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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KERA Gene

protein-coding   GIFtS: 57
GCID: GC12M091377

keratocan


(Previous symbol: CNA2)
 Explore 14 diseases affiliated with
KERA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KERA    

Aliases
for KERA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Keratocan1
SLRR2B1 2 3
CNA21 2 5
Keratan Sulfate Proteoglycan Keratocan2 3
KTN2 3

External Ids:    HGNC: 63091   Entrez Gene: 110812   Ensembl: ENSG000001393307   OMIM: 6032885   UniProtKB: O609383   

Export aliases for KERA gene to outside databases

Previous GC identifers: GC12M090766 GC12M091891 GC12M089946 GC12M088512


Summaries
for KERA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KERA:
The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in
this gene are a cause of autosomal recessive cornea plana 2 (CNA2).(provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: KERA_HUMAN, O60938
Function: May be important in developing and maintaining corneal transparency and for the structure of the stromal
matrix

Gene Wiki entry for KERA (Keratocan)


Genomic Views
for KERA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KERA gene promoter:
         Nkx3-1   Nkx3-1 v4   FOXF2   Nkx3-1 v1   CUTL1   GATA-1   Nkx3-1 v2   POU2F1   POU2F1a   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KERA promoter sequence
   Search SABiosciences Chromatin IP Primers for KERA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KERA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q22   Ensembl cytogenetic band:  12q21.33   HGNC cytogenetic band: 12q21.3-q22

KERA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KERA gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M091377:  view genomic region     (about GC identifiers)

Start:
 91,444,268 bp from pter      End:
 91,452,131 bp from pter
Size:
 7,864 bases      Orientation:
 minus strand

Proteins
for KERA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KERA_HUMAN, O60938 (See protein sequence)
Recommended Name: Keratocan precursor  
Size: 352 amino acids; 40509 Da
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)

Explore the universe of human proteins at neXtProt for KERA: NX_O60938

Post-translational modifications:

  • Binds keratan sulfate chains (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60938

    • KERA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_008966.1  
    ENSEMBL proteins: 
     ENSP00000266719  
    Reactome Protein details: O60938
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: KERA
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    Novus Biologicals KERA Protein
    Novus Biologicals KERA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KERA

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix NAS10802664
    GO:0005796Golgi lumen TAS--
    GO:0043202lysosomal lumen TAS--


    KERA for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for KERA

    Protein Domains /
    Families
    for KERA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KERA for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001611 Leu-rich_rpt
     IPR000372 LRR-contain_N

    Graphical View of Domain Structure for InterPro Entry O60938

    ProtoNet protein and cluster: O60938

    1 Blocks protein family: IPB000372 Cysteine-rich flanking region

    UniProtKB/Swiss-Prot: KERA_HUMAN, O60938
    Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily
    Similarity: Contains 10 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRNT domain


    Function
    for KERA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KERA_HUMAN, O60938
    Function: May be important in developing and maintaining corneal transparency and for the structure of the stromal
    matrix

         Genatlas biochemistry entry for KERA:
    keratocan,keratan sulfate proteoglycan,on of the three major constituents of corneal stroma,expressed during eye
    development and in adult corneal keratocytes,small leucine-rich proteoglycan family

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KERA
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate KERA:
    hsa-miR-219-1-3p hsa-miR-3664-5p hsa-miR-374b hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmid: KERA 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KERA (see all 7)
    OriGene shRNA RFP: KERA
    OriGene siRNA: KERA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KERA

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for KERA

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KERA 

    Cell Line
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    Search LifeMap BioReagents cell lines for KERA

    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--


    KERA for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for KERA:
     Bright nuclei  Increased S DNA content 

    Animal Models:
         Mouse knock-out Keratm1Cyl for KERA
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Kera):
     hematopoietic system  immune system  vision/eye 

    KERA for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KERA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1MPS IIIC - Sanfilippo syndrome C
    8/14 pathways (see all 14)
    		MPS IIIC - Sanfilippo syndrome C1.00
    		MPS IIIA - Sanfilippo syndrome A1.00
    		MPS I - Hurler syndrome1.00
    		MPS IIID - Sanfilippo syndrome D1.00
    		Mucopolysaccharidoses1.00
    		MPS IX - Natowicz syndrome1.00
    		MPS IV - Morquio syndrome A1.00
    		MPS II - Hunter syndrome1.00
    2Extracellular KSPG translocates to the lysosome for degradation
    		Extracellular KSPG translocates to the lysosome for degradation1.00
    		Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase1.00
    		KSPG is secreted from the cell1.00
    		Keratan sulfate degradation0.58
    3Keratan sulfate biosynthesis
    		Keratan sulfate biosynthesis1.00
    		Keratan sulfate/keratin metabolism0.84
    4Disease
    		Disease1.00
    5Metabolism
    		Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/22        Reactome Pathways for KERA (see all 22)
        MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    Keratan sulfate/keratin metabolism
    MPS IIIA - Sanfilippo syndrome A



    KERA for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KERA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/21 Interacting proteins for KERA (O609382, 3 ENSP000002667194) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CXCL2P198753I2D: score=1 
    B3GNT7ENSP000002875904STRING: ENSP00000287590
    CHST1ENSP000003092704STRING: ENSP00000309270
    CHST5ENSP000003387834STRING: ENSP00000338783
    CHST6ENSP000003289834STRING: ENSP00000328983
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0007601visual perception IEA--
    GO:0018146keratan sulfate biosynthetic process TAS--
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0042339keratan sulfate metabolic process TAS--


    KERA for ontologies           About GeneDecksing



    Drugs & Compounds
    for KERA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KERA

    1 HMDB Compound for KERA    About this table
    CompoundSynonyms CAS #PubMed Ids
    KeratanKerato sulfate (see all 4)69992-87-6--
    Search CenterWatch for drugs/clinical trials and news about KERA 

    Transcripts
    for KERA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KERA gene: 
    NM_007035.3  

    Unigene Cluster for KERA:

    Keratocan
    Hs.125750  [show with all ESTs]
    Unigene Representative Sequence: NM_007035
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000266719(uc001tbl.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KERA
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate KERA:
    hsa-miR-219-1-3p hsa-miR-3664-5p hsa-miR-374b hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmid: KERA 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KERA (see all 7)
    OriGene shRNA RFP: KERA
    OriGene siRNA: KERA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KERA
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KERA
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    GenScript: all cDNA clones in your preferred vector: KERA (NM_007035)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KERA
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KERA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KERA

    Additional cDNA sequence: 

    AF063301.1 AF205403.1 AK314990.1 BC032667.2 

    1 DOTS entry:

    DT.208708 

    19 AceView cDNA sequences:

    AA992157 AA884034 AA456434 AI340071 BM679097 AI278039 BM722156 BE041592 
    BC032667 AF063301 BG115424 AF205403 AI287530 BM722433 BM720651 BM468960 
    NM_007035 BM678956 BX100837 

    GeneLoc Exon Structure


    Expression
    for KERA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KERA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTAATAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KERA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneMaxillary ProcessBone
    BoneZeugopod Epiphyseal EndBone
    LimbAutopodLimb
    Skeletal MuscleExtraocular MusclesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KERA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KERA

    SOURCE GeneReport for Unigene cluster: Hs.125750

    UniProtKB/Swiss-Prot: KERA_HUMAN, O60938
    Tissue specificity: Cornea. Increased expression in the stroma of keratoconus corneas. Also detected in trachea, and in
    low levels, in intestine, skeletal muscle, ovary, lung and putamen

        SABiosciences Custom PCR Arrays for KERA
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    In Situ
    Assay Products:     
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    Orthologs
    for KERA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for KERA gene from 3/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KERA1 keratocan 70.79(n)
    70.4(a)    		   373995  NM_204176.1  NP_989507.1 
    lizard
    (Anolis carolinensis)    		 Reptilia KERA6
    		 --
    		 64(a)
    		 1 ↔ 1
    		 5(32370773-32375973)
    zebrafish
    (Danio rerio)    		 Actinopterygii kera1 keratocan 61.36(n)
    62.34(a)    		   567017  NM_001025548.2  NP_001020719.1 


    ENSEMBL Gene Tree for KERA (if available)
    TreeFam Gene Tree for KERA (if available) 

    Paralogs
    for KERA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KERA gene
    OGN2  OPTC2  PODN2  PODNL12  FMOD2  PRELP2  ASPN2  OMD2  
    BGN2  DCN2  EPYC2  ECM22  LUM2  
    6 SIMAP similar genes for KERA using alignment to 1 protein entry:     KERA_HUMAN:
    MST161    PRELP    FMOD    LUM    OMD    PODN

