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Aliases for KIAA0226L Gene

Aliases for KIAA0226L Gene

  • KIAA0226-Like 2 3 5
  • C13orf18 3 4
  • Chromosome 13 Open Reading Frame 18 2

External Ids for KIAA0226L Gene

Previous HGNC Symbols for KIAA0226L Gene

  • C13orf18

Previous GeneCards Identifiers for KIAA0226L Gene

  • GC13M046917

Summaries for KIAA0226L Gene

GeneCards Summary for KIAA0226L Gene

KIAA0226L (KIAA0226-Like) is a Protein Coding gene. An important paralog of this gene is PLEKHM1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA0226L Gene

Genomics for KIAA0226L Gene

Regulatory Elements for KIAA0226L Gene

Enhancers for KIAA0226L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KIAA0226L on UCSC Golden Path with GeneCards custom track

Promoters for KIAA0226L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KIAA0226L on UCSC Golden Path with GeneCards custom track

Genomic Location for KIAA0226L Gene

Chromosome:
13
Start:
46,342,000 bp from pter
End:
46,438,190 bp from pter
Size:
96,191 bases
Orientation:
Minus strand

Genomic View for KIAA0226L Gene

Genes around KIAA0226L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA0226L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA0226L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA0226L Gene

Proteins for KIAA0226L Gene

  • Protein details for KIAA0226L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H714-K226L_HUMAN
    Recommended name:
    Uncharacterized protein KIAA0226-like
    Protein Accession:
    Q9H714
    Secondary Accessions:
    • A8KAG9
    • A8XR19
    • B3KS87
    • Q5W051
    • Q5W053
    • Q6PJ74
    • Q6PK94
    • Q86XH7
    • Q8N5J6

    Protein attributes for KIAA0226L Gene

    Size:
    662 amino acids
    Molecular mass:
    73457 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIAA0226L Gene

neXtProt entry for KIAA0226L Gene

Proteomics data for KIAA0226L Gene at MOPED

Post-translational modifications for KIAA0226L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIAA0226L Gene

Domains & Families for KIAA0226L Gene

Protein Domains for KIAA0226L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA0226L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA0226L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KIAA0226L Gene

Function for KIAA0226L Gene

genes like me logo Genes that share phenotypes with KIAA0226L: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA0226L Gene

Localization for KIAA0226L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA0226L Gene COMPARTMENTS Subcellular localization image for KIAA0226L gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KIAA0226L Gene

Pathways & Interactions for KIAA0226L Gene

SuperPathways for KIAA0226L Gene

No Data Available

Interacting Proteins for KIAA0226L Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000374558%0d%0a9606.ENSP00000355231%0d%0a9606.ENSP00000403397%0d%0a9606.ENSP00000348455%0d%0a
Selected Interacting proteins: Q9H714-K226L_HUMAN ENSP00000374558 for KIAA0226L Gene via I2D STRING

Gene Ontology (GO) - Biological Process for KIAA0226L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA0226L Gene

Drugs & Compounds for KIAA0226L Gene

No Compound Related Data Available

Transcripts for KIAA0226L Gene

Unigene Clusters for KIAA0226L Gene

KIAA0226-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0226L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a ·
SP1: - - - - - - - - - - - - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - - - - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - - - - - - - -
SP9: - - - - - - - -
SP10: - - - - -
SP11: - - - - - -
SP12: -
SP13:
SP14: - - - - - - - - - - - - - -
SP15: - - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - - -
SP17: - - - -
SP18: -
SP19:
SP20: - - - - - - - - - - - - -
SP21:
SP22: - -
SP23:
SP24:

ExUns: 17b · 17c · 17d · 17e ^ 18a · 18b · 18c · 18d · 18e ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b · 23c ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b ^
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - - - - - - - - -
SP6: - - - -
SP7:
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - - - -
SP10:
SP11: - -
SP12: - - -
SP13: - -
SP14:
SP15: - - - -
SP16:
SP17:
SP18:
SP19:
SP20: - - - -
SP21:
SP22:
SP23:
SP24:

ExUns: 30a · 30b ^ 31 ^ 32 ^ 33
SP1: -
SP2: -
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:

Relevant External Links for KIAA0226L Gene

GeneLoc Exon Structure for
KIAA0226L
ECgene alternative splicing isoforms for
KIAA0226L

Expression for KIAA0226L Gene

mRNA expression in normal human tissues for KIAA0226L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIAA0226L Gene

This gene is overexpressed in Whole Blood (x10.4) and Spleen (x5.0).

