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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KDSR Gene

protein-coding   GIFtS: 57
GCID: GC18M060994

3-Ketodihydrosphingosine Reductase

(Previous name: follicular lymphoma variant translocation 1)
(Previous symbol: FVT1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
3-Ketodihydrosphingosine Reductase1 2     Member 11
FVT11 2 3 5     Short Chain Dehydrogenase/Reductase Family 35C1
3-Dehydrosphinganine Reductase1 2 3     DHSR2
Follicular Lymphoma Variant Translocation 11 2     SDR35C12
Follicular Variant Translocation Protein 12 3     Short Chain Dehydrogenase/Reductase Family 35C, Member 12
FVT-12 3     EC 1.1.1.1023
KDS Reductase2 3     

External Ids:    HGNC: 40211   Entrez Gene: 25312   Ensembl: ENSG000001195377   OMIM: 1364405   UniProtKB: Q061363   

Export aliases for KDSR gene to outside databases

Previous GC identifers: GC18M059145 GC18M057693


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KDSR Gene:
The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The
putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum
membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type
II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular
atrophy. (provided by RefSeq, Jul 2008)

GeneCards Summary for KDSR Gene: 
KDSR (3-ketodihydrosphingosine reductase) is a protein-coding gene. Diseases associated with KDSR include follicular lymphoma, and muscular atrophy, and among its related super-pathways are Sphingolipid metabolism and Metabolic pathways. GO annotations related to this gene include 3-dehydrosphinganine reductase activity and nucleotide binding. An important paralog of this gene is SDR9C7.

UniProtKB/Swiss-Prot: KDSR_HUMAN, Q06136
Function: Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS)

Gene Wiki entry for KDSR (3-dehydrosphinganine reductase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_025028.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KDSR gene promoter:
         STAT5B   GATA-3   STAT4   STAT1beta   STAT5A   HNF-4alpha2   FOXL1   HNF-4alpha1   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKDSR promoter sequence
   Search SABiosciences Chromatin IP Primers for KDSR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KDSR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.3   Ensembl cytogenetic band:  18q21.33   HGNC cytogenetic band: 18q21

KDSR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KDSR gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M060994:  view genomic region     (about GC identifiers)

Start:
60,994,959 bp from pter      End:
61,034,743 bp from pter
Size:
39,785 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KDSR_HUMAN, Q06136 (See protein sequence)
Recommended Name: 3-ketodihydrosphingosine reductase precursor  
Size: 332 amino acids; 36187 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: B2R5Y1

Explore the universe of human proteins at neXtProt for KDSR: NX_Q06136

Explore proteomics data for KDSR at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q06136

  • KDSR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KDSR Protein Expression
    REFSEQ proteins: NP_002026.1  
    ENSEMBL proteins: 
     ENSP00000385083   ENSP00000468203   ENSP00000312939   ENSP00000467962  
    Reactome Protein details: Q06136
    Human Recombinant Protein Products for KDSR: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS8417785
    GO:0005783endoplasmic reticulum IDA15364918
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral to membrane IEA--

    KDSR for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SDRC3: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 3

    4 InterPro protein domains:
     IPR020904 Sc_DH/Rdtase_CS
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q06136

    ProtoNet protein and cluster: Q06136

    2 Blocks protein domains:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: KDSR_HUMAN, Q06136
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    KDSR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KDSR_HUMAN, Q06136
    Function: Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS)
    Catalytic activity: Sphinganine + NADP(+) = 3-dehydrosphinganine + NADPH

         Enzyme Number (IUBMB): EC 1.1.1.1021

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016491oxidoreductase activity ----
    GO:00475603-dehydrosphinganine reductase activity IDA15364918
         
    KDSR for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KDSR:
     Increased G1 DNA content 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KDSR About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.63
    Sphingolipid de novo biosynthesis0.47
    Sphingolipid metabolism0.63
    Sphingolipid Metabolism0.42
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    3ceramide de novo biosynthesis
    ceramide de novo biosynthesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for KDSR
        Sphingolipid Metabolism
    ceramide de novo biosynthesis


    4        Reactome Pathways for KDSR
        Sphingolipid metabolism
    Metabolism
    Metabolism of lipids and lipoproteins
    Sphingolipid de novo biosynthesis


    2         Kegg Pathways  (Kegg details for KDSR):
        Sphingolipid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: KDSR_HUMAN, Q06136
    Pathway: Lipid metabolism; sphingolipid metabolism


