Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



KHDRBS2 Gene

protein-coding   GIFtS: 51
GCID: GC06M062447

KH Domain Containing, RNA Binding, Signal Transduction Associated...

  Search for KHDRBS2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
KH Domain Containing, RNA Binding, Signal Transduction Associated 21 2     hSLM-12 3
Sam68-Like Mammalian Protein 11 2 3     bA535F17.12
SLM12 3 5     KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein
22
SLM-12 3     

External Ids:    HGNC: 181141   Entrez Gene: 2025592   Ensembl: ENSG000001122327   OMIM: 6104875   UniProtKB: Q5VWX13   

Export aliases for KHDRBS2 gene to outside databases

Previous GC identifers: GC00U991173 GC06M062386 GC06M059556


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for KHDRBS2 Gene:
KHDRBS2 (KH domain containing, RNA binding, signal transduction associated 2) is a protein-coding gene. GO annotations related to this gene include SH2 domain binding and protein heterodimerization activity. An important paralog of this gene is SF1.

UniProtKB/Swiss-Prot: KHDR2_HUMAN, Q5VWX1
Function: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA
splice site selection and exon inclusion. Its phosphorylation by FYN inhibits its ability to regulate splice site
selection. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding
to purine-rich exonic enhancer. May function as an adapter protein for Src kinases during mitosis. Binds both
poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KHDRBS2 gene promoter:
         TBP   Nkx2-2   RORalpha2   Evi-1   SRY   Nkx6-1   HFH-1   NF-Y   RSRFC4   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKHDRBS2 promoter sequence
   Search Chromatin IP Primers for KHDRBS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KHDRBS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q11.1   Ensembl cytogenetic band:  6q11.1   HGNC cytogenetic band: 6q11.1

KHDRBS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KHDRBS2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M062447:  view genomic region     (about GC identifiers)

Start:
62,389,865 bp from pter      End:
62,996,132 bp from pter
Size:
606,268 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KHDR2_HUMAN, Q5VWX1 (See protein sequence)
Recommended Name: KH domain-containing, RNA-binding, signal transduction-associated protein 2  
Size: 349 amino acids; 38927 Da
Subunit: Self-associates to form homooligomers. Interacts with SAFB, SFRS9 and YTHDC1. Found in a complex with
KHDRBS1, KHDRBS2 and KHDRBS3. Interacts with the SH3 domains of FYN and PLCG1. Interacts with the SH2 domains of
FYN, GRAP2, PLCG1 and RASA1 (By similarity). Interacts with RBMX
Secondary accessions: A8K7M8 Q8N4I4 Q8TCZ4

Explore the universe of human proteins at neXtProt for KHDRBS2: NX_Q5VWX1

Explore proteomics data for KHDRBS2 at MOPED

Post-translational modifications: 

  • Methylated1
  • Tyrosine phosphorylated by FYN, PTK6 and SRC. Tyrosine phosphorylated by SRC during mitosis (By similarity)1
  • Ubiquitination2 at Lys69, Lys73
  • Modification sites at PhosphoSitePlus

  • See KHDRBS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689901.2  
    ENSEMBL proteins: 
     ENSP00000281156  

    KHDRBS2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for KHDRBS2
    OriGene Protein Over-expression Lysate for KHDRBS2
    OriGene MassSpec for KHDRBS2
    OriGene Custom Protein Services for KHDRBS2
    GenScript Custom Purified and Recombinant Proteins Services for KHDRBS2
    Novus Biologicals KHDRBS2 Protein
    Novus Biologicals KHDRBS2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for KHDRBS2 

    KHDRBS2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KHDRBS2
    Novus Biologicals KHDRBS2 Antibodies
    Abcam antibodies for KHDRBS2
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for KHDRBS2
    LSBio Antibodies in human, mouse, rat for KHDRBS2

    KHDRBS2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KHDRBS2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KHDRBS2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for KHDRBS2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR004087 KH_dom
     IPR004088 KH_dom_type_1

    Graphical View of Domain Structure for InterPro Entry Q5VWX1

    ProtoNet protein and cluster: Q5VWX1

    1 Blocks protein domain: IPB004087 KH domain

    UniProtKB/Swiss-Prot: KHDR2_HUMAN, Q5VWX1
    Similarity: Belongs to the KHDRBS family
    Similarity: Contains 1 KH domain


