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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIAA0319 Gene

protein-coding   GIFtS: 57
GCID: GC06M024493

KIAA0319

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
KIAA03191 2
DYLX22 5
DYX22 5
Dyslexia Susceptibility 22
Dyslexia-Associated Protein KIAA03192
DLX25

External Ids:    HGNC: 215801   Entrez Gene: 98562   Ensembl: ENSG000001372617   OMIM: 6092695   UniProtKB: Q5VV433   

Export aliases for KIAA0319 gene to outside databases

Previous GC identifers: GC06M024601 GC06M024652 GC06M024655


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KIAA0319 Gene:
This gene encodes a transmembrane protein that contains a large extracellular domain with multiple polycystic
kidney disease (PKD) domains. The encoded protein may play a role in the development of the cerebral cortex by
regulating neuronal migration and cell adhesion. Single nucleotide polymorphisms in this gene are associated with
dyslexia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
(provided by RefSeq, Nov 2011)

GeneCards Summary for KIAA0319 Gene: 
KIAA0319 (KIAA0319) is a protein-coding gene. Diseases associated with KIAA0319 include articulation disorder, and dyslexia. GO annotations related to this gene include protein binding. An important paralog of this gene is KIAA0319L.

UniProtKB/Swiss-Prot: K0319_HUMAN, Q5VV43
Function: Involved in neuronal migration during development of the cerebral neocortex. May function in a cell
autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and
radial glial fibers. May also regulate growth and differentiation of dendrites

Gene Wiki entry for KIAA0319 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIAA0319 gene promoter:
         STAT5B   POU2F1   AML1a   FOXJ2 (long isoform)   POU2F1a   FOXJ2   HNF-4alpha1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KIAA0319

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA0319


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.3-p22.2   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p22.3-p22.2

KIAA0319 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA0319 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M024493:  view genomic region     (about GC identifiers)

Start:
24,544,332 bp from pter      End:
24,646,383 bp from pter
Size:
102,052 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: K0319_HUMAN, Q5VV43 (See protein sequence)
Recommended Name: Dyslexia-associated protein KIAA0319 precursor  
Size: 1072 amino acids; 117763 Da
Subunit: Homodimer. Interacts with AP2M1; required for clathrin-mediated endocytosis
Subcellular location: Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass
type I membrane protein. Note=Low-abundance isoforms lacking the transmembrane domain have been described; these
are secreted
Developmental stage: Expressed in the developing cerebral neocortex and glanglionic eminence in 57 days
post-fertilization fetal brain
Sequence caution: Sequence=BAA20777.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for KIAA0319:
2E7M (3D)    
Secondary accessions: A7MD37 B2RTU7 B4DHA7 B4DK75 B7ZML3 F5H123 Q9UJC8 Q9Y4G7
Alternative splicing: 4 isoforms:  Q5VV43-1   Q5VV43-2   Q5VV43-3   Q5VV43-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KIAA0319: NX_Q5VV43

Explore proteomics data for KIAA0319 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • UniProtKB: O-glycosylated
  • UniProtKB: Shedding of the extracellular domain and intramembrane cleavage produce several proteolytic products. The
    intramembrane cleavage releases a soluble cytoplasmic polypeptide that translocates to the nucleolus
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5VV43

  • KIAA0319 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KIAA0319 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001161846.1  NP_001161847.1  NP_001161848.1  NP_001161849.1  NP_001239257.1  NP_055624.2  

    ENSEMBL proteins: 
     ENSP00000367459   ENSP00000439700   ENSP00000437656   ENSP00000442403   ENSP00000401086  

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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome IDA19419997
    GO:0005886plasma membrane IDA19419997
    GO:0016021integral to membrane IEA--
    GO:0031901early endosome membrane IEA--

    KIAA0319 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR022409 PKD/Chitinase_dom
     IPR002859 PKD/REJ-like
     IPR000601 PKD_dom
     IPR003961 Fibronectin_type3
     IPR011106 MANSC_N

    Graphical View of Domain Structure for InterPro Entry Q5VV43

    ProtoNet protein and cluster: Q5VV43

    1 Blocks protein domain: IPB011106 Seven cysteines

    UniProtKB/Swiss-Prot: K0319_HUMAN, Q5VV43
    Similarity: Contains 1 MANSC domain
    Similarity: Contains 5 PKD domains


    KIAA0319 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: K0319_HUMAN, Q5VV43
    Function: Involved in neuronal migration during development of the cerebral neocortex. May function in a cell
    autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and
    radial glial fibers. May also regulate growth and differentiation of dendrites

