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Aliases for KHSRP Gene

Aliases for KHSRP Gene

  • KH-Type Splicing Regulatory Protein 2 3
  • FUBP2 3 4 6
  • KSRP 3 4 6
  • KH Type-Splicing Regulatory Protein 3 4
  • FUSE Binding Protein 2 2 3
  • FUSE-Binding Protein 2 3 4
  • FBP2 3 6
  • P75 3 4
  • Far Upstream Element-Binding Protein 2 3

External Ids for KHSRP Gene

Previous GeneCards Identifiers for KHSRP Gene

  • GC19M006507
  • GC19M006481
  • GC19M006353
  • GC19M006364
  • GC19M006173

Summaries for KHSRP Gene

Entrez Gene Summary for KHSRP Gene

  • The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]

GeneCards Summary for KHSRP Gene

KHSRP (KH-Type Splicing Regulatory Protein) is a Protein Coding gene. Diseases associated with KHSRP include pheochromocytoma. Among its related pathways are Metabolism and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding. An important paralog of this gene is FUBP1.

UniProtKB/Swiss-Prot for KHSRP Gene

  • Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.

Gene Wiki entry for KHSRP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KHSRP Gene

Genomics for KHSRP Gene

Regulatory Elements for KHSRP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KHSRP Gene

Start:
6,413,104 bp from pter
End:
6,424,811 bp from pter
Size:
11,708 bases
Orientation:
Minus strand

Genomic View for KHSRP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KHSRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KHSRP Gene

Proteins for KHSRP Gene

  • Protein details for KHSRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92945-FUBP2_HUMAN
    Recommended name:
    Far upstream element-binding protein 2
    Protein Accession:
    Q92945
    Secondary Accessions:
    • O00301
    • Q59EZ9
    • Q5U4P6
    • Q9UNT5
    • Q9UQH5

    Protein attributes for KHSRP Gene

    Size:
    711 amino acids
    Molecular mass:
    73115 Da
    Quaternary structure:
    • Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRPH1. Interacts with PARN.
    SequenceCaution:
    • Sequence=AAC50892.1; Type=Frameshift; Positions=304, 309, 466, 473; Evidence={ECO:0000305}; Sequence=AAH85004.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KHSRP Gene

neXtProt entry for KHSRP Gene

Proteomics data for KHSRP Gene at MOPED

Post-translational modifications for KHSRP Gene

  • Phosphorylation at Ser-193 leads to the unfolding of the unstable KH domain 1, creating a site for 14-3-3 YWHAZ binding, which promotes nuclear localization and impairs the RNA degradation function.
  • Ubiquitination at Lys109, Lys257, and Lys488
  • Modification sites at PhosphoSitePlus

Other Protein References for KHSRP Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for KHSRP (KHSRP)

No data available for DME Specific Peptides for KHSRP Gene

Domains for KHSRP Gene

Protein Domains for KHSRP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for KHSRP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92945

UniProtKB/Swiss-Prot:

FUBP2_HUMAN :
  • Q92945
Domain:
  • KH domains KH 3 and KH 4 behave as independent binding modules and can interact with different regions of the AU-rich RNA targets of degradation
  • Contains 4 KH domains.
Family:
  • Belongs to the KHSRP family.
genes like me logo Genes that share domains with KHSRP: view

No data available for Gene Families for KHSRP Gene

Function for KHSRP Gene

Molecular function for KHSRP Gene

GENATLAS Biochemistry: K homology-type splicing regulatory protein,highly expressed in neural cells
UniProtKB/Swiss-Prot Function: Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.

Gene Ontology (GO) - Molecular Function for KHSRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding --
GO:0003729 mRNA binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with KHSRP: view
genes like me logo Genes that share phenotypes with KHSRP: view

Animal Models for KHSRP Gene

MGI Knock Outs for KHSRP:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KHSRP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KHSRP Gene

Localization for KHSRP Gene

Subcellular locations from UniProtKB/Swiss-Prot for KHSRP Gene

Nucleus. Cytoplasm. Note=A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KHSRP Gene COMPARTMENTS Subcellular localization image for KHSRP gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 1

Gene Ontology (GO) - Cellular Components for KHSRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0010494 cytoplasmic stress granule IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with KHSRP: view

Pathways for KHSRP Gene

genes like me logo Genes that share pathways with KHSRP: view

Pathways by source for KHSRP Gene

1 Cell Signaling Technology pathway for KHSRP Gene
2 BioSystems pathways for KHSRP Gene

Gene Ontology (GO) - Biological Process for KHSRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000375 RNA splicing, via transesterification reactions TAS 10911989
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006397 mRNA processing IEA --
GO:0006402 mRNA catabolic process IEA --
genes like me logo Genes that share ontologies with KHSRP: view

Compounds for KHSRP Gene

(5) Novoseek inferred chemical compound relationships for KHSRP Gene

Compound -log(P) Hits PubMed IDs
aspartate 3.91 1
nitric oxide 0 1
tyrosine 0 2
potassium 0 2
glutamate 0 1
genes like me logo Genes that share compounds with KHSRP: view

