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Aliases for KIAA0020 Gene

Aliases for KIAA0020 Gene

  • KIAA0020 2 3
  • Minor Histocompatibility Antigen HA-8 2 3 4
  • HLA-HA8 3 4 6
  • HBV X-Transactivated Gene 5 Protein 3 4
  • HBV XAg-Transactivated Protein 5 3 4
  • PUF-A 3 4
  • XTP5 3 4
  • Protein 5 Transactivated By Hepatitis B Virus X Antigen (HBxAg) 3
  • Pumilio Domain-Containing Protein KIAA0020 3
  • Penguin Homolog (Drosophila) 2
  • Penguin Homolog 3
  • HA-8 3
  • PUF6 3
  • PEN 3

External Ids for KIAA0020 Gene

Summaries for KIAA0020 Gene

GeneCards Summary for KIAA0020 Gene

KIAA0020 (KIAA0020) is a Protein Coding gene. Diseases associated with KIAA0020 include hepatitis b. GO annotations related to this gene include RNA binding.

Gene Wiki entry for KIAA0020 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA0020 Gene

Genomics for KIAA0020 Gene

Genomic Location for KIAA0020 Gene

Start:
2,720,469 bp from pter
End:
2,844,241 bp from pter
Size:
123,773 bases
Orientation:
Minus strand

Genomic View for KIAA0020 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIAA0020 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA0020 Gene

Regulatory Elements for KIAA0020 Gene

Proteins for KIAA0020 Gene

  • Protein details for KIAA0020 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15397-K0020_HUMAN
    Recommended name:
    Pumilio domain-containing protein KIAA0020
    Protein Accession:
    Q15397
    Secondary Accessions:
    • A8K804
    • Q547G7
    • Q5SZY9
    • Q6IB47
    • Q96B27
    • Q96L78
    • Q96L79
    • Q96L80

    Protein attributes for KIAA0020 Gene

    Size:
    648 amino acids
    Molecular mass:
    73584 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Binds to double-stranded RNA or DNA without sequence specificity.
    SequenceCaution:
    • Sequence=BAA02808.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI12924.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15123.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIAA0020 Gene

neXtProt entry for KIAA0020 Gene

Proteomics data for KIAA0020 Gene at MOPED

Post-translational modifications for KIAA0020 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIAA0020 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIAA0020 Gene

Domains for KIAA0020 Gene

Protein Domains for KIAA0020 Gene

UniProtKB/Swiss-Prot:

K0020_HUMAN
Domain:
  • The HA-8 region can be cleaved and exposed at the cell surface where it plays a role as a minor histocompatibility HLA-A*0201-restricted antigen:
    • Q15397
  • A 90 degree bend between Pumilio repeats 3 and 4 gives rise to a L-shaped protein.:
    • Q15397
  • Contains 1 PUM-HD domain.:
    • Q15397
Similarity:
  • Contains 11 pumilio repeats.:
    • Q15397
genes like me logo Genes that share domains with KIAA0020: view

No data available for Gene Families for KIAA0020 Gene

Function for KIAA0020 Gene

Gene Ontology (GO) - Molecular Function for KIAA0020 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding --
GO:0003729 mRNA binding IBA --
GO:0005488 binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with KIAA0020: view

Phenotypes for KIAA0020 Gene

GenomeRNAi human phenotypes for KIAA0020:
genes like me logo Genes that share phenotypes with KIAA0020: view

miRNA for KIAA0020 Gene

miRTarBase miRNAs that target KIAA0020

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KIAA0020 Gene

Localization for KIAA0020 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA0020 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA0020 Gene COMPARTMENTS Subcellular localization image for KIAA0020 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for KIAA0020 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005783 endoplasmic reticulum IDA 10942595
genes like me logo Genes that share ontologies with KIAA0020: view

Pathways for KIAA0020 Gene

SuperPathways for KIAA0020 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA0020 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IBA --
genes like me logo Genes that share ontologies with KIAA0020: view

No data available for Pathways by source for KIAA0020 Gene

Transcripts for KIAA0020 Gene

Unigene Clusters for KIAA0020 Gene

KIAA0020:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0020 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2:

Relevant External Links for KIAA0020 Gene

GeneLoc Exon Structure for
KIAA0020
ECgene alternative splicing isoforms for
KIAA0020

Expression for KIAA0020 Gene

mRNA expression in normal human tissues for KIAA0020 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIAA0020 Gene

