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Aliases for KHNYN Gene

Aliases for KHNYN Gene

  • KH And NYN Domain Containing 2 3 5
  • KIAA0323 2 3 4
  • KH And NYN Domain-Containing Protein 4
  • Protein KHNYN 3

External Ids for KHNYN Gene

Previous HGNC Symbols for KHNYN Gene

  • KIAA0323

Previous GeneCards Identifiers for KHNYN Gene

  • GC14P023969
  • GC14P024900
  • GC14P005013

Summaries for KHNYN Gene

Entrez Gene Summary for KHNYN Gene

  • This gene encodes a protein containing a ribonuclease NYN domain. The function of this protein has yet to be determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for KHNYN Gene

KHNYN (KH And NYN Domain Containing) is a Protein Coding gene. GO annotations related to this gene include RNA binding. An important paralog of this gene is NYNRIN.

Additional gene information for KHNYN Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KHNYN Gene

Genomics for KHNYN Gene

Regulatory Elements for KHNYN Gene

Enhancers for KHNYN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H024422 1.9 FANTOM5 Ensembl ENCODE dbSUPER 37.1 +4.6 4575 10 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 CBLN3 SDR39U1 KHNYN NYNRIN MDP1 NGDN NFATC4 ENSG00000259321 TINF2 ADCY4
GH14H024309 1.3 ENCODE dbSUPER 40.6 -109.4 -109442 8 PKNOX1 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF207 ZNF143 FOS PAF1 KHNYN NGDN NYNRIN LTB4R RNA5SP383 NFATC4 TM9SF1 SDR39U1 RNF31 CIDEB
GH14H023544 1.6 FANTOM5 Ensembl ENCODE dbSUPER 29.6 -877.9 -877875 2 FOXA2 ARNT ZNF473 KLF17 YBX1 SLC30A9 ZNF366 THAP11 ZNF202 CEBPB ACIN1 KHNYN NGDN RNF31 RNA5SP383 PRMT5 RBM23 PRMT5-AS1 TSSK4 TM9SF1
GH14H023566 1.4 Ensembl ENCODE 33.7 -854.8 -854848 3 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 KHNYN RNA5SP383 ACIN1 NGDN TM9SF1 MMP14 TINF2 PRMT5 C14orf93 AP1G2
GH14H024240 1.7 FANTOM5 ENCODE dbSUPER 25.6 -180.9 -180931 3 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 KHNYN RNA5SP383 LOC102724814 TINF2 NGDN NYNRIN RNF31 SDR39U1 ENSG00000259321 TGM1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KHNYN on UCSC Golden Path with GeneCards custom track

Genomic Location for KHNYN Gene

Chromosome:
14
Start:
24,423,171 bp from pter
End:
24,441,834 bp from pter
Size:
18,664 bases
Orientation:
Plus strand

Genomic View for KHNYN Gene

Genes around KHNYN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KHNYN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KHNYN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KHNYN Gene

Proteins for KHNYN Gene

  • Protein details for KHNYN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15037-KHNYN_HUMAN
    Recommended name:
    Protein KHNYN
    Protein Accession:
    O15037
    Secondary Accessions:
    • Q86TZ6
    • Q8IUQ2
    • Q96BA9

    Protein attributes for KHNYN Gene

    Size:
    678 amino acids
    Molecular mass:
    74534 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20781.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KHNYN Gene

neXtProt entry for KHNYN Gene

Post-translational modifications for KHNYN Gene

  • Ubiquitination at isoforms=554
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KHNYN Gene

Domains & Families for KHNYN Gene

Gene Families for KHNYN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KHNYN Gene

Suggested Antigen Peptide Sequences for KHNYN Gene

Graphical View of Domain Structure for InterPro Entry

O15037

UniProtKB/Swiss-Prot:

KHNYN_HUMAN :
  • Belongs to the N4BP1 family.
Family:
  • Belongs to the N4BP1 family.
genes like me logo Genes that share domains with KHNYN: view

Function for KHNYN Gene

Phenotypes From GWAS Catalog for KHNYN Gene

Gene Ontology (GO) - Molecular Function for KHNYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with KHNYN: view

Phenotypes for KHNYN Gene

GenomeRNAi human phenotypes for KHNYN:
genes like me logo Genes that share phenotypes with KHNYN: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KHNYN
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KHNYN Gene

