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KHK Gene

protein-coding GIFtS: 59

GC02P027221

ketohexokinase (fructokinase)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
EC 2.7.1.3 ^³
ketohexokinase ^²

Descriptions
Hepatic fructokinase ^³
ketohexokinase (fructokinase) ^²

External Ids
HGNC: 6315¹
Entrez Gene: 3795²
UniProtKB: P50053³
Ensembl: ENSG00000138030⁷

Search outside databases for aliases for KHK gene

Previous GC identifers: GC02P027231 GC02P027402 GC02P027267 GC02P027284

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for KHK:

This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The

product of this gene is the first enzyme with a specialized pathway that catabolizes dietary

fructose. Alternatively spliced transcript variants encoding different isoforms have been

identified. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KHK gene

Entrez Gene cytogenetic band: 2p23.3 Ensembl cytogenetic band: 2p23.3 HGNC cytogenetic band: 2p23.3-p23.2

KHK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P027221: (about GC identifiers)

Start:	27,163,115 bp from pter
End:	27,177,123 bp from pter
Size:	14,009 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_022184.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: KHK_HUMAN, P50053 (See protein sequence)

Recommended Name: Ketohexokinase

Size: 298 amino acids; 32730 Da

Subunit: Dimer of A-A, A-C or C-C (Probable)

Caution: Form C has not yet been fully sequenced in its N-terminal (from 1-69)

PDB structures from and Proteopedia :

2HLZ (3D)

2HQQ (3D)

2HW1 (3D)

3B3L (3D)

Secondary accessions: Q99532 Q9BRJ3 Q9UMN1

Alternative splicing: 2 isoforms: P50053-1 P50053-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_000212.1 NP_006479.1

ENSEMBL proteins:

ENSP00000260599 ENSP00000260598

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ketohexokinase)
	Human Recombinant Proteins from Abnova (KHK)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	11256614 18029348

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Antibodies for KHK:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for KHK
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ketohexokinase), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (KHK)
	Novus Biologicals Antibodies for KHK

Assays for KHK:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P50053

ProtoNet protein and cluster: P50053

1 Blocks protein family: IPB002173 Carbohydrate kinase

UniProtKB/Swiss-Prot: KHK_HUMAN, P50053

Similarity: Belongs to the carbohydrate kinase pfkB family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KHK)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KHK)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_006488

Applied Biosystems Silencer® siRNAs for KHK

Sigma-Aldrich siRNA and siRNA Panels for KHK

Sigma-Aldrich shRNA Panels and shRNA for KHK

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for KHK
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000221
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000221
untagged cDNA clones in CMV expression vector (see all 2): NM_000221

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000221

UniProtKB/Swiss-Prot: KHK_HUMAN, P50053

Catalytic activity: ATP + D-fructose = ADP + D-fructose 1-phosphate

Enzyme regulation: Requires potassium. Inhibition by ADP

Enzyme Number (IUBMB): EC 2.7.1.3

Genatlas biochemistry entry for KHK:

ketohexokinase,fructose metabolism,energy pathway,expressed in liver,renal cortex and small

intestine

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004454	ketohexokinase activity	TAS	7833921
GO:0005515	protein binding	IPI	17353931
GO:0016301	kinase activity	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for KHK (Your Favorite Gene powered by Ingenuity)

Fructose and Mannose Metabolism

GeneDecks KHK for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: KHK_HUMAN, P50053

Pathway: Carbohydrate metabolism; fructose metabolism

5/22 Interacting proteins for KHK (ENSP00000260599³ P50053¹) via UniProtKB, MINT, and/or STRING (see all 22 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARRB1	P49407¹	EBI-1053974, EBI-743313
CD2BP2	O95400¹	EBI-1053974, EBI-768015
CDK5RAP3	Q96JB5¹	EBI-1053974, EBI-718818
DEDD	O75618¹	EBI-1053974, EBI-1043164
LCN1	P31025¹	EBI-1053974, EBI-1052433

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for KHK
3 Novoseek chemical compound relationships for KHK gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fructose 1-phosphate	93.94	9	16372272 (1), 11264590 (1), 17510913 (1), 19237742 (1)
fructose	83.16	29	19158351 (3), 11264590 (2), 18395287 (2), 19237742 (2) (see all 10)
atp	27.18	4	19158351 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KHK)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KHK)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_006488

Sigma-Aldrich siRNA and siRNA Panels for KHK

Sigma-Aldrich shRNA Panels and shRNA for KHK

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000221 NM_006488

REFSEQ mRNAs for KHK gene (2 alternative transcripts):

