Start:	94,825,355 bp from pter
End:	94,916,465 bp from pter
Size:	91,111 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000005.8 NT_023148.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TTC37_HUMAN, Q6PGP7 (See protein sequence)

Recommended Name: Tetratricopeptide repeat protein 37

Size: 1564 amino acids; 175486 Da

Secondary accessions: O15077 Q6PJI3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_055454.1

ENSEMBL proteins:

ENSP00000351596

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for TTC37:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for TTC37

Assays for TTC37:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q6PGP7

ProtoNet protein and cluster: Q6PGP7

UniProtKB/Swiss-Prot: TTC37_HUMAN, Q6PGP7

Similarity: Contains 20 TPR repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TTC37)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014639

Applied Biosystems Silencer® siRNAs for TTC37

Sigma-Aldrich siRNA for TTC37

Sigma-Aldrich shRNA for TTC37

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TTC37
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_014639
Myc/DDK tagged cDNA clone in CMV expression vector: NM_014639
untagged cDNA clone in CMV expression vector: NM_014639

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014639

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005488	binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TTC37

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TTC37)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014639

Sigma-Aldrich siRNA for TTC37

Sigma-Aldrich shRNA for TTC37

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014639

REFSEQ mRNAs for TTC37 gene:

NM_014639.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014639

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014639
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014639
                                 untagged cDNA clone in CMV expression vector: NM_014639

Additional cDNA sequence:

AB002370.1 AK307531.1 BC009767.1 BC015163.2 BC056893.1

19 DOTS entries:

DT.453607 DT.92433999 DT.40209180 DT.120880323 DT.97775644 DT.92434001 DT.95178392 DT.97825721

DT.95178427 DT.100793201 DT.120880304 DT.120880335 DT.95178389 DT.100704646 DT.120880293 DT.75103583

DT.91664181 DT.70102937 DT.99956562

24/273 AceView cDNA sequences (see all 273 ):

BC015163 AU133390 BP870775 R51172 AL700405 BU189359 BQ229920 BM263400

AA776449 BQ776645 AA847148 BM788918 AA233339 AW157222 AI636382 BQ951548

BM721897 BQ020011 AI373330 AI658888 BP380078 F04818 AI669927 BF447107

Unigene Cluster for TTC37:

Tetratricopeptide repeat domain 37

Hs.482868 [show with all ESTs]

Unigene Representative Sequence: AB002370

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TTC37 (see all 8 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15a	·	15b	^	16	^	17	^	18	^	19a	·	19b	^	20	^
SP1:																							-						-
SP2:																																					-										-
SP3:
SP4:
SP5:

ExUns:	21	^	22	^	23a	·	23b	^	24a	·	24b	^	25	^	26	^	27	^	28a	·	28b	^	29a	·	29b	^	30	^	31	^	32	^	33a	·	33b	^	34	^	35	^	36	^	37	^	38	^	39	^	40	^	41	^
SP1:							-		-												-		-
SP2:
SP3:
SP4:																					-		-
SP5:

ExUns:	42	^	43	^	44
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for TTC37

1 Ensembl transcript including schematic representation:

ENST00000358746

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TTC37 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TTC37

¹ / ²

6 probe-sets matching TTC37 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40517_at²	U95-A	1	1.00	1.00	1.00	1.00	--	--	--	--	--
203048_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
203049_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
203048_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1554029_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203049_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CAATTCCTTC

SOURCE GeneReport for Unigene cluster: Hs.482868

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TTC37 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TTC37¹	--	tetratricopeptide repeat domain 37	91.63(n) 92.13(a)	479150 XM_536294.2 XP_536294.2
cow (Bos taurus)	TTC37¹	--	tetratricopeptide repeat domain 37	90.98(n) 91.67(a)	534095 XM_613739.3 XP_613739.3
rat (Rattus norvegicus)	Ttc37¹	--	tetratricopeptide repeat domain 37	84.96(n) 84.03(a)	294595 XM_226606.4 XP_226606.4
mouse (Mus musculus)	Ttc37^{1, 5}	13⁵	tetratricopeptide repeat domain 37^{1, 5}	85.01(n)¹ 84.71(a)¹	218343¹ NM_001081352.1¹ NP_001074821.1¹ AK079259⁵ AK129128⁵ (see all 17)
chicken (Gallus gallus)	KIAA0372¹	--	KIAA0372	70.94(n) 67.12(a)	427114 XM_424706.2 XP_424706.2

About this table Species with no ortholog for TTC37

ENSEMBL Gene Tree for TTC37

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/266 NCBI SNPs in TTC37 are shown (see all 266 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 106)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1062073^1,2	A,C,F,H	94825555(-)	`TCTCCA/GATTCT`	1	--	ng5¹		12	MN EU EA WA NA	1164
	rs1139111^1,2	A,C,F,H	94825638(-)	`TTCTTG/CCTATG`	1	--	ng5¹		8	MN EU EA WA NA	736
	rs2303650^1,2	A,C,F,H	94852411(+)	`TCTATC/ACTCTT`	1	S/R	mis¹ ese³		14	EA MN EU WA NA	2476
	rs7534^1,2	C,F,H	94825990(-)	`CCAAAG/ACAACA`	1	--	ut3¹ ese³		5	MN EU EA WA	604
--	rs1139114^1,2	A,C,F	94825609(-)	`ACCAAT/CTCATC`	1	--	ng5¹ ese³		4	MN NA	324
	rs1062075^1,2	A,C,F	94825534(-)	`CATAAT/CATAAA`	1	--	ng5¹		4	MN NA	306
	rs17084873^1,2	C,F,H	94886874(+)	`TTGTAG/CATAGT`	1	V/L	mis¹ ese³		16	NA EU EA WA	1472
	rs1062020^1,2	C,H	94846219(-)	`ACACAG/TGAAGA`	1	G/X	non¹ ese³		9	MN EU EA WA	1020
	rs9885158^1,2	F,H	94825978(+)	`AGTTTA/TAAAAA`	1	--	ut3¹		4	EU EA WA	406
	rs17084882^1,2	F,H	94912110(+)	`TTCCAT/ACTAAA`	1	--	ut5¹		7	NA EU EA WA	536

About this table

HapMap Linkage Disequilibrium images for TTC37 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

4 PubMed articles for TTC37 gene:

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)^{2, 3, 4} Nagase T....Ohara O. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)³ Colland F....Gauthier J.M. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9652	HGNC: 23639	AceView: KIAA0372	Ensembl:ENSG00000198677	euGenes: HUgn9652
ECgene: TTC37	H-InvDB: TTC37

(According to HUGE)
About This Section

HUGE: KIAA0372

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for TTC37
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for TTC37:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TTC37-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TTC37		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TTC37		Browse small molecules at Sigma-Aldrich
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	Recombinant & Natural Proteins

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Search Novus for antibodies for TTC37

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TTC37 Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for TTC37

Summaries
for TTC37

Genomic Location
for TTC37

Proteins
for TTC37

Protein Domains/
Families
for TTC37

Gene Function
for TTC37

Pathways & Interactions
for TTC37

Drugs & Compounds
for TTC37

Transcripts
for TTC37

Expression
for TTC37

Orthologs
for TTC37

Paralogs
for TTC37

SNPs/Variants
for TTC37

Disorders & Mutations
for TTC37

Medical News
for TTC37

Publications
for TTC37

Search for TTC37

Genome Databases showing TTC37

Other Databases showing TTC37

Specialized Databases showing TTC37

Licensable Technologies
for TTC37

Services
for TTC37

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TTC37 Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor TTC37

Summariesfor TTC37

Genomic Locationfor TTC37

Proteinsfor TTC37

Protein Domains/Familiesfor TTC37

Gene Functionfor TTC37

Pathways & Interactionsfor TTC37

Drugs & Compoundsfor TTC37

Transcriptsfor TTC37

Expression for TTC37

Orthologsfor TTC37

Paralogsfor TTC37

SNPs/Variantsfor TTC37

Disorders & Mutationsfor TTC37

Medical Newsfor TTC37

Publicationsfor TTC37

Search for TTC37

Genome Databases showing TTC37

Other Databases showing TTC37

Specialized Databases showing TTC37

Licensable Technologiesfor TTC37

Servicesfor TTC37

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TTC37

Summaries
for TTC37

Genomic Location
for TTC37

Proteins
for TTC37

Protein Domains/
Families
for TTC37

Gene Function
for TTC37

Pathways & Interactions
for TTC37

Drugs & Compounds
for TTC37

Transcripts
for TTC37

Expression
for TTC37

Orthologs
for TTC37

Paralogs
for TTC37

SNPs/Variants
for TTC37

Disorders & Mutations
for TTC37

Medical News
for TTC37

Publications
for TTC37

Licensable Technologies
for TTC37

Services
for TTC37