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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KHSRP Gene

protein-coding GIFtS: 60
GCID: GC19M006413

KH-type splicing regulatory protein

Explore 22 diseases affiliated with
KHSRP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
KH-Type Splicing Regulatory Protein¹ ²		KH Type-Splicing Regulatory Protein² ³
FUBP2¹ ² ³ ⁵		P75¹
KSRP¹ ² ³ ⁵		Far Upstream Element-Binding Protein 2²
FBP2¹ ² ⁵		FUSE Binding Protein 2²
FUSE-Binding Protein 2² ³

External Ids:	HGNC: 6316¹	Entrez Gene: 8570²	Ensembl: ENSG00000088247⁷	OMIM: 603445⁵	UniProtKB: Q92945³

Export aliases for KHSRP gene to outside databases

Previous GC identifers: GC19M006507 GC19M006481 GC19M006353 GC19M006364 GC19M006173

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KHSRP:

The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including

transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 (PubMed 9136930); Gherzi et al.,

2004 (PubMed 15175153)).(supplied by OMIM, Apr 2010)

UniProtKB/Swiss-Prot: FUBP2_HUMAN, Q92945

Function: Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a

ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in

transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the

far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs

that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing

mRNAs

Gene Wiki entry for KHSRP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011255.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KHSRP gene promoter:
E2F-4 E2F-3a E2F-5 Nkx2-5 E2F-2 NF-kappaB AREB6 E2F-1 COMP1 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KHSRP promoter sequence

Search SABiosciences Chromatin IP Primers for KHSRP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KHSRP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3

KHSRP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KHSRP gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M006413: view genomic region (about GC identifiers)

Start:	6,413,115 bp from pter	End:	6,424,822 bp from pter
Size:	11,708 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FUBP2_HUMAN, Q92945 (See protein sequence)

Recommended Name: Far upstream element-binding protein 2

Size: 711 amino acids; 73115 Da

Subunit: Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRPH1. Interacts with PARN

Subcellular location: Nucleus. Cytoplasm. Note=A small proportion is also found in the cytoplasm of neuronal cell

bodies and dendrites (By similarity)

Sequence caution: Sequence=AAC50892.1; Type=Frameshift; Positions=304, 309, 466, 473; Sequence=AAH85004.1;

Type=Miscellaneous discrepancy; Note=Aberrant splicing;

6 PDB 3D structures from and Proteopedia for KHSRP:

2HH2 (3D)

2HH3 (3D)

2JVZ (3D)

2OPU (3D)

2OPV (3D)

4B8T (3D)

Secondary accessions: O00301 Q59EZ9 Q5U4P6 Q9UNT5 Q9UQH5

Explore the universe of human proteins at neXtProt for KHSRP: NX_Q92945

Post-translational modifications:

Phosphorylation at Ser-193 leads to the unfolding of the unstable KH domain 1, creating a site for 14-3-3 YWHAZ

binding, which promotes nuclear localization and impairs the RNA degradation function¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92945

KHSRP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003676.2

ENSEMBL proteins:

ENSP00000381216

Reactome Protein details: Q92945
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals KHSRP Protein Novus Biologicals KHSRP Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KHSRP

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005829	cytosol	TAS	--
GO:0010494	cytoplasmic stress granule	IEA	--

KHSRP for ontologies About GeneDecksing

KHSRP Antibody Products:

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	Novus Biologicals KHSRP Antibodies
	Abcam antibodies for KHSRP
	Uscn Antibodies for KHSRP
	Search ThermoFisher Antibodies for KHSRP

Assay Products for KHSRP:

	Browse Kits and Assays available from EMD Millipore
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for KHSRP
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for KHSRP

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KHSRP for domains About GeneDecksing

3 InterPro domains/families:

IPR004087 KH_dom

IPR015096 DUF1897

IPR004088 KH_dom_type_1

Graphical View of Domain Structure for InterPro Entry Q92945

ProtoNet protein and cluster: Q92945

2 Blocks protein families:

IPB004087 KH domain

IPB004088 KH

UniProtKB/Swiss-Prot: FUBP2_HUMAN, Q92945

Domain: KH domains KH 3 and KH 4 behave as independent binding modules and can interact with different regions of the

