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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KERA Gene

protein-coding   GIFtS: 60
GCID: GC12M091377

Keratocan


(Previous symbol: CNA2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
keratocan1 2
CNA21 2 5
Keratan Sulfate Proteoglycan Keratocan2 3
KTN2 3
SLRR2B2 3
Keratocan Proteoglycan1

External Ids:    HGNC: 63091   Entrez Gene: 110812   Ensembl: ENSG000001393307   OMIM: 6032885   UniProtKB: O609383   

Export aliases for KERA gene to outside databases

Previous GC identifers: GC12M090766 GC12M091891 GC12M089946 GC12M088512


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KERA Gene:
The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency.
Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2).(provided by RefSeq, May 2010)

GeneCards Summary for KERA Gene: 
KERA (keratocan) is a protein-coding gene. Diseases associated with KERA include posterior amorphous corneal dystrophy, and arcus senilis, and among its related super-pathways are Metabolism of carbohydrates and Keratan sulfate/keratin metabolism. GO annotations related to this gene include molecular_function. An important paralog of this gene is PODN.

UniProtKB/Swiss-Prot: KERA_HUMAN, O60938
Function: May be important in developing and maintaining corneal transparency and for the structure of the stromal
matrix

Gene Wiki entry for KERA (Keratocan) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KERA gene promoter:
         Nkx3-1   Nkx3-1 v4   FOXF2   Nkx3-1 v1   CUTL1   GATA-1   Nkx3-1 v2   POU2F1   POU2F1a   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKERA promoter sequence
   Search SABiosciences Chromatin IP Primers for KERA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KERA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q22   Ensembl cytogenetic band:  12q21.33   HGNC cytogenetic band: 12q21.3-q22

KERA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KERA gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M091377:  view genomic region     (about GC identifiers)

Start:
91,444,268 bp from pter      End:
91,452,131 bp from pter
Size:
7,864 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KERA_HUMAN, O60938 (See protein sequence)
Recommended Name: Keratocan precursor  
Size: 352 amino acids; 40509 Da
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)

Explore the universe of human proteins at neXtProt for KERA: NX_O60938

Explore proteomics data for KERA at MOPED 

Post-translational modifications:

  • UniProtKB: Binds keratan sulfate chains (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60938

  • KERA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KERA Protein Expression
    REFSEQ proteins: NP_008966.1  
    ENSEMBL proteins: 
     ENSP00000266719  
    Reactome Protein details: O60938
    Human Recombinant Protein Products for KERA: 
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    OriGene Protein Over-expression Lysate for KERA
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    OriGene Custom Protein Services for KERA
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    Novus Biologicals KERA Protein
    Novus Biologicals KERA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KERA 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix NAS10802664
    GO:0005796Golgi lumen TAS--
    GO:0043202lysosomal lumen TAS--

    KERA for ontologies           About GeneDecksing



    KERA Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for KERA 

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    Cloud-Clone Corp. ELISAs for KERA 
    Cloud-Clone Corp. CLIAs for KERA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLRR: Proteoglycans / Extracellular Matrix : Small leucine-rich repeats

    2 InterPro protein domains:
     IPR000372 LRR-contain_N
     IPR001611 Leu-rich_rpt

    Graphical View of Domain Structure for InterPro Entry O60938

    ProtoNet protein and cluster: O60938

    1 Blocks protein domain: IPB000372 Cysteine-rich flanking region

    UniProtKB/Swiss-Prot: KERA_HUMAN, O60938
    Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily
    Similarity: Contains 10 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRNT domain


    KERA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KERA_HUMAN, O60938
    Function: May be important in developing and maintaining corneal transparency and for the structure of the stromal
    matrix

         Genatlas biochemistry entry for KERA:
    keratocan,keratan sulfate proteoglycan,on of the three major constituents of corneal stroma,expressed during eye
    development and in adult corneal keratocytes,small leucine-rich proteoglycan family

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    KERA for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for KERA:
     Bright nuclei  Increased S DNA content 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Kera):
     hematopoietic system  immune system  vision/eye 

    KERA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Keratm1Cyl for KERA

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KERA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KERA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KERA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KERA 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KERA
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate KERA:
    hsa-miR-219-1-3p hsa-miR-3664-5p hsa-miR-374b hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidKERA 3' UTR sequence
    Inhib. RNA
    Products:
        
