KHNYN Gene
protein-coding GIFtS: 45
GCID: GC14P024900
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|
KH and NYN domain containing(Previous name: KIAA0323 )
(Previous symbol: KIAA0323)
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Aliases
for KHNYN gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| KH And NYN Domain Containing1 2 | | KIAA03231 2 3 | | KH And NYN Domain-Containing Protein2 3 | | Protein KHNYN2 |
Export aliases for KHNYN gene to outside databasesPrevious GC identifers: GC14P023969 GC14P005013 |
Summaries
for KHNYN gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for KHNYN gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for KHNYN
Other transcription factors
Search SABiosciences Chromatin IP Primers for KHNYN
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KHNYN |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q12 Ensembl cytogenetic band: 14q12 HGNC cytogenetic band: 14q11.2KHNYN Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P024900: view genomic region
(about GC identifiers)
Start:
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24,898,492 bp from pter |
End:
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24,910,548 bp from pter |
Size:
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12,057 bases |
Orientation:
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plus strand |
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Proteins
for KHNYN gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KHNYN_HUMAN, O15037 (See
protein sequence)Recommended Name: Protein KHNYN Size: 678 amino acids; 74534 Da
Sequence caution: Sequence=BAA20781.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q86TZ6 Q8IUQ2 Q96BA9Explore the universe of human proteins at neXtProt for KHNYN: NX_O15037
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O15037
KHNYN Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056114.1
ENSEMBL proteins: ENSP00000251343 ENSP00000451106 ENSP00000450799 ENSP00000451004 ENSP00000451227
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
KHNYN for ontologies About GeneDecksing
KHNYN Antibody Products:
Assay Products for KHNYN: |
Protein
Domains /
Families
for KHNYN gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KHNYN for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O15037ProtoNet protein and cluster: O15037 UniProtKB/Swiss-Prot: KHNYN_HUMAN, O15037Similarity: Belongs to the N4BP1 family |
Function
for KHNYN gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KHNYN (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KHNYN
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KHNYN (NM_015299) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KHNYN | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KHNYN |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KHNYN |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
KHNYN for ontologies About GeneDecksing
|
Pathways & Interactions
for KHNYN gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KHNYN
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for KHNYN (ENSP000002513434) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
KHNYN for ontologies About GeneDecksing
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Drugs & Compounds
for KHNYN gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KHNYN
Search CenterWatch for drugs/clinical trials and news about KHNYN
|
Transcripts
for KHNYN gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KHNYN gene: NM_015299.2 Unigene Cluster for KHNYN: KH and NYN domain containing Hs.713590 [show with all ESTs]Unigene Representative Sequence: NM_0152996 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000251343(uc010tpc.2 uc001wph.4 uc010alw.3) ENST00000556842
ENST00000553935 ENST00000556510 ENST00000554268 ENST00000556255
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KHNYN (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KHNYN
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KHNYN (NM_015299) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KHNYN | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KHNYN |
Additional cDNA sequence: AB002321.1 AK291680.1 BC015780.1 BC042554.1 BX161465.1 17 DOTS entries: DT.91940952 DT.100651003 DT.100876010 DT.100745164 DT.120753156 DT.319218 DT.120753175 DT.100692655 DT.100745165 DT.120753077 DT.92036949 DT.95326679 DT.100764222 DT.100770772 DT.120753170 DT.75174154 DT.97855214 24/254 AceView cDNA sequences (see all 254): BM693424 BC042554 AA343637 BX161465 BM455115 BX421353 BQ894894 AA236912 BP428456 BU626256 BC015780 BU521389 AA825446 CK819377 BM128436 BU521509 BQ929272 AI379473 CF141348 BG772254 AI827107 BF327501 BM996094 BX382566
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for KHNYN About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
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| SP1: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KHNYN
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Expression
for KHNYN gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KHNYN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCTGAAGCG
About this image
See KHNYN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KHNYN
SOURCE GeneReport for Unigene cluster: Hs.713590
SABiosciences Custom PCR Arrays for KHNYN
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KHNYN
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KHNYN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KHNYN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KHNYN | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KHNYN |
Orthologs
for KHNYN gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KHNYN gene from 4/13 species (see all 13) About this table
ENSEMBL Gene Tree for KHNYN (if available)
TreeFam Gene Tree for KHNYN (if available) |
Paralogs
for KHNYN gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KHNYN gene
- NYNRIN2 N4BP12 ZC3H12C2 ZC3H12B2 ZC3H12D2 ZC3H12A2
3 SIMAP similar genes for KHNYN using alignment to 3 protein entries: KHNYN_HUMAN (see all proteins):KIAA0323 ZC3H12D ZC3H12B
KHNYN for paralogs About GeneDecksing
|
Genomic Variants
for KHNYN gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KHNYN (24898492 - 24910548 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KHNYN
1 Indel: 58662 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for KHNYN gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KHNYN for disorders About GeneDecksing
2  diseases for KHNYN: About MalaCardsintrahepatic cholangiocarcinoma cholangiocarcinoma
Human Genome Epidemiology (HuGE) Navigator: KHNYN (1 document)
Export disorders for KHNYN gene to outside databases
|
Publications
for KHNYN gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KHNYN gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with KHNYN) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The NYN domains: novel predicted RNAses with a PIN do main-like fold. (PubMed id 17114934)1, 3 Anantharaman V. and Aravind L. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2 Nagase T.... Ohara O. (1997)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)1 Teslovich T.M....Kathiresan S. (2010)
- Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1 Flachsbart F....Nebel A. (2010)
- CGIN1: a retroviral contribution to mammalian genomes . (PubMed id 19561090)1 Marco A. and MarA-n I. (2009)
- Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
|
External Searches for KHNYN gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KHNYN gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KHNYN gene
(According to HUGE)
About This Section
| |
Specialized Databases showing KHNYN gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KHNYN | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KHNYN gene:
Search GeneIP for patents involving KHNYN
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KHNYN gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | Browse OriGene 29mer shRNA kits in GFP-retroviral vector | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KHNYN | | | OriGene Protein Over-expression Lysate for KHNYN | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for KHNYN | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KHNYN | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KHNYN | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KHNYN | | OriGene Custom Protein Services for KHNYN | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KHNYN | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KHNYN | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KHNYN | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KHNYN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KHNYN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KHNYN |
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| | | | Search Tocris compounds for KHNYN |
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 | | | KHNYN Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KHNYN |
|  |  |  | | | | Search ThermoFisher Antibodies for KHNYN |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KHNYN |
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