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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KIAA0195 Gene

protein-coding GIFtS: 50
GCID: GC17P073452

KIAA0195

Explore 1 disease affiliated with
KIAA0195 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
KIAA0195¹ ²
TMEM94¹ ² ³
Transmembrane Protein 94² ³
Uncharacterized Protein KIAA0195²

External Ids:	HGNC: 28983¹	Entrez Gene: 9772²	Ensembl: ENSG00000177728⁷	UniProtKB: Q12767³

Export aliases for KIAA0195 gene to outside databases

Previous GC identifers: GC17U990148 GC17P076507 GC17P073916 GC17P074050 GC17P074051 GC17P070964 GC17P068876

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KIAA0195 gene promoter:
STAT5A YY1 C/EBPalpha FOXL1 CHOP-10 CREB deltaCREB c-Myb NF-E2 Ik-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KIAA0195 promoter sequence

Search SABiosciences Chromatin IP Primers for KIAA0195

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA0195

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25.1

KIAA0195 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA0195 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P073452: view genomic region (about GC identifiers)

Start:	73,437,240 bp from pter	End:	73,496,533 bp from pter
Size:	59,294 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: K0195_HUMAN, Q12767 (See protein sequence)

Recommended Name: Uncharacterized protein KIAA0195

Size: 1356 amino acids; 151151 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Sequence caution: Sequence=BAA12108.2; Type=Erroneous initiation;

Secondary accessions: O75536 Q86XF1

Alternative splicing: 2 isoforms: Q12767-1 Q12767-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KIAA0195: NX_Q12767

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q12767

KIAA0195 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055553.3

ENSEMBL proteins:

ENSP00000464479 ENSP00000313885 ENSP00000462821 ENSP00000462170 ENSP00000464370

ENSP00000463929 ENSP00000463620 ENSP00000364397 ENSP00000462344 ENSP00000464491

ENSP00000464679 ENSP00000463487 ENSP00000464375 ENSP00000464437 ENSP00000463046

ENSP00000462084

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	Uscn Proteins for KIAA0195

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

KIAA0195 for ontologies About GeneDecksing

KIAA0195 Antibody Products:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KIAA0195 for domains About GeneDecksing

2 InterPro domains/families:

IPR023298 ATPase_P-typ_TM_dom

IPR006068 ATPase_P-typ_cation-transptr_C

Graphical View of Domain Structure for InterPro Entry Q12767

ProtoNet protein and cluster: Q12767

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

Genatlas biochemistry entry for KIAA0195:

Null

Phenotypes:
2 GenomeRNAi human phenotypes for KIAA0195:

Decreased POU5F1-GFP protein e

Metaphase cells

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for 2310067B10Rik):

hematopoietic system

KIAA0195 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for KIAA0195

miRNA Products:		OriGene 3'-UTR Clone: KIAA0195 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KIAA0195
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate KIAA0195 (see all 18):
		hsa-miR-21* hsa-miR-3607-3p hsa-miR-181c hsa-miR-522 hsa-miR-374c hsa-miR-181b hsa-miR-433 hsa-miR-4324

		SwitchGear 3'UTR luciferase reporter plasmid: KIAA0195 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA0195

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KIAA0195

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for KIAA0195 (Q12767³ ENSP00000313885⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DENR	O43583³	I2D: score=5
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KIAA0195
Search CenterWatch for drugs/clinical trials and news about KIAA0195 / K0195

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KIAA0195 gene:

NM_014738.4

Unigene Cluster for KIAA0195:

KIAA0195

Hs.514474 [show with all ESTs]

Unigene Representative Sequence: NM_014738

18/33 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 33):

ENST00000577380 ENST00000314256(uc002jnz.4) ENST00000582186 ENST00000580416

ENST00000581085(uc010wsb.2) ENST00000582455 ENST00000581252 ENST00000579208

ENST00000585277 ENST00000581834 ENST00000581519 ENST00000375248 ENST00000585105(uc010wsa.2)

ENST00000579707 ENST00000584383 ENST00000580441 ENST00000583795 ENST00000580849

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		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate KIAA0195 (see all 18):
		hsa-miR-21* hsa-miR-3607-3p hsa-miR-181c hsa-miR-522 hsa-miR-374c hsa-miR-181b hsa-miR-433 hsa-miR-4324

		SwitchGear 3'UTR luciferase reporter plasmid: KIAA0195 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AK128508.1 AK294526.1 AK304819.1 AK308160.1 AK316060.1 BC045540.1 D83779.1

24/32 DOTS entries (see all 32):

DT.100818985 DT.101984047 DT.100038258 DT.97807331 DT.120921504 DT.91925284 DT.92030684 DT.100038256

DT.120921478 DT.120921499 DT.100840957 DT.120921456 DT.75119547 DT.91765257 DT.91765263 DT.91936286

DT.95322294 DT.95366369 DT.120921420 DT.120921427 DT.120921462 DT.120921463 DT.120921471 DT.120921503

24/284 AceView cDNA sequences (see all 284):

