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KIAA0355 Gene

protein-coding   GIFtS: 45
GCID: GC19P034745

KIAA0355

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
KIAA03551 2
Uncharacterized Protein KIAA03552

External Ids:    HGNC: 290161   Entrez Gene: 97102   Ensembl: ENSG000001663987   UniProtKB: O150633   

Export aliases for KIAA0355 gene to outside databases

Previous GC identifers: GC19P035363 GC19P035194 GC19P039421 GC19P039437 GC19P039482 GC19P031250


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KIAA0355 Gene:
KIAA0355 (KIAA0355) is a protein-coding gene. Diseases associated with KIAA0355 include bipolar disorder.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  NT_187619.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIAA0355 gene promoter:
         GATA-3   Evi-1   GATA-1   GATA-2   c-Ets-1   MEF-2A   FOXO1a   aMEF-2   c-Myc   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for KIAA0355

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIAA0355


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.11   Ensembl cytogenetic band:  19q13.11   HGNC cytogenetic band: 19q13.12

KIAA0355 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA0355 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P034745:  view genomic region     (about GC identifiers)

Start:
34,745,442 bp from pter      End:
34,846,491 bp from pter
Size:
101,050 bases      Orientation:
plus strand

1 alternative location:
Chr19+,NW_003315963 109,465-155,864     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: K0355_HUMAN, O15063 (See protein sequence)
Recommended Name: Uncharacterized protein KIAA0355  
Size: 1070 amino acids; 116020 Da
Sequence caution: Sequence=BAA20812.2; Type=Erroneous initiation;
Secondary accessions: Q2M3W4

Explore the universe of human proteins at neXtProt for KIAA0355: NX_O15063

Explore proteomics data for KIAA0355 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KIAA0355 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055501.2  
    ENSEMBL proteins: 
     ENSP00000299505   ENSP00000475249   ENSP00000465362   ENSP00000475445  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: O15063


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for KIAA0355:
    cDNA sequence,expressed in brain,>100kDa

    Phenotypes:
         1 GenomeRNAi human phenotype for KIAA0355:
     Synthetic lethal with Ras 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target KIAA0355:
    hsa-mir-20a-3p (MIRT038972), hsa-let-7e-5p (MIRT051510), hsa-mir-3687 (MIRT052879), hsa-mir-149-5p (MIRT045411)

    Block miRNA regulation of human, mouse, rat KIAA0355 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KIAA0355 (see all 75):
    hsa-miR-194* hsa-miR-124* hsa-miR-607 hsa-miR-3607-3p hsa-miR-485-3p hsa-miR-3138 hsa-miR-30d hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidKIAA0355 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIAA0355
    Interactions:

        Search GeneGlobe Interaction Network for KIAA0355

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIAA0355 (K0355)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KIAA0355 gene: 
    NM_014686.3  

    Unigene Cluster for KIAA0355:

    KIAA0355
    Hs.330073  [show with all ESTs]
    Unigene Representative Sequence: NM_014686
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299505(uc002nvd.4 uc010edk.1) ENST00000588470 ENST00000589583
    ENST00000588338 ENST00000592124 ENST00000585833 ENST00000588974
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate KIAA0355 (see all 75):
    hsa-miR-194* hsa-miR-124* hsa-miR-607 hsa-miR-3607-3p hsa-miR-485-3p hsa-miR-3138 hsa-miR-30d hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidKIAA0355 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KIAA0355
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      QuantiTect SYBR Green Assays in human, mouse, rat KIAA0355
      QuantiFast Probe-based Assays in human, mouse, rat KIAA0355

    Additional mRNA sequence: 

    AB002353.1 AK311350.1 BC017790.2 BC104761.1 BC104763.1 BC128232.1 

    7 DOTS entries:

    DT.75195399  DT.97803380  DT.97809498  DT.87016936  DT.92063657  DT.100021541  DT.121438417 

    Selected AceView cDNA sequences (see all 151):

    AL599597 AI889035 AL047419 AA446737 BM697526 AB002353 AI650546 AW075294 
    CD516586 CA426337 AW591253 BU620934 AI928484 AL079827 AL043781 AI801291 
    AI208024 BQ001697 AI334011 CA412177 AI633940 BQ018298 AI375228 AA299680 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0355    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                                                  
    SP2:                                                                  
    SP3:                    -                                             
    SP4:        -     -     -                                             
    SP5:                                                                  


    ECgene alternative splicing isoforms for KIAA0355

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIAA0355 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTGGGCGTG
    KIAA0355 Expression
    About this image

    KIAA0355 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIAA0355 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.330073
        Custom PCR Arrays for KIAA0355
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA0355

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KIAA0355 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 4931406P16Rik1 , 5 RIKEN cDNA 4931406P16 gene1, 5 89.89(n)1
    93.57(a)1
      7 (19.48 cM)5
    2331031  NM_172741.21  NP_766329.11 
     342367075 
    chicken
    (Gallus gallus)
    Aves KIAA03551 KIAA0355 74.92(n)
    81.14(a)
      415782  XM_004944239.1  XP_004944296.1 
    lizard
    (Anolis carolinensis)
    Reptilia KIAA03556
    KIAA0355
    78(a)
    1 ↔ 1
    GL343773.1(102046-111996)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ057771.12   -- 76.79(n)    BJ057771.1 
    zebrafish
    (Danio rerio)
    Actinopterygii KIAA03556
    KIAA0355
    64(a)
    1 ↔ 1
    13(52321599-52332448) ENSDARG00000087977


    ENSEMBL Gene Tree for KIAA0355 (if available)
    TreeFam Gene Tree for KIAA0355 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIAA0355 (see all 1909)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs557234231,2
    C--34743530(+) GGCTAA/GCTTTT 1 -- us2k10--------
    rs1510041511,2
    --34743606(+) GATCCA/GCCCAC 1 -- us2k10--------
    rs561110031,2
    C--34743682(+) TTTTGA/TGATAG 1 -- us2k10--------
    rs104230821,2
    C,F,A,H--34743781(+) cttcgG/Accttc 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1848954341,2
    --34743798(+) GCTGGA/GATTAT 1 -- us2k10--------
    rs1896170301,2
    --34743896(+) TGACCC/TCAGGT 1 -- us2k10--------
    rs1160383861,2
    F--34743965(+) GGCCCG/ATCTCT 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1931059201,2
    --34743990(+) TCTAGA/GTACCT 1 -- us2k10--------
    rs1842562841,2
    --34744100(+) CATGCA/GCCACC 1 -- us2k10--------
    rs1382466721,2
    C--34744108(+) ACCACC/GCCTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KIAA0355 (34745442 - 34846491 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KIAA0355:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509737CNV Insertion20534489
    nsv509738CNV Insertion20534489
    nsv2468CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for KIAA0355

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for KIAA0355:    
    About MalaCards
    bipolar disorder


    KIAA0355 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KIAA0355
    Human Genome Epidemiology (HuGE) Navigator: KIAA0355 (1 document)

    Export disorders for KIAA0355 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIAA0355 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with KIAA0355)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1997)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. A genome-wide association study of amygdala activation in youths with and without bipolar disorder. (PubMed id 20215924)1, 4 Liu X....McMahon F.J. (J Am Acad Child Adolesc Psychiatry 2010)
    4. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Identification and characterization of the potential promoter regions of 1031 kinds of human genes. (PubMed id 11337467)1 Suzuki Y....Sugano S. (Genome Res. 2001)
    10. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9710 HGNC: 29016 AceView: KIAA0355 Ensembl:ENSG00000166398 euGenes: HUgn9710
    ECgene: KIAA0355 H-InvDB: KIAA0355

    (According to HUGE)
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    HUGE: KIAA0355

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KIAA0355 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KIAA0355 gene:
    Search GeneIP for patents involving KIAA0355

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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