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Aliases for KIAA0368 Gene

Aliases for KIAA0368 Gene

  • KIAA0368 2 3
  • ECM29 3 4
  • ECM29 Homolog, Proteasome Accessory Protein 3
  • ECM29 Homolog (S. Cerevisiae) 2
  • Homolog Of Yeast Ecm29 3

External Ids for KIAA0368 Gene

Previous GeneCards Identifiers for KIAA0368 Gene

  • GC09M104921
  • GC09M105855
  • GC09M107580
  • GC09M109502
  • GC09M109504
  • GC09M111203
  • GC09M113162
  • GC09M114122
  • GC09M083721

Summaries for KIAA0368 Gene

GeneCards Summary for KIAA0368 Gene

KIAA0368 (KIAA0368) is a Protein Coding gene. GO annotations related to this gene include binding.

UniProtKB/Swiss-Prot for KIAA0368 Gene

  • Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolyis.

Gene Wiki entry for KIAA0368 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA0368 Gene

Genomics for KIAA0368 Gene

Regulatory Elements for KIAA0368 Gene

Enhancers for KIAA0368 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KIAA0368 on UCSC Golden Path with GeneCards custom track

Promoters for KIAA0368 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KIAA0368 on UCSC Golden Path with GeneCards custom track

Genomic Location for KIAA0368 Gene

Chromosome:
9
Start:
111,360,692 bp from pter
End:
111,484,745 bp from pter
Size:
124,054 bases
Orientation:
Minus strand

Genomic View for KIAA0368 Gene

Genes around KIAA0368 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA0368 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA0368 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA0368 Gene

Proteins for KIAA0368 Gene

  • Protein details for KIAA0368 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VYK3-ECM29_HUMAN
    Recommended name:
    Proteasome-associated protein ECM29 homolog
    Protein Accession:
    Q5VYK3
    Secondary Accessions:
    • O15074
    • Q8WU82

    Protein attributes for KIAA0368 Gene

    Size:
    1845 amino acids
    Molecular mass:
    204291 Da
    Quaternary structure:
    • Non-stoichiometric component of the proteasome; associates with the 26S proteasome. Interacts (via N-terminus) with VPS11, VPS26A, VPS36, RAB11FIP4 and RABEP1. Interacts (via C-terminus) with DCTN1, DCTN2, KIF5B, MYH7, MYH10, MYO10 and ARF6.
    SequenceCaution:
    • Sequence=AAH21127.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH73240.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH73465.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for KIAA0368 Gene

Proteomics data for KIAA0368 Gene at MOPED

Post-translational modifications for KIAA0368 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIAA0368 Gene

No data available for DME Specific Peptides for KIAA0368 Gene

Domains & Families for KIAA0368 Gene

Protein Domains for KIAA0368 Gene

Graphical View of Domain Structure for InterPro Entry

Q5VYK3

UniProtKB/Swiss-Prot:

ECM29_HUMAN :
  • Contains 27 HEAT repeats.
Similarity:
  • Contains 27 HEAT repeats.
genes like me logo Genes that share domains with KIAA0368: view

No data available for Gene Families for KIAA0368 Gene

Function for KIAA0368 Gene

Molecular function for KIAA0368 Gene

GENATLAS Biochemistry:
cDNA sequence,expressed in brain,>100kDa,related to C elegans cosmid D2045
UniProtKB/Swiss-Prot Function:
Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolyis.

Gene Ontology (GO) - Molecular Function for KIAA0368 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KIAA0368: view
genes like me logo Genes that share phenotypes with KIAA0368: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA0368 Gene

Localization for KIAA0368 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA0368 Gene

Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Endosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Endosome, multivesicular body. Cytoplasmic vesicle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA0368 Gene COMPARTMENTS Subcellular localization image for KIAA0368 gene
Compartment Confidence
cytoskeleton 5
endoplasmic reticulum 5
endosome 5
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KIAA0368 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15496406
GO:0005771 multivesicular body IDA 20682791
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA --
GO:0005802 NOT trans-Golgi network IDA 15496406
GO:0016023 cytoplasmic, membrane-bounded vesicle IDA 15496406
genes like me logo Genes that share ontologies with KIAA0368: view

Pathways & Interactions for KIAA0368 Gene

SuperPathways for KIAA0368 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA0368 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA0368 Gene

Drugs & Compounds for KIAA0368 Gene

No Compound Related Data Available

Transcripts for KIAA0368 Gene

Unigene Clusters for KIAA0368 Gene

KIAA0368:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0368 Gene

No ASD Table

Relevant External Links for KIAA0368 Gene

GeneLoc Exon Structure for
KIAA0368
ECgene alternative splicing isoforms for
KIAA0368

Expression for KIAA0368 Gene

mRNA expression in normal human tissues for KIAA0368 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIAA0368 Gene

This gene is overexpressed in Muscle - Skeletal (x7.4).

Protein differential expression in normal tissues from HIPED for KIAA0368 Gene

This gene is overexpressed in Bone (53.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIAA0368 Gene



SOURCE GeneReport for Unigene cluster for KIAA0368 Gene Hs.368255

genes like me logo Genes that share expression patterns with KIAA0368: view

Protein tissue co-expression partners for KIAA0368 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for KIAA0368 Gene

Orthologs for KIAA0368 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIAA0368 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIAA0368 35
  • 90.55 (n)
  • 95.71 (a)
KIAA0368 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA0368 35
  • 92.18 (n)
  • 96.07 (a)
KIAA0368 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia AI314180 35
  • 89.91 (n)
  • 95.58 (a)
AI314180 16
AI314180 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIAA0368 35
  • 99.45 (n)
  • 99.45 (a)
KIAA0368 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA0368 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
chicken
(Gallus gallus)
Aves KIAA0368 35
  • 78.27 (n)
  • 85.74 (a)
KIAA0368 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA0368 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa0368 35
  • 72.69 (n)
  • 78.98 (a)
Str.14108 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.27912 35
zebrafish
(Danio rerio)
Actinopterygii LOC563777 35
  • 68.5 (n)
  • 74.88 (a)
fbxo10 36
  • 73 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9920 35
fruit fly
(Drosophila melanogaster)
Insecta CG8858 37
  • 30 (a)
CG8858 35
  • 46.26 (n)
  • 35.72 (a)
CG8858 36
  • 29 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011822 35
  • 46.3 (n)
  • 38.14 (a)
worm
(Caenorhabditis elegans)
Secernentea D2045.2 37
  • 33 (a)
H04D03.3 36
  • 27 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM29 36
  • 23 (a)
OneToOne
ECM29 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G26780 35
  • 44.36 (n)
  • 32.16 (a)
rice
(Oryza sativa)
Liliopsida Os11g0137300 35
  • 45.64 (n)
  • 31.15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToOne
Species with no ortholog for KIAA0368:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIAA0368 Gene

ENSEMBL:
Gene Tree for KIAA0368 (if available)
TreeFam:
Gene Tree for KIAA0368 (if available)

Paralogs for KIAA0368 Gene

(1) SIMAP similar genes for KIAA0368 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for KIAA0368 Gene

genes like me logo Genes that share paralogs with KIAA0368: view

No data available for Paralogs for KIAA0368 Gene

Variants for KIAA0368 Gene

Sequence variations from dbSNP and Humsavar for KIAA0368 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs744324 -- 111,430,765(+) CATTG(C/T)AGAAG intron-variant
rs868405 -- 111,422,197(+) GGCAT(C/T)CGACT reference, synonymous-codon
rs914732 -- 111,369,259(+) AACCA(A/G)GGCAG intron-variant
rs943690 -- 111,454,467(-) TCATA(A/C)TTTTA intron-variant
rs953489 -- 111,426,391(-) AGAGT(A/G)TAGAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KIAA0368 Gene

Variant ID Type Subtype PubMed ID
nsv893722 CNV Gain 21882294
nsv525736 CNV Loss 19592680
nsv416941 CNV Loss 16902084
nsv825039 CNV Gain 20364138
esv2492334 CNV Deletion 19546169
nsv436620 CNV Deletion 17901297
esv2057050 CNV Deletion 18987734
esv2738934 CNV Deletion 23290073
esv2666027 CNV Deletion 23128226
esv29361 CNV Loss 19812545
esv2738935 CNV Deletion 23290073
nsv825040 CNV Gain 20364138
esv2659400 CNV Deletion 23128226

Variation tolerance for KIAA0368 Gene

Residual Variation Intolerance Score: 67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.39; 95.42% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KIAA0368 Gene

Disorders for KIAA0368 Gene

Relevant External Links for KIAA0368

Genetic Association Database (GAD)
KIAA0368
Human Genome Epidemiology (HuGE) Navigator
KIAA0368
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA0368

No disorders were found for KIAA0368 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA0368 Gene

Publications for KIAA0368 Gene

  1. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PMID: 20682791) Gorbea C. … Rechsteiner M. (J. Biol. Chem. 2010) 2 3 4 67
  2. Characterization of mammalian Ecm29, a 26 S proteasome-associated protein that localizes to the nucleus and membrane vesicles. (PMID: 15496406) Gorbea C. … Rechsteiner M. (J. Biol. Chem. 2004) 2 3
  3. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for KIAA0368 Gene

Sources for KIAA0368 Gene

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