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Aliases for KDR Gene

Aliases for KDR Gene

  • Kinase Insert Domain Receptor 2 3 4
  • Fetal Liver Kinase 1 2 3 4
  • Kinase Insert Domain Receptor (A Type III Receptor Tyrosine Kinase) 2 3
  • Vascular Endothelial Growth Factor Receptor 2 2 3
  • Protein-Tyrosine Kinase Receptor Flk-1 3 4
  • EC 2.7.10.1 4 63
  • VEGFR2 3 4
  • FLK1 3 4
  • Tyrosine Kinase Growth Factor Receptor 3
  • Fetal Liver Kinase-1 3
  • Soluble VEGFR2 3
  • CD309 Antigen 4
  • EC 2.7.10 63
  • VEGFR-2 4
  • CD309 3
  • VEGFR 3
  • FLK-1 4

External Ids for KDR Gene

Previous GeneCards Identifiers for KDR Gene

  • GC04M055748
  • GC04M055906
  • GC04M055860
  • GC04M055785
  • GC04M055639
  • GC04M055944
  • GC04M051893

Summaries for KDR Gene

Entrez Gene Summary for KDR Gene

  • Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]

GeneCards Summary for KDR Gene

KDR (Kinase Insert Domain Receptor) is a Protein Coding gene. Diseases associated with KDR include hemangioma, capillary infantile and familial capillary hemangioma. Among its related pathways are PI3K-Akt signaling pathway and RhoGDI Pathway. GO annotations related to this gene include protein tyrosine kinase activity and transmembrane receptor protein tyrosine kinase activity. An important paralog of this gene is FGFR3.

UniProtKB/Swiss-Prot for KDR Gene

  • Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC.

Gene Wiki entry for KDR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KDR Gene

Genomics for KDR Gene

Regulatory Elements for KDR Gene

Transcription factor binding sites by QIAGEN in the KDR gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KDR Gene

Start:
55,078,259 bp from pter
End:
55,125,595 bp from pter
Size:
47,337 bases
Orientation:
Minus strand

Genomic View for KDR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KDR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KDR Gene

Proteins for KDR Gene

  • Protein details for KDR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35968-VGFR2_HUMAN
    Recommended name:
    Vascular endothelial growth factor receptor 2
    Protein Accession:
    P35968
    Secondary Accessions:
    • A2RRS0
    • B5A925
    • C5IFA0
    • O60723
    • Q14178

    Protein attributes for KDR Gene

    Size:
    1356 amino acids
    Molecular mass:
    151527 Da
    Quaternary structure:
    • Homodimer in the presence of bound dimeric VEGFA, VEGFC or VEGFD ligands; monomeric in the absence of bound ligands. Can also form heterodimers with FLT1/VEGFR1 and FLT4/VEGFR2. Interacts (tyrosine phosphorylated) with LFYN, NCK1, PLCG1. Interacts (tyrosine-phosphorylated active form preferentially) with DAB2IP (via C2 domain and active form preferentially); the interaction occurs at the late phase of VEGFA response and inhibits KDR/VEGFR2 activity. Interacts with SHBSH2D2A/TSAD, GRB2, MYOF, CBL and PDCD6. Interacts with HIV-1 Tat (PubMed:10102632, PubMed:10590123, PubMed:12649282, PubMed:12881528, PubMed:1417831, PubMed:15026417, PubMed:15215251, PubMed:15837294, PubMed:15962004, PubMed:16966330, PubMed:17253678, PubMed:18529047, PubMed:18593464, PubMed:19033661, PubMed:19668192, PubMed:20080685, PubMed:20145116, PubMed:20224550, PubMed:20705758, PubMed:21827946, PubMed:21893193, PubMed:9160888). Interacts (via C-terminus domain) with ERN1 (via kinase domain); the interaction is facilitated in a XBP1 isoform 1- and vascular endothelial growth factor (VEGF)-dependent manner in endothelial cells (PubMed:23529610).

    Three dimensional structures from OCA and Proteopedia for KDR Gene

    Alternative splice isoforms for KDR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KDR Gene

Proteomics data for KDR Gene at MOPED

Post-translational modifications for KDR Gene

  • Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-951 is important for interaction with SH2D2A/TSAD and VEGFA-mediated reorganization of the actin cytoskeleton. Phosphorylation at Tyr-1175 is important for interaction with PLCG1 and SHB. Phosphorylation at Tyr-1214 is important for interaction with NCK1 and FYN. Dephosphorylated by PTPRB. Dephosphorylated by PTPRJ at Tyr-951, Tyr-996, Tyr-1054, Tyr-1059, Tyr-1175 and Tyr-1214.
  • N-glycosylated.
  • The inhibitory disulfide bond between Cys-1024 and Cys-1045 may serve as a specific molecular switch for H(2)S-induced modification that regulates VEGFR2 function
  • Ubiquitinated. Tyrosine phosphorylation of the receptor promotes its poly-ubiquitination, leading to its degradation via the proteasome or lysosomal proteases.
  • Glycosylation at Asn46, Asn66, Asn96, Asn143, Asn158, Asn245, Asn318, Asn374, Asn395, Asn511, Asn523, Asn580, Asn613, Asn619, Asn631, Asn675, Asn704, and Asn721
  • Modification sites at PhosphoSitePlus

Other Protein References for KDR Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for KDR (VEGF R2/KDR/Flk-1)
  • Cell Signaling Technology (CST) Antibodies for KDR (VEGFR2)

Domains for KDR Gene

Gene Families for KDR Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • VSET :Immunoglobulin superfamily / V-set domain containing
IUPHAR :

Suggested Antigen Peptide Sequences for KDR Gene

Graphical View of Domain Structure for InterPro Entry

P35968

UniProtKB/Swiss-Prot:

VGFR2_HUMAN :
  • P35968
Domain:
  • The second and third Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFC binding.
  • Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
genes like me logo Genes that share domains with KDR: view

Function for KDR Gene

Molecular function for KDR Gene

GENATLAS Biochemistry:
vascular endothelial growth factor receptor,expressed on the surface of endothelial cells,activated by VEGF in cooperation with integrin alpha V (ITGAV) beta 3 (ITGB3),involved in angiogenesis,also regulating the migration of early mesodermally derived precursors into a microenvironnement that is permissive for hematopoiesis (marker defining hematopoietic stem cells)
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Present in an inactive conformation in the absence of bound ligand. Binding of VEGFA, VEGFC or VEGFD leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by the small molecule PTK inhibitor SU5614 ((3Z)-5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one). May be regulated by hydrogen sulfide (H(2)S) levels via a H(2)S-sensitive intracellular disulfide bond.
UniProtKB/Swiss-Prot Function:
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC.

Enzyme Numbers (IUBMB) for KDR Gene

Gene Ontology (GO) - Molecular Function for KDR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity IDA 10037737
GO:0004714 transmembrane receptor protein tyrosine kinase activity TAS 1417831
GO:0004716 receptor signaling protein tyrosine kinase activity TAS 10022831
GO:0005021 vascular endothelial growth factor-activated receptor activity IDA 10022831
genes like me logo Genes that share ontologies with KDR: view
genes like me logo Genes that share phenotypes with KDR: view

Animal Models for KDR Gene

MGI Knock Outs for KDR:
  • Kdr tm1.2Jamb

miRNA for KDR Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KDR

Clone Products

  • Addgene plasmids for KDR

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for KDR Gene

Localization for KDR Gene

Subcellular locations from UniProtKB/Swiss-Prot for KDR Gene

Cell junction. Endoplasmic reticulum. Note=Localized with RAP1A at cell-cell junctions (By similarity). Colocalizes with ERN1 and XBP1 in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (PubMed:23529610). {ECO:0000250, ECO:0000269 PubMed:23529610}.
Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Cytoplasmic vesicle. Early endosome. Note=Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation. VEGFA binding triggers internalization and translocation to the nucleus.
Isoform 2: Secreted.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KDR Gene COMPARTMENTS Subcellular localization image for KDR gene
Compartment Confidence
endosome 5
extracellular 5
golgi apparatus 5
nucleus 5
plasma membrane 5
cytoskeleton 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for KDR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IEA --
GO:0005768 endosome IDA 23262137
GO:0005769 early endosome ISS --
GO:0005783 endoplasmic reticulum IDA 23529610
genes like me logo Genes that share ontologies with KDR: view

Pathways for KDR Gene

genes like me logo Genes that share pathways with KDR: view

PCR Array Products

Gene Ontology (GO) - Biological Process for KDR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis TAS 10022831
GO:0001541 ovarian follicle development IEA --
GO:0001570 vasculogenesis ISS --
GO:0001934 positive regulation of protein phosphorylation IDA 19033661
GO:0001938 positive regulation of endothelial cell proliferation IMP 10022831
genes like me logo Genes that share ontologies with KDR: view