Localization for KHNYN Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KHNYN gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KHNYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with KHNYN: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KHNYN Gene

Pathways & Interactions for KHNYN Gene

SuperPathways for KHNYN Gene

No Data Available

Interacting Proteins for KHNYN Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000251343%0d%0a9606.ENSP00000395259%0d%0a9606.ENSP00000377080%0d%0a9606.ENSP00000362773%0d%0a
Selected Interacting proteins: O15037-KHNYN_HUMAN ENSP00000251343 for KHNYN Gene via IID STRING

Gene Ontology (GO) - Biological Process for KHNYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with KHNYN: view

No data available for Pathways by source and SIGNOR curated interactions for KHNYN Gene

Drugs & Compounds for KHNYN Gene

No Compound Related Data Available

Transcripts for KHNYN Gene

Unigene Clusters for KHNYN Gene

KH and NYN domain containing:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KHNYN
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for KHNYN Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: - -
SP2:
SP3:
SP4: - - -
SP5:

Relevant External Links for KHNYN Gene

GeneLoc Exon Structure for
KHNYN
ECgene alternative splicing isoforms for
KHNYN

Expression for KHNYN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KHNYN Gene

Protein differential expression in normal tissues from HIPED for KHNYN Gene

This gene is overexpressed in Breast (38.9), Heart (14.8), and Peripheral blood mononuclear cells (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KHNYN Gene



NURSA nuclear receptor signaling pathways regulating expression of KHNYN Gene:

KHNYN

SOURCE GeneReport for Unigene cluster for KHNYN Gene:

Hs.713590

Evidence on tissue expression from TISSUES for KHNYN Gene

  • Nervous system(4.4)
  • Intestine(4.3)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with KHNYN: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KHNYN Gene

Orthologs for KHNYN Gene

This gene was present in the common ancestor of animals.

Orthologs for KHNYN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KHNYN 33 34
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia KHNYN 33 34
  • 86.19 (n)
cow
(Bos Taurus)
Mammalia KHNYN 33 34
  • 85.4 (n)
rat
(Rattus norvegicus)
Mammalia Khnyn 33
  • 82.25 (n)
mouse
(Mus musculus)
Mammalia Khnyn 33 16 34
  • 82.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 51 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 15 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 33 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii KHNYN 34
  • 29 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10889 34
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C30F12.1 34
  • 16 (a)
OneToMany
Species where no ortholog for KHNYN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KHNYN Gene

ENSEMBL:
Gene Tree for KHNYN (if available)
TreeFam:
Gene Tree for KHNYN (if available)

Paralogs for KHNYN Gene

Paralogs for KHNYN Gene

(3) SIMAP similar genes for KHNYN Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KHNYN: view

Variants for KHNYN Gene

Sequence variations from dbSNP and Humsavar for KHNYN Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000260818 -- 24,439,000(+) GCTGG(A/G)GGCAG utr-variant-3-prime
rs1000300505 -- 24,428,239(+) TTCCC(C/T)CTCCC intron-variant, upstream-variant-2KB
rs1000399866 -- 24,421,735(+) TCACT(A/G)CAACT upstream-variant-2KB
rs1000564660 -- 24,426,607(+) ACACC(C/T)GATCC intron-variant, utr-variant-3-prime
rs1000598011 -- 24,437,137(+) CATTC(A/G)GAAGA nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KHNYN Gene

Variant ID Type Subtype PubMed ID
dgv1854n100 CNV gain 25217958
nsv482171 CNV loss 20164927
nsv819071 CNV loss 19587683

Variation tolerance for KHNYN Gene

Residual Variation Intolerance Score: 12.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.75; 78.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KHNYN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KHNYN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KHNYN Gene

Disorders for KHNYN Gene

Relevant External Links for KHNYN

Genetic Association Database (GAD)
KHNYN
Human Genome Epidemiology (HuGE) Navigator
KHNYN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KHNYN

No disorders were found for KHNYN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KHNYN Gene

Publications for KHNYN Gene

  1. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 45 60
  2. The NYN domains: novel predicted RNAses with a PIN domain-like fold. (PMID: 17114934) Anantharaman V … Aravind L (RNA biology 2006) 2 3 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for KHNYN Gene

Sources for KHNYN Gene

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