    KDSR for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KDSR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/18 Interacting proteins for KDSR (ENSP000003850834) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPHK1ENSP000003136814STRING: ENSP00000313681
    SPHK2ENSP000002452224STRING: ENSP00000245222
    SPTLC1ENSP000002625544STRING: ENSP00000262554
    SPTLC2ENSP000002164844STRING: ENSP00000216484
    SPTLC3ENSP000003819684STRING: ENSP00000381968
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006665sphingolipid metabolic process TAS--
    GO:00066663-keto-sphinganine metabolic process IDA15364918
    GO:0008152metabolic process ----
    GO:0030148sphingolipid biosynthetic process TAS--
    GO:0044281small molecule metabolic process TAS--

    KDSR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KDSR

    4 HMDB Compounds for KDSR    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Dehydrosphinganine1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)16105-69-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    Sphinganine2-amino-D-erythro-1,3-Octadecanediol (see all 13)764-22-7--

    Search CenterWatch for drugs/clinical trials and news about KDSR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KDSR gene: 
    NM_002035.2  

    Unigene Cluster for KDSR:

    3-ketodihydrosphingosine reductase
    Hs.74050  [show with all ESTs]
    Unigene Representative Sequence: NM_002035
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406396(uc010dpw.3 uc010xem.2) ENST00000586791 ENST00000591902
    ENST00000588089 ENST00000589592 ENST00000326575 ENST00000585750 ENST00000592327
    ENST00000589530 ENST00000585456 ENST00000587292 ENST00000590056
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    Additional mRNA sequence: 

    AF086045.1 AK025120.1 AK093874.1 AK297670.1 AK312360.1 BT006782.1 X63657.1 

    13 DOTS entries:

    DT.317085  DT.92437163  DT.428248  DT.92062831  DT.97816320  DT.70105324  DT.100801515  DT.100801521 
    DT.40278781  DT.95375235  DT.75126660  DT.95103117  DT.100841662 

    24/251 AceView cDNA sequences (see all 251):

    CD676126 AA099730 BX480324 BX370283 AU121524 AF086045 BE301748 AA845580 
    AI418119 BE018271 N30152 AA745021 BF924361 AA400780 BX448427 AA047249 
    BX118052 AI754753 BF593778 AA226862 AA099731 AK093874 BC008797 AI811325 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for KDSR (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c
    SP1:        -                             -                 -     -                                       
    SP2:                                      -                 -     -                 -                     
    SP3:                                                                                                      
    SP4:        -                                                                                             
    SP5:                                                              -                                       


    ECgene alternative splicing isoforms for KDSR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KDSR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KDSR Expression
    About this image


    See KDSR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KDSR

    SOURCE GeneReport for Unigene cluster: Hs.74050

    UniProtKB/Swiss-Prot: KDSR_HUMAN, Q06136
    Tissue specificity: Expressed in all tissues examined. Highest expression in placenta. High expression in lung,
    kidney, stomach and small intestine, low expression in heart, spleen and skeletal muscle. Weakly expressed in
    normal hematopoietic tissues. Higher expression in some T-cell malignancies and PHA-stimulated lymphocytes

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KDSR gene from 9/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kdsr1 , 5 3-ketodihydrosphingosine reductase1, 5 87.95(n)1
    92.77(a)1
      1 (49.99 cM)5
    707501  NM_027534.21  NP_081810.11 
     1067204105 
    chicken
    (Gallus gallus)
    Aves FVT16
    3-ketodihydrosphingosine reductase
    85(a)
    1 ↔ 1
    2(67898884-67917107)
    lizard
    (Anolis carolinensis)
    Reptilia KDSR6
    Uncharacterized protein
    70(a)
    1 ↔ 1
    GL343247.1(2019994-2045752)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.160862 Xenopus laevis transcribed sequence with moderate similarity more 76.29(n)    CF288317.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc559472 similar to follicular lymphoma variant translocation more 76.07(n)   394114  BC044552.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG104251 CG10425 49.09(n)
    37.62(a)
      43043  NM_143106.3  NP_651363.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TSC10(YBR265W)4
    TSC101
    3-ketosphinganine reductase, catalyzes the second step more4
    Tsc10p1
    39.06(n)1
    26.67(a)1
      2(738582-739544)4
    8525681, 4  NP_009824.21  NP_009824.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G060601 Rossmann-fold NAD(P)-binding domain-containing protein 47.84(n)
    37.89(a)
      819779  NM_111481.3  NP_187257.2 
    rice
    (Oryza sativa)
    Liliopsida Os02g07019001 hypothetical protein 48.37(n)
    37.71(a)
      4330439  NM_001054381.1  NP_001047846.1 


