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Aliases for KIAA0141 Gene

Aliases for KIAA0141 Gene

  • KIAA0141 2 3
  • Death Ligand Signal Enhancer 2 3
  • DELE 3 4

External Ids for KIAA0141 Gene

Previous GeneCards Identifiers for KIAA0141 Gene

  • GC05P141124
  • GC05P141886
  • GC05P141286
  • GC05P141331
  • GC05P141283
  • GC05P136446
  • GC05P141323
  • GC05P141328
  • GC05P141401

Summaries for KIAA0141 Gene

GeneCards Summary for KIAA0141 Gene

KIAA0141 (KIAA0141) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KIAA0141 Gene

  • Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA0141 Gene

Genomics for KIAA0141 Gene

Regulatory Elements for KIAA0141 Gene

Enhancers for KIAA0141 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G142815 1.6 Ensembl ENCODE dbSUPER 24.4 +900.5 900493 17.2 PKNOX1 MLX ARID4B FEZF1 ZNF2 YY1 ZNF548 FOS ZNF263 SP3 KIAA0141 ENSG00000271871 ARHGAP26-AS1 GC05P142827 GC05P142826 ARHGAP26
GH05G141968 1.2 ENCODE 22.9 +45.8 45782 3.0 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NFYC TBX21 ZNF610 KIAA0141 PCDHGA5 PCDHB12 RNF14 PCDHB11 PCDHB4 PCDHB18P PCDHB15 PCDHB9 PCDHGA6
GH05G141679 1.3 ENCODE dbSUPER 20.1 -242.0 -241975 4.7 HDGF ARNT SIN3A ZNF2 CBX5 FOS KLF13 ZNF263 SP3 REST KIAA0141 PCDHB18P ARAP3 PCDHGA7 PCDH1 PCDH12 RNF14 HDAC3 PCDHGA6 PCDHB11
GH05G141882 1.5 FANTOM5 Ensembl ENCODE dbSUPER 15.6 -41.5 -41524 1.9 PKNOX1 KLF1 CBX3 BMI1 RBBP5 EBF1 ZBTB7B GLIS2 CBX5 ZNF143 KIAA0141 RNF14 PCDH12 ARAP3 PCDHGC4 PCDHGA9 PCDHGC5 NDFIP1 PCDH1 PCDHGB6
GH05G142388 1.5 FANTOM5 Ensembl ENCODE 13.9 +466.8 466754 3.9 ATF1 FEZF1 ZNF263 CAVIN1 ZNF623 ZNF592 MEF2D CREB3 SMARCA4 GLIS1 LOC102723915 HDAC3 LINC01844 FCHSD1 KIAA0141 ENSG00000271871 GC05M142394 GC05P142356
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIAA0141 on UCSC Golden Path with GeneCards custom track

Promoters for KIAA0141 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000187934 -85 1401 HDGF PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for KIAA0141 Gene

Chromosome:
5
Start:
141,923,785 bp from pter
End:
141,951,465 bp from pter
Size:
27,681 bases
Orientation:
Plus strand

Genomic View for KIAA0141 Gene

Genes around KIAA0141 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA0141 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA0141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA0141 Gene

Proteins for KIAA0141 Gene

  • Protein details for KIAA0141 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14154-DELE_HUMAN
    Recommended name:
    Death ligand signal enhancer
    Protein Accession:
    Q14154
    Secondary Accessions:
    • Q969R4
    • Q96EU9

    Protein attributes for KIAA0141 Gene

    Size:
    515 amino acids
    Molecular mass:
    55920 Da
    Quaternary structure:
    • Interacts with DAP3.
    SequenceCaution:
    • Sequence=BAA09490.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for KIAA0141 Gene

Post-translational modifications for KIAA0141 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for KIAA0141 Gene

Domains & Families for KIAA0141 Gene

Protein Domains for KIAA0141 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA0141 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA0141: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KIAA0141 Gene

Function for KIAA0141 Gene

Molecular function for KIAA0141 Gene

GENATLAS Biochemistry:
putative protein,expressed in fetal heart and kidney
UniProtKB/Swiss-Prot Function:
Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.

