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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIAA0226L Gene

protein-coding   GIFtS: 44
GCID: GC13M046917

KIAA0226-like

(Previous name: chromosome 13 open reading frame 18 )
(Previous symbol: C13orf18)
 Explore 2 diseases affiliated with
KIAA0226L via our new
 Human Malady Compendium 
Biological research products
for KIAA0226L
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
KIAA0226-Like1
C13orf181 2 3
FLJ215621
Chromosome 13 Open Reading Frame 181
Uncharacterized Protein KIAA0226-Like2

External Ids:    HGNC: 204201   Entrez Gene: 801832   Ensembl: ENSG000001024457   UniProtKB: Q9H7143   

Export aliases for KIAA0226L gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for KIAA0226L
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KIAA0226L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA0226L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.13   Ensembl cytogenetic band:  13q14.13   HGNC cytogenetic band: 13q14.11

KIAA0226L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA0226L gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M046917:  view genomic region     (about GC identifiers)

Start:
46,916,136 bp from pter      End:
47,012,325 bp from pter
Size:
96,190 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: K226L_HUMAN, Q9H714 (See protein sequence)
Recommended Name: Uncharacterized protein KIAA0226-like  
Size: 662 amino acids; 73457 Da
Secondary accessions: A8XR19 B3KS87 Q5W051 Q5W053 Q6PJ74 Q6PK94 Q86XH7 Q8N5J6
Alternative splicing: 5 isoforms:  Q9H714-5   Q9H714-4   Q9H714-3   Q9H714-1   Q9H714-2   (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for KIAA0226L: NX_Q9H714

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H714

  • KIAA0226L Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_079389.2  
    ENSEMBL proteins: 
     ENSP00000368061   ENSP00000412507   ENSP00000368064   ENSP00000374558   ENSP00000386578  
     ENSP00000402357   ENSP00000414579   ENSP00000368074   ENSP00000315633   ENSP00000396935  
     ENSP00000437501   ENSP00000368057  

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    OriGene Protein Over-expression Lysate: KIAA0226L
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    Novus Biologicals KIAA0226L Protein
    Novus Biologicals KIAA0226L Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KIAA0226L


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    Uscn ELISAs and CLIAs for KIAA0226L


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    KIAA0226L for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR025258 DUF4206

    Graphical View of Domain Structure for InterPro Entry Q9H714

    ProtoNet protein and cluster: Q9H714


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    OriGene 3'-UTR Clone: KIAA0226L
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA0226L


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA0226L

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for KIAA0226L (Q9H7143 ENSP000003745584) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BECN1Q144573, ENSP000003552314I2D: score=3 STRING: ENSP00000355231
    UVRAGQ9P2Y53, ENSP000003484554I2D: score=1 STRING: ENSP00000348455
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIAA0226L
    Search CenterWatch for drugs/clinical trials and news about KIAA0226L / K226L 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIAA0226L gene: 
    NM_025113.2  

    Unigene Cluster for KIAA0226L:

    KIAA0226-like
    Hs.98117  [show with all ESTs]
    Unigene Representative Sequence: NM_025113
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487195 ENST00000378784 ENST00000441284(uc010aco.1) ENST00000378787
    ENST00000389908 ENST00000409879 ENST00000417405 ENST00000439642 ENST00000480935
    ENST00000378797(uc001vbe.4) ENST00000322896 ENST00000429979(uc010acl.3 uc001vbf.4 uc010tfz.2 uc010acn.3 uc010acm.3 uc001vbh.4)
    ENST00000534925 ENST00000378781(uc010tfy.2)

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidKIAA0226L 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIAA0226L (see all 4)
    OriGene shRNA RFP: KIAA0226L
    OriGene siRNA: KIAA0226L
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIAA0226L
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIAA0226L
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIAA0226L

    Additional cDNA sequence: 

    AK025215.1 AK093073.1 AK125750.1 AK125950.1 AK293034.1 AK300183.1 AK307854.1 AK310264.1 
    BC004495.1 BC043488.1 BX641126.1 

    13 DOTS entries:

    DT.95166567  DT.208966  DT.100760399  DT.101955605  DT.99933141  DT.95127036  DT.75121377  DT.120771909 
    DT.95166569  DT.86839140  DT.95364254  DT.99979310  DT.75194010 

    24/111 AceView cDNA sequences (see all 111):

    AA970021 NM_025113 AI129310 AI830410 BC021097 BC043488 BM457669 AK025215 
    BE676568 AW014861 BG281146 AI972526 AW328103 CD632460 BM927653 BX365745 
    BC032311 AA463725 AA736772 BX641126 CD679213 BQ064904 AW575722 CR590165 

    GeneLoc Exon Structure

    5/24 Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0226L (see all 24)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a ·
    SP1:        -     -     -     -     -     -     -     -     -     -                 -     -     -     -     -     -     -     -     -     -           -     -   
    SP2:                                                                                                              -     -     -     -     -           -     -   
    SP3:                                                                                                              -     -     -     -     -     -     -         
    SP4:                                                                                                              -     -     -     -     -     -     -         
    SP5:                                                                                                              -     -     -     -     -     -     -     -   