BQ722978 BE888649 AU118765 BF969298 AI831107 BM757160 BC042942 BU188252

BG683148 BG820188 BM801642 BG152537 AI951770 AI867051 AW471166 BM763905

AW593077 BE552016 AI619854 BF063354 D83779 BM773131 BG911730 BM693684

GeneLoc Exon Structure

5/22 Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0195 (see all 22) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10a	·	10b	·	10c	^	11	^	12a	·	12b	^	13a	·	13b	·	13c	^	14a	·	14b	·	14c	·	14d	^	15a	·	15b	·	15c	·
SP1:																																													-		-		-		-
SP2:
SP3:
SP4:																																															-		-		-
SP5:																																					-								-		-		-		-

ExUns:	15d	^	16a	·	16b	·	16c	·	16d	^	17a	·	17b	·	17c	·	17d	^	18a	·	18b	·	18c	^	19a	·	19b	^	20a	·	20b	^	21	^	22	^	23	^	24a	·	24b	·	24c	^	25a	·	25b	^	26	^	27	^
SP1:	-								-								-		-		-
SP2:
SP3:
SP4:	-
SP5:	-								-								-		-		-

ExUns:	28	^	29a	·	29b	^	30a	·	30b	·	30c	^	31	^	32a	·	32b	·	32c	^	33a	·	33b
SP1:											-								-
SP2:																			-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for KIAA0195

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KIAA0195 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGTTTCCA

About this image
See KIAA0195 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIAA0195

SOURCE GeneReport for Unigene cluster: Hs.514474

UniProtKB/Swiss-Prot: K0195_HUMAN, Q12767

Tissue specificity: Expressed ubiquitously

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for KIAA0195 gene from 7/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	2310067B10Rik^{1 , 5}	RIKEN cDNA 2310067B10 gene^{1, 5}	89.28(n)¹ 95.5(a)¹		11 (80.91 cM)⁵ 71947¹ NM_028014.3¹ NP_082290.2¹ 115765433⁵
chicken (Gallus gallus)	Aves	KIAA0195¹	KIAA0195	76.07(n) 82.94(a)		422124 XM_420127.3 XP_420127.3
lizard (Anolis carolinensis)	Reptilia	KIAA0195⁶	--	80(a)	1 ↔ 1	2(114408911-114474650)
African clawed frog (Xenopus laevis)	Amphibia	BJ032113.1²	--	73.03(n)		BJ032113.1
zebrafish (Danio rerio)	Actinopterygii	LOC795408¹	uncharacterized protein KIAA0195-like	67.51(n) 69.55(a)		795408 XM_001335551.4 XP_001335587.4
fruit fly (Drosophila melanogaster)	Insecta	l(2)k05819^{1 , 3}	lethal (2) k05819¹	38(a)³ 49.13(n)¹ 38.65(a)¹		33644¹ NM_164582.2¹ NP_722974.1¹
worm (Caenorhabditis elegans)	Secernentea	D1007.15^{1 , 3}	Protein D1007.15¹	29(a)³ 41.41(n)¹ 33.65(a)¹		I(4557692-4563644)³ 172058¹ NM_058989.2¹ NP_491390.2¹

ENSEMBL Gene Tree for KIAA0195 (if available)
TreeFam Gene Tree for KIAA0195 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11331365^1,2	C,F	--	68905670(+)	`CCTCT-/CCAGCT`	1	--	int¹		6		NA CSA	12
rs142146719^1,2		--	73450710(+)	`GAAACC/TGCTAA`	1	--	us2k¹		0	--	--	--	--
rs190767389^1,2		--	73450799(+)	`GCAATA/GCAGAC`	1	--	us2k¹		0	--	--	--	--
rs4073989^1,2	C,F,A,H	--	73450862(+)	`AGGGAA/GAGGCT`	1	--	us2k¹		24		NS EA WA NA CSA	2351
rs4073990^1,2	C,A,H	--	73450924(+)	`GAGGAC/TTGCTT`	1	--	us2k¹		4		NA	8
rs183374060^1,2		--	73450940(+)	`CAGGAA/GTTTGA`	1	--	us2k¹		0	--	--	--	--
rs6501804^1,2	C,F	--	73451196(+)	`TCAAGG/AAAGGT`	1	--	us2k¹		16		NA WA CSA EA	517
rs11657932^1,2	H	--	73451223(+)	`CTTTAA/GGTTGA`	1	--	us2k¹		0	--	--	--	--
rs186591974^1,2		--	73451280(+)	`CAGGCC/TGGGTG`	1	--	us2k¹		0	--	--	--	--
rs148427458^1,2		--	73451287(+)	`GGTGCA/GGTGGC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KIAA0195 (73437240 - 73496533 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for KIAA0195
3 CNVs: 5030 49926 30023

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KIAA0195 for disorders About GeneDecksing

1 disease for KIAA0195: About MalaCards

malaria

Human Genome Epidemiology (HuGE) Navigator: KIAA0195 (1 document)

Export disorders for KIAA0195 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KIAA0195 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with KIAA0195)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849)^{1, 2, 3} Nagase T.... Nomura N. (1996)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)² Oppermann F.S.... Daub H. (2009)
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)² Daub H.... Mann M. (2008)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9772	HGNC: 28983	AceView: KIAA0195	Ensembl:ENSG00000177728	euGenes: HUgn9772
ECgene: KIAA0195	H-InvDB: KIAA0195

(According to HUGE)
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HUGE: KIAA0195

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KIAA0195	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KIAA0195 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KIAA0195 gene:
Search GeneIP for patents involving KIAA0195

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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