         Genatlas biochemistry entry for KIAA0319:
    cDNA sequence,expressed in brain,>100kDa,related to C elegans twitchin

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19419997
         
    KIAA0319 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KIAA0319:
     Increased G1 DNA content 

    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KIAA0319

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for KIAA0319 (Q5VV433 ENSP000003674594) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH2B1Q9NRF23, ENSP000003371634I2D: score=3 STRING: ENSP00000337163
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    FEM1BQ9UK733, ENSP000003072984I2D: score=3 STRING: ENSP00000307298
    FEM1AENSP000002698564STRING: ENSP00000269856
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IGI19679544
    GO:2000171negative regulation of dendrite development IGI19679544

    KIAA0319 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIAA0319 (K0319)

    Search CenterWatch for drugs/clinical trials and news about KIAA0319 / K0319

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIAA0319 gene (6 alternative transcripts): 
    NM_001168374.1  NM_001168375.1  NM_001168376.1  NM_001168377.1  NM_001252328.1  NM_014809.3  

    Unigene Cluster for KIAA0319:

    KIAA0319
    Hs.26441  [show with all ESTs]
    Unigene Representative Sequence: NM_001168374
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378214 ENST00000537886(uc011djr.1) ENST00000543707 ENST00000535378(uc011djo.2 uc003neh.1 uc011djq.1)
    ENST00000430948(uc010jpt.1 uc011djp.2)
    miRNA
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    hsa-miR-633 hsa-miR-205* hsa-miR-4290 hsa-miR-548aa
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    Inhib. RNA
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    Additional mRNA sequence: 

    AB002317.1 AF086065.1 AK295008.1 AK296310.1 AK296426.1 AK307503.1 AK310289.1 BC140821.1 
    BC144628.1 BC152460.1 

    2 DOTS entries:

    DT.441367  DT.121375996 

    24/35 AceView cDNA sequences (see all 35):

    BQ267742 BM793061 T24487 AI369208 Z40603 BU615315 AU130115 BX101658 
    Z44817 CB306587 N50160 BQ272350 BX646625 AF086065 BV173714 R61546 
    AB002317 BM724053 AL044313 AW025772 AI683434 R20983 AA907928 BF753409 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0319    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:                    -                                                                                                                                       
    SP2:        -     -     -                                                                                                                                       
    SP3:                                                                                                                                                            
    SP4:                          -                                                                                                                                 


    ECgene alternative splicing isoforms for KIAA0319

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIAA0319 expression in normal human tissues (normalized intensities)      KIAA0319 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAACTATAT
    KIAA0319 Expression
    About this image


    KIAA0319 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/25 selected tissues (see all 25) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             superior temporal gyrus   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Uterus (Reproductive System)    fully expand to see all 4 entries
             uterus, post-menopause ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   
     
     Thyroid (Endocrine System)    fully expand to see all 2 entries
             thyroid gland ; glandular cells   

    See KIAA0319 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIAA0319

    SOURCE GeneReport for Unigene cluster: Hs.26441

    UniProtKB/Swiss-Prot: K0319_HUMAN, Q5VV43
    Tissue specificity: Detected in adult brain cortex and fetal frontal lobe (at protein level). Highly expressed in
    brain cortex, putamen, amygdala, hippocampus and cerebellum

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KIAA0319 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia D130043K22Rik1 , 5 RIKEN cDNA D130043K22 gene1, 5 80.92(n)1
    76.66(a)1
      13 (10.72 cM)5
    2101081  NM_001081051.11  NP_001074520.11 
     248451355 
    chicken
    (Gallus gallus)
    Aves KIAA03191 KIAA0319 70.12(n)
    67.9(a)
      428476  XM_426033.3  XP_426033.3 
    lizard
    (Anolis carolinensis)
    Reptilia KIAA03196
    Uncharacterized protein
    61(a)
    1 ↔ 1
    4(53998635-54024678)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7946241 dyslexia-associated protein KIAA0319-like 54.54(n)
    47.7(a)
      794624  XM_001334594.4  XP_001334630.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG75651 , 3 chitinase3
    CG75651
    41(a)3
    48.53(n)1
    42.03(a)1
      66B53
    388931  NM_139914.31  NP_648171.11 


    ENSEMBL Gene Tree for KIAA0319 (if available)
    TreeFam Gene Tree for KIAA0319 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIAA0319 gene
    KIAA0319L2  LRP112  
    1 SIMAP similar gene for KIAA0319 using alignment to 2 protein entries:     K0319_HUMAN (see all proteins):
    KIAA0319L

