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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KHSRP Gene

protein-coding   GIFtS: 59
GCID: GC19M006413

KH-Type Splicing Regulatory Protein

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
KH-Type Splicing Regulatory Protein1 2     KH Type-Splicing Regulatory Protein2 3
FUBP22 3 5     p752 3
KSRP2 3 5     FBP22 5
FUSE Binding Protein 21 2     Far Upstream Element-Binding Protein 22
FUSE-Binding Protein 22 3     

External Ids:    HGNC: 63161   Entrez Gene: 85702   Ensembl: ENSG000000882477   OMIM: 6034455   UniProtKB: Q929453   

Export aliases for KHSRP gene to outside databases

Previous GC identifers: GC19M006507 GC19M006481 GC19M006353 GC19M006364 GC19M006173


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KHSRP Gene:
The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes,
including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 (PubMed 9136930);
Gherzi et al., 2004 (PubMed 15175153)).(supplied by OMIM, Apr 2010)

GeneCards Summary for KHSRP Gene: 
KHSRP (KH-type splicing regulatory protein) is a protein-coding gene. Diseases associated with KHSRP include spinocerebellar ataxia type 17, and poliomyelitis, and among its related super-pathways are Metabolism of RNA and Destabilization of mRNA by AUF1 (hnRNP D0). GO annotations related to this gene include RNA binding and DNA binding. An important paralog of this gene is FUBP1.

UniProtKB/Swiss-Prot: FUBP2_HUMAN, Q92945
Function: Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part
of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion
in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA
from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently
unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery
to ARE-containing mRNAs

Gene Wiki entry for KHSRP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011255.14  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KHSRP gene promoter:
         E2F-4   E2F-3a   E2F-5   Nkx2-5   E2F-2   NF-kappaB   AREB6   E2F-1   COMP1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKHSRP promoter sequence
   Search SABiosciences Chromatin IP Primers for KHSRP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KHSRP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

KHSRP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KHSRP gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M006413:  view genomic region     (about GC identifiers)

Start:
6,413,115 bp from pter      End:
6,424,822 bp from pter
Size:
11,708 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FUBP2_HUMAN, Q92945 (See protein sequence)
Recommended Name: Far upstream element-binding protein 2  
Size: 711 amino acids; 73115 Da
Subunit: Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRPH1. Interacts with PARN
Subcellular location: Nucleus. Cytoplasm. Note=A small proportion is also found in the cytoplasm of neuronal cell
bodies and dendrites (By similarity)
Sequence caution: Sequence=AAC50892.1; Type=Frameshift; Positions=304, 309, 466, 473; Sequence=AAH85004.1;
Type=Miscellaneous discrepancy; Note=Aberrant splicing;
6 PDB 3D structures from and Proteopedia for KHSRP:
2HH2 (3D)        2HH3 (3D)        2JVZ (3D)        2OPU (3D)        2OPV (3D)        4B8T (3D)    
Secondary accessions: O00301 Q59EZ9 Q5U4P6 Q9UNT5 Q9UQH5

Explore the universe of human proteins at neXtProt for KHSRP: NX_Q92945

Explore proteomics data for KHSRP at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at Ser-193 leads to the unfolding of the unstable KH domain 1, creating a site for 14-3-3 YWHAZ
    binding, which promotes nuclear localization and impairs the RNA degradation function
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92945

  • KHSRP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KHSRP Protein Expression
    REFSEQ proteins: NP_003676.2  
    ENSEMBL proteins: 
     ENSP00000381216   ENSP00000469804   ENSP00000472328   ENSP00000473254   ENSP00000472347  
     ENSP00000471146   ENSP00000471262   ENSP00000469830   ENSP00000469431  
    Reactome Protein details: Q92945
    Human Recombinant Protein Products for KHSRP: 
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    Novus Biologicals KHSRP Protein
    Novus Biologicals KHSRP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol TAS--
    GO:0010494cytoplasmic stress granule IEA--

    KHSRP for ontologies           About GeneDecksing



    KHSRP Antibody Products: 
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    Abcam antibodies for KHSRP
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    LSBio Antibodies in human, mouse, rat for KHSRP 

    Assay Products for KHSRP: 
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR015096 DUF1897
     IPR004087 KH_dom
     IPR004088 KH_dom_type_1

    Graphical View of Domain Structure for InterPro Entry Q92945

    ProtoNet protein and cluster: Q92945

    2 Blocks protein domains:
    IPB004087 KH domain
    IPB004088 KH


    UniProtKB/Swiss-Prot: FUBP2_HUMAN, Q92945
    Domain: KH domains KH 3 and KH 4 behave as independent binding modules and can interact with different regions of
    the AU-rich RNA targets of degradation
    Similarity: Belongs to the KHSRP family
    Similarity: Contains 4 KH domains


    KHSRP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FUBP2_HUMAN, Q92945
    Function: Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part
    of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion
    in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA
    from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently
    unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery
    to ARE-containing mRNAs

         Genatlas biochemistry entry for KHSRP:
    K homology-type splicing regulatory protein,highly expressed in neural cells