    Find genes that share domains with KHDRBS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KHDR2_HUMAN, Q5VWX1
    Function: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA
    splice site selection and exon inclusion. Its phosphorylation by FYN inhibits its ability to regulate splice site
    selection. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding
    to purine-rich exonic enhancer. May function as an adapter protein for Src kinases during mitosis. Binds both
    poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI16189514
    GO:0008143poly(A) binding IEA--
    GO:0008266poly(U) RNA binding IEA--
    GO:0017124SH3 domain binding IEA--
         
    Find genes that share ontologies with KHDRBS2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KHDRBS2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KHDRBS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KHDRBS2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KHDRBS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target KHDRBS2:
    hsa-mir-148b-3p (MIRT019320), hsa-mir-335-5p (MIRT018184)

    Block miRNA regulation of human, mouse, rat KHDRBS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KHDRBS2 (see all 42):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-3685 hsa-miR-200a hsa-miR-570 hsa-miR-374c hsa-miR-141 hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidKHDRBS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KHDRBS2
    Predesigned siRNA for gene silencing in human, mouse, rat KHDRBS2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KHDRBS2

    Clone
    Products:
         
    OriGene clones in human, mouse for KHDRBS2 (see all 6)
    OriGene ORF clones in mouse, rat for KHDRBS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KHDRBS2 (NM_152688)
    Sino Biological Human cDNA Clone for KHDRBS2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KHDRBS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KHDRBS2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KHDRBS2
    Browse ESI BIO Cell Lines and PureStem Progenitors for KHDRBS2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KHDRBS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    KHDR2_HUMAN, Q5VWX1: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with KHDRBS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KHDRBS2
    Interactions:

        Search GeneGlobe Interaction Network for KHDRBS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KHDRBS2 (Q5VWX11, 2, 3 ENSP000002811564) via UniProtKB, MINT, STRING, and/or I2D (see all 86)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KHDRBS3O755252, 3, ENSP000003481084MINT-67800 I2D: score=4 STRING: ENSP00000348108
    RBMXP381591, 3, ENSP000003596454EBI-742808,EBI-743526 I2D: score=4 STRING: ENSP00000359645
    ARID2Q68CP93, ENSP000003350444I2D: score=1 STRING: ENSP00000335044
    DDX17Q928413, ENSP000003800334I2D: score=1 STRING: ENSP00000380033
    EHBP1Q8NDI13, ENSP000002639914I2D: score=1 STRING: ENSP00000263991
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with KHDRBS2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KHDRBS2 (KHDR2)

    1 Novoseek inferred chemical compound relationship for KHDRBS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 21.6 1 10077576 (1)



    Find genes that share compounds with KHDRBS2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for KHDRBS2 gene: 
    NM_152688.2  

    Unigene Cluster for KHDRBS2:

    KH domain containing, RNA binding, signal transduction associated 2
    Hs.519794  [show with all ESTs]
    Unigene Representative Sequence: BC034043
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000281156(uc003peg.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KHDRBS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KHDRBS2 (see all 42):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-3685 hsa-miR-200a hsa-miR-570 hsa-miR-374c hsa-miR-141 hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidKHDRBS2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KHDRBS2
    Predesigned siRNA for gene silencing in human, mouse, rat KHDRBS2
    Clone
    Products:
         
    OriGene clones in human, mouse for KHDRBS2 (see all 6)
    OriGene ORF clones in mouse, rat for KHDRBS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KHDRBS2 (NM_152688)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KHDRBS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KHDRBS2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KHDRBS2
    OriGene qSTAR qPCR primer pairs in human, mouse for KHDRBS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KHDRBS2
      QuantiTect SYBR Green Assays in human, mouse, rat KHDRBS2
      QuantiFast Probe-based Assays in human, mouse, rat KHDRBS2

    Additional mRNA sequence: 

    AK095983.1 AK292043.1 AY077838.1 BC034043.1 

    5 DOTS entries:

    DT.86850461  DT.97789343  DT.70101114  DT.91804988  DT.40207375 

    17 AceView cDNA sequences:

    AI632331 BP348510 NM_152688 AY077838 BG706672 BM926834 AK095983 BC034043 
    AW003449 BG195963 BM545404 AA385275 R20052 BI597067 D60325 CB987746 
    BM926281 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    KHDRBS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAATGGAAA
    KHDRBS2 Expression
    About this image


    KHDRBS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
    KHDRBS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KHDRBS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.519794

    UniProtKB/Swiss-Prot: KHDR2_HUMAN, Q5VWX1
    Tissue specificity: Highly expressed in brain, lung, kidney and small intestine. Weakly expressed in placenta,
    liver, spleen, thymus, ovary and colon

        Custom PCR Arrays for KHDRBS2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for KHDRBS2
    OriGene qSTAR qPCR primer pairs in human, mouse for KHDRBS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KHDRBS2
    QuantiTect SYBR Green Assays in human, mouse, rat KHDRBS2
    QuantiFast Probe-based Assays in human, mouse, rat KHDRBS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KHDRBS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for KHDRBS2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Khdrbs21 , 5 KH domain containing, RNA binding, signal transduction more1, 5 91.21(n)1
    95.42(a)1
      1 (11.86 cM)5
    1707711  NM_133235.21  NP_573498.11 
     321728065 
    chicken
    (Gallus gallus)
    Aves KHDRBS21 KH domain containing, RNA binding, signal transduction more 83.81(n)
    91.38(a)
      428643  XM_426201.4  XP_426201.2 
    lizard
    (Anolis carolinensis)
    Reptilia KHDRBS26
    KH domain containing, RNA binding, signal transduc...
    90(a)
    1 ↔ 1
    1(163543177-163974148)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia khdrbs21 KH domain containing, RNA binding, signal transduction more 72.66(n)
    75.36(a)
      779662  NM_001078747.1  NP_001072215.1 
    zebrafish
    (Danio rerio)
    Actinopterygii khdrbs21 KH domain containing, RNA binding, signal transduction more 70.43(n)
    73.33(a)
      768147  NM_001077290.1  NP_001070758.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG39276
    qkr58E-36
    (see all 8)
    quaking related 58E-3
    (see all 8)
    33(a)
    32(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    2R(18482193-18483858)
    2R(18296797-18299049)
    worm
    (Caenorhabditis elegans)
    Secernentea K07H8.96
    Y57G11C.366
    (see all 5)
    Protein K07H8.9 (K07H8.9) mRNA, complete cds
    Protein Y57G11C.36 (Y57G11C.36) mRNA, complete cds...
    (see all 5)
    25(a)
    24(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    IV(8285175-8286470) WBGene00019509
    IV(14771419-14773535) WBGene00013325
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MSL56
    Component of the commitment complex, which defines...
    12(a)
    1 → many
    XII(380822-382252) YLR116W


    ENSEMBL Gene Tree for KHDRBS2 (if available)
    TreeFam Gene Tree for KHDRBS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for KHDRBS2 gene
    SF12  KHDRBS32  KHDRBS12  QKI2  
    3 SIMAP similar genes for KHDRBS2 using alignment to 2 protein entries:     KHDR2_HUMAN (see all proteins):
    KHDRBS3    KHDRBS1    QKI

    Find genes that share paralogs with KHDRBS2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for KHDRBS2 (see all 12100)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs117532211,2
    H--62389392(+) GAGTTA/TCTATT 1 -- int14Minor allele frequency- T:0.00NS EA 420
    rs1162403721,2
    F--62389402(+) TAGTGT/CTACCT 1 -- int11Minor allele frequency- C:0.01NA 120
    rs1471004501,2
    --62389552(+) AATAAA/CGTTTT 1 -- int10--------
    rs1903190481,2
    --62389716(+) TGTGCA/GGGGAA 1 -- int10--------
    rs1810821821,2
    --62389736(+) TTGAAA/GAACTA 1 -- int10--------
    rs1481278311,2
    --62389793(+) TTACTC/GTTTCT 1 -- int10--------
    rs1411032481,2
    --62389829(+) AGTCAA/GTCAGA 1 -- int10--------
    rs1857317211,2
    --62389879(+) AATCCA/TTTTAT 1 -- ut310--------
    rs1898012311,2
    --62390046(+) GGGTTA/CATTTT 1 -- ut310--------
    rs1824678791,2
    --62390116(+) TTAAAA/GCTAGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KHDRBS2 (62389865 - 62639865 bp, first 250kb of KHDRBS2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KHDRBS2 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1257101CNV Deletion17803354
    esv2670697CNV Deletion23128226
    esv2071676CNV Deletion18987734
    esv2732185CNV Deletion23290073
    dgv1056e201CNV Deletion23290073
    esv2732192CNV Deletion23290073
    esv2732189CNV Deletion23290073
    esv2667072CNV Deletion23128226
    esv2732188CNV Deletion23290073
    esv1332559CNV Deletion17803354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KHDRBS2
    DNA2.0 Custom Variant and Variant Library Synthesis for KHDRBS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610487    OMIM disorders: --


