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Aliases for KHDRBS1 Gene

Aliases for KHDRBS1 Gene

  • KH Domain Containing, RNA Binding, Signal Transduction Associated 1 2 3
  • Sam68 3 4 6
  • GAP-Associated Tyrosine Phosphoprotein P62 (Sam68) 2 3
  • P21 Ras GTPase-Activating Protein-Associated P62 3 4
  • Src-Associated In Mitosis 68 KDa Protein 3 4
  • P68 3 4
  • KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein 1 3
  • GAP-Associated Tyrosine Phosphoprotein P62 4
  • P62 3

External Ids for KHDRBS1 Gene

Previous GeneCards Identifiers for KHDRBS1 Gene

  • GC01P032294
  • GC01P031467
  • GC01P031906
  • GC01P032150
  • GC01P032479
  • GC01P030596

Summaries for KHDRBS1 Gene

Entrez Gene Summary for KHDRBS1 Gene

  • This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3'-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

GeneCards Summary for KHDRBS1 Gene

KHDRBS1 (KH Domain Containing, RNA Binding, Signal Transduction Associated 1) is a Protein Coding gene. Among its related pathways are Translational Control and Prolactin Signaling Pathway. GO annotations related to this gene include RNA binding and protein complex binding. An important paralog of this gene is QKI.

UniProtKB/Swiss-Prot for KHDRBS1 Gene

  • Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824).

  • Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase.

Gene Wiki entry for KHDRBS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KHDRBS1 Gene

Genomics for KHDRBS1 Gene

Regulatory Elements for KHDRBS1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KHDRBS1 Gene

Start:
32,013,694 bp from pter
End:
32,060,859 bp from pter
Size:
47,166 bases
Orientation:
Plus strand

Genomic View for KHDRBS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KHDRBS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KHDRBS1 Gene

Proteins for KHDRBS1 Gene

  • Protein details for KHDRBS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07666-KHDR1_HUMAN
    Recommended name:
    KH domain-containing, RNA-binding, signal transduction-associated protein 1
    Protein Accession:
    Q07666
    Secondary Accessions:
    • D3DPP3
    • Q6PJX7
    • Q8NB97
    • Q99760

    Protein attributes for KHDRBS1 Gene

    Size:
    443 amino acids
    Molecular mass:
    48227 Da
    Quaternary structure:
    • Self-associates to form homooligomers when bound to RNA, oligomerization appears to be limited when binding to proteins. Interacts with CBL, KHDRBS3, LCK, GRB2, JAK3, PIK3R1, PLCG1, PTPN6, RASA1, RBMY1A1 and STAT3. Interacts with PRMT1. Binds the WW domains of WBP4/FBP21, FNBP4/FBP30 and the SH3 domain of FYN through the Arg/Gly-rich-flanked Pro-rich regions (By similarity). Forms a complex with ILF2, ILF3, YLPM1, RBMX, NCOA5 and PPP1CA. Interacts with PTK6 (via SH3 and SH2 domains). Does not interact with TPR.
    SequenceCaution:
    • Sequence=AAH10132.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KHDRBS1 Gene

    Alternative splice isoforms for KHDRBS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KHDRBS1 Gene

Proteomics data for KHDRBS1 Gene at MOPED

Post-translational modifications for KHDRBS1 Gene

  • Acetylated. Positively correlates with ability to bind RNA.
  • Arginine methylation is required for nuclear localization. Also can affect interaction with other proteins. Inhibits interaction with Src-like SH3 domains, but not interaction with WW domains of WBP4/FBP21 AND FNBP4/FBP30.
  • Tyrosine phosphorylated by several non-receptor tyrosine kinases, LCK, FYN and JAK3. Negatively correlates with ability to bind RNA but required for many interactions with proteins. Phosphorylation by PTK6 negatively regulates its RNA binding ability. Phosphorylation by PTK6 at Tyr-440 dictates the nulear localization of KHDRBS1.
  • Ubiquitination at Lys165, Lys169, Lys175, Lys185, and Lys432
  • Modification sites at PhosphoSitePlus

Other Protein References for KHDRBS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for KHDRBS1 (KHDRBS1)

No data available for DME Specific Peptides for KHDRBS1 Gene

Domains for KHDRBS1 Gene

Suggested Antigen Peptide Sequences for KHDRBS1 Gene

Graphical View of Domain Structure for InterPro Entry

Q07666

UniProtKB/Swiss-Prot:

