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Set Analyses:

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KIAA0319 Gene

protein-coding GIFtS: 59
GCID: GC06M024544

KIAA0319

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
KIAA0319¹ ²		NMIG²
Neuronal Migration¹ ²		Dyslexia Susceptibility 2²
DYLX2² ⁵		Dyslexia-Associated Protein KIAA0319²
DYX2² ⁵		DLX2⁵

External Ids:	HGNC: 21580¹	Entrez Gene: 9856²	Ensembl: ENSG00000137261⁷	OMIM: 609269⁵	UniProtKB: Q5VV43³

Export aliases for KIAA0319 gene to outside databases

Previous GC identifers: GC06M024601 GC06M024652 GC06M024655 GC06M024493

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KIAA0319 Gene:

This gene encodes a transmembrane protein that contains a large extracellular domain with multiple polycystic

kidney disease (PKD) domains. The encoded protein may play a role in the development of the cerebral cortex by

regulating neuronal migration and cell adhesion. Single nucleotide polymorphisms in this gene are associated with

dyslexia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

(provided by RefSeq, Nov 2011)

GeneCards Summary for KIAA0319 Gene:

KIAA0319 (KIAA0319) is a protein-coding gene. Diseases associated with KIAA0319 include dyslexia 2, and articulation disorder. An important paralog of this gene is KIAA0319L.

UniProtKB/Swiss-Prot: K0319_HUMAN, Q5VV43

Function: Involved in neuronal migration during development of the cerebral neocortex. May function in a cell

autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and

radial glial fibers. May also regulate growth and differentiation of dendrites

Gene Wiki entry for KIAA0319 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000006.12 NT_007592.16 NC_018917.2

Regulatory elements:

Regulatory transcription factor binding sites in the KIAA0319 gene promoter:
STAT5B POU2F1 AML1a FOXJ2 (long isoform) POU2F1a FOXJ2 HNF-4alpha1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search Chromatin IP Primers for KIAA0319

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIAA0319

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.3 Ensembl cytogenetic band: 6p22.3 HGNC cytogenetic band: 6p22.3

KIAA0319 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA0319 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M024544: view genomic region (about GC identifiers)

Start:	24,544,332 bp from pter	End:	24,646,383 bp from pter
Size:	102,052 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: K0319_HUMAN, Q5VV43 (See protein sequence)

Recommended Name: Dyslexia-associated protein KIAA0319 precursor

Size: 1072 amino acids; 117763 Da

Subunit: Homodimer. Interacts with AP2M1; required for clathrin-mediated endocytosis

Developmental stage: Expressed in the developing cerebral neocortex and glanglionic eminence in 57 days

post-fertilization fetal brain

Sequence caution: Sequence=BAA20777.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

1 PDB 3D structure from and Proteopedia for KIAA0319:

2E7M (3D)

Secondary accessions: A7MD37 B2RTU7 B4DHA7 B4DK75 B7ZML3 F5H123 Q9UJC8 Q9Y4G7

Alternative splicing: 4 isoforms: Q5VV43-1 Q5VV43-2 Q5VV43-3 Q5VV43-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KIAA0319: NX_Q5VV43

Explore proteomics data for KIAA0319 at MOPED

Post-translational modifications:

N-glycosylated¹

O-glycosylated¹

Shedding of the extracellular domain and intramembrane cleavage produce several proteolytic products. The

intramembrane cleavage releases a soluble cytoplasmic polypeptide that translocates to the nucleolus¹

Glycosylation² at Asn196, Asn219, Asn262, Asn394, Asn421, Asn498, Asn513, Asn536, Asn551, Asn733

Modification sites at PhosphoSitePlus

See KIAA0319 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (6 alternative transcripts):

NP_001161846.1 NP_001161847.1 NP_001161848.1 NP_001161849.1 NP_001239257.1 NP_055624.2

ENSEMBL proteins:

ENSP00000367459 ENSP00000439700 ENSP00000437656 ENSP00000442403 ENSP00000401086

KIAA0319 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Selected InterPro protein domains (see all 6):

IPR022409 PKD/Chitinase_dom

IPR002859 PKD/REJ-like

IPR011106 MANSC_N

IPR000601 PKD_dom

IPR003961 Fibronectin_type3

Graphical View of Domain Structure for InterPro Entry Q5VV43

ProtoNet protein and cluster: Q5VV43

1 Blocks protein domain: IPB011106 Seven cysteines

UniProtKB/Swiss-Prot: K0319_HUMAN, Q5VV43

Similarity: Contains 1 MANSC domain

Similarity: Contains 5 PKD domains

KIAA0319 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: K0319_HUMAN, Q5VV43

Function: Involved in neuronal migration during development of the cerebral neocortex. May function in a cell

autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and

radial glial fibers. May also regulate growth and differentiation of dendrites

Genatlas biochemistry entry for KIAA0319:

cDNA sequence,expressed in brain,>100kDa,related to C elegans twitchin

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	19419997

KIAA0319 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for KIAA0319:

Increased G1 DNA content

Animal Models:

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Gene Editing
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA0319

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

K0319_HUMAN, Q5VV43: Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass

type I membrane protein. Note=Low-abundance isoforms lacking the transmembrane domain have been described; these

are secreted

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
endosome	5
plasma membrane	5
extracellular	2
endoplasmic reticulum	1
lysosome	1
nucleus	1
peroxisome	1

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Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005769	early endosome	IDA	19419997
GO:0005886	plasma membrane	IDA	19419997
GO:0016021	integral component of membrane	IEA	--
GO:0031901	early endosome membrane	IEA	--

KIAA0319 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for KIAA0319
Interactions:

GeneGlobe Interaction Network for KIAA0319

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for KIAA0319 (Q5VV43³ ENSP00000367459⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SH2B1	Q9NRF2³, ENSP00000337163⁴	I2D: score=3 STRING: ENSP00000337163
MYC	P01106³, ENSP00000367207⁴	I2D: score=1 STRING: ENSP00000367207
FEM1B	Q9UK73³, ENSP00000307298⁴	I2D: score=3 STRING: ENSP00000307298
FEM1A	ENSP00000269856⁴	STRING: ENSP00000269856

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Gene Ontology (GO): 2 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001764	neuron migration	IGI	19679544
GO:2000171	negative regulation of dendrite development	IGI	19679544

KIAA0319 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for KIAA0319 (K0319)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for KIAA0319 gene (6 alternative transcripts):

NM_001168374.1 NM_001168375.1 NM_001168376.1 NM_001168377.1 NM_001252328.1 NM_014809.3

Unigene Cluster for KIAA0319:

KIAA0319

Hs.26441 [show with all ESTs]

Unigene Representative Sequence: NM_001168374

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000378214 ENST00000537886(uc011djr.1) ENST00000543707 ENST00000535378(uc011djo.2 uc003neh.1 uc011djq.1)

ENST00000430948(uc010jpt.1 uc011djp.2)

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Additional mRNA sequence:

AB002317.1 AF086065.1 AK295008.1 AK296310.1 AK296426.1 AK307503.1 AK310289.1 BC140821.1

BC144628.1 BC152460.1

2 DOTS entries:

DT.441367 DT.121375996

Selected AceView cDNA sequences (see all 35):

BU615315 Z40603 BM793061 BQ267742 T24487 AI369208 AU130115 BX646625

R61546 BX101658 AW025772 AB002317 BQ272350 BV173714 AF086065 CB306587

Z44817 AL044313 N50160 BM724053 AI683434 R20983 AA907928 BF930670

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0319 About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	·	4c	·	4d	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21
SP1:							-
SP2:			-		-		-
SP3:
SP4:									-

ECgene alternative splicing isoforms for KIAA0319

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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KIAA0319 expression in normal human tissues (normalized intensities) KIAA0319 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TGAACTATAT

About this image

KIAA0319 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 3) fully expand


Brain (Nervous System) fully expand to see all 4 entries
Cerebral Cortex

Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast

Testis (Reproductive System)
Leydig Cells Testis Interstitium

KIAA0319 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

KIAA0319 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.26441

UniProtKB/Swiss-Prot: K0319_HUMAN, Q5VV43

Tissue specificity: Detected in adult brain cortex and fetal frontal lobe (at protein level). Highly expressed in

brain cortex, putamen, amygdala, hippocampus and cerebellum

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for KIAA0319 gene from Selected species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	D130043K22Rik^{1 , 5}	RIKEN cDNA D130043K22 gene^{1, 5}	81.16(n)¹ 77.03(a)¹		13 (10.72 cM)⁵ 210108¹ NM_001081051.1¹ NP_001074520.1¹ 24845135⁵
chicken (Gallus gallus)	Aves	KIAA0319¹	KIAA0319	70.24(n) 68.15(a)		428476 XM_426033.4 XP_426033.4
lizard (Anolis carolinensis)	Reptilia	KIAA0319⁶	KIAA0319	61(a)	1 ↔ 1	4(53998635-54024678)
tropical clawed frog (Xenopus tropicalis)	Amphibia	kiaa0319¹	KIAA0319 ortholog	61(n) 56.96(a)		100497843 XM_002936446.2 XP_002936492.2
zebrafish (Danio rerio)	Actinopterygii	LOC794624¹	dyslexia-associated protein KIAA0319-like	55.1(n) 48.04(a)		794624 XM_005158301.1 XP_005158358.1
fruit fly (Drosophila melanogaster)	Insecta	CG7565^{1 , 3}	chitinase³ CG7565¹	41(a)³ 49.05(n)¹ 43.18(a)¹		66B5³ 38893¹ NM_139914.4¹ NP_648171.1¹

ENSEMBL Gene Tree for KIAA0319 (if available)
TreeFam Gene Tree for KIAA0319 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for KIAA0319 gene

KIAA0319L²

1 SIMAP similar gene for KIAA0319 using alignment to 2 protein entries: K0319_HUMAN (see all proteins):

KIAA0319L

KIAA0319 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140038163^1,2	C	untested¹	24485468(+)	`TGTCCG/AAGTCC`	12	/S /L	mis¹		1		NA	4552
rs4504469^1,2,,4	C,F,H	untested¹	24510723(+)	`GGCTGC/TGCTAG`	10	T A	mis¹ ese³		11		NS EA NA EU	6869
rs117808421^1,2	F	--	24465797(+)	`ATGCCC/TGGCCC`	6	--	ds500¹		1		EA	120
rs188737954^1,2		--	24465857(+)	`AGTGTA/CAGTAT`	6	--	ds500¹		0	--	--	--	--
rs79426779^1,2	C,F	--	24465912(+)	`GGCACG/CAGGGA`	6	--	ds500¹		1		WA	118
rs114979321^1,2	C,F	--	24465982(+)	`TGCTCA/GGTTCT`	6	--	ds500¹		1		NA	120
rs192953547^1,2		--	24466024(+)	`GCAGGA/GGATGT`	6	--	ds500¹		0	--	--	--	--
rs28360750^1,2	C,F	--	24466135(+)	`GTAACA/GTAAGA`	6	--	ds500¹		1		WA	118
rs2744605^1,2	C,F,A,H	--	24466174(+)	`AATGTG/AGATAT`	6	--	ut3¹		24		NA NS EA WA CSA	2620
rs200686185^1,2	C	--	24466232(+)	`TTCAC-/ATGTTTC`	6	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KIAA0319 (24544332 - 24646383 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for KIAA0319: About this table

Variant ID	Type	Subtype	PubMed ID
esv2731714	CNV	Deletion	23290073
esv2731713	CNV	Deletion	23290073
esv34020	CNV	Loss	18971310

Human Gene Mutation Database (HGMD): KIAA0319

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing KIAA0319

DNA2.0 Custom Variant and Variant Library Synthesis for KIAA0319

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 609269
OMIM disorders: 600202
UniProtKB/Swiss-Prot: K0319_HUMAN, Q5VV43

Dyslexia 2 (DYX2) [MIM:600202]: A relatively common, complex cognitive disorder characterized by an

impairment of reading performance despite adequate motivational, educational and intellectual opportunities. It

is a multifactorial trait, with evidence for familial clustering and heritability. Note=Disease susceptibility is

associated with variations affecting the gene represented in this entry

13 diseases for KIAA0319: About MalaCards

dyslexia 2 articulation disorder dyslexia polycystic kidney disease

kidney disease cerebritis attention deficit hyperactivity disorder neuronitis

tonsillitis thyroiditis multiple myeloma myeloma

malaria

2 diseases from the University of Copenhagen DISEASES database for KIAA0319:

Dyslexia Articulation disorder

KIAA0319 for disorders About GeneDecksing

Genetic Association Database (GAD): KIAA0319
Human Genome Epidemiology (HuGE) Navigator: KIAA0319 (18 documents)

Export disorders for KIAA0319 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for KIAA0319 gene, integrated from 10 sources (see all 41):
(articles sorted by number of sources associating them with KIAA0319)

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Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia. (PubMed id 15717286)^{1, 2, 4} Cope N.... Williams J. (Am. J. Hum. Genet. 2005)
Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)^{1, 2, 3} Nagase T.... Ohara O. (DNA Res. 1997)
Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia. (PubMed id 17033633)^{1, 4, 9} Harold D....Monaco A.P. (Mol. Psychiatry 2006)
Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample. (PubMed id 18810304)^{1, 4, 9} Ludwig K.U....Hoffmann P. (J Neural Transm 2008)
Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. (PubMed id 20923822)^{1, 4} Niu N....Wang L. (Genome Res. 2010)
The effect of variation in expression of the candidate dyslexia susceptibility gene homolog Kiaa0319 on neuronal migration and dendritic morphology in the rat. (PubMed id 19679544)^{1, 2} Peschansky V.J.... Rosen G.D. (Cereb. Cortex 2010)
Association of reading disabilities with regions marked by acetylated H3 histones in KIAA0319. (PubMed id 19588467)^{1, 4} Couto J.M....Barr C.L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
The dyslexia-associated KIAA0319 protein undergoes proteolytic processing with {gamma}-secretase-independent intramembrane cleavage. (PubMed id 20943657)^{1, 2} Velayos-Baeza A....Monaco A.P. (J. Biol. Chem. 2010)
Dyslexia and DCDC2: normal variation in reading and spelling is associated with DCDC2 polymorphisms in an Australian population sample. (PubMed id 20068590)^{1, 4} Lind P.A....Bates T.C. (Eur. J. Hum. Genet. 2010)
Association of attention-deficit/hyperactivity disorder with a candidate region for reading disabilities on chromosome 6p. (PubMed id 19362708)^{1, 4} Couto J.M....Barr C.L. (Biol. Psychiatry 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9856	HGNC: 21580	AceView: KIAA0319	Ensembl:ENSG00000137261	euGenes: HUgn9856
ECgene: KIAA0319	H-InvDB: KIAA0319

(According to HUGE)
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HUGE: KIAA0319

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for KIAA0319	Pharmacogenomics, SNPs, Pathways
Protein Spotlight	http://web.expasy.org/spotlight/back_issues/125

Intellectual Property for KIAA0319 gene
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Patent Information for KIAA0319 gene:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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