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Aliases for KIAA0226L Gene

Aliases for KIAA0226L Gene

  • KIAA0226-Like 2 3
  • C13orf18 3 4
  • Chromosome 13 Open Reading Frame 18 2

External Ids for KIAA0226L Gene

Previous HGNC Symbols for KIAA0226L Gene

  • C13orf18

Previous GeneCards Identifiers for KIAA0226L Gene

  • GC13M046917

Summaries for KIAA0226L Gene

GeneCards Summary for KIAA0226L Gene

KIAA0226L (KIAA0226-Like) is a Protein Coding gene. An important paralog of this gene is PLEKHM1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA0226L Gene

Genomics for KIAA0226L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KIAA0226L Gene

Chromosome:
13
Start:
46,342,000 bp from pter
End:
46,438,190 bp from pter
Size:
96,191 bases
Orientation:
Minus strand

Genomic View for KIAA0226L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIAA0226L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA0226L Gene

No data available for Regulatory Elements for KIAA0226L Gene

Proteins for KIAA0226L Gene

  • Protein details for KIAA0226L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H714-K226L_HUMAN
    Recommended name:
    Uncharacterized protein KIAA0226-like
    Protein Accession:
    Q9H714
    Secondary Accessions:
    • A8KAG9
    • A8XR19
    • B3KS87
    • Q5W051
    • Q5W053
    • Q6PJ74
    • Q6PK94
    • Q86XH7
    • Q8N5J6

    Protein attributes for KIAA0226L Gene

    Size:
    662 amino acids
    Molecular mass:
    73457 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIAA0226L Gene

neXtProt entry for KIAA0226L Gene

Proteomics data for KIAA0226L Gene at MOPED

Post-translational modifications for KIAA0226L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIAA0226L Gene

Domains & Families for KIAA0226L Gene

Protein Domains for KIAA0226L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA0226L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA0226L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KIAA0226L Gene

Function for KIAA0226L Gene

Phenotypes for KIAA0226L Gene

genes like me logo Genes that share phenotypes with KIAA0226L: view

Animal Model Products

CRISPR Products

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate KIAA0226L
    • Block miRNA regulation of KIAA0226L using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for KIAA0226L

    In Situ Assay Products

    Flow Cytometry Products

    No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA0226L Gene

    Localization for KIAA0226L Gene

    Subcellular locations from

    COMPARTMENTS
    Jensen Localization Image for KIAA0226L Gene COMPARTMENTS Subcellular localization image for KIAA0226L gene
    Compartment Confidence
    cytosol 2

    No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KIAA0226L Gene

    Pathways & Interactions for KIAA0226L Gene

    SuperPathways for KIAA0226L Gene

    No Data Available

    Interacting Proteins for KIAA0226L Gene

    STRING Interaction Network Preview (showing 3 interactants - click image to see details)
    http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000374558%0d%0a9606.ENSP00000355231%0d%0a9606.ENSP00000403397%0d%0a9606.ENSP00000348455%0d%0a
    Selected Interacting proteins: ENSP00000374558 Q9H714-K226L_HUMAN for KIAA0226L Gene via STRING I2D

    Gene Ontology (GO) - Biological Process for KIAA0226L Gene

    None

    No data available for Pathways by source and SIGNOR curated interactions for KIAA0226L Gene

    Drugs & Compounds for KIAA0226L Gene

    No Compound Related Data Available

    Transcripts for KIAA0226L Gene

    Unigene Clusters for KIAA0226L Gene

    KIAA0226-like:
    Representative Sequences:

    CRISPR Products

    miRNA Products

    • QIAGEN qRT-PCR Assays for microRNAs that regulate KIAA0226L
      • Block miRNA regulation of KIAA0226L using miScript Target Protectors

      Inhibitory RNA Products

      • Predesigned siRNA for gene silencing in human,mouse,rat for KIAA0226L

      Flow Cytometry Products

      Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0226L Gene

      ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a ·
      SP1: - - - - - - - - - - - - - - - - - - - - - -
      SP2: - - - - - - -
      SP3: - - - - - - -
      SP4: - - - - - - -
      SP5: - - - - - - - -
      SP6: - - - - - - - - - - - - - - - - - -
      SP7: - - - - - -
      SP8: - - - - - - - - - - - - - - -
      SP9: - - - - - - - -
      SP10: - - - - -
      SP11: - - - - - -
      SP12: -
      SP13:
      SP14: - - - - - - - - - - - - - -
      SP15: - - - - - - - - - - - - - - -
      SP16: - - - - - - - - - - - - -
      SP17: - - - -
      SP18: -
      SP19:
      SP20: - - - - - - - - - - - - -
      SP21:
      SP22: - -
      SP23:
      SP24:

