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Aliases for KIAA0355 Gene

Aliases for KIAA0355 Gene

  • KIAA0355 2 3

External Ids for KIAA0355 Gene

Previous GeneCards Identifiers for KIAA0355 Gene

  • GC19P035363
  • GC19P035194
  • GC19P039421
  • GC19P039437
  • GC19P039482
  • GC19P034745
  • GC19P031250

Summaries for KIAA0355 Gene

GeneCards Summary for KIAA0355 Gene

KIAA0355 (KIAA0355) is a Protein Coding gene.

Additional gene information for KIAA0355 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA0355 Gene

Genomics for KIAA0355 Gene

Regulatory Elements for KIAA0355 Gene

Enhancers for KIAA0355 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H033273 1.9 FANTOM5 Ensembl ENCODE dbSUPER 89.6 -979.5 -979484 3 FOXA2 MLX ARID4B DMAP1 ZNF2 YY1 ZNF302 ZNF416 FOS ZNF548 GPATCH1 ZNF507 CEP89 LSM14A KIAA0355 PDCD5 WDR88 AKR1B1P7 LOC100996681 RPL21P131
GH19H033819 1.9 FANTOM5 Ensembl ENCODE dbSUPER 67.4 -433.9 -433895 2 ZFP64 ARID4B SIN3A FEZF1 ZNF302 ZNF416 SP3 ZC3H11A REST SMARCA4 GPATCH1 CEP89 ZNF599 LSM14A KIAA0355 ZNF181 ENSG00000267219 WTIP FAAP24 ENSG00000271049
GH19H034972 2 FANTOM5 Ensembl ENCODE dbSUPER 61.8 +719.5 719525 2 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF302 ZNF416 ZNF207 TMEM147-AS1 LSM14A PROSER3 ZNF599 ENSG00000267049 HAUS5 KIAA0355 ZNF181 KMT2B ZNF30
GH19H034994 2.1 FANTOM5 Ensembl ENCODE dbSUPER 51.9 +746.4 746395 13 MLX YBX1 DMAP1 YY1 SLC30A9 ZNF416 ZNF548 SP3 ZC3H11A NFYC TMEM147-AS1 ZNF599 LSM14A HAUS5 KMT2B ZNF792 ZNF302 KIAA0355 PROSER3 RBM42
GH19H033296 1.7 FANTOM5 ENCODE dbSUPER 63.3 -953.1 -953132 10 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF416 ZNF143 ZNF548 GPATCH1 ZNF507 CEP89 LSM14A KIAA0355 WDR88 PDCD5 AKR1B1P7 FAAP24 LOC100996681
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIAA0355 on UCSC Golden Path with GeneCards custom track

Promoters for KIAA0355 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000108871 363 2201 ARNT ARID4B SIN3A ZNF2 YY1 ZNF207 SP3 SP5 REST SMARCB1

Genomic Location for KIAA0355 Gene

Chromosome:
19
Start:
34,254,537 bp from pter
End:
34,355,586 bp from pter
Size:
101,050 bases
Orientation:
Plus strand

Genomic View for KIAA0355 Gene

Genes around KIAA0355 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA0355 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA0355 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA0355 Gene

Proteins for KIAA0355 Gene

  • Protein details for KIAA0355 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15063-K0355_HUMAN
    Recommended name:
    Uncharacterized protein KIAA0355
    Protein Accession:
    O15063
    Secondary Accessions:
    • Q2M3W4

    Protein attributes for KIAA0355 Gene

    Size:
    1070 amino acids
    Molecular mass:
    116020 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20812.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for KIAA0355 Gene

Post-translational modifications for KIAA0355 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIAA0355 Gene

No data available for DME Specific Peptides for KIAA0355 Gene

Domains & Families for KIAA0355 Gene

Gene Families for KIAA0355 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for KIAA0355 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA0355 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA0355: view

No data available for UniProtKB/Swiss-Prot for KIAA0355 Gene

Function for KIAA0355 Gene

Molecular function for KIAA0355 Gene

GENATLAS Biochemistry:
cDNA sequence,expressed in brain,>100kDa

Phenotypes From GWAS Catalog for KIAA0355 Gene

Phenotypes for KIAA0355 Gene

GenomeRNAi human phenotypes for KIAA0355:
genes like me logo Genes that share phenotypes with KIAA0355: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KIAA0355
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA0355 Gene

Localization for KIAA0355 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA0355 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KIAA0355 Gene