NM_000221.2 NM_006488.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000221 NM_006488

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000221
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000221
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000221

Additional cDNA sequence:

AK130033.1 AK223075.1 BC006233.2 BX648873.1 CR456801.1 CR591043.1 CR600808.1 CR603641.1

CR604516.1 CR608955.1 CR610051.1 CR612248.1 CR617023.1 CR618568.1 CR622392.1 CR622479.1

CR625259.1 X78677.1 X78678.1

6 DOTS entries:

DT.447396 DT.97794122 DT.100839952 DT.95104826 DT.95104793 DT.95104795

24/168 AceView cDNA sequences (see all 168 ):

AA342313 CB154910 CB137744 BM745791 CR600808 CR622479 BQ893175 CB148802

CR617023 CR610051 BM695404 CR622392 CB141195 NM_006488 CB148825 BM753815

CB148820 CB148348 AI347475 BQ064138 X78678 CB139063 CR625259 CR591043

highest scoring ESTs for KHK:

X78678 AA342313 AA714633 AA714645 AA858018 AI056782 AI078198 AI085406 AI245267 AI247727

Unigene Cluster for KHK:

Ketohexokinase (fructokinase)

Hs.567297 [show with all ESTs]

Unigene Representative Sequence: NM_000221

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for KHK (see all 8 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9a	·	9b	·	9c
SP1:													-				-		-
SP2:													-		-		-
SP3:											-		-		-		-		-
SP4:													-				-
SP5:													-				-		-

About this scheme

ECgene alternative splicing isoforms for KHK

2 Ensembl transcripts including schematic representations:

ENST00000260599 ENST00000260598

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KHK expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KHK

¹ / ² / ³

7 probe-sets matching KHK gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37608_g_at²^{, 3}	U95-A	1	1.00	1.00	0.98	1.28	AJ005168	0.20	1.00	0.72	1
37606_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.74	X78678	1.00	1.00	1.00	1
37607_at*²^{, 3}	U95-A	1	--	--	0.14	0.32	AJ005168	0.20	1.00	0.72	1
211028_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC006233	0.80	1.00	0.91	1
205175_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000221	0.60	1.00	0.82	1
211028_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205175_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks KHK for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.567297
Expression variation in blood from EXPOLDB for KHK
UniProtKB/Swiss-Prot: KHK_HUMAN, P50053
Tissue specificity: Most abundant in liver, kidney, gut, spleen and pancreas. Low levels also found
in adrenal, muscle, brain and eye

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KHK gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	KHK¹	--	ketohexokinase (fructokinase)	87.36(n) 88.26(a)	614868 NM_001076351.1 NP_001069819.1
rat (Rattus norvegicus)	Khk¹	--	ketohexokinase	87.25(n) 86.58(a)	25659 NM_031855.2 NP_114061.1
mouse (Mus musculus)	Khk^{1, 5}	5 (18.10 cM)⁵	ketohexokinase^{1, 5}	86.58(n)¹ 87.25(a)¹	16548¹ NM_008439.3¹ NP_032465.2¹ AK008326⁵ AK008503⁵ (see all 7)
zebrafish (Danio rerio)	khk¹	--	ketohexokinase	64.09(n) 62.75(a)	436909 NM_001002636.1 NP_001002636.1
fruit fly (Drosophila melanogaster)	CG7328³	76F2	ketohexokinase	35(a) (best of 2)	--

About this table Species with no ortholog for KHK

ENSEMBL Gene Tree for KHK

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/69 NCBI SNPs in KHK are shown (see all 69 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 44)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2304681^1,2	C,F,H	27168756(+)	`GCACCG/ATTCTC`	2	I/V	mis¹		13	EA EU WA	2744
	rs7588333^1,2	A,C,F,H	27165775(+)	`CAGGGG/CAACAG`	2	--	int¹		4	EU EA WA	406
	rs2119026^1,2	A,C,F,H	27163897(-)	`CCTTCT/CTCTCT`	2	--	int¹ trp³		4	EU EA WA	418
	rs12714092^1,2	A,C,F,H	27168386(+)	`AGGAGG/AAGATG`	2	--	int¹ trp³		4	EU EA WA	412
--	rs4665944^1,2	A,C,F,H	27175391(+)	`agaccA/Gtcttc`	2	--	int¹		4	EU EA WA	420
	rs6754371^1,2	A,C,F	27168568(+)	`GCCCCA/GGGTAC`	2	--	int¹		3	NA	124
	rs3769139^1,2	C,F,H	27169218(+)	`CCAGGT/CCCACA`	2	--	int¹		12	EU EA WA NA	1200
	rs9677784^1,2	A,C,H	27173330(+)	`GTGAGG/AAAACT`	2	--	int¹		4	EU EA WA	420
	rs2075862^1,2	C,F,H	27173782(+)	`CCTCTC/ACCTCC`	2	--	int¹ trp³		5	EA EU WA	1920
	rs7561117^1,2	F,H	27165936(+)	`GATGGG/AGCAGG`	2	--	int¹		4	EU EA WA	418