      ExUns: 17b · 17c · 17d · 17e ^ 18a · 18b · 18c · 18d · 18e ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b · 23c ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b ^
      SP1: - - - - - - - - - - - - - -
      SP2: - - - - - - - - -
      SP3: - - - - -
      SP4: - - - -
      SP5: - - - - - - - - - - - -
      SP6: - - - -
      SP7:
      SP8: - - - - - - - - - - - -
      SP9: - - - - - - - - - - -
      SP10:
      SP11: - -
      SP12: - - -
      SP13: - -
      SP14:
      SP15: - - - -
      SP16:
      SP17:
      SP18:
      SP19:
      SP20: - - - -
      SP21:
      SP22:
      SP23:
      SP24:

      ExUns: 30a · 30b ^ 31 ^ 32 ^ 33
      SP1: -
      SP2: -
      SP3: - -
      SP4: -
      SP5:
      SP6:
      SP7:
      SP8:
      SP9:
      SP10:
      SP11:
      SP12:
      SP13:
      SP14:
      SP15:
      SP16:
      SP17:
      SP18:
      SP19:
      SP20:
      SP21:
      SP22:
      SP23:
      SP24:

      Relevant External Links for KIAA0226L Gene

      GeneLoc Exon Structure for
      KIAA0226L
      ECgene alternative splicing isoforms for
      KIAA0226L

      Expression for KIAA0226L Gene

      mRNA expression in normal human tissues for KIAA0226L Gene

      mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

      mRNA differential expression in normal tissues according to GTEx for KIAA0226L Gene

      This gene is overexpressed in Whole Blood (x10.4) and Spleen (x5.0).

      Protein differential expression in normal tissues from HIPED for KIAA0226L Gene

      This gene is overexpressed in Blymphocyte (69.0).

      Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KIAA0226L Gene



      SOURCE GeneReport for Unigene cluster for KIAA0226L Gene Hs.98117

      genes like me logo Genes that share expression patterns with KIAA0226L: view

      Protein tissue co-expression partners for KIAA0226L Gene

      - Elite partner

      Primer Products

      • QuantiTect SYBR Green Assays in human,mouse,rat
      • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
      • QuantiFast Probe-based Assays in human,mouse,rat

      In Situ Assay Products

      No data available for mRNA Expression by UniProt/SwissProt for KIAA0226L Gene

      Orthologs for KIAA0226L Gene

      This gene was present in the common ancestor of chordates.

