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Aliases for KIAA0101 Gene

Aliases for KIAA0101 Gene

  • KIAA0101 2 3
  • PAF 3 4 6
  • Hepatitis C Virus NS5A-Transactivated Protein 9 3 4
  • Overexpressed In Anaplastic Thyroid Carcinoma 1 3 4
  • HCV NS5A-Transactivated Protein 9 3 4
  • PCNA-Associated Factor Of 15 KDa 3 4
  • PCNA-Associated Factor 2 3
  • NS5ATP9 3 4
  • OEATC-1 3 4
  • P15PAF 3 4
  • PAF15 3 4
  • P15(PAF) 3
  • P15/PAF 3
  • OEATC1, 6
  • OEATC1 3
  • OEATC 3
  • L5 3

External Ids for KIAA0101 Gene

Previous GeneCards Identifiers for KIAA0101 Gene

  • GC15M060468
  • GC15M057816
  • GC15M062171
  • GC15M062373
  • GC15M062444
  • GC15M064657
  • GC15M041482

Summaries for KIAA0101 Gene

GeneCards Summary for KIAA0101 Gene

KIAA0101 (KIAA0101) is a Protein Coding gene. Diseases associated with KIAA0101 include hepatitis c and hepatitis c virus. GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for KIAA0101 Gene

  • PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.

Gene Wiki entry for KIAA0101 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA0101 Gene

Genomics for KIAA0101 Gene

Regulatory Elements for KIAA0101 Gene

Genomic Location for KIAA0101 Gene

Start:
64,364,311 bp from pter
End:
64,387,687 bp from pter
Size:
23,377 bases
Orientation:
Minus strand

Genomic View for KIAA0101 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIAA0101 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA0101 Gene

Proteins for KIAA0101 Gene

  • Protein details for KIAA0101 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15004-PAF15_HUMAN
    Recommended name:
    PCNA-associated factor
    Protein Accession:
    Q15004
    Secondary Accessions:
    • A6NNU5
    • A8K3Y3
    • G9G694
    • G9G696

    Protein attributes for KIAA0101 Gene

    Size:
    111 amino acids
    Molecular mass:
    11986 Da
    Quaternary structure:
    • Interacts (when monoubiquitinated at Lys-15 and Lys-24) with PCNA. Interacts with isoform 2/p33ING1b of ING1. Interacts with BRCA1.
    Miscellaneous:
    • Overexpression in adrenocortical neoplasms (ACC), may promote growth and invasion in adrenal cancer.
    SequenceCaution:
    • Sequence=BAA03491.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA0101 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA0101 Gene

Proteomics data for KIAA0101 Gene at MOPED

Post-translational modifications for KIAA0101 Gene

  • Monoubiquitinated at Lys-15 and Lys-24 during normal S phase, promoting its association with PCNA. Also diubiquitinated at these 2 sites. Following DNA damage, monoubiquitin chains at Lys-15 and Lys-24 are probably extended, leading to disrupt the interaction with PCNA. Polyubiquitinated by the APC/C complex at the mitotic exit, leading to its degradation by the proteasome.
  • Ubiquitination at Lys15, Lys24, and Lys63
  • Modification sites at PhosphoSitePlus

Other Protein References for KIAA0101 Gene

No data available for DME Specific Peptides for KIAA0101 Gene

Domains for KIAA0101 Gene

Protein Domains for KIAA0101 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q15004

UniProtKB/Swiss-Prot:

PAF15_HUMAN :
  • Q15004
Domain:
  • The PIP-box mediates the interaction with PCNA (PubMed:21628590, PubMed:23000965).
  • The KEN box is required for the association with the APC/C complex.
  • The D-box (destruction box) mediates the interaction with APC/C proteins, and acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
  • The initiation motif is required for efficient chain initiation by the APC/C complex E2 ligase UBE2C. It determines the rate of substrates degradation without affecting its affinity for the APC/C, a mechanism used by the APC/C to control the timing of substrate proteolysis during the cell cycle (PubMed:21700221).
genes like me logo Genes that share domains with KIAA0101: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for KIAA0101 Gene

Function for KIAA0101 Gene

Molecular function for KIAA0101 Gene

UniProtKB/Swiss-Prot Function: PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.
UniProtKB/Swiss-Prot Induction: By UV irradiation. By ATF3 in response to UV-stress.

Gene Ontology (GO) - Molecular Function for KIAA0101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 23000965
GO:0005515 protein binding IPI 21628590
genes like me logo Genes that share ontologies with KIAA0101: view

Phenotypes for KIAA0101 Gene

MGI mutant phenotypes for KIAA0101:
inferred from 1 alleles
GenomeRNAi human phenotypes for KIAA0101:
genes like me logo Genes that share phenotypes with KIAA0101: view

Animal Models for KIAA0101 Gene

MGI Knock Outs for KIAA0101:

Animal Model Products

CRISPR Products

miRNA for KIAA0101 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIAA0101

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KIAA0101 Gene

Localization for KIAA0101 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA0101 Gene