    KIAA0319 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2373 SNPs in KIAA0319 are shown (see all 2373)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1400381631,2
    Cuntested124485468(+) TGTCCG/AAGTCC 12 /S /L mis11Minor allele frequency- A:0.00NA 4552
    rs45044691,2,4
    C,F,Huntested124510723(+) GGCTGC/TGCTAG 10 T A mis1 ese311Minor allele frequency- T:0.29NS EA NA EU 6869
    rs1178084211,2
    F--24465797(+) ATGCCC/TGGCCC 6 -- ds50011Minor allele frequency- T:0.03EA 120
    rs1887379541,2
    --24465857(+) AGTGTA/CAGTAT 6 -- ds50010--------
    rs794267791,2
    C,F--24465912(+) GGCACG/CAGGGA 6 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1149793211,2
    C,F--24465982(+) TGCTCA/GGTTCT 6 -- ds50011Minor allele frequency- G:0.06NA 120
    rs1929535471,2
    --24466024(+) GCAGGA/GGATGT 6 -- ds50010--------
    rs283607501,2
    C,F--24466135(+) GTAACA/GTAAGA 6 -- ds50011Minor allele frequency- G:0.21WA 118
    rs27446051,2
    C,F,A,H--24466174(+) AATGTG/AGATAT 6 -- ut3124Minor allele frequency- A:0.08NA NS EA WA CSA 2620
    rs2006861851,2
    C--24466232(+) TTCAC-/ATGTTTC 6 -- ut310--------

    HapMap Linkage Disequilibrium report for KIAA0319 (24544332 - 24646383 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KIAA0319:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2731714CNV Deletion23290073
    esv2731713CNV Deletion23290073
    esv34020CNV Loss18971310


    Human Gene Mutation Database (HGMD): KIAA0319
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KIAA0319
    DNA2.0 Custom Variant and Variant Library Synthesis for KIAA0319

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609269   
    OMIM disorders: 600202  
    UniProtKB/Swiss-Prot: K0319_HUMAN, Q5VV43
  • Dyslexia 2 (DYX2) [MIM:600202]: A relatively common, complex cognitive disorder characterized by an
    impairment of reading performance despite adequate motivational, educational and intellectual opportunities. It
    is a multifactorial trait, with evidence for familial clustering and heritability. Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry

  • 7 diseases for KIAA0319:    About MalaCards
    articulation disorder    dyslexia    polycystic kidney disease    kidney disease
    cerebritis    attention deficit hyperactivity disorder    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for KIAA0319:
    Dyslexia     Articulation disorder

    KIAA0319 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KIAA0319
    Human Genome Epidemiology (HuGE) Navigator: KIAA0319 (18 documents)

    Export disorders for KIAA0319 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIAA0319 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with KIAA0319)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia. (PubMed id 15717286)1, 2, 4 Cope N.... Williams J. (2005)
    2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
    3. Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia. (PubMed id 17033633)1, 4, 9 Harold D....Monaco A.P. (2006)
    4. Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample. (PubMed id 18810304)1, 4, 9 Ludwig K.U....Hoffmann P. (2008)
    5. Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. (PubMed id 20923822)1, 4 Niu N....Wang L. (2010)
    6. The effect of variation in expression of the candidat e dyslexia susceptibility gene homolog Kiaa0319 on neuronal migration and dendr itic morphology in the rat. (PubMed id 19679544)1, 2 Peschansky V.J....Rosen G.D. (2010)
    7. The dyslexia-associated KIAA0319 protein undergoes proteolytic processing with {gamma}-secretase-independent intramembrane cleavage. (PubMed id 20943657)1, 2 Velayos-Baeza A....Monaco A.P. (2010)
    8. Dyslexia and DCDC2: normal variation in reading and s pelling is associated with DCDC2 polymorphisms in an Australian population samp le. (PubMed id 20068590)1, 4 Lind P.A....Bates T.C. (2010)
    9. Association of Attention-Deficit/Hyperactivity Disorder with a Candidate Region for Reading Disabilities on Chromosome 6p. (PubMed id 19362708)1, 4 Couto J.M....Barr C.L. (2009)
    10. Association of reading disabilities with regions mark ed by acetylated H3 histones in KIAA0319. (PubMed id 19588467)1, 4 Couto J.M....Barr C.L. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9856 HGNC: 21580 AceView: KIAA0319 Ensembl:ENSG00000137261 euGenes: HUgn9856
    ECgene: KIAA0319 H-InvDB: KIAA0319

    (According to HUGE)
    About This Section
    HUGE: KIAA0319

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIAA0319 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt125.shtml

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIAA0319 gene:
    Search GeneIP for patents involving KIAA0319

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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