    ExUns: 17b · 17c · 17d · 17e ^ 18a · 18b · 18c · 18d · 18e ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b · 23c ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b ^
    SP1:  -     -     -     -     -     -     -     -     -     -     -                 -                                                           -     -         
    SP2:  -     -     -     -                                   -     -                 -                                                           -     -         
    SP3:                                                        -     -                 -                                                           -     -         
    SP4:                                                        -     -                 -                                   -                                       
    SP5:  -     -     -     -     -     -     -     -     -     -     -                 -                                                                           

    ExUns: 30a · 30b ^ 31 ^ 32 ^ 33
    SP1:  -                           
    SP2:  -                           
    SP3:  -           -               
    SP4:  -                           
    SP5:                              


    ECgene alternative splicing isoforms for KIAA0226L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIAA0226L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTTATGATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    KIAA0226L expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Primitive gut tube-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KIAA0226L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIAA0226L

    SOURCE GeneReport for Unigene cluster: Hs.98117
        SABiosciences Custom PCR Arrays for KIAA0226L
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA0226L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KIAA0226L gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves KIAA0226L1 KIAA0226-like ortholog 58.07(n)
    50.32(a)
      418854  XM_417049.3  XP_417049.3 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.152132 Transcribed sequence with weak similarity to protein more 79.13(n)    142015713 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-260b17.61 si:ch211-260b17.6 54.44(n)
    47.99(a)
      561574  XM_684987.2  XP_690079.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG127726
    --
    15(a)
    1 → many
    X(8571096-8574946)
    worm
    (Caenorhabditis elegans)
    Secernentea Y56A3A.166
    --
    17(a)
    possible ortholog
    III(11911011-11914215)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G481956
    Phox (PX) domain-containing protein
    11(a)
    1 → many
    3(17828572-17832731)
    rice
    (Oryza sativa)
    Liliopsida --
    phox domain-containing protein, putative, expresse...
    15(a)
    1 → many
    1(20534041-20537900)


    ENSEMBL Gene Tree for KIAA0226L (if available)
    TreeFam Gene Tree for KIAA0226L (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIAA0226L gene
    PLEKHM32  DEF82  KIAA02262  PLEKHM12  
    1 SIMAP similar gene for KIAA0226L using alignment to 7 protein entries:     K226L_HUMAN (see all proteins):
    KIAA0226

    KIAA0226L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/844 NCBI SNPs in KIAA0226L are shown (see all 844    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1381680091,2
    --46915646(+) AAAATA/CAAAAG 1 -- ds50010--------
    rs1162549291,2
    C,--46915656(+) GCATCA/GCTTCC 1 -- ds50011Minor allele frequency- G:0.01WA 118
    rs734793521,2
    C,F,--46915686(+) TTCCTT/CAATAT 1 -- ds50014Minor allele frequency- C:0.20WA EA 242
    rs1411985771,2
    --46915700(+) AGATAC/TGTAAC 1 -- ds50010--------
    rs1885223891,2
    --46915736(+) AAACAC/TACAAA 1 -- ds50010--------
    rs1432567171,2
    --46915793(+) CCTTAA/CATCAA 1 -- ds50010--------
    rs1913943101,2
    --46916162(+) TTCTAA/TGTGCC 1 -- ut310--------
    rs1832275621,2
    --46916237(+) AGAGGC/TACTGC 1 -- ut310--------
    rs1414548521,2
    --46916242(+) CACTGC/GGGATG 1 -- ut310--------
    rs1508531151,2
    --46916263(+) TGACAA/GAATGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KIAA0226L (46916136 - 47012325 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KIAA0226L: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KIAA0226L for disorders           About GeneDecksing

    2 diseases for KIAA0226L:    About MalaCards
    cervical intraepithelial neoplasia    cervicitis


    Export disorders for KIAA0226L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIAA0226L gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with KIAA0226L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. A four-gene methylation marker panel as triage test in high-risk human papillomavirus positive patients. (PubMed id 21796628)1 Eijsink J.J....Wisman G.B. (2012)
    5. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
    6. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
    7. Methylation markers for CCNA1 and C13ORF18 are strong ly associated with high-grade cervical intraepithelial neoplasia and cervical c ancer in cervical scrapings. (PubMed id 19843677)1 Yang N....Wisman G.B. (2009)
    8. Screening for replication of genome-wide SNP associations in sporadic ALS. (PubMed id 18987618)1 Cronin S....Hardiman O. (2008)
    9. Replication of a genome-wide case-control study of esophageal squamous cell carcinoma. (PubMed id 18649358)1 Ng D....Taylor P.R. (2008)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80183 HGNC: 20420 AceView: C13orf18 Ensembl:ENSG00000102445 euGenes: HUgn80183
    ECgene: KIAA0226L H-InvDB: KIAA0226L

    (According to HUGE)
    About This Section
    HUGE: KIAA0226L

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIAA0226L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIAA0226L gene:
    Search GeneIP for patents involving KIAA0226L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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