Gene Ontology (GO) - Molecular Function for KIAA0141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20563667
genes like me logo Genes that share ontologies with KIAA0141: view

Phenotypes for KIAA0141 Gene

genes like me logo Genes that share phenotypes with KIAA0141: view

Animal Model Products

CRISPR Products

miRNA for KIAA0141 Gene

miRTarBase miRNAs that target KIAA0141

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA0141 Gene

Localization for KIAA0141 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA0141 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA0141 gene
Compartment Confidence
mitochondrion 5
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for KIAA0141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA,IEA 10942595
genes like me logo Genes that share ontologies with KIAA0141: view

Pathways & Interactions for KIAA0141 Gene

SuperPathways for KIAA0141 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA0141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IDA 20563667
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA 20563667
genes like me logo Genes that share ontologies with KIAA0141: view

No data available for Pathways by source and SIGNOR curated interactions for KIAA0141 Gene

Transcripts for KIAA0141 Gene

Unigene Clusters for KIAA0141 Gene

KIAA0141:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0141 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16a ·
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - - - - - - -
SP9: -
SP10: -
SP11:

ExUns: 16b · 16c · 16d · 16e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for KIAA0141 Gene

GeneLoc Exon Structure for
KIAA0141
ECgene alternative splicing isoforms for
KIAA0141

Expression for KIAA0141 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIAA0141 Gene

Protein differential expression in normal tissues from HIPED for KIAA0141 Gene

This gene is overexpressed in Oral epithelium (8.6), Nasopharynx (7.8), and Uterus (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KIAA0141 Gene



Protein tissue co-expression partners for KIAA0141 Gene

NURSA nuclear receptor signaling pathways regulating expression of KIAA0141 Gene:

KIAA0141

SOURCE GeneReport for Unigene cluster for KIAA0141 Gene:

Hs.210532

mRNA Expression by UniProt/SwissProt for KIAA0141 Gene:

Q14154-DELE_HUMAN
Tissue specificity: Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Evidence on tissue expression from TISSUES for KIAA0141 Gene

  • Nervous system(4.8)
  • Bone marrow(4.3)
  • Lung(2.5)
genes like me logo Genes that share expression patterns with KIAA0141: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA0141 Gene

Orthologs for KIAA0141 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA0141 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA0141 34 35
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia KIAA0141 34 35
  • 86.8 (n)
dog
(Canis familiaris)
Mammalia KIAA0141 34 35
  • 84.92 (n)
mouse
(Mus musculus)
Mammalia 0610009O20Rik 34 16 35
  • 79.29 (n)
rat
(Rattus norvegicus)
Mammalia RGD735029 34
  • 78.96 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA0141 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA0141 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA0141 34
  • 67.05 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa0141 34
  • 49.55 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:158257 34 35
  • 47.12 (n)
Species where no ortholog for KIAA0141 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA0141 Gene

ENSEMBL:
Gene Tree for KIAA0141 (if available)
TreeFam:
Gene Tree for KIAA0141 (if available)

Paralogs for KIAA0141 Gene

No data available for Paralogs for KIAA0141 Gene

Variants for KIAA0141 Gene

Sequence variations from dbSNP and Humsavar for KIAA0141 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000284609 -- 141,927,042(+) TATGC(C/T)CTGTG intron-variant
rs1000465484 -- 141,922,030(+) ATTCC(A/C)AAAAC upstream-variant-2KB
rs1000649715 -- 141,922,859(+) GTCTC(A/G)CTCTG upstream-variant-2KB
rs1000840304 -- 141,937,998(+) TTTTT(A/G)TATTT intron-variant
rs1000894208 -- 141,937,598(+) ACCCC(A/G)TCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA0141 Gene

Variant ID Type Subtype PubMed ID
esv2667575 CNV deletion 23128226
nsv1117586 CNV deletion 24896259
nsv1154058 CNV deletion 26484159
nsv599924 CNV gain 21841781

Variation tolerance for KIAA0141 Gene

Residual Variation Intolerance Score: 61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.85; 89.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA0141 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA0141

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA0141 Gene

Disorders for KIAA0141 Gene

Relevant External Links for KIAA0141

Genetic Association Database (GAD)
KIAA0141
Human Genome Epidemiology (HuGE) Navigator
KIAA0141
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA0141

No disorders were found for KIAA0141 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA0141 Gene

Publications for KIAA0141 Gene

  1. Identification of DELE, a novel DAP3-binding protein which is crucial for death receptor-mediated apoptosis induction. (PMID: 20563667) Harada T. … Miyazaki T. (Apoptosis 2010) 2 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for KIAA0141 Gene

Sources for KIAA0141 Gene

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