Aliases for KHDRBS3 Gene
External Ids for KHDRBS3 Gene
Previous GeneCards Identifiers for KHDRBS3 Gene
GeneCards Summary for KHDRBS3 Gene
KHDRBS3 (KH Domain Containing, RNA Binding, Signal Transduction Associated 3) is a Protein Coding gene. Diseases associated with KHDRBS3 include childhood absence epilepsy and transvestism. Among its related pathways are Signaling by GPCR and Signaling by PTK6. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is KHDRBS1.
UniProtKB/Swiss-Prot for KHDRBS3 Gene
RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression. Binds preferentially to the 5-[AU]UAAA-3 motif in vitro.