Transcripts for KHSRP Gene

Unigene Clusters for KHSRP Gene

KH-type splicing regulatory protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KHSRP

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KHSRP
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KHSRP Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a ·
SP1:
SP2:
SP3: -
SP4: -
SP5: - - -
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 17b · 17c · 17d ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - - -
SP11: - -
SP12: -
SP13:

Relevant External Links for KHSRP Gene

GeneLoc Exon Structure for
KHSRP
ECgene alternative splicing isoforms for
KHSRP

Expression for KHSRP Gene

mRNA expression in normal human tissues for KHSRP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KHSRP Gene

SOURCE GeneReport for Unigene cluster for KHSRP Gene Hs.727344

mRNA Expression by UniProt/SwissProt for KHSRP Gene

Q92945-FUBP2_HUMAN
Tissue specificity: Detected in neural and non-neural cell lines
genes like me logo Genes that share expressions with KHSRP: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for KHSRP Gene

Orthologs for KHSRP Gene

This gene was present in the common ancestor of animals.

Orthologs for KHSRP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KHSRP 35
  • 99.62 (n)
  • 100 (a)
KHSRP 36
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KHSRP 35
  • 90.16 (n)
  • 99.39 (a)
KHSRP 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KHSRP 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Khsrp 35
  • 87.55 (n)
  • 98.71 (a)
Khsrp 16
Khsrp 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KHSRP 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KHSRP 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Khsrp 35
  • 87.92 (n)
  • 98.39 (a)
lizard
(Anolis carolinensis)
Reptilia KHSRP 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia khsrp 35
  • 73.36 (n)
  • 81.24 (a)
zebrafish
(Danio rerio)
Actinopterygii khsrp 35
  • 71.18 (n)
  • 77.02 (a)
khsrp 36
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Psi 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C12D8.1 36
  • 27 (a)
ManyToMany
C36E6.1 36
  • 26 (a)
ManyToMany
M01A10.1 36
  • 25 (a)
ManyToMany
ZK418.9 36
  • 27 (a)
ManyToMany
ZK418.9 37
  • 32 (a)
C12D8.1a 37
  • 38 (a)
C36E6.1a 37
  • 35 (a)
C12D8.1b 37
  • 38 (a)
C36E6.1b 37
  • 35 (a)
M01A10.1 37
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
Species with no ortholog for KHSRP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KHSRP Gene

ENSEMBL:
Gene Tree for KHSRP (if available)
TreeFam:
Gene Tree for KHSRP (if available)

Paralogs for KHSRP Gene

Paralogs for KHSRP Gene

Selected SIMAP similar genes for KHSRP Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for KHSRP Gene

genes like me logo Genes that share paralogs with KHSRP: view

Variants for KHSRP Gene

Sequence variations from dbSNP and Humsavar for KHSRP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs15383 -- 6,413,715(-) TCTGA(G/T)GATAA utr-variant-3-prime
rs1051784 -- 6,414,440(-) GTCGT(A/C/T)GTGCT intron-variant, utr-variant-3-prime
rs1613070 -- 6,412,918(-) GCGCT(C/T)AGGAG downstream-variant-500B
rs1616305 -- 6,415,432(+) GGGGG(C/T)GCTCC reference, synonymous-codon
rs1654586 -- 6,414,635(-) CGGCC(C/G/T)GGCTC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KHSRP Gene

Variant ID Type Subtype PubMed ID
dgv3698n71 CNV Loss 21882294
nsv910916 CNV Loss 21882294
nsv833727 CNV Loss 17160897
nsv910922 CNV Loss 21882294
nsv910923 CNV Loss 21882294

Relevant External Links for KHSRP Gene

HapMap Linkage Disequilibrium report
KHSRP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KHSRP Gene

Disorders for KHSRP Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for KHSRP Gene including...

Search for KHSRP Gene in MalaCards »

(1) University of Copenhagen DISEASES for KHSRP Gene

(2) Novoseek inferred disease relationships for KHSRP Gene

Disease -log(P) Hits PubMed IDs
pheochromocytoma 19 2
neurodegeneration 12.4 1
genes like me logo Genes that share disorders with KHSRP: view

No data available for UniProtKB/Swiss-Prot for KHSRP Gene

Publications for KHSRP Gene

  1. A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer. (PMID: 9136930) Min H. … Black D.L. (Genes Dev. 1997) 2 3 4 23
  2. The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators. (PMID: 8940189) Davis-Smyth T. … Levens D. (J. Biol. Chem. 1996) 2 3 4 23
  3. A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery. (PMID: 15175153) Gherzi R. … Chen C.-Y. (Mol. Cell 2004) 3 4 23
  4. Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein. (PMID: 11003644) Markovtsov V. … Black D.L. (Mol. Cell. Biol. 2000) 3 4 23
  5. Mapping of the KHSRP gene to a region of conserved synteny on human chromosome 19p13.3 and mouse chromosome 17. (PMID: 10087204) Ring H.Z. … Francke U. (Genomics 1999) 3 4 23

Products for KHSRP Gene

Sources for KHSRP Gene

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