Nucleus. Cytoplasm, perinuclear region. Note=Following DNA damage, localizes to DNA damage sites. Colocalizes with centrosomes in perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA0101 Gene COMPARTMENTS Subcellular localization image for KIAA0101 gene
Compartment Confidence
nucleus 5
extracellular 3
mitochondrion 3
plasma membrane 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KIAA0101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0048471 perinuclear region of cytoplasm IDA 21673012
genes like me logo Genes that share ontologies with KIAA0101: view

Pathways for KIAA0101 Gene

SuperPathways for KIAA0101 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA0101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IDA 23000965
GO:0006281 DNA repair TAS --
GO:0006974 cellular response to DNA damage stimulus IDA 21628590
GO:0009411 response to UV IDA 23000965
GO:0019985 translesion synthesis TAS --
genes like me logo Genes that share ontologies with KIAA0101: view

No data available for Pathways by source for KIAA0101 Gene

Transcripts for KIAA0101 Gene

Unigene Clusters for KIAA0101 Gene

KIAA0101:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIAA0101

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0101 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - - -
SP5:
SP6: -

Relevant External Links for KIAA0101 Gene

GeneLoc Exon Structure for
KIAA0101
ECgene alternative splicing isoforms for
KIAA0101

Expression for KIAA0101 Gene

mRNA expression in normal human tissues for KIAA0101 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIAA0101 Gene

SOURCE GeneReport for Unigene cluster for KIAA0101 Gene Hs.81892

mRNA Expression by UniProt/SwissProt for KIAA0101 Gene

Q15004-PAF15_HUMAN
Tissue specificity: Expressed predominantly in liver, pancreas and placenta. Not detected in heart or brain. Highly expressed in a number of tumors, especially esophageal tumors, in anaplastic thyroid carcinomas, adrenocortical carcinomas, and in non-small-cell lung cancer lines.
genes like me logo Genes that share expressions with KIAA0101: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for KIAA0101 Gene

Orthologs for KIAA0101 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA0101 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA0101 35
  • 99.1 (n)
  • 100 (a)
KIAA0101 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA0101 35
  • 90.09 (n)
  • 90.99 (a)
PAF 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA0101 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2810417H13Rik 35
  • 84.85 (n)
  • 84.55 (a)
2810417H13Rik 16
2810417H13Rik 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA0101 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA0101 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ns5atp9 35
  • 86.06 (n)
  • 87.27 (a)
lizard
(Anolis carolinensis)
Reptilia KIAA0101 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa0101 35
  • 63.11 (n)
  • 71.84 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8724 35
zebrafish
(Danio rerio)
Actinopterygii Dr.12145 35
LOC100333229 35
  • 54.21 (n)
  • 50.51 (a)
Species with no ortholog for KIAA0101:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA0101 Gene

ENSEMBL:
Gene Tree for KIAA0101 (if available)
TreeFam:
Gene Tree for KIAA0101 (if available)

Paralogs for KIAA0101 Gene

No data available for Paralogs for KIAA0101 Gene

Variants for KIAA0101 Gene

Sequence variations from dbSNP and Humsavar for KIAA0101 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1033203 -- 64,365,468(-) TAAAC(A/G)GTTGA utr-variant-3-prime, nc-transcript-variant
rs1033204 -- 64,364,626(-) GGCAC(A/G)CACAG downstream-variant-500B
rs1033205 -- 64,364,565(-) ATTCG(C/G)TATCA downstream-variant-500B
rs1033206 -- 64,364,563(-) TCGCT(A/G)TCATA downstream-variant-500B
rs1185269 -- 64,377,892(-) cgcct(G/T)taatc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA0101 Gene

Variant ID Type Subtype PubMed ID
nsv904306 CNV Loss 21882294
esv267794 CNV Insertion 20981092
esv2749782 CNV Deletion 23290073
esv2319425 CNV Deletion 18987734
esv4243 CNV Deletion 18987735
esv2749783 CNV Deletion 23290073
esv2675981 CNV Deletion 23128226
nsv94581 CNV Loss 16902084
esv1497681 CNV Deletion 17803354

Relevant External Links for KIAA0101 Gene

HapMap Linkage Disequilibrium report
KIAA0101

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA0101 Gene

Disorders for KIAA0101 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for KIAA0101 Gene including...

Search for KIAA0101 Gene in MalaCards »

(5) University of Copenhagen DISEASES for KIAA0101 Gene

genes like me logo Genes that share disorders with KIAA0101: view

No data available for UniProtKB/Swiss-Prot for KIAA0101 Gene

Publications for KIAA0101 Gene

  1. p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues. (PMID: 11313979) Yu P. … Luo Y. (Oncogene 2001) 2 3 4 23
  2. The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b. (PMID: 16288740) Simpson F. … Wicking C. (Exp. Cell Res. 2006) 2 3 4
  3. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T. … Nomura N. (DNA Res. 1995) 3 4
  4. ATF3 and p15PAF are novel gatekeepers of genomic integrity upon UV stress. (PMID: 19219066) Turchi L. … Virolle T. (Cell Death Differ. 2009) 3 4
  5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PMID: 23000965) Povlsen L.K. … Choudhary C. (Nat. Cell Biol. 2012) 3 4

Products for KIAA0101 Gene

Sources for KIAA0101 Gene

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