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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KHDRBS3 Gene

protein-coding GIFtS: 55
GCID: GC08P136538

KH domain containing, RNA binding, signal transduction associated...

Explore 27 diseases affiliated with
KHDRBS3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
KH Domain Containing, RNA Binding, Signal Transduction Associated 3¹ ²		Sam68-Like Mammalian Protein 2² ³
SALP¹ ² ³ ⁵		RNA-Binding Protein T-Star² ³
SLM2¹ ² ³ ⁵		TSTAR² ⁵
SLM-2¹ ² ³		KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein 3²
Etle¹ ²		Sam68-Like Phosphotyrosine Protein, T-STAR²
T-STAR¹ ²		Sam68-Like Phosphotyrosine Protein³
Etoile¹		ETOILE⁵

External Ids:	HGNC: 18117¹	Entrez Gene: 10656²	Ensembl: ENSG00000131773⁷	OMIM: 610421⁵	UniProtKB: O75525³

Export aliases for KHDRBS3 gene to outside databases

Previous GC identifers: GC08P135242 GC08P136579 GC08P136154 GC08P136440 GC08P131785

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: KHDR3_HUMAN, O75525

Function: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice

site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell

proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased

concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer.

RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1

gene expression. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro

Gene Wiki entry for KHDRBS3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008046.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KHDRBS3 gene promoter:
GR p300 NRSF form 1 GR-alpha NRSF form 2
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for KHDRBS3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KHDRBS3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.2 Ensembl cytogenetic band: 8q24.23 HGNC cytogenetic band: 8q24.23

KHDRBS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KHDRBS3 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P136538: view genomic region (about GC identifiers)

Start:	136,469,700 bp from pter	End:	136,668,965 bp from pter
Size:	199,266 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KHDR3_HUMAN, O75525 (See protein sequence)

Recommended Name: KH domain-containing, RNA-binding, signal transduction-associated protein 3

Size: 346 amino acids; 38800 Da

Subunit: Self-associates to form homooligomers. Interacts with the splicing regulatory proteins SFRS9, SAFB and YTHDC1.

Interacts also with HNRPL and SLM1/KHDRBS2 (By similarity). Interacts with KHDRBS1, RBMX, RBMY1A1 and with p85 subunit

of PI3-kinase. Interacts also with SIAH1 which promotes targeting for degradation

Subcellular location: Nucleus. Note=Localized in a compartment adjacent to the nucleolus, but distinct from the

peri-nucleolar one

Secondary accessions: Q6NUL8 Q9UPA8

Alternative splicing: 2 isoforms: O75525-1 O75525-2

Explore the universe of human proteins at neXtProt for KHDRBS3: NX_O75525

Post-translational modifications:

Phosphorylated on tyrosine residues. Isoform 1 C-terminal region is tyrosine-rich, but isoform 2 lacking this

C-terminal region is also tyrosine-phosphorylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75525

KHDRBS3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006549.1

ENSEMBL proteins:

ENSP00000348108 ENSP00000431022 ENSP00000428607 ENSP00000430284 ENSP00000427851

ENSP00000427841 ENSP00000428643

Human Recombinant Protein Products for KHDRBS3:

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	Novus Biologicals KHDRBS3 Protein Novus Biologicals KHDRBS3 Lysates
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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KHDRBS3

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--

KHDRBS3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for KHDRBS3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KHDRBS3 for domains About GeneDecksing

1 InterPro domain/family:

IPR004087 KH_dom

Graphical View of Domain Structure for InterPro Entry O75525

ProtoNet protein and cluster: O75525

UniProtKB/Swiss-Prot: KHDR3_HUMAN, O75525

Domain: The proline-rich site binds the SH3 domain of the p85 subunit of PI3-kinase

Similarity: Belongs to the KHDRBS family

Similarity: Contains 1 KH domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: KHDR3_HUMAN, O75525

Function: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice

site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell

proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased

concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer.

RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1

gene expression. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro

Induction: Induced in proteinuric diseases. Down-regulated in immortalized fibroblasts isolated after a proliferative

crisis accompanied with massive cell death

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IDA	19561594
GO:0003727	single-stranded RNA binding	--	--
GO:0005515	protein binding	IPI	--
GO:0017124	SH3 domain binding	IEA	--

KHDRBS3 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for KHDRBS3:

Increased cell number in G1, a

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for KHDRBS3

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		hsa-miR-520d-5p hsa-miR-376b hsa-miR-144 hsa-miR-4325 hsa-miR-204 hsa-miR-186 hsa-miR-3662 hsa-miR-31

		SwitchGear 3'UTR luciferase reporter plasmid: KHDRBS3 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KHDRBS3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KHDRBS3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/47 Interacting proteins for KHDRBS3 (O75525^{1, 2, 3} ENSP00000348108⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 47)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LNX1	Q8TBB1²^,³, ENSP00000263925⁴	MINT-66718 I2D: score=5 STRING: ENSP00000263925
RBM7	Q9Y580²^,³, ENSP00000364639⁴	MINT-67619 I2D: score=5 STRING: ENSP00000364639
SIAH1	Q8IUQ4²^,³, ENSP00000349156⁴	MINT-68424 I2D: score=5 STRING: ENSP00000349156
KHDRBS2	Q5VWX1²^,³, ENSP00000281156⁴	MINT-67800 I2D: score=4 STRING: ENSP00000281156
KHDRBS1	Q07666²^,³, ENSP00000313829⁴	MINT-8339510 I2D: score=2 STRING: ENSP00000313829

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006397	mRNA processing	--	--
GO:0007283	spermatogenesis	TAS	10332027
GO:0033120	positive regulation of RNA splicing	--	--

KHDRBS3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

KHDRBS3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KHDRBS3
6 Novoseek chemical compound relationships for KHDRBS3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
deoxypyridinoline	50.2	2	14555415 (1)
hydroxyproline	36.5	1	9355672 (1)
triiodothyronine	33.5	1	16541206 (1)
calcium	8.35	3	9115154 (1), 16541206 (1), 16500882 (1)
alanine	7.64	2	9444780 (1), 15835237 (1)
tyrosine	0	1	10077576 (1)

Search CenterWatch for drugs/clinical trials and news about KHDRBS3 / KHDR3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KHDRBS3 gene:

NM_006558.1

Unigene Cluster for KHDRBS3:

KH domain containing, RNA binding, signal transduction associated 3

Hs.444558 [show with all ESTs]

Unigene Representative Sequence: BX537666

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000355849(uc003yuv.3 uc003yuw.3 uc010mek.3) ENST00000524199

ENST00000520981 ENST00000517394 ENST00000519600 ENST00000517859 ENST00000524282

ENST00000522079 ENST00000522433 ENST00000518728 ENST00000521461 ENST00000522578

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		hsa-miR-520d-5p hsa-miR-376b hsa-miR-144 hsa-miR-4325 hsa-miR-204 hsa-miR-186 hsa-miR-3662 hsa-miR-31

		SwitchGear 3'UTR luciferase reporter plasmid: KHDRBS3 3' UTR sequence

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Additional cDNA sequence:

AF051321.1 AF051322.1 AF069681.1 BC032606.2 BC068536.1 BX537666.1

10 DOTS entries:

DT.445615 DT.99953290 DT.100788077 DT.92444378 DT.95271104 DT.40237733 DT.95271103 DT.95074232

DT.95305926 DT.92444379

24/145 AceView cDNA sequences (see all 145):

AI650382 AA954323 BE275166 AA907358 AF051322 BG215534 T18913 CR591014

BQ878314 BQ673257 BG181314 AI638608 BX103812 BQ670932 BC032606 AA456299

AI239592 BQ672815 BX537666 AA948596 CD244637 AF069681 AA007604 BC068536

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for KHDRBS3 About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b
SP1:							-						-
SP2:							-						-								-
SP3:																							-
SP4:

ECgene alternative splicing isoforms for KHDRBS3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KHDRBS3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGTAAAAAGG

About this image

KHDRBS3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Nkx2-1 GFP+ cells (Efficient derivation...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KHDRBS3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KHDRBS3

SOURCE GeneReport for Unigene cluster: Hs.444558

UniProtKB/Swiss-Prot: KHDR3_HUMAN, O75525

Tissue specificity: Ubiquitous with higher expression in testis, skeletal muscle and brain. Expressed in the kidney

only in podocytes, the glomerular epithelial cells of the kidney. Strongly expressed after meiosis

SABiosciences Custom PCR Arrays for KHDRBS3

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for KHDRBS3 gene from 8/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Khdrbs3^{1 , 5}	KH domain containing, RNA binding, signal transduction more^{1, 5}	89.4(n)¹ 97.11(a)¹		15 (30.36 cM)⁵ 13992¹ NM_010158.2¹ NP_034288.2¹ 68928420⁵
chicken (Gallus gallus)	Aves	KHDRBS3¹	KH domain containing, RNA binding, signal transduction more	82.07(n) 90.99(a)		420317 XM_001231271.2 XP_001231272.1
lizard (Anolis carolinensis)	Reptilia	KHDRBS3⁶	--	84(a)	1 ↔ 1	4(2226136-2291836)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.11350²	Transcribed sequence with moderate similarity to protein more	77.35(n)		137696087
zebrafish (Danio rerio)	Actinopterygii	LOC100537663¹	KH domain-containing, RNA-binding, signal transduction-associated more	69.08(n) 75(a)		100537663 XM_003199259.1 XP_003199307.1
fruit fly (Drosophila melanogaster)	Insecta	CG10384³ qkr58E-1¹	quaking related 58E-1¹	62(a) (best of 8)³ 54.49(n)¹ 53.29(a)¹		58E2³ 37561¹ NM_079085.4¹ NP_523809.2¹
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G38610⁶ AT4G26480⁶ (see all 5)	RNA-binding KH domain-containing protein (see all 5)	26(a) 24(a) (see all 5)	many ↔ many many ↔ many (see all 5)	2(16147113-16149873) 4(13372422-13375963)
rice (Oryza sativa)	Liliopsida	-- -- (see all 7)	KH domain containing protein, putative, expressed (see all 7)	26(a) 26(a) (see all 7)	many ↔ many many ↔ many (see all 7)	3(34179264-34183709) 7(7119724-7125463)

