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Aliases for KIAA0141 Gene

Aliases for KIAA0141 Gene

  • KIAA0141 2 3
  • DELE 3 4
  • Death Ligand Signal Enhancer 2

External Ids for KIAA0141 Gene

Previous GeneCards Identifiers for KIAA0141 Gene

  • GC05P141124
  • GC05P141286
  • GC05P141331
  • GC05P141283
  • GC05P136446
  • GC05P141323
  • GC05P141328
  • GC05P141401

Summaries for KIAA0141 Gene

GeneCards Summary for KIAA0141 Gene

KIAA0141 (KIAA0141) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KIAA0141 Gene

  • Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA0141 Gene

Genomics for KIAA0141 Gene

Regulatory Elements for KIAA0141 Gene

Promoters for KIAA0141 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KIAA0141 on UCSC Golden Path with GeneCards custom track

Genomic Location for KIAA0141 Gene

Chromosome:
5
Start:
141,923,785 bp from pter
End:
141,951,465 bp from pter
Size:
27,681 bases
Orientation:
Plus strand

Genomic View for KIAA0141 Gene

Genes around KIAA0141 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA0141 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA0141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA0141 Gene

Proteins for KIAA0141 Gene

  • Protein details for KIAA0141 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14154-DELE_HUMAN
    Recommended name:
    Death ligand signal enhancer
    Protein Accession:
    Q14154
    Secondary Accessions:
    • Q969R4
    • Q96EU9

    Protein attributes for KIAA0141 Gene

    Size:
    515 amino acids
    Molecular mass:
    55920 Da
    Quaternary structure:
    • Interacts with DAP3.
    SequenceCaution:
    • Sequence=BAA09490.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for KIAA0141 Gene

Proteomics data for KIAA0141 Gene at MOPED

Post-translational modifications for KIAA0141 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIAA0141 Gene

Antibody Products

No data available for DME Specific Peptides for KIAA0141 Gene

Domains & Families for KIAA0141 Gene

Protein Domains for KIAA0141 Gene

Suggested Antigen Peptide Sequences for KIAA0141 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14154

UniProtKB/Swiss-Prot:

DELE_HUMAN :
  • Contains 7 TPR repeats.
Similarity:
  • Contains 7 TPR repeats.
genes like me logo Genes that share domains with KIAA0141: view

No data available for Gene Families for KIAA0141 Gene

Function for KIAA0141 Gene

Molecular function for KIAA0141 Gene

GENATLAS Biochemistry:
putative protein,expressed in fetal heart and kidney
UniProtKB/Swiss-Prot Function:
Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.

Phenotypes for KIAA0141 Gene

genes like me logo Genes that share phenotypes with KIAA0141: view

Animal Model Products

CRISPR Products

miRNA for KIAA0141 Gene

miRTarBase miRNAs that target KIAA0141

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA0141 Gene

Localization for KIAA0141 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA0141 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA0141 Gene COMPARTMENTS Subcellular localization image for KIAA0141 gene
Compartment Confidence
mitochondrion 5
cytosol 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for KIAA0141 Gene

Pathways & Interactions for KIAA0141 Gene

SuperPathways for KIAA0141 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA0141 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA0141 Gene

Drugs & Compounds for KIAA0141 Gene

No Compound Related Data Available

Transcripts for KIAA0141 Gene

Unigene Clusters for KIAA0141 Gene

KIAA0141:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0141 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16a ·
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - - - - - - -
SP9: -
SP10: -
SP11:

ExUns: 16b · 16c · 16d · 16e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for KIAA0141 Gene

GeneLoc Exon Structure for
KIAA0141
ECgene alternative splicing isoforms for
KIAA0141

Expression for KIAA0141 Gene

mRNA expression in normal human tissues for KIAA0141 Gene

Protein differential expression in normal tissues from HIPED for KIAA0141 Gene

This gene is overexpressed in Oral epithelium (8.6), Nasopharynx (7.8), and Uterus (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KIAA0141 Gene



SOURCE GeneReport for Unigene cluster for KIAA0141 Gene Hs.210532

mRNA Expression by UniProt/SwissProt for KIAA0141 Gene

Q14154-DELE_HUMAN
Tissue specificity: Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.
genes like me logo Genes that share expression patterns with KIAA0141: view

Protein tissue co-expression partners for KIAA0141 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for KIAA0141 Gene

Orthologs for KIAA0141 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA0141 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIAA0141 35
  • 86.8 (n)
  • 84.08 (a)
KIAA0141 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA0141 35
  • 84.92 (n)
  • 81.75 (a)
KIAA0141 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 0610009O20Rik 35
  • 79.29 (n)
  • 74.36 (a)
0610009O20Rik 16
0610009O20Rik 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIAA0141 35
  • 99.35 (n)
  • 99.22 (a)
KIAA0141 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD735029 35
  • 78.96 (n)
  • 75.15 (a)
oppossum
(Monodelphis domestica)
Mammalia KIAA0141 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA0141 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA0141 35
  • 67.05 (n)
  • 58.62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa0141 35
  • 49.55 (n)
  • 40.18 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:158257 35
  • 47.12 (n)
  • 37.5 (a)
zgc:158257 36
  • 38 (a)
OneToOne
Species with no ortholog for KIAA0141:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA0141 Gene

ENSEMBL:
Gene Tree for KIAA0141 (if available)
TreeFam:
Gene Tree for KIAA0141 (if available)

Paralogs for KIAA0141 Gene

No data available for Paralogs for KIAA0141 Gene

Variants for KIAA0141 Gene

Sequence variations from dbSNP and Humsavar for KIAA0141 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10036567 - 141,928,268(+) GTTTC(C/T)TCTCA nc-transcript-variant, reference, missense
rs351260 - 141,930,259(-) GAAAG(C/T)GATGG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs17850821 - 141,928,169(+) TGCTG(A/G)CCCTG nc-transcript-variant, reference, missense
rs10056676 - 141,938,613(+) CCTCA(C/T)GCCTA intron-variant, nc-transcript-variant, reference, missense, utr-variant-3-prime
rs34438707 - 141,925,442(-) TTGGA(C/T)CCCCG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KIAA0141 Gene

Variant ID Type Subtype PubMed ID
esv2667575 CNV Deletion 23128226

Variation tolerance for KIAA0141 Gene

Residual Variation Intolerance Score: 61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.85; 89.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA0141 Gene

HapMap Linkage Disequilibrium report
KIAA0141

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA0141 Gene

Disorders for KIAA0141 Gene

Relevant External Links for KIAA0141

Genetic Association Database (GAD)
KIAA0141
Human Genome Epidemiology (HuGE) Navigator
KIAA0141
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA0141

No disorders were found for KIAA0141 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA0141 Gene

Publications for KIAA0141 Gene

  1. Identification of DELE, a novel DAP3-binding protein which is crucial for death receptor-mediated apoptosis induction. (PMID: 20563667) Harada T. … Miyazaki T. (Apoptosis 2010) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3

Products for KIAA0141 Gene

Sources for KIAA0141 Gene

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