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding IEA--
         
    KHSRP for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for KHSRP:
     Cell cycle / mitosis defect  Decreased DCP1a protein expres 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Khsrp):
     immune system  mortality/aging 

    KHSRP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Khsrptm1.1Cyc for KHSRP

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KHSRP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KHSRP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KHSRP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KHSRP 

    miRNA
    Products:
        
    miRTarBase miRNAs that target KHSRP:
    hsa-mir-24 (MIRT005397)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KHSRP
    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate KHSRP (see all 42):
    hsa-miR-548j hsa-miR-3164 hsa-miR-513a-5p hsa-miR-374a* hsa-miR-3613-3p hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidKHSRP 3' UTR sequence
    Inhib. RNA
    Products:
        
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KHSRP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KHSRP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    2CDK-mediated phosphorylation and removal of Cdc6
    Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.63
    3Destabilization of mRNA by Tristetraprolin (TTP)
    Destabilization of mRNA by KSRP0.56
    4Generic Transcription Pathway
    Gene Expression0.47
    5Translational Control
    Translational Control

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for KHSRP
        Translational Control

    5        Reactome Pathways for KHSRP
        Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
    Destabilization of mRNA by KSRP
    Metabolism of RNA
    Metabolism of mRNA
    Gene Expression



    KHSRP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KHSRP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/96 Interacting proteins for KHSRP (Q929452, 3 ENSP000003812164) via UniProtKB, MINT, STRING, and/or I2D (see all 96)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK3Q131882, 3, ENSP000003905004MINT-8272243 I2D: score=3 STRING: ENSP00000390500
    GSK3BP498412, 3MINT-8257361 I2D: score=2 
    GADD45AP245222, 3, ENSP000003600254MINT-8255890 I2D: score=2 STRING: ENSP00000360025
    PARNO954533, ENSP000003879114I2D: score=3 STRING: ENSP00000387911
    APBB1O002133, ENSP000002994024I2D: score=2 STRING: ENSP00000299402
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000375RNA splicing, via transesterification reactions TAS10911989
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing TAS10911989

    KHSRP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KHSRP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KHSRP (FUBP2)

    5 Novoseek inferred chemical compound relationships for KHSRP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aspartate 3.91 1 8094340 (1)
    nitric oxide 0 1 16126846 (1)
    tyrosine 0 2 7512816 (1), 10524342 (1)
    potassium 0 2 8187634 (1), 8094340 (1)
    glutamate 0 2 12902347 (1)

    Search CenterWatch for drugs/clinical trials and news about KHSRP / FUBP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KHSRP gene: 
    NM_003685.2  

    Unigene Cluster for KHSRP:

    KH-type splicing regulatory protein
    Hs.727344  [show with all ESTs]
    Unigene Representative Sequence: NM_003685
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398148(uc002mer.4) ENST00000594745 ENST00000597656 ENST00000595223
    ENST00000594496 ENST00000600480 ENST00000599642 ENST00000595112 ENST00000599395
    ENST00000595548 ENST00000595258 ENST00000597704

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KHSRP
    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate KHSRP (see all 42):
    hsa-miR-548j hsa-miR-3164 hsa-miR-513a-5p hsa-miR-374a* hsa-miR-3613-3p hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidKHSRP 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KHSRP

    Additional mRNA sequence: 

    AB209662.1 AK300957.1 BC085004.1 U69126.1 U94832.1 

    24/27 DOTS entries (see all 27):

    DT.450522  DT.102833878  DT.95201177  DT.95131908  DT.121505026  DT.99982283  DT.100841431  DT.100841430 
    DT.92451901  DT.97855581  DT.100038918  DT.121505024  DT.121505044  DT.86844296  DT.91790383  DT.92451912 
    DT.95131947  DT.121505004  DT.95131949  DT.95175684  DT.95226246  DT.95280390  DT.100841433  DT.121505015 

    24/550 AceView cDNA sequences (see all 550):

    CA426796 BG166442 AA811702 BX385194 AI970872 AI766575 W19136 AI700954 
    AW402223 AI049661 BQ186293 BM727302 BG115664 BG150698 BM142121 AA570316 
    BU784853 BU849959 BM743461 BM725181 BU786597 BM676951 AI571405 BG152579 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for KHSRP (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                -                           
    SP4:        -                                                                                                                                                   
    SP5:        -                                   -     -                                                                                                         

    ExUns: 17b · 17c · 17d ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for KHSRP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KHSRP expression in normal human tissues (normalized intensities)      KHSRP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAGCCAGC
    KHSRP Expression
    About this image


    KHSRP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Testis (Reproductive System)    fully expand to see all 5 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             superior temporal gyrus   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus (Reproductive System)    fully expand to see all 5 entries
             uterus, post-menopause ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             umbilical cord reticulocytes   

    See KHSRP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KHSRP

    SOURCE GeneReport for Unigene cluster: Hs.727344

    UniProtKB/Swiss-Prot: FUBP2_HUMAN, Q92945
    Tissue specificity: Detected in neural and non-neural cell lines