    KERA for paralogs           About GeneDecksing



    Genomic Variants
    for KERA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/258 NCBI SNPs in KERA are shown (see all 258)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1219178601,2
    		Cpathogenic124362411(-) ACCTAC/TAGAAC 2 Q * stg10--------
    rs1219178621,2
    		Cpathogenic124362535(-) CAATAA/CAATGC 2 K T mis10--------
    rs111059501,2
    		C,F,H,--88511929(+) AAATAT/AGTCAA 1 -- ds500110Minor allele frequency- A:0.04NS EA NA CSA WA 802
    rs108591001,2
    		C,F,A,H,--88512115(+) TGTTAG/AAAAGC 1 -- ut31 ese325Minor allele frequency- A:0.14NS EA NA WA CSA 2506
    rs111059511,2
    		C,F,H,--88512148(+) ATCCAA/GAAAAC 1 -- ut31 ese312Minor allele frequency- G:0.12NS EA NA WA CSA 686
    rs108591011,2
    		C,F,A,H,--88512229(+) AAATGC/AATTAT 1 -- ut31 ese318Minor allele frequency- A:0.15NS EA NA WA CSA 1697
    rs111059521,2
    		C,F,H,--88512272(+) CAGTGG/AACTAT 1 -- ut31 ese315Minor allele frequency- A:0.03NS EA NA WA 1624
    rs111059531,2
    		C,F,H,--88512548(+) NNNNCG/AGTATC 1 -- ut3113Minor allele frequency- A:0.07NS EA NA WA CSA 800
    rs25400071,2
    		H--88512589(-) TAAAAA/GGGACA 1 -- ut314Minor allele frequency- G:0.00NS EA 408
    rs27011701,2
    		H--88512604(-) TACATT/CCTTAT 1 -- ut314Minor allele frequency- C:0.00NS EA 402

    HapMap Linkage Disequilibrium report for KERA (91444268 - 91452131 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KERA: --
    Human Gene Mutation Database (HGMD): KERA

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KERA
    DNA2.0 Custom Variant and Variant Library Synthesis for KERA

    Disorders / Diseases
    for KERA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KERA for disorders           About GeneDecksing

    OMIM gene information: 603288   
    OMIM disorders: 217300  
    UniProtKB/Swiss-Prot: KERA_HUMAN, O60938
  • Defects in KERA are the cause of the autosomal recessive cornea plana 2 (CNA2) [MIM:217300]. In CNA2, the
    • forward convex curvature is flattened, leading to a decrease in refraction, reduced visual activity, extreme hyperopia
    (usually plus 10 d or more), hazy corneal limbus, opacities in the corneal parenchyma, and marked arcus senilis (often
    detected at an early age). CNA2 is a rare disorder with a worldwide distribution, but a high prevalence in the Finnish
    population

    14 diseases for KERA:    About MalaCards
    cornea plana congenita    cornea plana congenita, recessive    arcus senilis    exposure keratitis
    bullous keratopathy    cycloplegia    cloacogenic carcinoma    corneal dystrophy
    keratitis    hyperopia    keratopathy    keratoconus
    glaucoma    carcinoma

    3 diseases from the University of Copenhagen DISEASES database for KERA:
    Exposure keratitis     Keratoconus     Cloacogenic carcinoma
    Human Genome Epidemiology (HuGE) Navigator: KERA (3 documents)

    Export disorders for KERA gene to outside databases

    Publications
    for KERA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KERA gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with KERA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in KERA, encoding keratocan, cause cornea plana. (PubMed id 10802664)1, 2, 3, 9 Pellegata N.S....de la Chapelle A. (2000)
    2. Structure and sequence of the gene encoding human keratocan. (PubMed id 10565548)1, 2, 3, 9 Tasheva E.S....Conrad G.W. (1999)
    3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Keratocan expression is increased in the stroma of keratoconus corneas. (PubMed id 11683372)1, 2 Wentz-Hunter K.... Yue B.Y.J.T. (2001)
    6. A novel keratocan mutation causing autosomal recessive cornea plana. (PubMed id 11726611)1, 2 Lehmann O.J....Bhattacharya S.S. (2001)
    7. Clinical and molecular characterization of a family with autosomal recessive cornea plana. (PubMed id 16157807)1, 9 Ebenezer N.D....Allen R.C. (2005)
    8. Recessive cornea plana in the Kingdom of Saudi Arabia. (PubMed id 17011957)1, 9 Khan A.O....Meyer B. (2006)
    9. Assignment of keratocan gene (KERA) to human chromosome band 12q22 by in situ hybridization. (PubMed id 10828599)1, 9 Tasheva E.S....Conrad G.W. (2000)
    10. Identification and characterization of conserved cis-regulatory elements in the human keratocan gene promoter. (PubMed id 10899581)1, 9 Tasheva E.S....Conrad G.W. (2000)

    External Searches for KERA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing KERA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11081 HGNC: 6309 AceView: KERA Ensembl:ENSG00000139330 euGenes: HUgn11081
    ECgene: KERA H-InvDB: KERA

    Other Databases showing KERA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KERA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KERA Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KERA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KERA gene:
    Search GeneIP for patents involving KERA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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