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KERA About                                                                                                See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS IIIC - Sanfilippo syndrome C
    MPS IIIC - Sanfilippo syndrome C0.48
    Glycosaminoglycan metabolism0.48
    MPS IV - Morquio syndrome A0.48
    MPS IIID - Sanfilippo syndrome D0.48
    MPS VI - Maroteaux-Lamy syndrome0.48
    MPS I - Hurler syndrome0.48
    MPS IV - Morquio syndrome B0.48
    MPS IX - Natowicz syndrome0.48
    2Keratan sulfate biosynthesis
    Keratan sulfate biosynthesis0.82
    Keratan sulfate degradation0.38
    Keratan sulfate/keratin metabolism0.82
    3Metabolism
    Metabolism0.40
    4Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/19        Reactome Pathways for KERA (see all 19)
        MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    Keratan sulfate/keratin metabolism
    MPS II - Hunter syndrome



    KERA for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KERA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/21 Interacting proteins for KERA (O609382, 3 ENSP000002667194) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CXCL2P198753I2D: score=1 
    B3GNT7ENSP000002875904STRING: ENSP00000287590
    CHST1ENSP000003092704STRING: ENSP00000309270
    CHST5ENSP000003387834STRING: ENSP00000338783
    CHST6ENSP000003289834STRING: ENSP00000328983
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0007601visual perception IEA--
    GO:0018146keratan sulfate biosynthetic process TAS--
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0042339keratan sulfate metabolic process TAS--

    KERA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KERA

    1 HMDB Compound for KERA    About this table
    CompoundSynonyms CAS #PubMed Ids
    KeratanKerato sulfate (see all 4)69992-87-6--

    Search CenterWatch for drugs/clinical trials and news about KERA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KERA gene: 
    NM_007035.3  

    Unigene Cluster for KERA:

    Keratocan
    Hs.125750  [show with all ESTs]
    Unigene Representative Sequence: NM_007035
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000266719(uc001tbl.3)
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KERA
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate KERA:
    hsa-miR-219-1-3p hsa-miR-3664-5p hsa-miR-374b hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidKERA 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KERA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KERA
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KERA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KERA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KERA

    Additional mRNA sequence: 

    AF063301.1 AF205403.1 AK314990.1 BC032667.2 

    1 DOTS entry:

    DT.208708 

    19 AceView cDNA sequences:

    AA992157 BE041592 BM722156 AA456434 BM679097 AI340071 AA884034 BC032667 
    AI278039 NM_007035 BM720651 AF063301 BX100837 AI287530 AF205403 BG115424 
    BM722433 BM678956 BM468960 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KERA expression in normal human tissues (normalized intensities)      KERA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTAATAAA
    KERA Expression
    About this image


    KERA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Hippocampus
             Entorhinal Cortex   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Extraocular Muscles
             cranial muscle/skeletal muscle   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             sensory organ/nose/nasal septum   
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal septum   
     
     Bone (Muscoskeletal System)
             Zeugopod Epiphyseal End

    See KERA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KERA

    SOURCE GeneReport for Unigene cluster: Hs.125750

    UniProtKB/Swiss-Prot: KERA_HUMAN, O60938
    Tissue specificity: Cornea. Increased expression in the stroma of keratoconus corneas. Also detected in trachea,
    and in low levels, in intestine, skeletal muscle, ovary, lung and putamen

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KERA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KERA gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kera1 , 5 keratocan1, 5 83.33(n)1
    86.57(a)1
      10 (50.34 cM)5
    165451  NM_008438.31  NP_032464.11 
     976072055 
    chicken
    (Gallus gallus)
    Aves KERA1 keratocan 70.79(n)
    70.4(a)
      373995  NM_204176.1  NP_989507.1 
    lizard
    (Anolis carolinensis)
    Reptilia KERA6
    keratocan
    64(a)
    1 ↔ 1
    5(32369442-32376285)
    zebrafish
    (Danio rerio)
    Actinopterygii kera1 keratocan 61.36(n)
    62.34(a)
      567017  NM_001025548.2  NP_001020719.1 


    ENSEMBL Gene Tree for KERA (if available)
    TreeFam Gene Tree for KERA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KERA gene
    PODN2  FLRT12  PODNL12  FMOD2  PRELP2  FLRT32  OMD2  ASPN2  
    BGN2  DCN2  FLRT22  ECM22  LUM2  
    6 SIMAP similar genes for KERA using alignment to 1 protein entry:     KERA_HUMAN:
    MST161    PRELP    FMOD    LUM    OMD    PODN