SOURCE GeneReport for Unigene cluster for KIAA0020 Gene Hs.493309

mRNA Expression by UniProt/SwissProt for KIAA0020 Gene

Q15397-K0020_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with KIAA0020: view

Orthologs for KIAA0020 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIAA0020 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA0020 36
  • 99.43 (n)
  • 99.38 (a)
KIAA0020 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA0020 36
  • 89.85 (n)
  • 91.5 (a)
KIAA0020 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA0020 36
  • 90.06 (n)
  • 91.65 (a)
KIAA0020 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia D19Bwg1357e 36
  • 85.99 (n)
  • 89.64 (a)
D19Bwg1357e 16
D19Bwg1357e 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA0020 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA0020 37
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA0020 36
  • 72.11 (n)
  • 71.78 (a)
KIAA0020 37
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA0020 37
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398471 36
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa0020 36
  • 68.14 (n)
  • 66.61 (a)
Str.15416 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.952 36
zebrafish
(Danio rerio)
Actinopterygii im:7148292 36
  • 65.3 (n)
  • 66.72 (a)
im:7148292 37
  • 65 (a)
OneToOne
sbcb379 36
fruit fly
(Drosophila melanogaster)
Insecta pen 37
  • 25 (a)
OneToOne
pen 38
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea puf-12 36
  • 47.89 (n)
  • 33.26 (a)
puf-12 37
  • 22 (a)
OneToOne
ZK945.3 38
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUF6 37
  • 21 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons PUM24 36
  • 45.53 (n)
  • 32.11 (a)
rice
(Oryza sativa)
Liliopsida Os03g0831100 36
  • 43.72 (n)
  • 31.97 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2908 37
  • 40 (a)
OneToOne
Species with no ortholog for KIAA0020:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIAA0020 Gene

ENSEMBL:
Gene Tree for KIAA0020 (if available)
TreeFam:
Gene Tree for KIAA0020 (if available)

Paralogs for KIAA0020 Gene

Pseudogenes.org Pseudogenes for KIAA0020 Gene

genes like me logo Genes that share paralogs with KIAA0020: view

No data available for Paralogs for KIAA0020 Gene

Variants for KIAA0020 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA0020 Gene

Q15397-K0020_HUMAN
The following alleles of HA-8 are known: HA-8R, HA-8P, HA-8PL, of which only HA-8R leads to specific cytotoxic T lymphocyte (CTL) recognition. The lack of CTL recognition of cells expressing HA-8P may be due to impaired transport associated with antigen processing. The sequence shown is that of HA-8R

Sequence variations from dbSNP and Humsavar for KIAA0020 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2747 -- 2,837,232(+) TTTGC(C/T)GGCTG synonymous-codon, reference
rs12171 -- 2,804,393(-) CTACA(C/T)TGGAA synonymous-codon, reference
rs1139545 -- 2,829,792(-) GGGAA(C/G)ACATT reference, missense
rs1393043 -- 2,835,137(+) GCCAG(C/G)TGCAG intron-variant
rs1393044 -- 2,835,181(+) GCTGA(A/G)GAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA0020 Gene

Variant ID Type Subtype PubMed ID
nsv892079 CNV Gain 21882294
dgv8011n71 CNV Gain 21882294
nsv892083 CNV Gain 21882294
esv2594391 CNV Insertion 19546169

Relevant External Links for KIAA0020 Gene

HapMap Linkage Disequilibrium report
KIAA0020

Disorders for KIAA0020 Gene

(1) MalaCards Diseases for KIAA0020 Gene

Search for KIAA0020 Gene in MalaCards »

Relevant External Links for KIAA0020

Genetic Association Database (GAD)
KIAA0020
Human Genome Epidemiology (HuGE) Navigator
KIAA0020
genes like me logo Genes that share disorders with KIAA0020: view

No data available for UniProtKB/Swiss-Prot for KIAA0020 Gene

Publications for KIAA0020 Gene

  1. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PMID: 7584026) Nomura N. … Tabata S. (DNA Res. 1994) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). (PMID: 7584028) Nomura N. … Tabata S. (DNA Res. 1994) 2 3
  3. The immunogenicity of a new human minor histocompatibility antigen results from differential antigen processing. (PMID: 11148223) Brickner A.G. … Riddell S.R. (J. Exp. Med. 2001) 3 4
  4. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4

Products for KIAA0020 Gene

Sources for KIAA0020 Gene

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