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Aliases for KHNYN Gene

Aliases for KHNYN Gene

  • KH And NYN Domain Containing 2 3 5
  • KIAA0323 2 3 4
  • KH And NYN Domain-Containing Protein 4

External Ids for KHNYN Gene

Previous HGNC Symbols for KHNYN Gene

  • KIAA0323

Previous GeneCards Identifiers for KHNYN Gene

  • GC14P023969
  • GC14P024900
  • GC14P005013

Summaries for KHNYN Gene

Entrez Gene Summary for KHNYN Gene

  • This gene encodes a protein containing a ribonuclease NYN domain. The function of this protein has yet to be determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for KHNYN Gene

KHNYN (KH And NYN Domain Containing) is a Protein Coding gene. GO annotations related to this gene include RNA binding. An important paralog of this gene is N4BP1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KHNYN Gene

Genomics for KHNYN Gene

Regulatory Elements for KHNYN Gene

Enhancers for KHNYN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KHNYN on UCSC Golden Path with GeneCards custom track

Genomic Location for KHNYN Gene

24,423,171 bp from pter
24,441,834 bp from pter
18,664 bases
Plus strand

Genomic View for KHNYN Gene

Genes around KHNYN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KHNYN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KHNYN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KHNYN Gene

Proteins for KHNYN Gene

  • Protein details for KHNYN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein KHNYN
    Protein Accession:
    Secondary Accessions:
    • Q86TZ6
    • Q8IUQ2
    • Q96BA9

    Protein attributes for KHNYN Gene

    678 amino acids
    Molecular mass:
    74534 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA20781.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for KHNYN Gene

Proteomics data for KHNYN Gene at MOPED

Post-translational modifications for KHNYN Gene

  • Ubiquitination at Lys 554
  • Modification sites at PhosphoSitePlus

Other Protein References for KHNYN Gene

No data available for DME Specific Peptides for KHNYN Gene

Domains & Families for KHNYN Gene

Protein Domains for KHNYN Gene


Suggested Antigen Peptide Sequences for KHNYN Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the N4BP1 family.
  • Belongs to the N4BP1 family.
genes like me logo Genes that share domains with KHNYN: view

No data available for Gene Families for KHNYN Gene

Function for KHNYN Gene

Gene Ontology (GO) - Molecular Function for KHNYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with KHNYN: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KHNYN Gene

Localization for KHNYN Gene

Subcellular locations from

Jensen Localization Image for KHNYN Gene COMPARTMENTS Subcellular localization image for KHNYN gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KHNYN Gene

Pathways & Interactions for KHNYN Gene

SuperPathways for KHNYN Gene

No Data Available

Interacting Proteins for KHNYN Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000251343 for KHNYN Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for KHNYN Gene


No data available for Pathways by source and SIGNOR curated interactions for KHNYN Gene

Drugs & Compounds for KHNYN Gene

No Compound Related Data Available

Transcripts for KHNYN Gene

Unigene Clusters for KHNYN Gene

KH and NYN domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KHNYN Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: - -
SP4: - - -

Relevant External Links for KHNYN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KHNYN Gene

mRNA expression in normal human tissues for KHNYN Gene

Protein differential expression in normal tissues from HIPED for KHNYN Gene

This gene is overexpressed in Breast (38.9), Heart (14.8), and Peripheral blood mononuclear cells (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KHNYN Gene

SOURCE GeneReport for Unigene cluster for KHNYN Gene Hs.713590

genes like me logo Genes that share expression patterns with KHNYN: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KHNYN Gene

Orthologs for KHNYN Gene

This gene was present in the common ancestor of animals.

Orthologs for KHNYN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KHNYN 35
  • 85.4 (n)
  • 83.56 (a)
  • 83 (a)
(Canis familiaris)
Mammalia KHNYN 35
  • 86.19 (n)
  • 84.21 (a)
  • 84 (a)
(Mus musculus)
Mammalia Khnyn 35
  • 82.22 (n)
  • 80.03 (a)
Khnyn 16
Khnyn 36
  • 80 (a)
(Pan troglodytes)
Mammalia KHNYN 35
  • 99.56 (n)
  • 99.26 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Khnyn 35
  • 82.25 (n)
  • 80.38 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 15 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 51 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 33 (a)
(Danio rerio)
Actinopterygii KHNYN 36
  • 29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10889 36
  • 21 (a)
(Caenorhabditis elegans)
Secernentea C30F12.1 36
  • 16 (a)
Species with no ortholog for KHNYN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KHNYN Gene

Gene Tree for KHNYN (if available)
Gene Tree for KHNYN (if available)

Paralogs for KHNYN Gene

Paralogs for KHNYN Gene

(3) SIMAP similar genes for KHNYN Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KHNYN: view

Variants for KHNYN Gene

Sequence variations from dbSNP and Humsavar for KHNYN Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs3742520 - 24,432,043(+) AGGGA(A/C)ACAGG nc-transcript-variant, reference, missense
rs7151995 - 24,432,070(+) GGATT(G/T)GGGGT nc-transcript-variant, reference, missense
rs1475026 -- 24,425,726(-) TCTGT(A/C)TTACC intron-variant
rs1475027 -- 24,424,466(-) gacat(C/T)ttcag intron-variant
rs7493701 -- 24,438,811(+) GGGTT(C/T)TGTTC downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KHNYN Gene

Variant ID Type Subtype PubMed ID
nsv819071 CNV Loss 19587683
nsv482171 CNV Loss 20164927

Variation tolerance for KHNYN Gene

Residual Variation Intolerance Score: 12.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.75; 78.87% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KHNYN Gene

Disorders for KHNYN Gene

Relevant External Links for KHNYN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KHNYN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KHNYN Gene

Publications for KHNYN Gene

  1. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 48 67
  2. The NYN domains: novel predicted RNAses with a PIN domain-like fold. (PMID: 17114934) Anantharaman V. … Aravind L. (RNA Biol 2006) 2 3
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  4. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich T.M. … Kathiresan S. (Nature 2010) 3
  5. CGIN1: a retroviral contribution to mammalian genomes. (PMID: 19561090) Marco A. … MarA-n I. (Mol. Biol. Evol. 2009) 3

Products for KHNYN Gene

Sources for KHNYN Gene