    Find genes that share disorders with KHDRBS2           About GenesLikeMe

    Genetic Association Database (GAD): KHDRBS2

    Export disorders for KHDRBS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for KHDRBS2 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with KHDRBS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel human STAR domain containing cDNA KHDRBS2. (PubMed id 12549823)1, 2, 9 Wang L.... Mao Y. (Mol. Biol. Rep. 2002)
    2. Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA. (PubMed id 19282290)1, 2 Heinrich B.... Stamm S. (J. Biol. Chem. 2009)
    3. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PubMed id 18464913)1, 4 Melzer D....Ferrucci L. (PLoS Genet. 2008)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1. (PubMed id 12529443)1, 2 Cote J.... Richard S. (Mol. Biol. Cell 2003)
    6. Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis. (PubMed id 10077576)1, 9 Di Fruscio M.... Richard S. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    7. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (Nat. Biotechnol. 2013)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 202559 HGNC: 18114 AceView: KHDRBS2 Ensembl:ENSG00000112232 euGenes: HUgn202559
    ECgene: KHDRBS2 H-InvDB: KHDRBS2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for KHDRBS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KHDRBS2 gene:
    Search GeneIP for patents involving KHDRBS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KHDRBS2  
     OriGene qPCR primer pairs and template standards for KHDRBS2   OriGene Protein Over-expression Lysate for KHDRBS2  
     OriGene MassSpec something-or-other for KHDRBS2   OriGene clones in human, mouse for KHDRBS2  
     OriGene qSTAR qPCR primer pairs in human, mouse for KHDRBS2   OriGene Purified Protein for KHDRBS2  
     OriGene ORF clones in mouse, rat for KHDRBS2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KHDRBS2   OriGene Custom Protein Services for KHDRBS2  

     
     
     Block miRNA regulation of human, mouse, rat KHDRBS2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KHDRBS2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KHDRBS2 Predesigned siRNA for gene silencing in human, mouse, rat KHDRBS2
     QuantiFast Probe-based Assays in human, mouse, rat KHDRBS2 QuantiTect SYBR Green Assays in human, mouse, rat KHDRBS2
     Custom PCR Arrays for KHDRBS2 Search Chromatin IP Primers for KHDRBS2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KHDRBS2  Search GeneGlobe Interaction Network for KHDRBS2
     Regulatory tfbs in KHDRBS2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for KHDRBS2 GenScript cDNA clones with any tag delivered in your preferred vector for KHDRBS2
     GenScript Custom Assay Services for KHDRBS2 GenScript Custom overexpressing Cell Line Services for KHDRBS2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for KHDRBS2 (KHDR2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for KHDRBS2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     KHDRBS2 antibodies
     KHDRBS2 proteins
     KHDRBS2 lysates
     Antibodies for KHDRBS2
     See all of Abcam's Antibodies, Kits and Proteins for KHDRBS2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for KHDRBS2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KHDRBS2
     SwitchGear 3'UTR luciferase reporter plasmids for KHDRBS2
     SwitchGear Promoter luciferase reporter plasmids for KHDRBS2
     Search ThermoFisher Antibodies for KHDRBS2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KHDRBS2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KHDRBS2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KHDRBS2
     LSBio Antibodies in human, mouse, rat for KHDRBS2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for KHDRBS2
      Search eBioscience for proteins for KHDRBS2
      Search eBioscience for elisas for KHDRBS2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KHDRBS2 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4