KIAA0040 Gene
protein-coding GIFtS : 39
GCID: GC01 M175126
KIAA0040
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Aliasesfor KIAA0040 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section This gene clusters with an RNA geneSubcategory (RNA class): lncRNAQuality score for the ORGUL clustered with this gene is 3 Aliases KIAA0040 1 2 Uncharacterized Protein KIAA00402
External Ids: HGNC: 28950 1 Entrez Gene: 9674 2 Ensembl: ENSG00000235750 7 UniProtKB: Q15053 3 ORGUL members: NONCODE:n378134
Export aliases for KIAA0040 gene to outside databases Previous GC identifers: GC01M172650 GC01M170554 GC01M171706 GC01M172365 GC01M171857 GC01M173392 GC01M146352
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Summariesfor KIAA0040 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor KIAA0040 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_004487.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the KIAA0040 gene promoter: IRF-2 AML1a IRF-7A ARP-1 IRF-1 LCR-F1 C/EBPalpha FOXL1 Gfi-1 Other transcription factors Search SABiosciences Chromatin IP Primers for KIAA0040 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA0040
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q24-q25 Ensembl cytogenetic band: 1q25.1 HGNC cytogenetic band: 1q24-q25 KIAA0040 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M175126: view genomic region
(about GC identifiers )
Start:
175,126,123 bp from pter
End:
175,162,229 bp from pter
Size:
36,107 bases
Orientation:
minus strand
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Proteinsfor KIAA0040 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
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ProSpec , and/or
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Biochemical Assays by
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R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: K0040_HUMAN, Q15053 (See
protein sequence )Recommended Name: Uncharacterized protein KIAA0040 Size : 153 amino acids; 17035 Da
Sequence caution : Sequence=BAA05022.2; Type=Erroneous initiation;
Secondary accessions : A8K9H6 Q2NKQ0Explore the universe of human proteins at neXtProt for KIAA0040: NX_Q15053 KIAA0040 Protein expression data from MOPED and PaxDb : --
REFSEQ proteins (4 alternative transcripts):
NP_001156365.1 NP_001156366.1 NP_001156367.1 NP_055471.2 ENSEMBL proteins: ENSP00000462172 ENSP00000463734 ENSP00000464040 Human Recombinant Protein Products: KIAA0040 Antibody Products: Assay Products for KIAA0040:
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Protein
Domains / Familiesfor KIAA0040 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q15053
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Functionfor KIAA0040 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KIAA0040 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KIAA0040 (see all 5 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 4 ): KIAA0040 (NM_001162895 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIAA0040 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KIAA0040
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA0040
1 GenomeRNAi human phenotype for KIAA0040 :
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Pathways & Interactionsfor KIAA0040 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA0040
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Drugs & Compoundsfor KIAA0040 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for KIAA0040 Search CenterWatch for drugs/clinical trials and news about KIAA0040 / K0040
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Transcriptsfor KIAA0040 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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siRNAs from
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Tagged/untagged cDNA clones from
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Primers from
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)About This Section REFSEQ mRNAs for KIAA0040 gene (4 alternative transcripts): NM_001162893.1 NM_001162894.1 NM_001162895.1 NM_014656.2 Unigene Cluster for KIAA0040:
KIAA0040 Hs.518138 [show with all ESTs ] Unigene Representative Sequence: NM_001162893 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000423313 (uc009wws.2 uc001gkn.3 ) ENST00000444639 (uc010pmy.1 uc001gko.3 )ENST00000545251 ENST00000567124 ENST00000563563 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KIAA0040 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KIAA0040 (see all 5 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 4 ): KIAA0040 (NM_001162895 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIAA0040 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KIAA0040
Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for KIAA0040Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat KIAA0040 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat KIAA0040 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat KIAA0040
Additional cDNA sequence: AK292691.1 AL049799.1 AL049800.1 BC032361.1 BC050374.1 BC111699.1 D25539.1
10 DOTS entries : DT.216458 DT.97869885
DT.86855609 DT.121384391 DT.121384385 DT.100844067 DT.121384356 DT.70103637 DT.92424801 DT.99998425 24/148 AceView cDNA sequences (see all 148 ):
BQ433299 AW080522 AL049800 AI834294 CR618094 AI087326 NM_014656 AA443568 CR602920 AL049799 CA395631 AW963093 AW102804 AA296438 BP344817 AA443567 BG743303 AA359242 CR625052 AW000797 AI828958 CA310601 BI818404 CB120310 GeneLoc Exon Structure
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Expression for KIAA0040 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section KIAA0040 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGACTATTTA
About this image KIAA0040 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Kidney Renal Vesicle Kidney Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell Name Category Definitive endoderm-like cells (A scalable, suspensi... )
Genevestigator expression for KIAA0040 SOURCE GeneReport for Unigene cluster: Hs.518138 SABiosciences Custom PCR Arrays for KIAA0040 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for KIAA0040Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat KIAA0040 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat KIAA0040 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat KIAA0040 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA0040
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Orthologsfor KIAA0040 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for KIAA0040 gene from 2/5 species (see all 5 ) About this table
ENSEMBL Gene Tree for KIAA0040 (if available)TreeFam Gene Tree for KIAA0040 (if available)
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Paralogsfor KIAA0040 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor KIAA0040 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for KIAA0040 (175126123 - 175162229 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for KIAA0040 1 CNV : 70442
SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor KIAA0040 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
KIAA0040 for disorders About GeneDecksing 2 diseases for KIAA0040 : About MalaCards alcohol dependence alcoholism Export disorders for KIAA0040 gene to outside databases
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Publicationsfor KIAA0040 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for KIAA0040 gene integrated from 9 sources : (articles sorted by number of sources associating them with KIAA0040) Utopia : connect your pdf to the dynamic world of online information
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 1 , 2 Gregory S.G.... Bentley D.R. (2006) Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026) 1 , 2 Nomura N.... Tabata S. (1994) Genome-wide association study of alcohol dependence im plicates KIAA0040 on chromosome 1q. (PubMed id 21956439) 1 Zuo L....Luo X. (2012) A meta-analysis of two genome-wide association studie s identifies 3 new loci for alcohol dependence. (PubMed id 21703634) 1 Wang K.S....Zeng M. (2011) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Prediction of the coding sequences of unidentified hu man genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell li ne KG-1 (supplement). (PubMed id 7584028) 1 Nomura N....Tabata S. (1994)
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External Searches for KIAA0040 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing KIAA0040 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing KIAA0040 gene
(According to HUGE )
About This Section
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Specialized Databases showing KIAA0040 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for KIAA0040 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for KIAA0040 gene: Search GeneIP for patents involving KIAA0040 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor KIAA0040 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for KIAA0040 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for KIAA0040 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for KIAA0040 OriGene Protein Over-expression Lysate for KIAA0040 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for KIAA0040 OriGene 3'-UTR Clone for KIAA0040 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KIAA0040 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KIAA0040 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for KIAA0040 OriGene Custom Protein Services for KIAA0040 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KIAA0040 Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIAA0040 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA0040 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat KIAA0040 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat KIAA0040 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat KIAA0040
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA0040
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KIAA0040
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Last full update: 18 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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