ENSEMBL Gene Tree for KHDRBS3 (if available)
TreeFam Gene Tree for KHDRBS3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KHDRBS3 gene

KHDRBS2² SF1² KHDRBS1² QKI²

3 SIMAP similar genes for KHDRBS3 using alignment to 9 protein entries: KHDR3_HUMAN (see all proteins):

KHDRBS2 KHDRBS1 QKI

KHDRBS3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs56134499^1,2	C	--	136467740(+)	`CTTTTT/CGTTTC`	1	--	us2k¹		4		WA NA EA	360
rs80161648^1,2	C,F	--	136467786(+)	`GAAGAG/ACAGCC`	1	--	us2k¹		1		WA	118
rs111452990^1,2		--	136467798(+)	`CAAGCC/AGCCTA`	1	--	us2k¹		3		CSA	4
rs73712031^1,2	C	--	136467866(+)	`CTCAGC/TTGGCC`	1	--	us2k¹		1		WA	2
rs112249374^1,2	F	--	136467881(+)	`CGGGGC/TGAAGC`	1	--	us2k¹		2		CSA	4
rs138134061^1,2		--	136467891(+)	`CACCAC/TGACCA`	1	--	us2k¹		0	--	--	--	--
rs142715100^1,2		--	136467999(+)	`GCAGCC/GGGAAA`	1	--	us2k¹		0	--	--	--	--
rs189525262^1,2		--	136468036(+)	`ATTTCC/TGATAG`	1	--	us2k¹		0	--	--	--	--
rs3735865^1,2	C	--	136468145(-)	`CTCAGG/CGTCCT`	1	--	us2k¹		6		NA WA EA	364
rs181899292^1,2		--	136468181(+)	`GCTAGC/TGAGCA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KHDRBS3 (136469700 - 136668965 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for KHDRBS3
4 CNVs: 65274 95701 70441 38703
3 Indels: 60733 47468 60732

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KHDRBS3 for disorders           About GeneDecksing

OMIM gene information: 610421    OMIM disorders: --

20/27 diseases for KHDRBS3 (see all 27):    About MalaCards

rocky mountain spotted fever spotted fever childhood absence epilepsy absence epilepsy

extratemporal epilepsy osteogenesis imperfecta transvestism anorexia nervosa

hypophosphatasia macular degeneration ulcerative colitis osteomalacia

osteopetrosis rheumatoid arthritis osteosarcoma proteinuria

liver cancer osteoporosis medulloblastoma colon cancer

4 diseases from the University of Copenhagen DISEASES database for KHDRBS3:

Extratemporal epilepsy Transvestism Hypophosphatasia Osteomalacia

2 Novoseek disease relationships for KHDRBS3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
osteosarcoma	26.3	6	12037623 (2), 15478002 (1)
liver diseases	23	2	9355672 (1), 9148865 (1)

Genetic Association Database (GAD): KHDRBS3
Human Genome Epidemiology (HuGE) Navigator: KHDRBS3 (1 document)

Export disorders for KHDRBS3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KHDRBS3 gene, integrated from 9 sources (see all 57):
(articles sorted by number of sources associating them with KHDRBS3)

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world of online information

T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA- binding protein implicated in spermatogenesis. (PubMed id 10332027)^{1, 2, 3} Venables J.P.... Eperon I.C. (1999)
Salpalpha and Salpbeta, growth-arresting homologs of Sam68. (PubMed id 10564820)^{1, 2, 3} Lee J.-S. and Burr J.G. (1999)
Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis. (PubMed id 10077576)^{1, 2, 9} Di Fruscio M.... Richard S. (1999)
Sam68-like mammalian protein 2, identified by digital differential display as expressed by podocytes, is induced in proteinuria and involved in splice site selection of vascular endothelial growth factor. (PubMed id 15901763)^{1, 2, 9} Cohen C.D....Kretzler M. (2005)
A role for KH domain proteins (Sam68-like mammalian proteins and quaking proteins) in the post-transcriptional regulation of HIV replication. (PubMed id 11741900)^{1, 2, 9} Reddy T.R.... Wong-Staal F. (2002)
Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. (PubMed id 19561594)^{1, 2} Ray D....Hughes T.R. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
SIAH1 targets the alternative splicing factor T-STAR for degradation by the proteasome. (PubMed id 15163637)^{1, 2} Venables J.P.... Elliott D.J. (2004)
[Association of child absence epilepsy with T-STAR gene] (PubMed id 12921630)^{1, 4} Chen Y.C....Wu X.R. (2003)
Down-regulation of T-STAR, a growth inhibitory protein, after SV40- mediated immortalization. (PubMed id 11714634)^{1, 2} Kool J.... Terleth C. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10656	HGNC: 18117	AceView: KHDRBS3	Ensembl:ENSG00000131773	euGenes: HUgn10656
ECgene: KHDRBS3	H-InvDB: KHDRBS3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KHDRBS3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KHDRBS3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KHDRBS3 gene:
Search GeneIP for patents involving KHDRBS3

GeneCards and IP:
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