Aliases for KHDRBS2 Gene
External Ids for KHDRBS2 Gene
Previous GeneCards Identifiers for KHDRBS2 Gene
GeneCards Summary for KHDRBS2 Gene
KHDRBS2 (KH RNA Binding Domain Containing, Signal Transduction Associated 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by PTK6. GO annotations related to this gene include nucleic acid binding and protein heterodimerization activity. An important paralog of this gene is KHDRBS3.
UniProtKB/Swiss-Prot for KHDRBS2 Gene
RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis.