Aliases for KIAA0232 Gene
External Ids for KIAA0232 Gene
- HGNC: 28992
- Entrez Gene: 9778
- Ensembl: ENSG00000170871
- UniProtKB: Q92628
Previous GeneCards Identifiers for KIAA0232 Gene
- GC04P006690
- GC04P006906
- GC04P006849
- GC04P006902
- GC04P006715
Summaries for KIAA0232 Gene
GeneCards Summary for KIAA0232 Gene
KIAA0232 (KIAA0232) is a Protein Coding gene.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA0232 Gene
Genomics for KIAA0232 Gene
Regulatory Elements for KIAA0232 Gene
Enhancers for KIAA0232 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around KIAA0232 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the KIAA0232 gene promoter:
Regulatory Element Products
Genomic Location for KIAA0232 Gene
- Chromosome:
- 4
- Start:
- 6,781,375 bp from pter
- End:
- 6,884,172 bp from pter
- Size:
- 102,798 bases
- Orientation:
- Plus strand
Genomic View for KIAA0232 Gene
Genes around KIAA0232 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4p16.1 by Ensembl
- 4p16.1 by Entrez Gene
- 4p16.1 by HGNC
KIAA0232 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KIAA0232 Gene
Proteins for KIAA0232 Gene
-
Protein details for KIAA0232 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92628-K0232_HUMAN
- Recommended name:
- Uncharacterized protein KIAA0232
- Protein Accession:
- Q92628
- A7E2D2
Protein attributes for KIAA0232 Gene
- Size:
- 1395 amino acids
- Molecular mass:
- 154789 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA13221.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for KIAA0232 Gene
Post-translational modifications for KIAA0232 Gene
Other Protein References for KIAA0232 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for KIAA0232
- Invitrogen Antibodies for KIAA0232
- Search GeneTex for Antibodies for KIAA0232
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for KIAA0232
- Origene Custom Protein Services for KIAA0232
- Novus Biologicals proteins for KIAA0232
- Search GeneTex for Proteins for KIAA0232
No data available for DME Specific Peptides for KIAA0232 Gene
Domains & Families for KIAA0232 Gene
Suggested Antigen Peptide Sequences for KIAA0232 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for KIAA0232 Gene
Function for KIAA0232 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for KIAA0232 Gene
- GenomeRNAi human phenotypes for KIAA0232:
-
- Increased viability
- Increased transferrin (TF) endocytosis
- FOXO1 nuclear localization
- Decreased Hepatitis C virus replication
- Decreased mitophagy mCherry-Parkin protein expression after carbonyl cyanide m-chlorphenylhydrazone (CCCP) stimulation
- Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for KIAA0232
-
-
ViGene Biosciences lentiviral particle packaged cDNA for KIAA0232 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KIAA0232 gene
- Search ViGene Biosciences for KIAA0232
CRISPR Products
-
OriGene CRISPR knockouts for KIAA0232
-
Santa Cruz Biotechnology (SCBT) CRISPR for KIAA0232
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miRNA for KIAA0232 Gene
- miRTarBase miRNAs that target KIAA0232
-
- hsa-mir-375 (MIRT019736)
- hsa-mir-26b-5p (MIRT029109)
- hsa-mir-106b-3p (MIRT038590)
- hsa-mir-125a-5p (MIRT045711)
- hsa-mir-17-5p (MIRT213320)
- hsa-mir-20a-5p (MIRT213321)
- hsa-mir-93-5p (MIRT213322)
- hsa-mir-106a-5p (MIRT213323)
- hsa-mir-106b-5p (MIRT213324)
- hsa-mir-20b-5p (MIRT213325)
- hsa-mir-526b-3p (MIRT213327)
- hsa-mir-519d-3p (MIRT213328)
- hsa-mir-3609 (MIRT213330)
- hsa-mir-548ah-5p (MIRT213334)
- hsa-mir-4796-3p (MIRT213335)
- hsa-mir-152-3p (MIRT437644)
- hsa-mir-362-3p (MIRT541776)
- hsa-mir-329-3p (MIRT541777)
- hsa-mir-8485 (MIRT541778)
- hsa-mir-3689f (MIRT572509)
- hsa-mir-3689e (MIRT572510)
- hsa-mir-3689b-5p (MIRT572511)
- hsa-mir-3689a-5p (MIRT572512)
- hsa-mir-142-3p (MIRT572513)
- hsa-mir-6073 (MIRT572514)
- hsa-mir-190a-5p (MIRT572515)
- hsa-mir-190b (MIRT572516)
- hsa-mir-20b-3p (MIRT572517)
- hsa-mir-1208 (MIRT572518)
- hsa-mir-6760-3p (MIRT572519)
- hsa-mir-8062 (MIRT572520)
- hsa-mir-8079 (MIRT572521)
- hsa-mir-1245a (MIRT572522)
- hsa-mir-1183 (MIRT572523)
- hsa-mir-1224-3p (MIRT609807)
miRNA Products
- Search ViGene Biosciences for KIAA0232
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for KIAA0232
- Browse OriGene Inhibitory RNA Products For KIAA0232
-
ViGene Biosciences ready-to-package AAV shRNAs for KIAA0232 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for KIAA0232
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KIAA0232
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for KIAA0232
-
ViGene Biosciences adenoviral particle packaged cDNA for KIAA0232 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for KIAA0232 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KIAA0232 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA0232 Gene
Localization for KIAA0232 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 3 |
| nucleus | 2 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KIAA0232 Gene
Pathways & Interactions for KIAA0232 Gene
No Data Available
No data available for Pathways by source and SIGNOR curated interactions for KIAA0232 Gene
Transcripts for KIAA0232 Gene
mRNA/cDNA for KIAA0232 Gene
- (8) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (230) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for KIAA0232
-
Santa Cruz Biotechnology (SCBT) CRISPR for KIAA0232
- GenScript: Design CRISPR guide RNA sequences for KIAA0232
miRNA Products
- Search ViGene Biosciences for KIAA0232
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for KIAA0232
- Browse OriGene Inhibitory RNA Products For KIAA0232