    ENSEMBL Gene Tree for KDSR (if available)
    TreeFam Gene Tree for KDSR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KDSR gene
    SDR9C72  DHRS92  HSD11B22  HSD17B62  HSD17B22  BDH12  RDH162  RDH82  
    DHRS7B2  DHRS72  HSD17B12  DHRS7C2  RDH52  
    1 SIMAP similar gene for KDSR using alignment to 4 protein entries:     KDSR_HUMAN (see all proteins):
    DHRS4L2

    KDSR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/819 SNPs in KDSR are shown (see all 819)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs563278371,2
    C--57702838(+) TATAT-/GTGA  
            
    ATATA
    1 -- int10--------
    rs1393836351,2
    --57702841(+) TGTGA-/ATATATA 1 -- int10--------
    rs105679801,2
    C--57707635(+) CCTGG-/CCAA  
            
    CATGG
    1 -- int10--------
    rs113352691,2
    C,F--57713997(+) AAAAA-/A/AAA 
            
    GTATC
    2 -- int1 cds1 trp32NA 4
    rs359270211,2
    C--57734622(+) ACTCT-/ATGTTTA 1 -- us2k10--------
    rs2020808581,2
    C--57734622(+) ACTCTA/GTGTTT 1 -- us2k10--------
    rs1840624801,2
    --60850460(+) GTTTAC/TGAACT 1 -- ds50010--------
    rs1416026091,2
    --60850481(+) GAGGCA/TTGTTC 1 -- ds50010--------
    rs1459975501,2
    C--60850525(+) ATCAGC/GATCTG 1 -- ds50010--------
    rs1511863191,2
    --60850593(+) GTATAA/GAAAAC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for KDSR (60994959 - 61034743 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for KDSR:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2671992CNV Deletion23128226
    esv2657702CNV Deletion23128226
    esv2717201CNV Deletion23290073
    esv270155CNV Insertion20981092
    esv1455992CNV Insertion17803354

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 136440    OMIM disorders: --

    UniProtKB/Swiss-Prot: KDSR_HUMAN, Q06136
  • Note=A chromosomal aberration involving KDSR is a cause of follicular lymphoma; also known as type II
    chronic lymphatic leukemia. Translocation t(2;18)(p11;q21) with a Ig J kappa chain region

  • 12 diseases for KDSR:    About MalaCards
    follicular lymphoma    muscular atrophy    spinal muscular atrophy    non-hodgkin lymphoma
    hodgkin's lymphoma    diffuse large b-cell lymphoma    b-cell lymphomas    coronary heart disease
    leukemia    tuberculosis    alcoholism    neuronitis


    KDSR for disorders           About GeneDecksing

    Genetic Association Database (GAD): KDSR
    Human Genome Epidemiology (HuGE) Navigator: KDSR (0 documents)

    Export disorders for KDSR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KDSR gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with KDSR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane. (PubMed id 15328338)1, 2, 3, 9 Kihara A. and Igarashi Y. (2004)
    2. FVT-1, a novel human transcription unit affected by variant translocation t(2;18)(p11;q21) of follicular lymphoma. (PubMed id 8417785)1, 2, 3, 9 Rimokh R.... Magaud J.-P. (1993)
    3. A missense mutation in the 3-ketodihydrosphingosine r eductase FVT1 as candidate causal mutation for bovine spinal muscular atrophy. (PubMed id 17420465)1, 3, 9 Krebs S....FAPrster M. (2007)
    4. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    5. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. B-cell non-Hodgkin's lymphoma cell line (Karpas 1106) with complex translocation involving 18q21.3 but lacking BCL2 rearrangement and expression. (PubMed id 7949096)1, 9 Nacheva E....Bevan P.C. (1994)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2531 HGNC: 4021 AceView: FVT1 Ensembl:ENSG00000119537 euGenes: HUgn2531
    ECgene: KDSR Kegg: 2531 H-InvDB: KDSR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KDSR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KDSR gene:
    Search GeneIP for patents involving KDSR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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