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KHSRP gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Khsrp1 , 5 KH-type splicing regulatory protein1, 5 87.32(n)1
    98.45(a)1
      17 (29.63 cM)5
    165491  NM_010613.31  NP_034743.31 
     570210585 
    lizard
    (Anolis carolinensis)
    Reptilia KHSRP6
    KH-type splicing regulatory protein
    91(a)
    1 ↔ 1
    2(76375754-76409162)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF533513.12   -- 77.9(n)    AF533513.1 
    zebrafish
    (Danio rerio)
    Actinopterygii khsrp1 KH-type splicing regulatory protein 72.07(n)
    79.21(a)
      573145  NM_001089428.1  NP_001082897.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Psi1 P-element somatic inhibitor 48.48(n)
    41.07(a)
      36889  NM_057775.3  NP_477123.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C12D8.1b3 RNA binding protein 38(a)
    (best of 6)
      V(10238862-10240838)   --


    ENSEMBL Gene Tree for KHSRP (if available)
    TreeFam Gene Tree for KHSRP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KHSRP gene
    FUBP12  FUBP32  
    5 SIMAP similar genes for KHSRP using alignment to 9 protein entries:     FUBP2_HUMAN (see all proteins):
    FUBP1    NOVA1    FUBP3    PCBP2    IGF2BP2

    KHSRP for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KHSRP
    PGOHUM00000263229


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/314 SNPs in KHSRP are shown (see all 314)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1913953261,2
    --6412917(+) GTCCCC/TGAGGC 1 -- ds50010--------
    rs16130701,2
    C,F,A,H--6412929(-) GCGCTT/CAGGAG 1 -- ds500127Minor allele frequency- C:0.46NS EA NA WA CSA 2771
    rs2002160251,2
    C--6413010(+) CTTCC-/CACATGG 1 -- ds50010--------
    rs16638021,2
    C,F,H--6413015(+) CACATC/GGGAAG 1 -- ds500111Minor allele frequency- G:0.36MN NA WA CSA EA 556
    rs1835920161,2
    --6413069(+) CTTGCC/TCAACT 1 -- ds50010--------
    rs673545901,2
    C--6413144(+) AAAAA-/AGGGGG 1 -- ut310--------
    rs603658881,2
    C--6413155(+) AAAAAG/AGGGGG 1 -- ut312Minor allele frequency- A:0.00NA 4
    rs1893594961,2
    --6413235(+) ACACAA/CAGTTT 1 -- ut310--------
    rs579188121,2
    --6413433(+) TTTTTG/TTTGTT 1 -- ut310--------
    rs1424233161,2
    --6413505(+) GGGAGA/GGGGGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KHSRP (6413115 - 6424822 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for KHSRP:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv910916CNV Loss21882294
    nsv910922CNV Loss21882294
    nsv910923CNV Loss21882294
    nsv833727CNV Loss17160897
    dgv3698n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603445    OMIM disorders: --

    18 diseases for KHSRP:    About MalaCards
    spinocerebellar ataxia type 17    poliomyelitis    pheochromocytoma    endocarditis
    spinal muscular atrophy    spinocerebellar ataxia    muscular atrophy    ataxia
    ischemia    hypoxia    neuroblastoma    alzheimer's disease
    hepatocellular carcinoma    cervicitis    melanoma    neuronitis
    breast cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for KHSRP:
    Poliomyelitis

    KHSRP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for KHSRP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pheochromocytoma 19 2 8930347 (1), 11027214 (1)
    neurodegeneration 12.4 1 10213477 (1)


    Export disorders for KHSRP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KHSRP gene, integrated from 9 sources (see all 127):
    (articles sorted by number of sources associating them with KHSRP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer. (PubMed id 9136930)1, 2, 3, 9 Min H.... Black D.L. (1997)
    2. The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators. (PubMed id 8940189)1, 2, 3, 9 Davis-Smyth T....Levens D. (1996)
    3. Mapping of the KHSRP gene to a region of conserved synteny on human chromosome 19p13.3 and mouse chromosome 17. (PubMed id 10087204)1, 2, 9 Ring H.Z....Francke U. (1999)
    4. A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery. (PubMed id 15175153)1, 2, 9 Gherzi R....Chen C.-Y. (2004)
    5. Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein. (PubMed id 11003644)1, 2, 9 Markovtsov V....Black D.L. (2000)
    6. Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding. (PubMed id 19198587)1, 2 DA-az-Moreno I....Ramos A. (2009)
    7. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    9. KSRP-PMR1-exosome association determines parathyroid hormone mRNA levels and stability in transfected cells. (PubMed id 19775426)1, 9 Nechama M....Naveh-Many T. (2009)
    10. The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. (PubMed id 19458619)1, 9 Trabucchi M....Rosenfeld M.G. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8570 HGNC: 6316 AceView: KHSRP Ensembl:ENSG00000088247 euGenes: HUgn8570
    ECgene: KHSRP H-InvDB: KHSRP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KHSRP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KHSRP gene:
    Search GeneIP for patents involving KHSRP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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