KIAA0020 Gene
protein-coding GIFtS: 53
GCID: GC09M002720
|
|
KIAA0020
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Aliases
for KIAA0020 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| KIAA00201 2 | | Minor Histocompatibility Antigen HA-82 3 | | XTP51 2 3 | | HBV X-Transactivated Gene 5 Protein2 3 | | HLA-HA82 3 5 | | HBV XAg-Transactivated Protein 52 3 | | HA-81 2 | | Penguin Homolog2 | | PEN1 2 | | Protein 5 Transactivated By Hepatitis B Virus X Antigen (HBxAg)2 | | PUF61 2 | | Pumilio Domain-Containing Protein KIAA00202 | | HPUF-A1 | | |
Export aliases for KIAA0020 gene to outside databasesPrevious GC identifers: GC09M002958 GC09M002785 GC09M002795 GC09M002796 GC09M002797 |
Summaries
for KIAA0020 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for KIAA0020
|
Genomic Views
for KIAA0020 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KIAA0020 gene promoter:
E2F-4 E2F-3a E2F-5 Sp1 MEF-2 E2F-2 MEF-2A E2F E2F-1 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for KIAA0020
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA0020 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p24.2 Ensembl cytogenetic band: 9p24.2 HGNC cytogenetic band: 9p24.2KIAA0020 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M002720: view genomic region
(about GC identifiers)
Start:
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2,720,469 bp from pter |
End:
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2,844,241 bp from pter |
Size:
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123,773 bases |
Orientation:
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minus strand |
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Proteins
for KIAA0020 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: K0020_HUMAN, Q15397 (See
protein sequence)Recommended Name: Pumilio domain-containing protein KIAA0020 Size: 648 amino acids; 73584 Da
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=BAA02808.1; Type=Erroneous initiation; Sequence=CAI12924.2; Type=Erroneous gene modelprediction; Sequence=CAI15123.2; Type=Erroneous gene model prediction;
Secondary accessions: A8K804 Q547G7 Q5SZY9 Q6IB47 Q96B27 Q96L78 Q96L79 Q96L80Explore the universe of human proteins at neXtProt for KIAA0020: NX_Q15397
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15397
KIAA0020 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055693.4
ENSEMBL proteins: ENSP00000380982
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
KIAA0020 for ontologies About GeneDecksing
KIAA0020 Antibody Products:
Assay Products for KIAA0020: |
Protein
Domains /
Families
for KIAA0020 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KIAA0020 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15397ProtoNet protein and cluster: Q15397 2 Blocks protein families: IPB001313 Pumilio/Puf RNA-binding IPB012959 CPL
UniProtKB/Swiss-Prot: K0020_HUMAN, Q15397Domain: The HA-8 region can be cleaved and exposed at the cell surface where it plays a role as a minorhistocompatibility HLA-A*0201-restricted antigenSimilarity: Contains 1 PUM-HD domainSimilarity: Contains 6 pumilio repeats |
Function
for KIAA0020 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA0020 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA0020 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA0020 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003723 | RNA binding |
IEA | -- |
KIAA0020 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for KIAA0020:
|
Pathways & Interactions
for KIAA0020 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA0020
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/203 Interacting proteins for KIAA0020 (Q153972, 3 ENSP000003809824) via UniProtKB, MINT, STRING, and/or I2D (see all 203)About this table
|
Drugs & Compounds
for KIAA0020 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KIAA0020
Search CenterWatch for drugs/clinical trials and news about KIAA0020 / K0020
|
Transcripts
for KIAA0020 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KIAA0020 gene (2 alternative transcripts): NM_001031691.1 NM_014878.4 Unigene Cluster for KIAA0020: KIAA0020 Hs.493309 [show with all ESTs]Unigene Representative Sequence: NM_0148784 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000490444 ENST00000397885(uc003zhp.1 uc003zhq.1) ENST00000382032
ENST00000469168
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA0020 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA0020 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KIAA0020 (NM_014878) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIAA0020 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA0020 |
Additional cDNA sequence: AF490254.1 AK225953.1 AK292169.1 AK315531.1 AL832239.1 AL832245.1 AY047588.1 AY047589.1 AY047590.1 BC016137.2 BC020598.1 CR456957.1 D13645.1 9 DOTS entries: DT.212586 DT.40131893 DT.100810484 DT.91648820 DT.100809145 DT.100810491 DT.120794743 DT.121198176 DT.99952277 24/177 AceView cDNA sequences (see all 177): CA442401 CR605925 NM_014878 AY047590 BU194185 CB162869 CR607424 AF490254 BM015604 BX388854 BX330429 BU688253 BM917085 AA577507 BX349676 BP341803 BP364867 AI936509 BF431123 AA454662 BU194937 BP364238 BM789425 BG109169
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0020 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KIAA0020
|
Expression
for KIAA0020 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KIAA0020 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGGTATGAA
About this image
See KIAA0020 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIAA0020
SOURCE GeneReport for Unigene cluster: Hs.493309
UniProtKB/Swiss-Prot: K0020_HUMAN, Q15397Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for KIAA0020
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIAA0020
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIAA0020 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIAA0020 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIAA0020 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA0020 |
Orthologs
for KIAA0020 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for KIAA0020 gene from 10/31 species (see all 31) About this table
ENSEMBL Gene Tree for KIAA0020 (if available)
TreeFam Gene Tree for KIAA0020 (if available) |
Paralogs
for KIAA0020 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KIAA0020 gene
KIAA0020 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for KIAA0020
PGOHUM00000248172 PGOHUM00000245490
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Genomic Variants
for KIAA0020 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: K0020_HUMAN, Q15397Polymorphism: The following alleles of HA-8 are known: HA-8R, HA-8P, HA-8PL, of which only HA-8R leads to specificcytotoxic T lymphocyte (CTL) recognition. The lack of CTL recognition of cells expressing HA-8P may be due to impairedtransport associated with antigen processing. The sequence shown is that of HA-8R
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KIAA0020 (2720469 - 2844241 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KIAA0020
1 CNV: 100559 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIAA0020 |
|
Disorders
/ Diseases
for KIAA0020 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KIAA0020 for disorders About GeneDecksing
OMIM gene information: 609960
OMIM disorders: --
3  diseases for KIAA0020: About MalaCardshepatitis b hepatitis celiac disease
Human Genome Epidemiology (HuGE) Navigator: KIAA0020 (3 documents)
Export disorders for KIAA0020 gene to outside databases
|
Publications
for KIAA0020 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KIAA0020 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with KIAA0020) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2, 3 Nomura N.... Tabata S. (1994)
- hPuf-A/KIAA0020 modulates PARP-1 cleavage upon genoto xic stress. (PubMed id 21266351)1, 3 Chang H.Y....Chang M.S. (2011)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
- The immunogenicity of a new human minor histocompatibility antigen results from differential antigen processing. (PubMed id 11148223)1, 2 Brickner A.G.... Riddell S.R. (2001)
- Prediction of the coding sequences of unidentified hu man genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell li ne KG-1 (supplement). (PubMed id 7584028)1, 3 Nomura N....Tabata S. (1994)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for KIAA0020 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KIAA0020 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KIAA0020 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing KIAA0020 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KIAA0020 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KIAA0020 gene:
Search GeneIP for patents involving KIAA0020
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KIAA0020 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | KIAA0020 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA0020 |
|  |  |  | | | | Search ThermoFisher Antibodies for KIAA0020 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA0020 |
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