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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIAA0355 Gene

protein-coding   GIFtS: 43
GCID: GC19P034745

KIAA0355

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
KIAA03551 2
Uncharacterized Protein KIAA03552

External Ids:    HGNC: 290161   Entrez Gene: 97102   Ensembl: ENSG000001663987   UniProtKB: O150633   

Export aliases for KIAA0355 gene to outside databases

Previous GC identifers: GC19P035363 GC19P035194 GC19P039421 GC19P039437 GC19P039482 GC19P031250


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KIAA0355 Gene: 
KIAA0355 (KIAA0355) is a protein-coding gene. Diseases associated with KIAA0355 include bipolar disorder.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIAA0355 gene promoter:
         GATA-3   Evi-1   GATA-1   GATA-2   c-Ets-1   MEF-2A   FOXO1a   aMEF-2   c-Myc   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KIAA0355

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA0355


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.11   Ensembl cytogenetic band:  19q13.11   HGNC cytogenetic band: 19q13.12

KIAA0355 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA0355 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P034745:  view genomic region     (about GC identifiers)

Start:
34,745,442 bp from pter      End:
34,846,491 bp from pter
Size:
101,050 bases      Orientation:
plus strand

1 alternative location:
Chr19+,NW_003315963 109,465-155,864     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: K0355_HUMAN, O15063 (See protein sequence)
Recommended Name: Uncharacterized protein KIAA0355  
Size: 1070 amino acids; 116020 Da
Sequence caution: Sequence=BAA20812.2; Type=Erroneous initiation;
Secondary accessions: Q2M3W4

Explore the universe of human proteins at neXtProt for KIAA0355: NX_O15063

Explore proteomics data for KIAA0355 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15063

  • KIAA0355 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KIAA0355 Protein Expression
    REFSEQ proteins: NP_055501.2  
    ENSEMBL proteins: 
     ENSP00000299505   ENSP00000475249   ENSP00000465362   ENSP00000475445  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: O15063


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for KIAA0355:
    cDNA sequence,expressed in brain,>100kDa

    Phenotypes:
         1 GenomeRNAi human phenotype for KIAA0355:
     Synthetic lethal with Ras 

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    SwitchGear 3'UTR luciferase reporter plasmidKIAA0355 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA0355

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIAA0355 (K0355)

    Search CenterWatch for drugs/clinical trials and news about KIAA0355 / K0355

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIAA0355 gene: 
    NM_014686.3  

    Unigene Cluster for KIAA0355:

    KIAA0355
    Hs.330073  [show with all ESTs]
    Unigene Representative Sequence: NM_014686
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299505(uc002nvd.4 uc010edk.1) ENST00000588470 ENST00000589583
    ENST00000588338 ENST00000592124 ENST00000585833 ENST00000588974
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AB002353.1 AK311350.1 BC017790.2 BC104761.1 BC104763.1 BC128232.1 

    7 DOTS entries:

    DT.75195399  DT.97803380  DT.97809498  DT.87016936  DT.92063657  DT.100021541  DT.121438417 

    24/151 AceView cDNA sequences (see all 151):

    AL043780 AA577108 AW075294 BM697526 AU108095 BQ001697 BF941095 AW674631 
    AI633940 AL043781 AI334011 NM_014686 AI628923 AI637983 CA412177 AA400633 
    AL047419 AW591253 BQ018298 BU620934 BX090723 AI928484 AI800777 AA304857 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0355    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                                                  
    SP2:                                                                  
    SP3:                    -                                             
    SP4:        -     -     -                                             
    SP5:                                                                  


    ECgene alternative splicing isoforms for KIAA0355

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIAA0355 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTGGGCGTG
    KIAA0355 Expression
    About this image


    See KIAA0355 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIAA0355

    SOURCE GeneReport for Unigene cluster: Hs.330073
        SABiosciences Custom PCR Arrays for KIAA0355
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA0355

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KIAA0355 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 4931406P16Rik1 , 5 RIKEN cDNA 4931406P16 gene1, 5 90.26(n)1
    94.05(a)1
      7 (19.48 cM)5
    2331031  NM_172741.21  NP_766329.11 
     342367075 
    chicken
    (Gallus gallus)
    Aves KIAA03551 KIAA0355 75.46(n)
    82.19(a)
      415782  XM_414143.3  XP_414143.2 
    lizard
    (Anolis carolinensis)
    Reptilia KIAA03556
    Uncharacterized protein
    76(a)
    1 ↔ 1
    GL343773.1(102046-111996)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ057771.12   -- 76.79(n)    BJ057771.1 
    zebrafish
    (Danio rerio)
    Actinopterygii --
    CU611056.16
    Uncharacterized protein
    67(a)
    64(a)
    1 ↔ 1
    possible ortholog
    13(51939463-51967110)
    13(52321599-52332448)


    ENSEMBL Gene Tree for KIAA0355 (if available)
    TreeFam Gene Tree for KIAA0355 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1909 SNPs in KIAA0355 are shown (see all 1909)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs557234231,2
    C--34743530(+) GGCTAA/GCTTTT 1 -- us2k10--------
    rs1510041511,2
    --34743606(+) GATCCA/GCCCAC 1 -- us2k10--------
    rs561110031,2
    C--34743682(+) TTTTGA/TGATAG 1 -- us2k10--------
    rs104230821,2
    C,F,A,H--34743781(+) cttcgG/Accttc 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1848954341,2
    --34743798(+) GCTGGA/GATTAT 1 -- us2k10--------
    rs1896170301,2
    --34743896(+) TGACCC/TCAGGT 1 -- us2k10--------
    rs1160383861,2
    F--34743965(+) GGCCCG/ATCTCT 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1931059201,2
    --34743990(+) TCTAGA/GTACCT 1 -- us2k10--------
    rs1842562841,2
    --34744100(+) CATGCA/GCCACC 1 -- us2k10--------
    rs1382466721,2
    C--34744108(+) ACCACC/GCCTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KIAA0355 (34745442 - 34846491 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KIAA0355:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509737CNV Insertion20534489
    nsv509738CNV Insertion20534489
    nsv2468CNV Insertion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for KIAA0355:    About MalaCards
    bipolar disorder    


    KIAA0355 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KIAA0355
    Human Genome Epidemiology (HuGE) Navigator: KIAA0355 (1 document)

    Export disorders for KIAA0355 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIAA0355 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KIAA0355)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. A genome-wide association study of amygdala activatio n in youths with and without bipolar disorder. (PubMed id 20215924)1, 4 Liu X....McMahon F.J. (2010)
    4. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Identification and characterization of the potential promoter regions of 1031 kinds of human genes. (PubMed id 11337467)1 Suzuki Y....Sugano S. (2001)
    8. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9710 HGNC: 29016 AceView: KIAA0355 Ensembl:ENSG00000166398 euGenes: HUgn9710
    ECgene: KIAA0355 H-InvDB: KIAA0355

    (According to HUGE)
    About This Section
    HUGE: KIAA0355

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIAA0355 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIAA0355 gene:
    Search GeneIP for patents involving KIAA0355

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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