Pathways & Interactions for KIAA0355 Gene

SuperPathways for KIAA0355 Gene

No Data Available

Interacting Proteins for KIAA0355 Gene

Gene Ontology (GO) - Biological Process for KIAA0355 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA0355 Gene

Drugs & Compounds for KIAA0355 Gene

No Compound Related Data Available

Transcripts for KIAA0355 Gene

Unigene Clusters for KIAA0355 Gene

KIAA0355:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KIAA0355
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0355 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2:
SP3: -
SP4: - - -
SP5:

Relevant External Links for KIAA0355 Gene

GeneLoc Exon Structure for
KIAA0355
ECgene alternative splicing isoforms for
KIAA0355

Expression for KIAA0355 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIAA0355 Gene

Protein differential expression in normal tissues from HIPED for KIAA0355 Gene

This gene is overexpressed in Placenta (40.0) and Testis (24.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIAA0355 Gene



Protein tissue co-expression partners for KIAA0355 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KIAA0355 Gene:

KIAA0355

SOURCE GeneReport for Unigene cluster for KIAA0355 Gene:

Hs.330073
genes like me logo Genes that share expression patterns with KIAA0355: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA0355 Gene

Orthologs for KIAA0355 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA0355 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA0355 33 34
  • 99.38 (n)
dog
(Canis familiaris)
Mammalia KIAA0355 33 34
  • 91.33 (n)
cow
(Bos Taurus)
Mammalia KIAA0355 33 34
  • 91.09 (n)
mouse
(Mus musculus)
Mammalia 4931406P16Rik 33 16 34
  • 89.89 (n)
rat
(Rattus norvegicus)
Mammalia RGD1308428 33
  • 89.64 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA0355 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA0355 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA0355 33 34
  • 74.92 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA0355 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa0355 33
  • 70.81 (n)
Str.19353 33
zebrafish
(Danio rerio)
Actinopterygii KIAA0355 34
  • 64 (a)
OneToOne
Species where no ortholog for KIAA0355 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA0355 Gene

ENSEMBL:
Gene Tree for KIAA0355 (if available)
TreeFam:
Gene Tree for KIAA0355 (if available)

Paralogs for KIAA0355 Gene

No data available for Paralogs for KIAA0355 Gene

Variants for KIAA0355 Gene

Sequence variations from dbSNP and Humsavar for KIAA0355 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000058391 -- 34,353,711(+) GTGGC(A/G)GTGGA utr-variant-3-prime
rs1000066670 -- 34,311,665(+) GAGTA(C/T)AGTGG intron-variant
rs1000111999 -- 34,311,088(+) CCTGG(G/T)CTCAA intron-variant
rs1000138045 -- 34,304,680(+) GCCAT(A/C/G)TTTGT intron-variant
rs1000221531 -- 34,316,988(+) AGGGC(C/T)TCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA0355 Gene

Variant ID Type Subtype PubMed ID
esv3644205 CNV loss 21293372
esv3644206 CNV loss 21293372
nsv1121979 CNV deletion 24896259
nsv1143915 CNV deletion 24896259
nsv2468 CNV insertion 18451855
nsv474884 CNV novel sequence insertion 20440878
nsv474905 CNV novel sequence insertion 20440878
nsv474923 CNV novel sequence insertion 20440878
nsv475034 CNV novel sequence insertion 20440878
nsv475206 CNV novel sequence insertion 20440878
nsv475303 CNV novel sequence insertion 20440878
nsv475634 CNV novel sequence insertion 20440878
nsv476189 CNV novel sequence insertion 20440878
nsv478015 CNV novel sequence insertion 20440878
nsv480065 CNV novel sequence insertion 20440878
nsv480180 CNV novel sequence insertion 20440878
nsv509737 CNV insertion 20534489
nsv509738 CNV insertion 20534489
nsv961210 CNV duplication 23825009

Variation tolerance for KIAA0355 Gene

Residual Variation Intolerance Score: 10% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.37; 53.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA0355 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA0355

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA0355 Gene

Disorders for KIAA0355 Gene

Relevant External Links for KIAA0355

Genetic Association Database (GAD)
KIAA0355
Human Genome Epidemiology (HuGE) Navigator
KIAA0355
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA0355

No disorders were found for KIAA0355 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA0355 Gene

Publications for KIAA0355 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. A genome-wide association study of amygdala activation in youths with and without bipolar disorder. (PMID: 20215924) Liu X … McMahon FJ (Journal of the American Academy of Child and Adolescent Psychiatry 2010) 3 45 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for KIAA0355 Gene

Sources for KIAA0355 Gene

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