    KERA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/300 SNPs in KERA are shown (see all 300)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0127544
    The autosomal recessive cornea plana 2 (CNA2)4--see VAR_0127542 N S mis40--------
    VAR_0127534
    The autosomal recessive cornea plana 2 (CNA2)4--see VAR_0127532 T K mis40--------
    rs1219178631,2
    Cpathogenic191287834(-) CAGAAC/TGAGAT 2 R * stg10--------
    rs1219178581,2
    Cpathogenic191291908(-) TCACAA/GCAAAC 2 N S mis11Minor allele frequency- G:0.00NA 4516
    rs1219178621,2
    Cpathogenic191292004(-) CAATAA/CAATGC 2 K T mis10--------
    rs1219178601,2
    Cpathogenic191292128(-) ACCTAC/TAGAAC 2 Q * stg10--------
    rs1881387971,2
    --91286422(+) ACATTA/GTATTA 1 -- ds50010--------
    rs1931183281,2
    --91286465(+) ATTACA/GTTTCT 1 -- ds50010--------
    rs1849752031,2
    --91286572(+) TTTAAA/GGAATA 1 -- ds50010--------
    rs1902665851,2
    --91286578(+) GAATAA/CTGTTG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for KERA (91444268 - 91452131 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for KERA:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv899425CNV Gain21882294


    Human Gene Mutation Database (HGMD): KERA
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KERA
    DNA2.0 Custom Variant and Variant Library Synthesis for KERA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603288   
    OMIM disorders: 217300  
    UniProtKB/Swiss-Prot: KERA_HUMAN, O60938
  • The autosomal recessive cornea plana 2 (CNA2) [MIM:217300]: In CNA2, the forward convex curvature is
    flattened, leading to a decrease in refraction, reduced visual activity, extreme hyperopia (usually plus 10 d or
    more), hazy corneal limbus, opacities in the corneal parenchyma, and marked arcus senilis (often detected at an
    early age). CNA2 is a rare disorder with a worldwide distribution, but a high prevalence in the Finnish
    population. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 14 diseases for KERA:    About MalaCards
    posterior amorphous corneal dystrophy    arcus senilis    cornea plana congenita, recessive    cycloplegia
    exposure keratitis    cloacogenic carcinoma    keratitis    morquio syndrome b
    hyperopia    keratopathy    bullous keratopathy    keratoconus
    corneal dystrophy    glaucoma

    3 diseases from the University of Copenhagen DISEASES database for KERA:
    Exposure keratitis     Keratoconus     Cloacogenic carcinoma

    KERA for disorders           About GeneDecksing

    Genetic Association Database (GAD): KERA
    Human Genome Epidemiology (HuGE) Navigator: KERA (3 documents)

    Export disorders for KERA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KERA gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with KERA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in KERA, encoding keratocan, cause cornea plana. (PubMed id 10802664)1, 2, 3, 9 Pellegata N.S....de la Chapelle A. (2000)
    2. Structure and sequence of the gene encoding human keratocan. (PubMed id 10565548)1, 2, 3, 9 Tasheva E.S....Conrad G.W. (1999)
    3. Sequential use of transcriptional profiling, expressi on quantitative trait mapping, and gene association implicates MMP20 in human k idney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (2009)
    4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Keratocan expression is increased in the stroma of keratoconus corneas. (PubMed id 11683372)1, 2 Wentz-Hunter K.... Yue B.Y.J.T. (2001)
    7. A novel keratocan mutation causing autosomal recessive cornea plana. (PubMed id 11726611)1, 2 Lehmann O.J....Bhattacharya S.S. (2001)
    8. Clinical and molecular characterization of a family with autosomal recessive cornea plana. (PubMed id 16157807)1, 9 Ebenezer N.D....Allen R.C. (2005)
    9. Recessive cornea plana in the Kingdom of Saudi Arabia. (PubMed id 17011957)1, 9 Khan A.O....Meyer B. (2006)
    10. Assignment of keratocan gene (KERA) to human chromosome band 12q22 by in situ hybridization. (PubMed id 10828599)1, 9 Tasheva E.S....Conrad G.W. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11081 HGNC: 6309 AceView: KERA Ensembl:ENSG00000139330 euGenes: HUgn11081
    ECgene: KERA H-InvDB: KERA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KERA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KERA gene:
    Search GeneIP for patents involving KERA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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