Compounds for KDR Gene

Compound Products

(31) ApexBio Compounds for KDR Gene

Compound Action Cas Number
"Cabozantinib (XL184, BMS-907351)" VEGFR2/Met/Ret/Kit/FLT//AXL inhibitor [849217-68-1]
Apatinib "VEGFR2 inhibitor, orally bioavailable, selective" [811803-05-1]
Axitinib (AG 013736) VEGFR1/ c-Kit inhibitor [319460-85-0]
BIBF 1120 VEGFR/PDGF/FGFR inhibitor [656247-17-5]
Brivanib (BMS-540215) "VEGFR-2 inhibitor,ATP-competitive" [649735-46-6]
Brivanib Alaninate (BMS-582664) "VEGFR2 inhibitor,ATP-competitive" [649735-63-7]
Cediranib (AZD217) "VEGFR inhibitor receptor,highly potent" [288383-20-0]
Dovitinib Dilactic acid [852433-84-2]
Foretinib (GSK1363089) VEGF and HGF receptor inhibitor [849217-64-7]
Ki8751 "VEGFR-2 inhibitor,potent and selective" [228559-41-9]
KRN 633 "VEGFR inhibitor,ATP-competitive" [286370-15-8]
Lenvatinib (E7080) VEGFR inhibitor [417716-92-8]
Linifanib (ABT-869) VEGFR/PDGFR inhibitor [796967-16-3]
Motesanib Diphosphate (AMG-706) VEGFR/ PDGFR/c-Kit/Ret inhibitor [857876-30-3]
Pazopanib (GW-786034) VEGFR/PDGFR/FGFR inhibitor [635702-64-6]
Pazopanib Hydrochloride VEGFR/PDGFR/FGFR/c-Kit/ c-Fms inhibitor [635702-64-6]
PD 173074 FGFR inhibitor [219580-11-7]
PF-477736 Chk1 inhibitor [952021-60-2]
RAF265 Multiple intracellular kinases inhibitor [927880-90-8]
Semaxanib (SU5416) VEGFR(Flk-1/KDR) inhibitor [194413-58-6]
SKLB1002 "VEGFR2 inhibitor,potent and ATP-competitve" [1225451-84-2]
SKLB610 Potent VEGFR inhibitor [1125780-41-7]
Sorafenib Tosylate Raf kinases and tyrosine kinases inhibitor [475207-59-1]
SU 4312 [5812-7-7]
SU5416 VEGF receptor inhibitor and AHR agonist [204005-46-9]
Sunitinib RTK inhibitor [557795-19-4]
Sunitinib malate VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor [341031-54-7]
Telatinib (BAY 57-9352) "VEGFR-2/-3,PDGFR-β and c-Kit inhibitor" [332012-40-5]
Tivozanib (AV-951) "VEGFR inhibitor,potent and selective" [475108-18-0]
Vandetanib (ZD6474) VEGFR2/EGFR antagonist [443913-73-3]
Vatalanib (PTK787) 2HCl Tyrosine kinase receptor inhibitor [212141-51-0]

(2) HMDB Compounds for KDR Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(3) IUPHAR Ligand for KDR Gene

Ligand Type Action Affinity Pubmed IDs
VEGFC None None
VEGFA None None
VEGFE None None

(86) Novoseek inferred chemical compound relationships for KDR Gene

Compound -log(P) Hits PubMed IDs
vegf 96.8 463
zd6474 91.8 70
su5416 87.2 39
tyrosine 85.2 168
azd 2171 85 15

(3) PharmGKB related drug/compound annotations for KDR Gene

Drug/compound Annotation
pazopanib
regorafenib
vandetanib
genes like me logo Genes that share compounds with KDR: view

Transcripts for KDR Gene

mRNA/cDNA for KDR Gene

Unigene Clusters for KDR Gene

Kinase insert domain receptor (a type III receptor tyrosine kinase):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KDR

Clone Products

  • Addgene plasmids for KDR

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KDR Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^
SP1: -
SP2:
SP3:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b
SP1:
SP2:
SP3:

Relevant External Links for KDR Gene

GeneLoc Exon Structure for
KDR
ECgene alternative splicing isoforms for
KDR

Expression for KDR Gene

mRNA expression in normal human tissues for KDR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KDR Gene

This gene is overexpressed in Uterus (4.4) and Adipose - Visceral (Omentum) (4.1).

Protein differential expression in normal tissues for KDR Gene

This gene is overexpressed in Heart (25.4), Placenta (14.9), Lymph node (13.5), and Brain (10.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KDR Gene

SOURCE GeneReport for Unigene cluster for KDR Gene Hs.479756

mRNA Expression by UniProt/SwissProt for KDR Gene

P35968-VGFR2_HUMAN
Tissue specificity: Detected in cornea (at protein level). Widely expressed.
genes like me logo Genes that share expressions with KDR: view

Expression partners for KDR Gene

In Situ Assay Products

Orthologs for KDR Gene

This gene was present in the common ancestor of animals.

