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KGFLP1 Gene

pseudogene   GIFtS: 27
GCID: GC09P046688

Fibroblast Growth Factor 7 Pseudogene


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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 2

Aliases
Fibroblast Growth Factor 7 Pseudogene2
KGF-Like Protein 13

External Ids:    Entrez Gene: 3876282   Ensembl: ENSG000002274497   UniProtKB: Q2TVT43   
ORGUL members:         

Export aliases for KGFLP1 gene to outside databases

Previous GC identifers: GC09P065012 GC09P046527


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KGFLP1 Gene:
KGFLP1 is a pseudogene, and is affiliated with the lncRNA class. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_086755.3  
Regulatory elements:
   Regulatory transcription factor binding sites in the KGFLP1 gene promoter:
         RelA   Arnt   POU2F1   FOXO4   POU2F1a   HSF2   FOXO1a   FOXO1   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KGFLP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p11.2   Ensembl cytogenetic band:  9p11.2   

KGFLP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KGFLP1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P046688:  view genomic region     (about GC identifiers)

Start:
46,687,462 bp from pter      End:
46,748,386 bp from pter
Size:
60,925 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KGFL1_HUMAN, Q2TVT4 (See protein sequence)
Recommended Name: Putative keratinocyte growth factor-like protein 1  
Size: 97 amino acids; 11079 Da
Caution: Could be the product of a pseudogene. Highly similar to the C-terminus of FGF7 but lacks the N-terminal
part. As it has lost it signal peptide it is unlikely to be active. Maps to a duplicated region on chromosome 9

Explore the universe of human proteins at neXtProt for KGFLP1: NX_Q2TVT4


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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR028247 FGF7
 IPR028142 IL-1_fam/FGF_fam
 IPR008996 Cytokine_IL1-like
 IPR002209 Fibroblast_GF_fam

Graphical View of Domain Structure for InterPro Entry Q2TVT4

ProtoNet protein and cluster: Q2TVT4

1 Blocks protein domain: IPB002348 IL1/HBGF family signature

UniProtKB/Swiss-Prot: KGFL1_HUMAN, Q2TVT4
Similarity: Belongs to the heparin-binding growth factors family


Find genes that share domains with KGFLP1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005104fibroblast growth factor receptor binding IEA--
GO:0008083growth factor activity IEA--
     
Find genes that share ontologies with KGFLP1           About GenesLikeMe


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

Find genes that share ontologies with KGFLP1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

    Search GeneGlobe Interaction Network for KGFLP1

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008543fibroblast growth factor receptor signaling pathway IEA--

Find genes that share ontologies with KGFLP1           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for KGFLP1 (KGFL1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for KGFLP1 gene: 
NM_174950.2  

Unigene Cluster for KGFLP1:

Fibroblast growth factor 7 pseudogene
Hs.439341  [show with all ESTs]
Unigene Representative Sequence: AY098593
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000377614(uc011lrd.2) ENST00000452826 ENST00000451282
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Additional mRNA sequence: 

AF523265.1 AK307215.1 AY098593.1 BC101842.1 BC112977.1 BC112978.1 NR_003674.2 NR_047527.1 

11 DOTS entries:

DT.92426456  DT.110426  DT.121159705  DT.121207073  DT.121212171  DT.121212214  DT.121212304  DT.95115743 
DT.97776272  DT.99939955  DT.99955001 

Selected AceView cDNA sequences (see all 31):

NM_174950 AW168170 AF523265 BG188472 AK054997 BG426408 BM728755 BV198487 
BI047259 BV167881 BM925376 AI244161 BX509336 BV167955 AW291998 BG190094 
BI768457 BX390829 BG699277 BX492480 BI914008 BG708001 BC030269 BG569894 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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KGFLP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTTTTTTCCT
KGFLP1 Expression
About this image

KGFLP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.439341
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for KGFLP1 (if available)
TreeFam Gene Tree for KGFLP1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for KGFLP1 gene
16 SIMAP similar genes for KGFLP1 using alignment to 1 protein entry:     KGFL1_HUMAN:
FGF7    KGFLP2    PRED3    FGF10    FGF13    FGF16
FGF22    FGF5    FGF12    FGF8    FGF11    FGF20
FGF1    FGF2    FGF3    fgf gene

Find genes that share paralogs with KGFLP1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for KGFLP1 (see all 62)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs625577211,2
--46696576(+) GATCAC/GCCTCT 2 -- int10--------
rs123380801,2
C,A--46696878(+) AGGTAC/TGAGCC 2 -- int10--------
rs609063161,2
C--46696920(+) TATCCC/GTGGTG 2 -- int10--------
rs1840811591,2
--46699409(+) GGCTGA/GCGGAG 2 -- int10--------
rs49292471,2
A--46699489(+) gtgagA/Ggagtg 2 -- int10--------
rs1173569391,2
C,F--46700193(+) GTTCCG/AGCACA 2 -- int11Minor allele frequency- A:0.27NA 120
rs1885331781,2
--46701132(+) GGTGGA/GCCCTC 2 -- int10--------
rs2011287021,2
--46702205(+) GATTG-/AAAAAA 2 -- int10--------
rs749262041,2
C--46702396(+) GAGCGA/GTAACA 2 -- int10--------
rs1144415781,2
F--46703421(+) GTGAAT/GGAATT 2 -- int11Minor allele frequency- G:0.05WA 118

HapMap Linkage Disequilibrium report for KGFLP1 (46687462 - 46748386 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for KGFLP1:    About this table    
Variant IDTypeSubtypePubMed ID
esv1001418CNV Gain20482838
esv26894CNV Gain+Loss19812545

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for KGFLP1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with KGFLP1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. FGF7-like gene is associated with pericentric inversion of chromosome 9, and FGF7 is involved in the development of ovarian cancer. (PubMed id 15809711)1, 2 Yasuhara T.... Ohtake Y. (Int. J. Oncol. 2005)
  2. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  5. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 387628 AceView: FLJ30435 Ensembl:ENSG00000227449 euGenes: HUgn387628

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for KGFLP1 gene:
Search GeneIP for patents involving KGFLP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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