KIAA0141 Gene
protein-coding GIFtS: 45
GCID: GC05P141323
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|
KIAA0141
| |
Aliases
for KIAA0141 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| KIAA01411 2 | | DELE1 2 3 | | Death Ligand Signal Enhancer2 |
Export aliases for KIAA0141 gene to outside databasesPrevious GC identifers: GC05P141124 GC05P141886 GC05P141286 GC05P141331 GC05P141283 GC05P136446 |
Summaries
for KIAA0141 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: DELE_HUMAN, Q14154Function: Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation
|
Genomic Views
for KIAA0141 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_029289.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KIAA0141 gene promoter:
C/EBPbeta NRSF form 1 NF-E2 p45 NRSF form 2 POU2F1 POU2F1a HOXA5 NF-E2
Other transcription factors
Search SABiosciences Chromatin IP Primers for KIAA0141
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA0141 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31.3 Ensembl cytogenetic band: 5q31.3 HGNC cytogenetic band: 5q31KIAA0141 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P141323: view genomic region
(about GC identifiers)
Start:
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141,303,373 bp from pter |
End:
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141,321,612 bp from pter |
Size:
|
18,240 bases |
Orientation:
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plus strand |
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Proteins
for KIAA0141 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DELE_HUMAN, Q14154 (See
protein sequence)Recommended Name: Death ligand signal enhancer precursor Size: 515 amino acids; 55920 Da
Subunit: Interacts with DAP3
Subcellular location: Mitochondrion
Sequence caution: Sequence=BAA09490.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q969R4 Q96EU9Explore the universe of human proteins at neXtProt for KIAA0141: NX_Q14154
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14154
KIAA0141 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001136075.1 NP_055588.3
ENSEMBL proteins: ENSP00000396225 ENSP00000194118 ENSP00000422686 ENSP00000426138
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IDA | -- |
KIAA0141 for ontologies About GeneDecksing
KIAA0141 Antibody Products:
Assay Products for KIAA0141: |
Protein
Domains /
Families
for KIAA0141 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KIAA0141 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14154ProtoNet protein and cluster: Q14154 1 Blocks protein family: IPB006597 Sel1-like repeat
UniProtKB/Swiss-Prot: DELE_HUMAN, Q14154Similarity: Contains 7 TPR repeats |
Function
for KIAA0141 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DELE_HUMAN, Q14154Function: Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation Genatlas biochemistry entry for KIAA0141:putative protein,expressed in fetal heart and kidney
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA0141 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA0141 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA0141 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
KIAA0141 for ontologies About GeneDecksing
|
Pathways & Interactions
for KIAA0141 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA0141
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006915 | apoptotic process |
IDA | -- | | GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process |
IDA | -- |
KIAA0141 for ontologies About GeneDecksing
|
Drugs & Compounds
for KIAA0141 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KIAA0141
Search CenterWatch for drugs/clinical trials and news about KIAA0141 / DELE
|
Transcripts
for KIAA0141 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KIAA0141 gene (2 alternative transcripts): NM_001142603.1 NM_014773.3 Unigene Cluster for KIAA0141: KIAA0141 Hs.210532 [show with all ESTs]Unigene Representative Sequence: NM_0147737 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000432126(uc003lls.3 uc003llt.3) ENST00000194118 ENST00000508751
ENST00000502729 ENST00000506775 ENST00000507481 ENST00000509110
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA0141 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA0141 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): KIAA0141 (NM_014773) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIAA0141 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA0141 |
Additional cDNA sequence: AK093504.1 AK292869.1 BC007855.2 BC010452.1 BC011269.1 BC011926.1 BC035486.1 D50931.1 17 DOTS entries: DT.218624 DT.97759913 DT.425478 DT.100887426 DT.100887447 DT.100747186 DT.112579 DT.91866801 DT.97779154 DT.100695070 DT.120818672 DT.91667479 DT.120818652 DT.40228844 DT.95265537 DT.120818670 DT.120818671 24/471 AceView cDNA sequences (see all 471): BC010452 AW304839 BE298114 AI263956 BM662342 BE138824 CK819953 CR598527 BM833016 BQ642581 D50931 AW207238 AA034508 AA889392 BM978753 BQ058348 BI832504 BI770290 AA449482 BM928733 AA815057 AA449645 AI569054 BU845629
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0141 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16a | · |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | - | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | |
| ExUns: | 16b | · | 16c | · | 16d | · | 16e |
|---|
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| SP1: | | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for KIAA0141
|
Expression
for KIAA0141 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KIAA0141 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCCAGAAAT
About this image
See KIAA0141 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIAA0141
SOURCE GeneReport for Unigene cluster: Hs.210532
UniProtKB/Swiss-Prot: DELE_HUMAN, Q14154Tissue specificity: Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, smallintestine and colon
SABiosciences Custom PCR Arrays for KIAA0141
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIAA0141
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIAA0141 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIAA0141 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIAA0141 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA0141 |
Orthologs
for KIAA0141 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KIAA0141 gene from 2/11 species (see all 11) About this table
ENSEMBL Gene Tree for KIAA0141 (if available)
TreeFam Gene Tree for KIAA0141 (if available) |
Paralogs
for KIAA0141 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for KIAA0141 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KIAA0141 (141303373 - 141321612 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KIAA0141: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIAA0141 |
|
Disorders
/ Diseases
for KIAA0141 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KIAA0141 for disorders About GeneDecksing
1  disease for KIAA0141: About MalaCardsthyroiditis
Human Genome Epidemiology (HuGE) Navigator: KIAA0141 (1 document)
Export disorders for KIAA0141 gene to outside databases
|
Publications
for KIAA0141 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KIAA0141 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KIAA0141) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of DELE, a novel DAP3-binding protein which is crucial for death receptor-mediated apoptosis induction. (PubMed id 20563667)1, 2, 3 Harada T....Miyazaki T. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2 Nagase T....Nomura N. (1995)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- A visual intracellular classification strategy for uncharacterized human proteins. (PubMed id 10942595)1 Hoja M.R....Hoog C. (2000)
|
External Searches for KIAA0141 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KIAA0141 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KIAA0141 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing KIAA0141 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KIAA0141 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KIAA0141 gene:
Search GeneIP for patents involving KIAA0141
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KIAA0141 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KIAA0141 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIAA0141 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIAA0141 | | | OriGene Protein Over-expression Lysate for KIAA0141 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KIAA0141 | | OriGene 3'-UTR Clone for KIAA0141 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA0141 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA0141 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KIAA0141 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIAA0141 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA0141 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIAA0141 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIAA0141 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIAA0141 |
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 | | | KIAA0141 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA0141 |
|  |  |  | | | | Search ThermoFisher Antibodies for KIAA0141 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA0141 |
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