Orthologs for KDR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KDR 35
  • 89.72 (n)
  • 91.08 (a)
KDR 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KDR 35
  • 91.39 (n)
  • 93.06 (a)
KDR 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kdr 35
  • 85.46 (n)
  • 86.75 (a)
Kdr 16
Kdr 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KDR 35
  • 99.75 (n)
  • 99.78 (a)
KDR 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kdr 35
  • 85.55 (n)
  • 86.37 (a)
oppossum
(Monodelphis domestica)
Mammalia KDR 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KDR 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves KDR 35
  • 72.17 (n)
  • 73.73 (a)
KDR 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KDR 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kdr 35
  • 65.84 (n)
  • 62.66 (a)
African clawed frog
(Xenopus laevis)
Amphibia kdr-A-prov 35
zebrafish
(Danio rerio)
Actinopterygii kdr 35
  • 58.06 (n)
  • 53.32 (a)
kdr 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta tor 37
  • 45 (a)
Cad96Ca 36
  • 27 (a)
ManyToMany
Pvr 36
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea R09D1.12 37
  • 30 (a)
ver-2 37
  • 27 (a)
ver-3 37
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for KDR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KDR Gene

ENSEMBL:
Gene Tree for KDR (if available)
TreeFam:
Gene Tree for KDR (if available)

Paralogs for KDR Gene

Paralogs for KDR Gene

Selected SIMAP similar genes for KDR Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KDR: view

Variants for KDR Gene

Sequence variations from dbSNP and Humsavar for KDR Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1062832 -- 55,098,756(-) GCACG(A/G)CGGTG missense, reference
rs1125304 -- 55,097,432(-) GCCTG(A/G)TTACC intron-variant
rs1127904 -- 55,079,881(-) ATTTT(C/G)AAGTG utr-variant-3-prime
rs1139774 -- 55,098,711(-) TCCTA(C/G/T)GGACC reference, missense
rs1139775 -- 55,098,141(-) CTGAA(A/C/G)CTAGG synonymous-codon, missense, reference

Structural Variations from Database of Genomic Variants (DGV) for KDR Gene

Variant ID Type Subtype PubMed ID
nsv526344 CNV Gain 19592680
nsv829939 CNV Gain 17160897

Relevant External Links for KDR Gene

HapMap Linkage Disequilibrium report
KDR
Human Gene Mutation Database (HGMD)
KDR
Locus Specific Mutation Databases (LSDB)
KDR

PCR Panel Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KDR Gene

Disorders for KDR Gene

(1) OMIM Diseases for KDR Gene (191306)

UniProtKB/Swiss-Prot

VGFR2_HUMAN
  • Hemangioma, capillary infantile (HCI) [MIM:602089]: A condition characterized by dull red, firm, dome-shaped hemangiomas, sharply demarcated from surrounding skin, usually presenting at birth or occurring within the first two or three months of life. They result from highly proliferative, localized growth of capillary endothelium and generally undergo regression and involution without scarring. {ECO:0000269 PubMed:11807987, ECO:0000269 PubMed:18931684}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Note=Plays a major role in tumor angiogenesis. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions.

(3) University of Copenhagen DISEASES for KDR Gene

(93) Novoseek inferred disease relationships for KDR Gene

Disease -log(P) Hits PubMed IDs
neovascularization 83.2 44
tumors 74 264
solid tumor 68 18
blood vessel tumors 64.5 5
metastasis 63.9 81

Relevant External Links for KDR

Genetic Association Database (GAD)
KDR
Human Genome Epidemiology (HuGE) Navigator
KDR
genes like me logo Genes that share disorders with KDR: view

No data available for Genatlas for KDR Gene

Publications for KDR Gene

  1. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. (PMID: 1417831) Terman B.I. … Boehlen P. (Biochem. Biophys. Res. Commun. 1992) 2 3 4 23
  2. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. (PMID: 7929439) Waltenberger J. … Heldin C.H. (J. Biol. Chem. 1994) 3 4 23
  3. Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues. (PMID: 10037737) Kendall R.L. … Thomas K.A. (J. Biol. Chem. 1999) 3 4 23
  4. A novel function of VEGF receptor-2 (KDR): rapid release of nitric oxide in response to VEGF-A stimulation in endothelial cells. (PMID: 10600473) Kroll J. … Waltenberger J. (Biochem. Biophys. Res. Commun. 1999) 3 4 23
  5. Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma. (PMID: 11807987) Walter J.W. … Marchuk D.A. (Genes Chromosomes Cancer 2002) 3 4 23

Products for KDR Gene

  • Addgene plasmids for KDR

Sources for KDR Gene

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