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HapMap Linkage Disequilibrium images for KHK (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 229800

UniProtKB/Swiss-Prot: KHK_HUMAN, P50053

Defects in KHK are the cause of fructosuria [MIM:229800]. Fructosuria is a benign defect

of intermediary metabolism

3 Novoseek disease relationships for KHK gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma renal cell	27.61	1	16372272 (1)
cancer	0.00	1	16372272 (1)
tumors	0.00	2	16372272 (2)

About this table

Genatlas disease: KHK

fructosuria

Human Gene Mutation Database: KHK

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/29 PubMed articles for KHK gene (see all 29 ):

Molecular basis of essential fructosuria: molecular cloning and mutational analysis of human ketohexokinase (fructokinase). (PubMed id 7833921)^{1, 2, 3, 4} Bonthron D.T.... Steinmann B. (1994)
Structure and alternative splicing of the ketohexokinase gene. (PubMed id 9799106)^{1, 3, 4} Hayward B.E. and Bonthron D.T. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Co-localization of the ketohexokinase and glucokinase regulator genes to a 500-kb region of chromosome 2p23. (PubMed id 8662230)^{1, 3} Hayward B.E....Bonthron D.T. (1996)
The expression of ketohexokinase is diminished in human clear cell type of renal cell carcinoma. (PubMed id 16372272)^{1, 3} Hwa J.S....Kang K.R. (2006)
Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. (PubMed id 19158351)^{1, 3} Cirillo P....Sautin Y.Y. (2009)
Properties of normal and mutant recombinant human ketohexokinases and implications for the pathogenesis of essential fructosuria. (PubMed id 12941785)^{1, 3} Asipu A....Bonthron D.T. (2003)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)³ Barbe L....Andersson-Svahn H. (2008)
Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)³ Ewing R.M....Figeys D. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3795	HGNC: 6315	AceView: KHK	Ensembl:ENSG00000138030	euGenes: HUgn3795
ECgene: KHK	H-InvDB: KHK

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for KHK
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KHK:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KHK-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KHK		Antibodies for KHK
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KHK		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (KHK)
	Antibodies (KHK)
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	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Search Tocris compounds for KHK

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Antibodies for KHK

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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KHK Gene at Home site.
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KHK Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for KHK

Summaries
for KHK

Genomic Location
for KHK

Proteins
for KHK

Protein Domains/
Families
for KHK

Gene Function
for KHK

Pathways & Interactions
for KHK

Drugs & Compounds
for KHK

Transcripts
for KHK

Expression
for KHK

Orthologs
for KHK

Paralogs
for KHK

SNPs/Variants
for KHK

Disorders & Mutations
for KHK

Medical News
for KHK

Publications
for KHK

Search for KHK

Genome Databases showing KHK

Other Databases showing KHK

Specialized Databases showing KHK

Licensable Technologies
for KHK

Services
for KHK

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KHK Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor KHK

Summariesfor KHK

Genomic Locationfor KHK

Proteinsfor KHK

Protein Domains/Familiesfor KHK

Gene Functionfor KHK

Pathways & Interactionsfor KHK

Drugs & Compoundsfor KHK

Transcriptsfor KHK

Expression for KHK

Orthologsfor KHK

Paralogsfor KHK

SNPs/Variantsfor KHK

Disorders & Mutationsfor KHK

Medical Newsfor KHK

Publicationsfor KHK

Search for KHK

Genome Databases showing KHK

Other Databases showing KHK

Specialized Databases showing KHK

Licensable Technologiesfor KHK

Servicesfor KHK

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KHK

Summaries
for KHK

Genomic Location
for KHK

Proteins
for KHK

Protein Domains/
Families
for KHK

Gene Function
for KHK

Pathways & Interactions
for KHK

Drugs & Compounds
for KHK

Transcripts
for KHK

Expression
for KHK

Orthologs
for KHK

Paralogs
for KHK

SNPs/Variants
for KHK

Disorders & Mutations
for KHK

Medical News
for KHK

Publications
for KHK

Licensable Technologies
for KHK

Services
for KHK