Protein differential expression in normal tissues from HIPED for KIAA0226L Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KIAA0226L Gene



SOURCE GeneReport for Unigene cluster for KIAA0226L Gene Hs.98117

genes like me logo Genes that share expression patterns with KIAA0226L: view

Protein tissue co-expression partners for KIAA0226L Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KIAA0226L Gene

Orthologs for KIAA0226L Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA0226L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIAA0226L 35
  • 80.38 (n)
  • 72.31 (a)
KIAA0226L 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA0226L 35
  • 83.23 (n)
  • 78.88 (a)
KIAA0226L 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 5031414D18Rik 35
  • 73.04 (n)
  • 62.83 (a)
5031414D18Rik 16
5031414D18Rik 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIAA0226L 35
  • 99.35 (n)
  • 98.64 (a)
KIAA0226L 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1304929 35
  • 72.17 (n)
  • 60.49 (a)
oppossum
(Monodelphis domestica)
Mammalia KIAA0226L 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA0226L 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA0226L 35
  • 65.86 (n)
  • 60.04 (a)
KIAA0226L 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15213 35
zebrafish
(Danio rerio)
Actinopterygii si:ch211-260b17.6 36
  • 55 (a)
OneToOne
Species with no ortholog for KIAA0226L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA0226L Gene

ENSEMBL:
Gene Tree for KIAA0226L (if available)
TreeFam:
Gene Tree for KIAA0226L (if available)

Paralogs for KIAA0226L Gene

Paralogs for KIAA0226L Gene

(1) SIMAP similar genes for KIAA0226L Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with KIAA0226L: view

Variants for KIAA0226L Gene

Sequence variations from dbSNP and Humsavar for KIAA0226L Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1408184 - 46,372,022(-) GCCCT(A/G)GGATT intron-variant, reference, missense
rs168950 -- 46,362,151(+) agaat(C/T)gcttg intron-variant
rs181977 -- 46,356,401(+) CACAT(A/C)ATAAG intron-variant
rs183775 -- 46,362,091(+) aatta(A/G)ccagg intron-variant
rs187742 -- 46,362,232(+) aactc(A/C/G)gtctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA0226L Gene

Variant ID Type Subtype PubMed ID
dgv250e201 CNV Deletion 23290073
nsv455876 CNV Gain 19166990

Variation tolerance for KIAA0226L Gene

Residual Variation Intolerance Score: 93.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.74; 83.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA0226L Gene

HapMap Linkage Disequilibrium report
KIAA0226L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA0226L Gene

Disorders for KIAA0226L Gene

Relevant External Links for KIAA0226L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA0226L

No disorders were found for KIAA0226L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA0226L Gene

Publications for KIAA0226L Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4 67
  2. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3
  3. C13orf18 and C1orf166 (MULAN) DNA genes methylation are not associated with cervical cancer and precancerous lesions of human papillomavirus genotypes in Iranian women. (PMID: 25169519) Sohrabi A. … Modarresl M.H. (Asian Pac. J. Cancer Prev. 2014) 3
  4. Functional validation of putative tumor suppressor gene C13ORF18 in cervical cancer by Artificial Transcription Factors. (PMID: 23522960) Huisman C. … Rots M.G. (Mol Oncol 2013) 3
  5. A four-gene methylation marker panel as triage test in high-risk human papillomavirus positive patients. (PMID: 21796628) Eijsink J.J. … Wisman G.B. (Int. J. Cancer 2012) 3

Products for KIAA0226L Gene

Sources for KIAA0226L Gene

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