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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KIAA0146 Gene

protein-coding GIFtS: 39
GCID: GC08P048173

KIAA0146

Explore 1 disease affiliated with
KIAA0146 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
KIAA0146¹ ²
Uncharacterized Protein KIAA0146²

External Ids:	HGNC: 28971¹	Entrez Gene: 23514²	Ensembl: ENSG00000164808⁷	UniProtKB: Q14159³

Export aliases for KIAA0146 gene to outside databases

Previous GC identifers: GC08P047438 GC08P048190 GC08P047915 GC08P048242 GC08P048223 GC08P048335 GC08P043638

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008183.19

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for KIAA0146
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for KIAA0146

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA0146

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q11.21 Ensembl cytogenetic band: 8q11.21 HGNC cytogenetic band: 8q11.21

KIAA0146 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA0146 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P048173: view genomic region (about GC identifiers)

Start:	48,173,167 bp from pter	End:	48,648,868 bp from pter
Size:	475,702 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: K0146_HUMAN, Q14159 (See protein sequence)

Recommended Name: Uncharacterized protein KIAA0146

Size: 915 amino acids; 100316 Da

Sequence caution: Sequence=BAA09767.1; Type=Erroneous initiation;

Secondary accessions: Q96BI5

Explore the universe of human proteins at neXtProt for KIAA0146: NX_Q14159

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q14159

KIAA0146 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001073863.1

ENSEMBL proteins:

ENSP00000297423 ENSP00000428222 ENSP00000429487 ENSP00000430965 ENSP00000430941

ENSP00000430664 ENSP00000428287 ENSP00000430300 ENSP00000429997 ENSP00000429805

ENSP00000430091 ENSP00000429193 ENSP00000429303 ENSP00000427889 ENSP00000429964

ENSP00000428374 ENSP00000430520 ENSP00000427790 ENSP00000427878 ENSP00000429448

ENSP00000444061

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q14159

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: K0146_HUMAN, Q14159

Induction: Up-regulated in vascular endothelial cells treated with IL4. Up-regulated upon human SARS coronavirus

infection

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1 GenomeRNAi human phenotype for KIAA0146:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KIAA0146

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KIAA0146
Search CenterWatch for drugs/clinical trials and news about KIAA0146 / K0146

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for KIAA0146 gene:

NM_001080394.2

Unigene Cluster for KIAA0146:

KIAA0146

Hs.381058 [show with all ESTs]

Unigene Representative Sequence: AK122820

18/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):

ENST00000297423(uc011lcz.2 uc011lda.2 uc003xqd.3 uc011ldc.2 uc011ldd.2 uc003xqe.3 uc010lxt.3 uc011ldf.2)

ENST00000523814 ENST00000518074 ENST00000522900 ENST00000517824 ENST00000521550

ENST00000524126 ENST00000522222 ENST00000519661 ENST00000524141(uc011ldb.2 uc010lxs.3 uc011lde.1)

ENST00000524033 ENST00000522117 ENST00000524006 ENST00000521214(uc003xqf.3)

ENST00000521798 ENST00000521918 ENST00000524157 ENST00000519401

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Additional cDNA sequence:

AK026929.1 AK055680.1 AK056102.1 AK095778.1 AK122820.1 AK293809.1 AK293972.1 AK294248.1

AK294275.1 AK297681.1 AK301677.1 AK303140.1 AK303579.1 AK309842.1 AK310584.1 BC015561.2

D63480.1 U00948.1

24/34 DOTS entries (see all 34):

DT.91742328 DT.92374056 DT.100801040 DT.100796903 DT.75167499 DT.95351623 DT.91954400 DT.92326660

DT.91955777 DT.439618 DT.91742329 DT.95297664 DT.95361404 DT.100034367 DT.40216829 DT.95297675

DT.100796907 DT.100815837 DT.101983960 DT.120650802 DT.120650915 DT.95363027 DT.100815838 DT.100815840

24/774 AceView cDNA sequences (see all 774):

AI631938 AI830696 AI341131 AW236007 AK092336 BE500986 AA045033 BM128572

AI694005 AI766886 BX376009 AI762201 AI347518 BU932087 R68751 AI470599

AI498925 AK026929 BE551862 BE219192 BE048559 BI827346 AI431822 AI912982

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KIAA0146 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTTATTAC

About this image
See KIAA0146 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIAA0146

SOURCE GeneReport for Unigene cluster: Hs.381058

SABiosciences Custom PCR Arrays for KIAA0146

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for KIAA0146 gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	2310008H04Rik^{1 , 5}	RIKEN cDNA 2310008H04 gene^{1, 5}	75.54(n)¹ 66.15(a)¹		16 (10.09 cM)⁵ 224008¹ NM_146068.3¹ NP_666180.2¹ 15889227⁵
chicken (Gallus gallus)	Aves	KIAA0146¹	KIAA0146	61.06(n) 55.16(a)		421107 XM_419190.3 XP_419190.3
lizard (Anolis carolinensis)	Reptilia	-- KIAA0146⁶	--	52(a) 48(a)	many → 1 many → 1	GL343207.1(1686781-1721465) GL343207.1(1802670-1815446)
zebrafish (Danio rerio)	Actinopterygii	LOC100535045¹	uncharacterized protein KIAA0146-like	48.03(n) 37.88(a)		100535045 XM_003201338.1 XP_003201386.1

ENSEMBL Gene Tree for KIAA0146 (if available)
TreeFam Gene Tree for KIAA0146 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185465653^1,2		--	48171886(+)	`CTGTGG/TTGTCT`	1	--	us2k¹		0	--	--	--	--
rs77224628^1,2	C,F,	--	48171952(+)	`GACATG/AGGTTA`	1	--	us2k¹		2		WA EA	238
rs115626413^1,2	C,F,	--	48172112(+)	`CTGAGA/GTGGCG`	1	--	us2k¹		1		WA	118
rs79500054^1,2		--	48172359(+)	`CAACTA/CGATTG`	1	--	us2k¹		0	--	--	--	--
rs7841467^1,2	C,	--	48172406(+)	`ATGGCA/TCTAGC`	1	--	us2k¹		4		CSA WA EA	241
rs189833918^1,2		--	48172436(+)	`AAAGAC/TGGTTT`	1	--	us2k¹		0	--	--	--	--
rs182525284^1,2		--	48172467(+)	`CTGCAC/GAGTGG`	1	--	us2k¹		0	--	--	--	--
rs147755635^1,2		--	48172493(+)	`CAAGTA/GTCTGC`	1	--	us2k¹		0	--	--	--	--
rs189130029^1,2		--	48172739(+)	`CTCCAC/TGGGAG`	1	--	us2k¹		0	--	--	--	--
rs191858177^1,2		--	48172951(+)	`TCCTCA/GGGCTC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KIAA0146 (48173167 - 48423167 bp, first 250kb of KIAA0146)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for KIAA0146
2 CNVs: 7689 3729
4 Inversions: 37299 29452 37300 29451

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KIAA0146 for disorders About GeneDecksing

1 disease for KIAA0146: About MalaCards

severe acute respiratory syndrome

Export disorders for KIAA0146 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KIAA0146 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KIAA0146)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)^{1, 2, 3} Nagase T....Nomura N. (1995)
Comparative host gene transcription by microarray analysis early after infection of the Huh7 cell line by severe acute respiratory syndrome coronavirus and human coronavirus 229E. (PubMed id 15858003)^{1, 2} Tang B.S.F....Yuen K.-Y. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Gene expression profile in interleukin-4-stimulated human vascular endothelial cells. (PubMed id 15502879)^{1, 2} Lee Y.W.... Toborek M. (2004)
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)¹ Fox C.S....Borecki I.B. (2012)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23514	HGNC: 28971	AceView: KIAA0146	Ensembl:ENSG00000164808	euGenes: HUgn23514
ECgene: KIAA0146	H-InvDB: KIAA0146

(According to HUGE)
About This Section

HUGE: KIAA0146

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KIAA0146	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KIAA0146 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for KIAA0146 gene:
Search GeneIP for patents involving KIAA0146

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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KIAA0146 Gene

KIAA0146

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KIAA0146 Gene

KIAA0146

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