KIAA0368 Gene
protein-coding GIFtS: 52
GCID: GC09M114122
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KIAA0368
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Aliases
for KIAA0368 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| KIAA03681 2 | | Homolog Of Yeast Ecm292 | | ECM291 2 | | Proteasome-Associated Protein ECM29 Homolog2 | | FLJ220361 | | Ecm293 | | ECM29 Homolog, Proteasome Accessory Protein2 | | |
Export aliases for KIAA0368 gene to outside databasesPrevious GC identifers: GC09M104921 GC09M105855 GC09M107580 GC09M109502 GC09M109504 GC09M111203 GC09M113162 GC09M083721 |
Summaries
for KIAA0368 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ECM29_HUMAN, Q5VYK3Function: Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specificproteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum andcentrosome. May play a role in ERAD and other enhanced proteolyis
Gene Wiki entry for KIAA0368
|
Genomic Views
for KIAA0368 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KIAA0368 gene promoter:
c-Fos TBP AP-1 E4BP4 Evi-1 Max Meis-1a c-Jun Meis-1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for KIAA0368
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA0368 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q31.3 Ensembl cytogenetic band: 9q31.3 HGNC cytogenetic band: 9q32KIAA0368 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M114122: view genomic region
(about GC identifiers)
Start:
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114,122,972 bp from pter |
End:
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114,247,025 bp from pter |
Size:
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124,054 bases |
Orientation:
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minus strand |
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Proteins
for KIAA0368 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ECM29_HUMAN, Q5VYK3 (See
protein sequence)Recommended Name: Proteasome-associated protein ECM29 homolog Size: 1845 amino acids; 204291 Da
Subunit: Non-stoichiometric component of the proteasome; associates with the 26S proteasome. Interacts (via N-terminus)with VPS11, VPS26A, VPS36, RAB11FIP4 and RABEP1. Interacts (via C-terminus) with DCTN1, DCTN2, KIF5B, MYH7, MYH10,MYO10 and ARF6
Subcellular location: Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Endosome. Cytoplasm,cytoskeleton, centrosome. Nucleus. Endosome, multivesicular body. Cytoplasmic vesicle
Sequence caution: Sequence=AAH21127.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=CAH73240.1; Type=Erroneous gene model prediction; Sequence=CAH73465.1; Type=Erroneous gene model prediction;
Secondary accessions: O15074 Q8WU82Explore the universe of human proteins at neXtProt for KIAA0368: NX_Q5VYK3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5VYK3
KIAA0368 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001073867.1
ENSEMBL proteins: ENSP00000339889 ENSP00000363504 ENSP00000259335 ENSP00000363499
Human Recombinant Protein Products:
Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12): About this table
KIAA0368 for ontologies About GeneDecksing
KIAA0368 Antibody Products:
Assay Products for KIAA0368: |
Protein
Domains /
Families
for KIAA0368 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KIAA0368 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5VYK3ProtoNet protein and cluster: Q5VYK3 UniProtKB/Swiss-Prot: ECM29_HUMAN, Q5VYK3Similarity: Contains 27 HEAT repeats |
Function
for KIAA0368 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ECM29_HUMAN, Q5VYK3Function: Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specificproteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum andcentrosome. May play a role in ERAD and other enhanced proteolyis Genatlas biochemistry entry for KIAA0368:cDNA sequence,expressed in brain,>100kDa,related to C elegans cosmid D2045
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA0368
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA0368 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
KIAA0368 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for KIAA0368:
|
Pathways & Interactions
for KIAA0368 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA0368
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/289 Interacting proteins for KIAA0368 (Q5VYK32, 3 ENSP000002593354) via UniProtKB, MINT, STRING, and/or I2D (see all 289)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030433 | ER-associated protein catabolic process |
IMP | 15496406 |
KIAA0368 for ontologies About GeneDecksing
|
Drugs & Compounds
for KIAA0368 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KIAA0368
Search CenterWatch for drugs/clinical trials and news about KIAA0368 / ECM29
|
Transcripts