AU-rich RNA targets of degradation

Similarity: Belongs to the KHSRP family

Similarity: Contains 4 KH domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FUBP2_HUMAN, Q92945

Function: Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a

ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in

transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the

far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs

that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing

mRNAs

Genatlas biochemistry entry for KHSRP:

K homology-type splicing regulatory protein,highly expressed in neural cells

miRNA Products:		miRTarBase miRNAs that target KHSRP: hsa-mir-24 (MIRT005397)

		OriGene 3'-UTR Clone: KHSRP Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KHSRP
		8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate KHSRP (see all 42):
		hsa-miR-548j hsa-miR-3164 hsa-miR-513a-5p hsa-miR-374a* hsa-miR-3613-3p hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-23a

		SwitchGear 3'UTR luciferase reporter plasmid: KHSRP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KHSRP (see all 6) OriGene siRNA: KHSRP
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for KHSRP

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		GenScript: all cDNA clones in your preferred vector: KHSRP (NM_003685)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KHSRP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KHSRP

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KHSRP
		Search LifeMap BioReagents cell lines for KHSRP

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KHSRP

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003723	RNA binding	IEA	--

KHSRP for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for KHSRP:

Cell cycle / mitosis defect

Decreased DCP1a protein expres

Animal Models:
Mouse knock-out Khsrp^tm1.1Cyc for KHSRP
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Khsrp):

immune system

mortality/aging

KHSRP for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Metabolism of mRNA

Metabolism of mRNA

1.00

Metabolism of RNA

0.92

Phosphorylated KSRP (Ser193) Binds 14-3-3zeta in the Nucleus

Phosphorylated KSRP (Ser193) Binds 14-3-3zeta in the Nucleus

1.00

Translational Control

Translational Control

1.00

Ubiquitinated Orc1 is degraded by the proteasome

Regulation of mRNA Stability by Proteins that Bind AU-rich Elements

0.55

Destabilization of mRNA by Tristetraprolin (TTP)

Destabilization of mRNA by KSRP

0.48

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for KHSRP

Translational Control

5/6 Reactome Pathways for KHSRP (see all 6)

	Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
	Destabilization of mRNA by KSRP
	Metabolism of RNA
	Metabolism of mRNA
	Phosphorylated KSRP (Ser193) Binds 14-3-3zeta in the Nucleus

KHSRP for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KHSRP

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/96 Interacting proteins for KHSRP (Q92945^{2, 3} ENSP00000381216⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 96)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STK3	Q13188²^,³, ENSP00000390500⁴	MINT-8272243 I2D: score=3 STRING: ENSP00000390500
GSK3B	P49841²^,³	MINT-8257361 I2D: score=2
GADD45A	P24522²^,³, ENSP00000360025⁴	MINT-8255890 I2D: score=2 STRING: ENSP00000360025
PARN	O95453³, ENSP00000387911⁴	I2D: score=3 STRING: ENSP00000387911
APBB1	O00213³, ENSP00000299402⁴	I2D: score=2 STRING: ENSP00000299402

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000375	RNA splicing, via transesterification reactions	TAS	10911989
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006397	mRNA processing	IEA	--
GO:0008380	RNA splicing	TAS	10911989

KHSRP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

KHSRP for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KHSRP
5 Novoseek chemical compound relationships for KHSRP gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
aspartate	3.91	1	8094340 (1)
nitric oxide	0	1	16126846 (1)
tyrosine	0	2	7512816 (1), 10524342 (1)
potassium	0	2	8187634 (1), 8094340 (1)
glutamate	0	2	12902347 (1)

Search CenterWatch for drugs/clinical trials and news about KHSRP / FUBP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KHSRP gene:

NM_003685.2

Unigene Cluster for KHSRP:

KH-type splicing regulatory protein

Hs.727344 [show with all ESTs]

Unigene Representative Sequence: NM_003685

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000398148(uc002mer.4)

miRNA Products:		OriGene 3'-UTR Clone: KHSRP Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KHSRP
		8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate KHSRP (see all 42):
		hsa-miR-548j hsa-miR-3164 hsa-miR-513a-5p hsa-miR-374a* hsa-miR-3613-3p hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-23a

		SwitchGear 3'UTR luciferase reporter plasmid: KHSRP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KHSRP (see all 6) OriGene siRNA: KHSRP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KHSRP

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KHSRP (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KHSRP OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KHSRP (NM_003685)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KHSRP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KHSRP

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		SABiosciences RT² qPCR Primer Assay in human, mouse / rat KHSRP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KHSRP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KHSRP

Additional cDNA sequence:

AB209662.1 AK300957.1 BC085004.1 U69126.1 U94832.1

24/27 DOTS entries (see all 27):

DT.450522 DT.102833878 DT.95201177 DT.95131908 DT.121505026 DT.99982283 DT.100841431 DT.100841430

DT.92451901 DT.97855581 DT.100038918 DT.121505024 DT.121505044 DT.86844296 DT.91790383 DT.92451912

DT.95131947 DT.121505004 DT.95131949 DT.95175684 DT.95226246 DT.95280390 DT.100841433 DT.121505015

24/550 AceView cDNA sequences (see all 550):

AW338388 AA251928 BM931235 AI571405 BQ271345 AI656182 BM692316 BE270259

AI217268 AW058481 AI624123 CB216491 BG152579 BG166442 CA426796 BM930697

BQ212164 BQ065367 BU729479 BM719533 W46407 BM676951 BM557921 H25814

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for KHSRP (see all 13) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10a	·	10b	^	11a	·	11b	·	11c	^	12	^	13a	·	13b	·	13c	^	14a	·	14b	·	14c	^	15	^	16	^	17a	·
SP1:
SP2:
SP3:																																											-
SP4:			-
SP5:			-												-		-

ExUns:	17b	·	17c	·	17d	^	18a	·	18b	^	19	^	20a	·	20b	·	20c	^	21a	·	21b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for KHSRP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KHSRP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGAGCCAGC

About this image

KHSRP expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Reproductive System

Early Gonad

Testis Somatic Cells

Testis

Limb

Limb Bud

Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KHSRP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KHSRP

SOURCE GeneReport for Unigene cluster: Hs.727344

UniProtKB/Swiss-Prot: FUBP2_HUMAN, Q92945

Tissue specificity: Detected in neural and non-neural cell lines

SABiosciences Custom PCR Arrays for KHSRP

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KHSRP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat KHSRP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KHSRP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KHSRP

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KHSRP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for KHSRP gene from 8/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FUBP3⁶	--	53(a)	possible ortholog	Un(63862637-63863565)
lizard (Anolis carolinensis)	Reptilia	KHSRP⁶	--	90(a)	1 ↔ 1	2(76376007-76402869)
African clawed frog (Xenopus laevis)	Amphibia	AF533513.1²	--	77.9(n)		AF533513.1
zebrafish (Danio rerio)	Actinopterygii	khsrp¹	KH-type splicing regulatory protein	72.07(n) 79.21(a)		573145 NM_001089428.1 NP_001082897.1
fruit fly (Drosophila melanogaster)	Insecta	Psi¹	P-element somatic inhibitor	48.48(n) 41.07(a)		36889 NM_057775.3 NP_477123.1
worm (Caenorhabditis elegans)	Secernentea	C12D8.1b³	RNA binding protein	38(a) (best of 6)		V(10238862-10240838) --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G25970⁶ AT4G10070⁶ (see all 3)	KH domain-containing protein (see all 3)	12(a) 11(a) (see all 3)	possible ortholog possible ortholog (see all 3)	2(11071651-11075669) 4(6295608-6299836)
rice (Oryza sativa)	Liliopsida	-- --	KH domain-containing protein, putative, expressed	11(a) 11(a)	possible ortholog possible ortholog	2(6979511-6985051) 8(571856-577417)

ENSEMBL Gene Tree for KHSRP (if available)
TreeFam Gene Tree for KHSRP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KHSRP gene

PCBP2² FUBP1² PCBP4² NOVA2² HNRNPK² PCBP1² NOVA1² PCBP3²

FUBP3²

4 SIMAP similar genes for KHSRP using alignment to 9 protein entries: FUBP2_HUMAN (see all proteins):

FUBP1 FUBP3 NOVA1 PCBP2

KHSRP for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for KHSRP
PGOHUM00000263229

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs151113169^1,2		--	6412635(+)	`CGGGGC/GTATCA`	1	--	ds500¹		0	--	--	--	--
rs192958073^1,2		--	6412641(+)	`TATCAC/GCAGGC`	1	--	ds500¹		0	--	--	--	--
rs182417533^1,2		--	6412669(+)	`CTAAGA/TTGAAG`	1	--	ds500¹		0	--	--	--	--
rs111667349^1,2	C,	--	6412729(+)	`GCATGC/TGGGGC`	1	--	ds500¹		1		WA	2
rs150292036^1,2		--	6412746(+)	`ACACCC/TGCCCA`	1	--	ds500¹		0	--	--	--	--
rs115779317^1,2	F,	--	6412778(+)	`CCCTCG/AGTGCC`	1	--	ds500¹		1		WA	118
rs77781404^1,2	C	--	6412843(+)	`CTCCCA/CCCTCA`	1	--	ds500¹		0	--	--	--	--
rs137944331^1,2		--	6412852(+)	`CAGGGA/CTCTGA`	1	--	ds500¹		0	--	--	--	--
rs186951318^1,2		--	6412884(+)	`TCCTGA/TAGCAA`	1	--	ds500¹		0	--	--	--	--
rs191395326^1,2		--	6412917(+)	`GTCCCC/TGAGGC`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KHSRP (6413115 - 6424822 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KHSRP: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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KHSRP for disorders           About GeneDecksing

OMIM gene information: 603445    OMIM disorders: --

20/22 diseases for KHSRP (see all 22):    About MalaCards

spinal muscular atrophy spinocerebellar ataxia type 17 spinocerebellar ataxia muscular atrophy

poliomyelitis pheochromocytoma neurodegeneration endocarditis

ataxia liver cancer hepatocellular carcinoma alzheimer's disease

breast cancer ischemia cervicitis hypoxia

neuroblastoma melanoma carcinoma malaria

1 disease from the University of Copenhagen DISEASES database for KHSRP:

Poliomyelitis

2 Novoseek disease relationships for KHSRP gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pheochromocytoma	19	2	8930347 (1), 11027214 (1)
neurodegeneration	12.4	1	10213477 (1)

Export disorders for KHSRP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for KHSRP gene, integrated from 9 sources (see all 117):
(articles sorted by number of sources associating them with KHSRP)

Utopia: connect your pdf to the dynamic
world of online information

A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer. (PubMed id 9136930)^{1, 2, 3, 9} Min H.... Black D.L. (1997)
The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators. (PubMed id 8940189)^{1, 2, 3, 9} Davis-Smyth T....Levens D. (1996)
Mapping of the KHSRP gene to a region of conserved synteny on human chromosome 19p13.3 and mouse chromosome 17. (PubMed id 10087204)^{1, 2, 9} Ring H.Z....Francke U. (1999)
A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery. (PubMed id 15175153)^{1, 2, 9} Gherzi R....Chen C.-Y. (2004)
Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein. (PubMed id 11003644)^{1, 2, 9} Markovtsov V....Black D.L. (2000)
Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding. (PubMed id 19198587)^{1, 2} DA-az-Moreno I....Ramos A. (2009)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
KSRP-PMR1-exosome association determines parathyroid hormone mRNA levels and stability in transfected cells. (PubMed id 19775426)^{1, 9} Nechama M....Naveh-Many T. (2009)
The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. (PubMed id 19458619)^{1, 9} Trabucchi M....Rosenfeld M.G. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8570	HGNC: 6316	AceView: KHSRP	Ensembl:ENSG00000088247	euGenes: HUgn8570
ECgene: KHSRP	H-InvDB: KHSRP

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for KHSRP	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KHSRP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KHSRP gene:
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GeneCards and IP:
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