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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIAA0232 Gene

protein-coding   GIFtS: 44
GCID: GC04P006783

KIAA0232
  Search for KIAA0232
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KIAA0232    

Aliases
for KIAA0232 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
KIAA02321 2
Uncharacterized Protein KIAA02322

External Ids:    HGNC: 289921   Entrez Gene: 97782   Ensembl: ENSG000001708717   UniProtKB: Q926283   

Export aliases for KIAA0232 gene to outside databases

Previous GC identifers: GC04P006690 GC04P006906 GC04P006849 GC04P006902 GC04P006715


Summaries
for KIAA0232 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for KIAA0232 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006051.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIAA0232 gene promoter:
         Max1   ER-alpha   STAT5B   STAT1   Pax-6   STAT1alpha   Gfi-1   MZF-1   Pax-3   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KIAA0232

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA0232


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16.1

KIAA0232 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA0232 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P006783:  view genomic region     (about GC identifiers)

Start:
 6,783,102 bp from pter      End:
 6,885,899 bp from pter
Size:
 102,798 bases      Orientation:
 plus strand

Proteins
for KIAA0232 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: K0232_HUMAN, Q92628 (See protein sequence)
Recommended Name: Uncharacterized protein KIAA0232  
Size: 1395 amino acids; 154789 Da
Sequence caution: Sequence=BAA13221.3; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A7E2D2

Explore the universe of human proteins at neXtProt for KIAA0232: NX_Q92628

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92628

    • KIAA0232 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001094060.1  NP_055558.2  

    ENSEMBL proteins: 
     ENSP00000426815   ENSP00000303928   ENSP00000413739  

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    Protein Domains /
    Families
    for KIAA0232 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q92628


    Function
    for KIAA0232 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--


    KIAA0232 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for KIAA0232:
     Increased Hepatitis C virus re 


    Pathways & Interactions
    for KIAA0232 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA0232

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for KIAA0232 (Q926282, 3 ENSP000003039284) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC35F6Q8N3572, 3MINT-65063 I2D: score=4 
    YWHAEP622583, ENSP000002643354I2D: score=2 STRING: ENSP00000264335
    YWHAZP631043, ENSP000003095034I2D: score=2 STRING: ENSP00000309503
    WNK1Q9H4A33, ENSP000003130594I2D: score=1 STRING: ENSP00000313059
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    About this table

    Drugs & Compounds
    for KIAA0232 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for KIAA0232
    Search CenterWatch for drugs/clinical trials and news about KIAA0232 / K0232 

    Transcripts
    for KIAA0232 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KIAA0232 gene (2 alternative transcripts): 
    NM_001100590.1  NM_014743.2  

    Unigene Cluster for KIAA0232:

    KIAA0232
    Hs.79276  [show with all ESTs]
    Unigene Representative Sequence: NM_014743
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503278 ENST00000508423 ENST00000307659(uc003gjr.4) ENST00000503069
    ENST00000425103(uc003gjq.4)

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    8/77 QIAGEN miScript miRNA Assays for microRNAs that regulate KIAA0232 (see all 77):
    hsa-miR-607 hsa-miR-106a hsa-miR-485-3p hsa-miR-128 hsa-miR-138-2* hsa-miR-371-5p hsa-miR-3921 hsa-miR-3916
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIAA0232 (see all 4)
    OriGene shRNA RFP: KIAA0232
    OriGene siRNA: KIAA0232
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    Clone
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    Additional cDNA sequence: 

    AF143884.1 AK124715.1 BC150286.1 CR457160.1 D86985.3 EF553521.1 

    8 DOTS entries:

    DT.118111  DT.91701977  DT.100700972  DT.100785040  DT.121260491  DT.92433565  DT.100012762  DT.121260484 

    24/230 AceView cDNA sequences (see all 230):

    BE466521 AI826314 AA702636 AA663574 CA307271 CK300683 AW069515 BG387474 
    AI184742 CK821744 AU119640 CD679592 AI810199 Z42913 BM997466 AA406589 
    AI656648 AI434782 AA709473 AI208859 BE501060 BM718132 AA421928 AI420199 

    GeneLoc Exon Structure


    Expression
    for KIAA0232 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIAA0232 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAAATGGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KIAA0232 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PancreasDorsal Pancreatic BudImmature Beta Progenitor CellsPancreas
    PancreasVentral Pancreatic BudImmature Beta Progenitor CellsPancreas
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KIAA0232 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIAA0232

    SOURCE GeneReport for Unigene cluster: Hs.79276
        SABiosciences Custom PCR Arrays for KIAA0232
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA0232

    Orthologs
    for KIAA0232 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KIAA0232 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia D5Ertd579e1 , 5 DNA segment, Chr 5, ERATO Doi 579, expressed1, 5 88.53(n)1
    88.72(a)1    		   5 (19.18 cM)5
    3206611  NM_001081232.21  NP_001074701.21 
     365847885 
    chicken
    (Gallus gallus)    		 Aves KIAA02321 KIAA0232 84.51(n)
    86.51(a)    		   422860  XM_420806.2  XP_420806.2 
    lizard
    (Anolis carolinensis)    		 Reptilia KIAA02326
    		 --
    		 79(a)
    		 1 ↔ 1
    		 4(79425460-79456463)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.309502 Xenopus laevis transcribed sequences 80.57(n)    48033214 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufc44c062 Transcribed sequence with weak similarity to protein more 70.1(n)    57050020 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 25(a)
    		 1 ↔ 1
    		 Group1.37(537383-542319)


    ENSEMBL Gene Tree for KIAA0232 (if available)
    TreeFam Gene Tree for KIAA0232 (if available) 

    Paralogs
    for KIAA0232 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for KIAA0232 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for KIAA0232
         3 CNVs: 36291 51446 63735
         1 Indel: 68647
    Human Gene Mutation Database (HGMD): KIAA0232
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for KIAA0232

    Disorders / Diseases
    for KIAA0232 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KIAA0232 for disorders           About MalaCards

    KIAA0232 for disorders           About GeneDecksing


    Export disorders for KIAA0232 gene to outside databases

    Publications
    for KIAA0232 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIAA0232 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with KIAA0232)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2, 3 Nagase T....Nomura N. (1996)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    4. New gene functions in megakaryopoiesis and platelet fo rmation. (PubMed id 22139419)1 Gieger C....Soranzo N. (2011)
    5. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    External Searches for KIAA0232 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KIAA0232 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9778 HGNC: 28992 AceView: KIAA0232 Ensembl:ENSG00000170871 euGenes: HUgn9778
    ECgene: KIAA0232 H-InvDB: KIAA0232

    Other Databases showing KIAA0232 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0232

    Specialized Databases showing KIAA0232 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIAA0232 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KIAA0232 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KIAA0232 gene:
    Search GeneIP for patents involving KIAA0232

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for KIAA0232 gene

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    Advanced Cell Diagnostics
    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    von Willebrand factor
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