for KIAA0368 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KIAA0368 gene: NM_001080398.1 Unigene Cluster for KIAA0368: KIAA0368 Hs.368255 [show with all ESTs]Unigene Representative Sequence: NM_0010803985 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000338205(uc010muc.1) ENST00000374383 ENST00000465499 ENST00000259335(uc004bfe.1)
ENST00000374378
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA0368 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA0368
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KIAA0368 (NM_001080398) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIAA0368 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA0368 |
Additional cDNA sequence: AB002366.1 AF052139.1 AK024705.1 AK025689.1 AK027063.1 AK122712.1 AK124590.1 AK127247.1 AK308313.1 BC021127.1 19 DOTS entries: DT.117279 DT.97847982 DT.434076 DT.121158767 DT.97780216 DT.121158786 DT.75131147 DT.100665929 DT.121158775 DT.121158783 DT.95183944 DT.97777994 DT.100675564 DT.100792160 DT.121158749 DT.91757306 DT.92029372 DT.75118687 DT.91654203 24/267 AceView cDNA sequences (see all 267): BQ448494 BX504414 AA453758 AK027063 AA454671 CR617979 BM789643 CA944571 BM905947 BM765572 BM765608 AI683301 AI911691 BQ437531 BM713378 BE855545 AA683594 AA322214 C00385 BE378250 AF052139 BE693877 BM674714 BM764473
GeneLoc Exon Structure
|
Expression
for KIAA0368 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KIAA0368 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See KIAA0368 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIAA0368
SOURCE GeneReport for Unigene cluster: Hs.368255
SABiosciences Custom PCR Arrays for KIAA0368
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIAA0368
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIAA0368 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIAA0368 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIAA0368 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA0368 |
Orthologs
for KIAA0368 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for KIAA0368 gene from 9/28 species (see all 28) About this table
ENSEMBL Gene Tree for KIAA0368 (if available)
TreeFam Gene Tree for KIAA0368 (if available) |
Paralogs
for KIAA0368 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KIAA0368 gene
1 SIMAP similar gene for KIAA0368 using alignment to 2 protein entries: J3KN16_HUMAN (see all proteins):ECM29
KIAA0368 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for KIAA0368
PGOHUM00000250507
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Genomic Variants
for KIAA0368 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KIAA0368 (114122972 - 114247025 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for KIAA0368
6 CNVs: 22566 96252 100751 83148 44371 65496
2 Indels: 96254 96253 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIAA0368 |
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Disorders
/ Diseases
for KIAA0368 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KIAA0368 for disorders About GeneDecksing
3  diseases for KIAA0368: About MalaCardsallergic contact dermatitis contact dermatitis dermatitis
1 disease from the University of Copenhagen DISEASES database for KIAA0368:Allergic contact dermatitis Human Genome Epidemiology (HuGE) Navigator: KIAA0368 (1 document)
Export disorders for KIAA0368 gene to outside databases
|
Publications
for KIAA0368 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KIAA0368 gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with KIAA0368) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PubMed id 20682791)1, 2, 3 Gorbea C.... Rechsteiner M. (2010)
- Characterization of mammalian Ecm29, a 26 S proteasome-associated protein that localizes to the nucleus and membrane vesicles. (PubMed id 15496406)1, 2, 3 Gorbea C....Rechsteiner M. (2004)
- Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
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External Searches for KIAA0368 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing KIAA0368 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KIAA0368 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing KIAA0368 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KIAA0368 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for KIAA0368 gene:
Search GeneIP for patents involving KIAA0368
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KIAA0368 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KIAA0368 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIAA0368 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIAA0368 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KIAA0368 | | OriGene 3'-UTR Clone for KIAA0368 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA0368 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA0368 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | KIAA0368 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA0368 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA0368 |
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