-
ViGene Biosciences ready-to-package AAV shRNAs for KIAA0232 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for KIAA0232
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KIAA0232
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for KIAA0232 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
This gene is overexpressed in Bone (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIAA0232 Gene
NURSA nuclear receptor signaling pathways regulating expression of KIAA0232 Gene:
KIAA0232SOURCE GeneReport for Unigene cluster for KIAA0232 Gene:
Hs.79276Evidence on tissue expression from TISSUES for KIAA0232 Gene
- Bone marrow(4.3)
- Liver(4.2)
- Nervous system(2.8)
- Heart(2)
Primer Products
-
OriGene qPCR primer pairs for KIAA0232
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA0232 Gene
Orthologs for KIAA0232 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KIAA0232 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | KIAA0232 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | KIAA0232 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC680039 34 |
|
||
| mouse (Mus musculus) |
Mammalia | D5Ertd579e 34 16 35 |
|
||
| cow (Bos Taurus) |
Mammalia | KIAA0232 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | KIAA0232 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | KIAA0232 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | KIAA0232 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | kiaa0232 34 |
|
||
| Str.10272 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.30950 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:158564 35 |
|
OneToOne | |
| wufc44c06 34 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.120 35 |
|
OneToOne |
- Species where no ortholog for KIAA0232 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for KIAA0232 Gene
No data available for Paralogs for KIAA0232 Gene
Variants for KIAA0232 Gene
| SNP ID | Clin | Chr 04 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000002594 | -- | 6,795,849(+) | GCCTC(C/T)GCAAG | intron-variant | |
| rs1000009897 | -- | 6,787,106(+) | AACCC(A/G)GGAGG | intron-variant | |
| rs1000015413 | -- | 6,869,978(+) | GATGT(A/G)GGTGG | intron-variant | |
| rs1000047904 | -- | 6,870,135(+) | CTATT(G/T)ACCAC | intron-variant | |
| rs1000054699 | -- | 6,826,829(+) | GTGCT(A/G)GGTGC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2722n106 | CNV | deletion | 24896259 |
| dgv812e201 | CNV | deletion | 23290073 |
| dgv8937n54 | CNV | gain+loss | 21841781 |
| dgv8938n54 | CNV | gain | 21841781 |
| dgv8939n54 | CNV | loss | 21841781 |
| dgv8940n54 | CNV | gain | 21841781 |
| esv1098216 | CNV | insertion | 17803354 |
| esv1704198 | CNV | insertion | 17803354 |
| esv23110 | CNV | gain | 19812545 |
| esv23947 | CNV | loss | 19812545 |
| esv2727009 | CNV | deletion | 23290073 |
| esv2727010 | CNV | deletion | 23290073 |
| esv2727011 | CNV | deletion | 23290073 |
| esv34196 | OTHER | inversion | 12058347 |
| esv3563336 | CNV | deletion | 23714750 |
| esv3599511 | CNV | loss | 21293372 |
| nsv1010710 | CNV | gain | 25217958 |
| nsv1112848 | CNV | deletion | 24896259 |
| nsv4216 | CNV | deletion | 18451855 |
| nsv519565 | CNV | gain+loss | 19592680 |
| nsv526314 | CNV | gain | 19592680 |
| nsv593525 | CNV | loss | 21841781 |
| nsv593526 | CNV | gain | 21841781 |
| nsv593527 | CNV | gain | 21841781 |
| nsv593532 | CNV | gain | 21841781 |
| nsv949779 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
6.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.49;
64.42% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for KIAA0232 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA0232 Gene
Disorders for KIAA0232 Gene
Relevant External Links for KIAA0232
No disorders were found for KIAA0232 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA0232 Gene
Publications for KIAA0232 Gene
- Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4 64
- New gene functions in megakaryopoiesis and platelet formation. (PMID: 22139419) Gieger C. … Soranzo N. (Nature 2011) 3 46 64
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
Products for KIAA0232 Gene
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- OriGene qPCR primer pairs for KIAA0232
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- Novus Biologicals Antibodies for KIAA0232
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- Invitrogen Antibodies for KIAA0232
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Search GeneTex for Antibodies for KIAA0232
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- ViGene Biosciences adenoviral particle packaged cDNA for KIAA0232 gene
- ViGene Biosciences lentiviral particle packaged cDNA for KIAA0232 gene
- ViGene Biosciences ready-to-package AAV shRNAs for KIAA0232 gene
- Search ViGene Biosciences for KIAA0232
- Horizon Cell Lines for KIAA0232
- Cyagen custom Knockout/knockin (KOKI) mouse models for KIAA0232
- VectorBuilder custom plasmid, inducible vectors for KIAA0232
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KIAA0232
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for KIAA0232 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
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- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
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- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
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- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
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- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer