Aliases for KHSRP Gene
External Ids for KHSRP Gene
Previous GeneCards Identifiers for KHSRP Gene
The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]
GeneCards Summary for KHSRP Gene
KHSRP (KH-Type Splicing Regulatory Protein) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Regulation of activated PAK-2p34 by proteasome mediated degradation. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is FUBP1.
UniProtKB/Swiss-Prot for KHSRP Gene
Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.