KHDR1_HUMAN :
  • Q07666
Domain:
  • The KH domain is required for binding to RNA.
  • The Pro-rich domains are flanked by Arg/Gly-rich motifs which can be asymmetric dimethylated on arginine residues to give the DMA/Gly-rich regions. Selective methylation on these motifs can modulate protein-protein interactions (By similarity).
  • Contains 1 KH domain.
Family:
  • Belongs to the KHDRBS family.
genes like me logo Genes that share domains with KHDRBS1: view

No data available for Gene Families for KHDRBS1 Gene

Function for KHDRBS1 Gene

Molecular function for KHDRBS1 Gene

UniProtKB/Swiss-Prot Function: Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824).
UniProtKB/Swiss-Prot Function: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase.

Gene Ontology (GO) - Molecular Function for KHDRBS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding TAS 1374686
GO:0003723 RNA binding IDA 1374686
GO:0005070 SH3/SH2 adaptor activity IPI 9045636
GO:0005515 protein binding IPI 10913193
genes like me logo Genes that share ontologies with KHDRBS1: view
genes like me logo Genes that share phenotypes with KHDRBS1: view

Animal Models for KHDRBS1 Gene

MGI Knock Outs for KHDRBS1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KHDRBS1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KHDRBS1 Gene

Localization for KHDRBS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KHDRBS1 Gene

Nucleus. Membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KHDRBS1 Gene COMPARTMENTS Subcellular localization image for KHDRBS1 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KHDRBS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 1374686
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IDA 1374686
GO:0070618 Grb2-Sos complex IEA --
genes like me logo Genes that share ontologies with KHDRBS1: view

Pathways for KHDRBS1 Gene

genes like me logo Genes that share pathways with KHDRBS1: view

Pathways by source for KHDRBS1 Gene

1 Cell Signaling Technology pathway for KHDRBS1 Gene
1 BioSystems pathway for KHDRBS1 Gene

Gene Ontology (GO) - Biological Process for KHDRBS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006397 mRNA processing TAS 1374686
GO:0007050 cell cycle arrest TAS 9013542
GO:0007165 signal transduction TAS 9013542
genes like me logo Genes that share ontologies with KHDRBS1: view

Compounds for KHDRBS1 Gene

(12) Novoseek inferred chemical compound relationships for KHDRBS1 Gene

Compound -log(P) Hits PubMed IDs
ucs15a 85.3 2
tyrosine 70.7 78
olomoucine 56.9 1
leptomycin b 54.7 1
radicicol 54.5 1
genes like me logo Genes that share compounds with KHDRBS1: view

Transcripts for KHDRBS1 Gene

Unigene Clusters for KHDRBS1 Gene

KH domain containing, RNA binding, signal transduction associated 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KHDRBS1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KHDRBS1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^ 11
SP1: - - -
SP2: -
SP3:
SP4: - -
SP5: - - - - -

Relevant External Links for KHDRBS1 Gene

GeneLoc Exon Structure for
KHDRBS1
ECgene alternative splicing isoforms for
KHDRBS1

Expression for KHDRBS1 Gene

mRNA expression in normal human tissues for KHDRBS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KHDRBS1 Gene

SOURCE GeneReport for Unigene cluster for KHDRBS1 Gene Hs.445893

mRNA Expression by UniProt/SwissProt for KHDRBS1 Gene

Q07666-KHDR1_HUMAN
Tissue specificity: Ubiquitously expressed in all tissue examined. Isoform 1 is expressed at lower levels in brain, skeletal muscle, and liver whereas isoform 3 is intensified in skeletal muscle and in liver.
genes like me logo Genes that share expressions with KHDRBS1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for KHDRBS1 Gene

