Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KHNYN Gene

Aliases for KHNYN Gene

  • KH And NYN Domain Containing 2 3
  • KIAA0323 2 3 4
  • KH And NYN Domain-Containing Protein 4
  • Protein KHNYN 3

External Ids for KHNYN Gene

Previous HGNC Symbols for KHNYN Gene

  • KIAA0323

Previous GeneCards Identifiers for KHNYN Gene

  • GC14P023969
  • GC14P024900
  • GC14P005013

Summaries for KHNYN Gene

Entrez Gene Summary for KHNYN Gene

  • This gene encodes a protein containing a ribonuclease NYN domain. The function of this protein has yet to be determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for KHNYN Gene

KHNYN (KH And NYN Domain Containing) is a Protein Coding gene. An important paralog of this gene is N4BP1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KHNYN Gene

Genomics for KHNYN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KHNYN Gene

24,429,286 bp from pter
24,441,834 bp from pter
12,549 bases
Plus strand

Genomic View for KHNYN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KHNYN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KHNYN Gene

No data available for Regulatory Elements for KHNYN Gene

Proteins for KHNYN Gene

  • Protein details for KHNYN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein KHNYN
    Protein Accession:
    Secondary Accessions:
    • Q86TZ6
    • Q8IUQ2
    • Q96BA9

    Protein attributes for KHNYN Gene

    678 amino acids
    Molecular mass:
    74534 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA20781.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for KHNYN Gene

Proteomics data for KHNYN Gene at MOPED

Post-translational modifications for KHNYN Gene

  • Ubiquitination at Lys554
  • Modification sites at PhosphoSitePlus

Other Protein References for KHNYN Gene

No data available for DME Specific Peptides for KHNYN Gene

Domains for KHNYN Gene

Protein Domains for KHNYN Gene


Suggested Antigen Peptide Sequences for KHNYN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the N4BP1 family.
  • Belongs to the N4BP1 family.
genes like me logo Genes that share domains with KHNYN: view

No data available for Gene Families for KHNYN Gene

Function for KHNYN Gene

Gene Ontology (GO) - Molecular Function for KHNYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with KHNYN: view

Animal Model Products

CRISPR Products

miRNA for KHNYN Gene

miRTarBase miRNAs that target KHNYN

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KHNYN

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for KHNYN Gene

Localization for KHNYN Gene

Subcellular locations from

Jensen Localization Image for KHNYN Gene COMPARTMENTS Subcellular localization image for KHNYN gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for KHNYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with KHNYN: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KHNYN Gene

Pathways for KHNYN Gene

SuperPathways for KHNYN Gene

No Data Available

Interacting Proteins for KHNYN Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000251343 for KHNYN Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for KHNYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with KHNYN: view

No data available for Pathways by source for KHNYN Gene

Transcripts for KHNYN Gene

Unigene Clusters for KHNYN Gene

KH and NYN domain containing:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KHNYN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KHNYN Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: - -
SP4: - - -

Relevant External Links for KHNYN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KHNYN Gene

mRNA expression in normal human tissues for KHNYN Gene

Protein differential expression in normal tissues for KHNYN Gene

This gene is overexpressed in Breast (38.9), Heart (14.8), and Peripheral blood mononuclear cells (9.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KHNYN Gene

SOURCE GeneReport for Unigene cluster for KHNYN Gene Hs.713590

genes like me logo Genes that share expressions with KHNYN: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for KHNYN Gene

Orthologs for KHNYN Gene

This gene was present in the common ancestor of animals.

Orthologs for KHNYN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KHNYN 35
  • 85.4 (n)
  • 83.56 (a)
  • 83 (a)
(Canis familiaris)
Mammalia KHNYN 35
  • 86.19 (n)
  • 84.21 (a)
  • 84 (a)
(Mus musculus)
Mammalia Khnyn 35
  • 82.22 (n)
  • 80.03 (a)
Khnyn 16
Khnyn 36
  • 80 (a)
(Pan troglodytes)
Mammalia KHNYN 35
  • 99.56 (n)
  • 99.26 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Khnyn 35
  • 82.25 (n)
  • 80.38 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 15 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 51 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 33 (a)
(Danio rerio)
Actinopterygii KHNYN 36
  • 29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10889 36
  • 21 (a)
(Caenorhabditis elegans)
Secernentea C30F12.1 36
  • 16 (a)
Species with no ortholog for KHNYN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KHNYN Gene

Gene Tree for KHNYN (if available)
Gene Tree for KHNYN (if available)

Paralogs for KHNYN Gene

Paralogs for KHNYN Gene

(3) SIMAP similar genes for KHNYN Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KHNYN: view

Variants for KHNYN Gene

Sequence variations from dbSNP and Humsavar for KHNYN Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1956904 -- 24,439,060(-) GGACC(A/G)CTGGG utr-variant-3-prime
rs2038502 -- 24,435,917(-) ATCTA(C/T)AAAAA intron-variant
rs2255591 -- 24,432,638(-) TCTCC(C/T)AGGCC intron-variant
rs2277488 -- 24,436,327(+) GTCTC(A/G)GTTGT intron-variant, downstream-variant-500B
rs2277489 -- 24,436,342(+) GAGGT(A/G)GGCAA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for KHNYN Gene

Variant ID Type Subtype PubMed ID
nsv819071 CNV Loss 19587683
nsv482171 CNV Loss 20164927

Relevant External Links for KHNYN Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KHNYN Gene

Disorders for KHNYN Gene

Relevant External Links for KHNYN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for KHNYN Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for KHNYN Gene

Publications for KHNYN Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. The NYN domains: novel predicted RNAses with a PIN domain-like fold. (PMID: 17114934) Anantharaman V. … Aravind L. (RNA Biol 2006) 2 3
  3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 48
  4. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for KHNYN Gene

Sources for KHNYN Gene

Back to Top