      Orthologs for KIAA0226L Gene

      Organism Taxonomy Gene Similarity Type Details
      cow
      (Bos Taurus)
      Mammalia KIAA0226L 35
      • 80.38 (n)
      • 72.31 (a)
      KIAA0226L 36
      • 72 (a)
      OneToOne
      dog
      (Canis familiaris)
      Mammalia KIAA0226L 35
      • 83.23 (n)
      • 78.88 (a)
      KIAA0226L 36
      • 78 (a)
      OneToOne
      mouse
      (Mus musculus)
      Mammalia 5031414D18Rik 35
      • 73.04 (n)
      • 62.83 (a)
      5031414D18Rik 16
      5031414D18Rik 36
      • 60 (a)
      OneToOne
      chimpanzee
      (Pan troglodytes)
      Mammalia KIAA0226L 35
      • 99.35 (n)
      • 98.64 (a)
      KIAA0226L 36
      • 98 (a)
      OneToOne
      rat
      (Rattus norvegicus)
      Mammalia RGD1304929 35
      • 72.17 (n)
      • 60.49 (a)
      oppossum
      (Monodelphis domestica)
      Mammalia KIAA0226L 36
      • 50 (a)
      OneToOne
      platypus
      (Ornithorhynchus anatinus)
      Mammalia KIAA0226L 36
      • 55 (a)
      OneToOne
      chicken
      (Gallus gallus)
      Aves KIAA0226L 35
      • 65.86 (n)
      • 60.04 (a)
      KIAA0226L 36
      • 40 (a)
      OneToOne
      tropical clawed frog
      (Silurana tropicalis)
      Amphibia Str.15213 35
      zebrafish
      (Danio rerio)
      Actinopterygii si:ch211-260b17.6 36
      • 55 (a)
      OneToOne
      Species with no ortholog for KIAA0226L:
      • A. gosspyii yeast (Ashbya gossypii)
      • Actinobacteria (Mycobacterium tuberculosis)
      • African clawed frog (Xenopus laevis)
      • African malaria mosquito (Anopheles gambiae)
      • Alicante grape (Vitis vinifera)
      • alpha proteobacteria (Wolbachia pipientis)
      • amoeba (Dictyostelium discoideum)
      • Archea (Pyrococcus horikoshii)
      • baker's yeast (Saccharomyces cerevisiae)
      • barley (Hordeum vulgare)
      • beta proteobacteria (Neisseria meningitidis)
      • bread mold (Neurospora crassa)
      • Chromalveolata (Phytophthora infestans)
      • common water flea (Daphnia pulex)
      • corn (Zea mays)
      • E. coli (Escherichia coli)
      • filamentous fungi (Aspergillus nidulans)
      • Firmicute bacteria (Streptococcus pneumoniae)
      • fission yeast (Schizosaccharomyces pombe)
      • fruit fly (Drosophila melanogaster)
      • green algae (Chlamydomonas reinhardtii)
      • honey bee (Apis mellifera)
      • K. lactis yeast (Kluyveromyces lactis)
      • lizard (Anolis carolinensis)
      • loblloly pine (Pinus taeda)
      • malaria parasite (Plasmodium falciparum)
      • medicago trunc (Medicago Truncatula)
      • moss (Physcomitrella patens)
      • orangutan (Pongo pygmaeus)
      • pig (Sus scrofa)
      • rainbow trout (Oncorhynchus mykiss)
      • rice (Oryza sativa)
      • rice blast fungus (Magnaporthe grisea)
      • schistosome parasite (Schistosoma mansoni)
      • sea anemone (Nematostella vectensis)
      • sea squirt (Ciona intestinalis)
      • sea squirt (Ciona savignyi)
      • sea urchin (Strongylocentrotus purpuratus)
      • sorghum (Sorghum bicolor)
      • soybean (Glycine max)
      • stem rust fungus (Puccinia graminis)
      • sugarcane (Saccharum officinarum)
      • thale cress (Arabidopsis thaliana)
      • tomato (Lycopersicon esculentum)
      • toxoplasmosis (Toxoplasma gondii)
      • Trichoplax (Trichoplax adhaerens)
      • wheat (Triticum aestivum)
      • worm (Caenorhabditis elegans)

      Evolution for KIAA0226L Gene

      ENSEMBL:
      Gene Tree for KIAA0226L (if available)
      TreeFam:
      Gene Tree for KIAA0226L (if available)

      Paralogs for KIAA0226L Gene

      Paralogs for KIAA0226L Gene

      (1) SIMAP similar genes for KIAA0226L Gene using alignment to 6 proteins:

      genes like me logo Genes that share paralogs with KIAA0226L: view

      Variants for KIAA0226L Gene

      Sequence variations from dbSNP and Humsavar for KIAA0226L Gene

      SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
      VAR_022912 -

      Structural Variations from Database of Genomic Variants (DGV) for KIAA0226L Gene

      Variant ID Type Subtype PubMed ID
      dgv250e201 CNV Deletion 23290073
      nsv455876 CNV Gain 19166990

      Variation tolerance for KIAA0226L Gene

      Residual Variation Intolerance Score: 93.42% of all genes are more intolerant (likely to be disease-causing)
      Gene Damage Index Score: 7.74; 83.18% of all genes are more intolerant (likely to be disease-causing)

      Relevant External Links for KIAA0226L Gene

      HapMap Linkage Disequilibrium report
      KIAA0226L

      No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA0226L Gene

      Disorders for KIAA0226L Gene

      Relevant External Links for KIAA0226L

      Atlas of Genetics and Cytogenetics in Oncology and Haematology:
      KIAA0226L
      genes like me logo Genes that share disorders with KIAA0226L: view

      No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA0226L Gene

      Publications for KIAA0226L Gene

      1. C13orf18 and C1orf166 (MULAN) DNA genes methylation are not associated with cervical cancer and precancerous lesions of human papillomavirus genotypes in Iranian women. (PMID: 25169519) Sohrabi A. … Modarresl M.H. (Asian Pac. J. Cancer Prev. 2014) 67
      2. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 67
      3. Functional validation of putative tumor suppressor gene C13ORF18 in cervical cancer by Artificial Transcription Factors. (PMID: 23522960) Huisman C. … Rots M.G. (Mol Oncol 2013) 67
      4. A four-gene methylation marker panel as triage test in high-risk human papillomavirus positive patients. (PMID: 21796628) Eijsink J.J. … Wisman G.B. (Int. J. Cancer 2012) 67
      5. Network organization of the human autophagy system. (PMID: 20562859) Behrends C. … Harper J.W. (Nature 2010) 67

      Products for KIAA0226L Gene

      Sources for KIAA0226L Gene

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