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Aliases for KIAA0141 Gene

Aliases for KIAA0141 Gene

  • KIAA0141 2 3
  • Death Ligand Signal Enhancer 2 3
  • DELE 3 4

External Ids for KIAA0141 Gene

Summaries for KIAA0141 Gene

GeneCards Summary for KIAA0141 Gene

KIAA0141 (KIAA0141) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KIAA0141 Gene

  • Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA0141 Gene

Genomics for KIAA0141 Gene

Genomic Location for KIAA0141 Gene

Start:
141,923,785 bp from pter
End:
141,950,453 bp from pter
Size:
26,669 bases
Orientation:
Plus strand

Genomic View for KIAA0141 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIAA0141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA0141 Gene

Regulatory Elements for KIAA0141 Gene

Proteins for KIAA0141 Gene

  • Protein details for KIAA0141 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14154-DELE_HUMAN
    Recommended name:
    Death ligand signal enhancer
    Protein Accession:
    Q14154
    Secondary Accessions:
    • Q969R4
    • Q96EU9

    Protein attributes for KIAA0141 Gene

    Size:
    515 amino acids
    Molecular mass:
    55920 Da
    Quaternary structure:
    • Interacts with DAP3.
    SequenceCaution:
    • Sequence=BAA09490.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for KIAA0141 Gene

Proteomics data for KIAA0141 Gene at MOPED

Post-translational modifications for KIAA0141 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIAA0141 Gene

No data available for DME Specific Peptides for KIAA0141 Gene

Domains for KIAA0141 Gene

Protein Domains for KIAA0141 Gene

UniProtKB/Swiss-Prot:

DELE_HUMAN
Similarity:
  • Contains 7 TPR repeats.:
    • Q14154
genes like me logo Genes that share domains with KIAA0141: view

No data available for Gene Families for KIAA0141 Gene

Function for KIAA0141 Gene

Molecular function for KIAA0141 Gene

GENATLAS Biochemistry: putative protein,expressed in fetal heart and kidney
UniProtKB/Swiss-Prot Function: Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.

Gene Ontology (GO) - Molecular Function for KIAA0141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20563667
genes like me logo Genes that share ontologies with KIAA0141: view

miRNA for KIAA0141 Gene

miRTarBase miRNAs that target KIAA0141

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KIAA0141 Gene

Localization for KIAA0141 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA0141 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA0141 Gene COMPARTMENTS Subcellular localization image for KIAA0141 gene
Compartment Confidence
mitochondrion 5
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KIAA0141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 10942595
genes like me logo Genes that share ontologies with KIAA0141: view

Pathways for KIAA0141 Gene

SuperPathways for KIAA0141 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA0141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IDA 20563667
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA 20563667
genes like me logo Genes that share ontologies with KIAA0141: view

No data available for Pathways by source for KIAA0141 Gene

Transcripts for KIAA0141 Gene

Unigene Clusters for KIAA0141 Gene

KIAA0141:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0141 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16a ·
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - - - - - - -
SP9: -
SP10: -
SP11:

ExUns: 16b · 16c · 16d · 16e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for KIAA0141 Gene

GeneLoc Exon Structure for
KIAA0141
ECgene alternative splicing isoforms for
KIAA0141

Expression for KIAA0141 Gene

mRNA expression in normal human tissues for KIAA0141 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KIAA0141 Gene

SOURCE GeneReport for Unigene cluster for KIAA0141 Gene Hs.210532

mRNA Expression by UniProt/SwissProt for KIAA0141 Gene

Q14154-DELE_HUMAN
Tissue specificity: Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.
genes like me logo Genes that share expressions with KIAA0141: view

Orthologs for KIAA0141 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA0141 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA0141 36
  • 99.35 (n)
  • 99.22 (a)
KIAA0141 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA0141 36
  • 86.8 (n)
  • 84.08 (a)
KIAA0141 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA0141 36
  • 84.92 (n)
  • 81.75 (a)
KIAA0141 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 0610009O20Rik 36
  • 79.29 (n)
  • 74.36 (a)
0610009O20Rik 16
0610009O20Rik 37
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA0141 37
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA0141 37
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD735029 36
  • 78.96 (n)
  • 75.15 (a)
chicken
(Gallus gallus)
Aves KIAA0141 36
  • 67.05 (n)
  • 58.62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa0141 36
  • 49.55 (n)
  • 40.18 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:158257 36
  • 47.12 (n)
  • 37.5 (a)
zgc:158257 37
  • 38 (a)
OneToOne
Species with no ortholog for KIAA0141:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA0141 Gene

ENSEMBL:
Gene Tree for KIAA0141 (if available)
TreeFam:
Gene Tree for KIAA0141 (if available)

Paralogs for KIAA0141 Gene

No data available for Paralogs for KIAA0141 Gene

Variants for KIAA0141 Gene

Sequence variations from dbSNP and Humsavar for KIAA0141 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs9241 -- 141,939,147(+) TCTGA(A/T)GTGTG intron-variant, utr-variant-3-prime, downstream-variant-500B
rs9356 -- 141,939,973(+) TTGTC(A/C)ATCAG utr-variant-3-prime, intron-variant, nc-transcript-variant
rs10323 -- 141,940,073(+) AGAGT(A/G)TAGAT utr-variant-3-prime, intron-variant, nc-transcript-variant
rs13197 -- 141,940,114(+) AGAAA(A/T)GTCTA utr-variant-3-prime, intron-variant, nc-transcript-variant
rs168434 -- 141,933,113(-) tatat(A/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA0141 Gene

Variant ID Type Subtype PubMed ID
esv2667575 CNV Deletion 23128226

Relevant External Links for KIAA0141 Gene

HapMap Linkage Disequilibrium report
KIAA0141

Disorders for KIAA0141 Gene

Relevant External Links for KIAA0141

Genetic Association Database (GAD)
KIAA0141
Human Genome Epidemiology (HuGE) Navigator
KIAA0141
genes like me logo Genes that share disorders with KIAA0141: view

No data available for UniProtKB/Swiss-Prot for KIAA0141 Gene

Publications for KIAA0141 Gene

  1. Identification of DELE, a novel DAP3-binding protein which is crucial for death receptor-mediated apoptosis induction. (PMID: 20563667) Harada T. … Miyazaki T. (Apoptosis 2010) 2 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  3. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for KIAA0141 Gene

Sources for KIAA0141 Gene

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