Orthologs for KHDRBS1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KHDRBS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KHDRBS1 35
  • 99.92 (n)
  • 100 (a)
KHDRBS1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KHDRBS1 35
  • 94.66 (n)
  • 99.55 (a)
KHDRBS1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KHDRBS1 35
  • 94.88 (n)
  • 99.76 (a)
KHDRBS1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Khdrbs1 35
  • 90.52 (n)
  • 94.36 (a)
Khdrbs1 16
Khdrbs1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia KHDRBS1 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Khdrbs1 35
  • 90.59 (n)
  • 94.36 (a)
chicken
(Gallus gallus)
Aves KHDRBS1 35
  • 78.3 (n)
  • 87.66 (a)
KHDRBS1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KHDRBS1 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398660 35
tropical clawed frog
(Silurana tropicalis)
Amphibia khdrbs1 35
  • 72.25 (n)
  • 79.19 (a)
Str.20538 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
khdrbs1a 36
  • 61 (a)
OneToMany
khdrbs1b 35
  • 65.11 (n)
  • 67.64 (a)
khdrbs1b 36
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10384 36
  • 22 (a)
ManyToMany
CG3927 36
  • 34 (a)
ManyToMany
CG4021 36
  • 30 (a)
ManyToMany
nsr 36
  • 29 (a)
ManyToMany
qkr54B 36
  • 34 (a)
ManyToMany
qkr58E-1 36
  • 33 (a)
ManyToMany
qkr58E-2 36
  • 28 (a)
ManyToMany
qkr58E-3 36
  • 31 (a)
ManyToMany
CG10384 37
  • 59 (a)
qkr54B 37
  • 51 (a)
qkr58E-3 37
  • 41 (a)
CG3927 37
  • 43 (a)
CG3875 37
  • 41 (a)
qkr58E-1 37
  • 48 (a)
qkr58E-2 37
  • 36 (a)
CG4021 37
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea B0280.17 36
  • 18 (a)
ManyToMany
F54D1.1 36
  • 20 (a)
ManyToMany
K07H8.9 36
  • 25 (a)
ManyToMany
Y57G11C.36 36
  • 21 (a)
ManyToMany
Y69A2AR.32 36
  • 23 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSL5 36
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11338 36
  • 35 (a)
OneToMany
Species with no ortholog for KHDRBS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KHDRBS1 Gene

ENSEMBL:
Gene Tree for KHDRBS1 (if available)
TreeFam:
Gene Tree for KHDRBS1 (if available)

Paralogs for KHDRBS1 Gene

Paralogs for KHDRBS1 Gene

Selected SIMAP similar genes for KHDRBS1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KHDRBS1: view

Variants for KHDRBS1 Gene

Sequence variations from dbSNP and Humsavar for KHDRBS1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs482923 -- 32,040,591(-) TAACC(A/C)AACCT intron-variant
rs508433 -- 32,021,313(+) TAGCC(A/C)ATATT intron-variant
rs514219 -- 32,049,322(-) atccc(A/C)aactt intron-variant
rs550411 -- 32,046,164(-) GATAA(A/G)GGaca intron-variant
rs601152 -- 32,049,227(-) aatac(A/C)aaaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KHDRBS1 Gene

Variant ID Type Subtype PubMed ID
nsv834591 CNV Loss 17160897

Relevant External Links for KHDRBS1 Gene

HapMap Linkage Disequilibrium report
KHDRBS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KHDRBS1 Gene

Disorders for KHDRBS1 Gene

(7) Novoseek inferred disease relationships for KHDRBS1 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 24.1 3
prostate cancer 8.89 5
aids 0 1
breast cancer 0 5
tumors 0 14
genes like me logo Genes that share disorders with KHDRBS1: view

No data available for UniProtKB/Swiss-Prot for KHDRBS1 Gene

Publications for KHDRBS1 Gene

  1. Molecular cloning and nucleic acid binding properties of the GAP- associated tyrosine phosphoprotein p62. (PMID: 1374686) Wong G. … McCormick F. (Cell 1992) 2 3 4 23
  2. A role for Sam68 in cell cycle progression antagonized by a spliced variant within the KH domain. (PMID: 9013542) Barlat I. … Schweighoffer F. (J. Biol. Chem. 1997) 3 4 23
  3. Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling. (PMID: 9045636) Fusaki N. … Fujisawa J. (J. Biol. Chem. 1997) 3 4 23
  4. The RNA binding protein Sam68 is acetylated in tumor cell lines, and its acetylation correlates with enhanced RNA binding activity. (PMID: 15021911) Babic I. … Fujita D.J. (Oncogene 2004) 3 4 23
  5. Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression. (PMID: 16179349) Lukong K.E. … Richard S. (J. Biol. Chem. 2005) 3 4 23

Products for KHDRBS1 Gene

Sources for KHDRBS1 Gene

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