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Aliases for KIAA0101 Gene

Aliases for KIAA0101 Gene

  • KIAA0101 2 3
  • Hepatitis C Virus NS5A-Transactivated Protein 9 3 4
  • Overexpressed In Anaplastic Thyroid Carcinoma 1 3 4
  • HCV NS5A-Transactivated Protein 9 3 4
  • PCNA-Associated Factor Of 15 KDa 3 4
  • PCNA-Associated Factor 2 3
  • NS5ATP9 3 4
  • OEATC-1 3 4
  • P15PAF 3 4
  • PAF15 3 4
  • PAF 3 4
  • P15(PAF) 3
  • P15/PAF 3
  • OEATC1 3
  • OEATC 3
  • L5 3

External Ids for KIAA0101 Gene

Previous GeneCards Identifiers for KIAA0101 Gene

  • GC15M060468
  • GC15M057816
  • GC15M062171
  • GC15M062373
  • GC15M062444
  • GC15M064657
  • GC15M041482

Summaries for KIAA0101 Gene

GeneCards Summary for KIAA0101 Gene

KIAA0101 (KIAA0101) is a Protein Coding gene. Diseases associated with KIAA0101 include Posterolateral Myocardial Infarction and Hepatitis C Virus. Among its related pathways are Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template and DNA Double-Strand Break Repair. GO annotations related to this gene include chromatin binding. An important paralog of this gene is ENSG00000259316.

UniProtKB/Swiss-Prot for KIAA0101 Gene

  • PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.

Gene Wiki entry for KIAA0101 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA0101 Gene

Genomics for KIAA0101 Gene

Regulatory Elements for KIAA0101 Gene

Enhancers for KIAA0101 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around KIAA0101 on UCSC Golden Path with GeneCards custom track

Promoters for KIAA0101 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for KIAA0101 Gene

Chromosome:
15
Start:
64,364,311 bp from pter
End:
64,387,687 bp from pter
Size:
23,377 bases
Orientation:
Minus strand

Genomic View for KIAA0101 Gene

Genes around KIAA0101 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA0101 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA0101 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA0101 Gene

Proteins for KIAA0101 Gene

  • Protein details for KIAA0101 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15004-PAF15_HUMAN
    Recommended name:
    PCNA-associated factor
    Protein Accession:
    Q15004
    Secondary Accessions:
    • A6NNU5
    • A8K3Y3
    • G9G694
    • G9G696

    Protein attributes for KIAA0101 Gene

    Size:
    111 amino acids
    Molecular mass:
    11986 Da
    Quaternary structure:
    • Interacts (when monoubiquitinated at Lys-15 and Lys-24) with PCNA. Interacts with isoform 2/p33ING1b of ING1. Interacts with BRCA1.
    Miscellaneous:
    • Overexpression in adrenocortical neoplasms (ACC), may promote growth and invasion in adrenal cancer.
    SequenceCaution:
    • Sequence=BAA03491.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIAA0101 Gene

    Alternative splice isoforms for KIAA0101 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA0101 Gene

Post-translational modifications for KIAA0101 Gene

  • Monoubiquitinated at Lys-15 and Lys-24 during normal S phase, promoting its association with PCNA. Also diubiquitinated at these 2 sites. Following DNA damage, monoubiquitin chains at Lys-15 and Lys-24 are probably extended, leading to disrupt the interaction with PCNA. Polyubiquitinated by the APC/C complex at the mitotic exit, leading to its degradation by the proteasome.
  • Ubiquitination at Lys 15 and Lys 63
  • Modification sites at PhosphoSitePlus

Other Protein References for KIAA0101 Gene

No data available for DME Specific Peptides for KIAA0101 Gene

Domains & Families for KIAA0101 Gene

Protein Domains for KIAA0101 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA0101 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15004

UniProtKB/Swiss-Prot:

PAF15_HUMAN :
  • The PIP-box mediates the interaction with PCNA (PubMed:21628590, PubMed:23000965).
Domain:
  • The PIP-box mediates the interaction with PCNA (PubMed:21628590, PubMed:23000965).
  • The KEN box is required for the association with the APC/C complex.
  • The D-box (destruction box) mediates the interaction with APC/C proteins, and acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
  • The initiation motif is required for efficient chain initiation by the APC/C complex E2 ligase UBE2C. It determines the rate of substrates degradation without affecting its affinity for the APC/C, a mechanism used by the APC/C to control the timing of substrate proteolysis during the cell cycle (PubMed:21700221).
genes like me logo Genes that share domains with KIAA0101: view

No data available for Gene Families for KIAA0101 Gene

Function for KIAA0101 Gene

Molecular function for KIAA0101 Gene

UniProtKB/Swiss-Prot Function:
PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.
UniProtKB/Swiss-Prot Induction:
By UV irradiation. By ATF3 in response to UV-stress.

Gene Ontology (GO) - Molecular Function for KIAA0101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 23000965
GO:0005515 protein binding IPI 21628590
genes like me logo Genes that share ontologies with KIAA0101: view
genes like me logo Genes that share phenotypes with KIAA0101: view

Animal Models for KIAA0101 Gene

MGI Knock Outs for KIAA0101:

Animal Model Products

CRISPR Products

miRNA for KIAA0101 Gene

miRTarBase miRNAs that target KIAA0101

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIAA0101 Gene

Localization for KIAA0101 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA0101 Gene

Nucleus. Cytoplasm, perinuclear region. Note=Following DNA damage, localizes to DNA damage sites (PubMed:21628590). Colocalizes with centrosomes in perinuclear region (PubMed:21673012).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA0101 Gene COMPARTMENTS Subcellular localization image for KIAA0101 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 3
extracellular 2
lysosome 2
plasma membrane 2
vacuole 2
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KIAA0101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21628590
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0048471 perinuclear region of cytoplasm IDA 21673012
genes like me logo Genes that share ontologies with KIAA0101: view

Pathways & Interactions for KIAA0101 Gene

genes like me logo Genes that share pathways with KIAA0101: view

SIGNOR curated interactions for KIAA0101 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for KIAA0101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IDA 23000965
GO:0006974 cellular response to DNA damage stimulus IDA 21628590
GO:0009411 response to UV IDA 23000965
GO:0019985 translesion synthesis TAS --
GO:0051297 centrosome organization IMP 21673012
genes like me logo Genes that share ontologies with KIAA0101: view

Drugs & Compounds for KIAA0101 Gene

No Compound Related Data Available

Transcripts for KIAA0101 Gene

Unigene Clusters for KIAA0101 Gene

KIAA0101:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0101 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - - -
SP5:
SP6: -

Relevant External Links for KIAA0101 Gene

GeneLoc Exon Structure for
KIAA0101
ECgene alternative splicing isoforms for
KIAA0101

Expression for KIAA0101 Gene

mRNA expression in normal human tissues for KIAA0101 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KIAA0101 Gene

This gene is overexpressed in Breast (65.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIAA0101 Gene



Protein tissue co-expression partners for KIAA0101 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KIAA0101 Gene:

KIAA0101

SOURCE GeneReport for Unigene cluster for KIAA0101 Gene:

Hs.81892

mRNA Expression by UniProt/SwissProt for KIAA0101 Gene:

Q15004-PAF15_HUMAN
Tissue specificity: Expressed predominantly in liver, pancreas and placenta. Not detected in heart or brain. Highly expressed in a number of tumors, especially esophageal tumors, in anaplastic thyroid carcinomas, adrenocortical carcinomas, and in non-small-cell lung cancer lines.
genes like me logo Genes that share expression patterns with KIAA0101: view

Primer Products

No data available for mRNA differential expression in normal tissues for KIAA0101 Gene

Orthologs for KIAA0101 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA0101 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIAA0101 34
  • 90.09 (n)
  • 90.99 (a)
PAF 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2810417H13Rik 34
  • 84.85 (n)
  • 84.55 (a)
2810417H13Rik 16
2810417H13Rik 35
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIAA0101 34
  • 99.1 (n)
  • 100 (a)
KIAA0101 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ns5atp9 34
  • 86.06 (n)
  • 87.27 (a)
dog
(Canis familiaris)
Mammalia KIAA0101 35
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA0101 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA0101 35
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA0101 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa0101 34
  • 63.11 (n)
  • 71.84 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.12145 34
LOC100333229 34
  • 54.21 (n)
  • 50.51 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8724 34
Species where no ortholog for KIAA0101 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA0101 Gene

ENSEMBL:
Gene Tree for KIAA0101 (if available)
TreeFam:
Gene Tree for KIAA0101 (if available)

Paralogs for KIAA0101 Gene

Paralogs for KIAA0101 Gene

genes like me logo Genes that share paralogs with KIAA0101: view

Variants for KIAA0101 Gene

Sequence variations from dbSNP and Humsavar for KIAA0101 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs11554313 - 64,376,798(-) AAAAA(A/G)AGAAT intron-variant, nc-transcript-variant, reference, missense
rs3764188 -- 64,383,662(-) TGGCC(A/G)GGTGT intron-variant
rs4238425 -- 64,378,994(+) ataac(A/C)agata intron-variant
rs4777181 -- 64,378,367(+) AACTC(C/T)AGTTG intron-variant
rs4777185 -- 64,380,394(+) agaaa(A/G)agaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA0101 Gene

Variant ID Type Subtype PubMed ID
dgv1224n106 CNV deletion 24896259
esv1497681 CNV deletion 17803354
esv2319425 CNV deletion 18987734
esv2675981 CNV deletion 23128226
esv2749782 CNV deletion 23290073
esv2749783 CNV deletion 23290073
esv3337124 CNV insertion 20981092
esv3552562 CNV deletion 23714750
esv3636733 CNV loss 21293372
esv3892709 CNV loss 25118596
esv4243 CNV loss 18987735
nsv94581 CNV deletion 16902084

Variation tolerance for KIAA0101 Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA0101 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA0101

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA0101 Gene

Disorders for KIAA0101 Gene

MalaCards: The human disease database

(9) MalaCards diseases for KIAA0101 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
posterolateral myocardial infarction
hepatitis c virus
  • hepatitic c virus
lateral myocardial infarction
  • lateral myocardial infarction nos
heart conduction disease
  • heart rhythm disease
erysipeloid
  • infection due to erysipelothrix rhusiopathiae
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for KIAA0101

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA0101
genes like me logo Genes that share disorders with KIAA0101: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIAA0101 Gene

Publications for KIAA0101 Gene

  1. p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues. (PMID: 11313979) Yu P. … Luo Y. (Oncogene 2001) 2 3 4 22 65
  2. The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b. (PMID: 16288740) Simpson F. … Wicking C. (Exp. Cell Res. 2006) 2 3 4 65
  3. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PMID: 23000965) Povlsen L.K. … Choudhary C. (Nat. Cell Biol. 2012) 3 4 65
  4. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate. (PMID: 21628590) Emanuele M.J. … Elledge S.J. (Proc. Natl. Acad. Sci. U.S.A. 2011) 3 4 65
  5. KIAA0101 interacts with BRCA1 and regulates centrosome number. (PMID: 21673012) Kais Z. … Parvin J.D. (Mol. Cancer Res. 2011) 3 4 65

Products for KIAA0101 Gene

Sources for KIAA0101 Gene

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