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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KDR Gene

protein-coding   GIFtS: 79
GCID: GC04M055944

kinase insert domain receptor (a type III receptor tyrosine...
 Explore 203 diseases affiliated with
KDR via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KDR    

Aliases
for KDR gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Kinase Insert Domain Receptor (A Type III Receptor Tyrosine Kinase)1 2     Soluble VEGFR22
FLK11 2 3     Tyrosine Kinase Growth Factor Receptor2
VEGFR21 2 3     Vascular Endothelial Growth Factor Receptor 22
CD3091 2     FLK-13
VEGFR1 2     VEGFR-23
Fetal Liver Kinase 12 3     CD309 Antigen3
Protein-Tyrosine Kinase Receptor Flk-12 3     Kinase Insert Domain Receptor3
EC 2.7.10.13 8     EC 2.7.108
Fetal Liver Kinase-12     

External Ids:    HGNC: 63071   Entrez Gene: 37912   Ensembl: ENSG000001280527   OMIM: 1913065   UniProtKB: P359683   

Export aliases for KDR gene to outside databases

Previous GC identifers: GC04M055748 GC04M055906 GC04M055860 GC04M055785 GC04M055639 GC04M051893


Summaries
for KDR gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KDR:
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the
two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine
kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular
morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors,
including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc..
Mutations of this gene are implicated in infantile capillary hemangiomas. (provided by RefSeq, May 2009)

UniProtKB/Swiss-Prot: VGFR2_HUMAN, P35968
Function: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential
role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis.
Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the
actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy
receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and
VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to
FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads
to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling
molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation
of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates
phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin
cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the
production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes
phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC

summary for KDR:
Vascular endothelial growth factor is a signaling protein involved in the regulation of angiogenesis and
vasculogenesis. VEGF binds to and activates a receptor tyrosine kinase, VEGFR. Three VEGFR isoforms have
been identified in humans; VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1) and VEGFR-3 (Flt-4). VEGFR-2 mediates the
majority of cellular responses to VEGF. VEGFR-1 is thought to modulate VEGFR-2 signaling or to act as a
dummy/decoy receptor to sequester VEGF away from VEGFR-2.

Gene Wiki entry for KDR (Kinase insert domain receptor)


Genomic Views
for KDR gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022853.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KDR gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KDR promoter sequence
   Search SABiosciences Chromatin IP Primers for KDR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KDR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q11-q12   Ensembl cytogenetic band:  4q12   HGNC cytogenetic band: 4q11-q12

KDR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KDR gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M055944:  view genomic region     (about GC identifiers)

Start:
 55,944,426 bp from pter      End:
 55,991,762 bp from pter
Size:
 47,337 bases      Orientation:
 minus strand

Proteins
for KDR gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: VGFR2_HUMAN, P35968 (See protein sequence)
Recommended Name: Vascular endothelial growth factor receptor 2 precursor  
Size: 1356 amino acids; 151527 Da
Subunit: Interacts with MYOF (By similarity). Interacts with VEGFA, VEGFC and VEGFD. Monomer in the absence of bound
VEGFA, VEGFC or VEGFD. Homodimer in the presence of bound dimeric VEGFA, VEGFC or VEGFD. Can also form heterodimers
with FLT1 and FLT4. Interacts (tyrosine phosphorylated) with FYN, NCK1, PLCG1 and SHB. Interacts with HIV-1 Tat.
Interacts with CBL. Interacts with SH2D2A/TSAD and GRB2
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Cytoplasmic
vesicle. Early endosome. Note=Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the
plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and
subsequent degradation. VEGFA binding triggers internalization and translocation to the nucleus
Subcellular location: Isoform 2: Secreted (Probable)
Subcellular location: Isoform 3: Secreted
6/39 PDB 3D structures from and Proteopedia for KDR (see all 39):
1VR2 (3D)        1Y6A (3D)        1Y6B (3D)        1YWN (3D)        2OH4 (3D)        2P2H (3D)    
Secondary accessions: A2RRS0 B5A925 C5IFA0 O60723 Q14178
Alternative splicing: 3 isoforms:  P35968-1   P35968-2   P35968-3   

Explore the universe of human proteins at neXtProt for KDR: NX_P35968

Post-translational modifications:

  • N-glycosylated1
  • Ubiquitinated. Tyrosine phosphorylation of the receptor promotes its poly-ubiquitination, leading to its degradation
    • via the proteasome or lysosomal proteases1
  • Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of
    • the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-951 is important
    for interaction with SH2D2A/TSAD and VEGFA-mediated reorganization of the actin cytoskeleton. Phosphorylation at
    Tyr-1175 is important for interaction with PLCG1 and SHB. Phosphorylation at Tyr-1214 is important for interaction
    with NCK1 and FYN. Dephosphorylated by PTPRB. Dephosphorylated by PTPRJ at Tyr-951, Tyr-996, Tyr-1054, Tyr-1059,
    Tyr-1175 and Tyr-12141
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P35968

    • 4/29 DME Specific Peptides for KDR (P35968) (see all 29)
     GTRMRAP  RDLAARN  ALMSELK  WEIFSLG 

    KDR Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002244.1  
    ENSEMBL proteins: 
     ENSP00000263923  
    Reactome Protein details: P35968
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant KDR Protein
    R&D Systems Recombinant & Natural Proteins for KDR (VEGF R2/KDR/Flk-1)
    Enzo Life Sciences proteins for KDR
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: KDR
    OriGene Custom Protein Services for KDR 
    GenScript Custom Purified and Recombinant Proteins Services for KDR
    Novus Biologicals KDR Proteins
    Novus Biologicals KDR Lysate
    Sino Biological Recombinant Protein for KDR
    ProSpec Recombinant Protein for KDR
    Uscn Proteins for KDR

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005634nucleus IEA--
    GO:0005768endosome IDA--
    GO:0005769early endosome ISS--
    GO:0005794Golgi apparatus IDA--


    KDR for ontologies           About GeneDecksing



    KDR Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of KDR
    R&D Systems Antibodies for KDR (VEGF R2/KDR/Flk-1)
    Cell Signaling Technology (CST) Antibodies for KDR  (VEGFR-2)
    OriGene Antibodies (see all 5): KDR
    OriGene Custom Antibody Services for KDR 
    GenScript Superior Antibodies for KDR
    Novus Biologicals KDR Antibodies
    Abcam antibodies for KDR 
    Uscn Antibodies for KDR
    ThermoFisher Antibody for KDR

    Assay Products for KDR: 
    EMD Millipore Kits and Assays for the Analysis of KDR
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for KDR (VEGF R2/KDR/Flk-1)         (see all)
    GenScript KDR-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for KDR (VEGFR-2)
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for KDR

    Protein Domains /
    Families
    for KDR gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KDR for domains           About GeneDecksing

    5/15 InterPro domains/families (see all 15):
     IPR003598 Ig_sub2
     IPR017441 Protein_kinase_ATP_BS
     IPR013098 Ig_I-set
     IPR011009 Kinase-like_dom
     IPR009134 Tyr_kinase_VEGFR_rcpt_N

    Graphical View of Domain Structure for InterPro Entry P35968

    ProtoNet protein and cluster: P35968

    5 Blocks protein families:
    IPB001824 Receptor tyrosine kinase
    IPB003598 Immunoglobulin C-2 type
    IPB008266 Tyrosine protein kinase
    IPB009134 Vascular endothelial growth factor receptor signature
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: VGFR2_HUMAN, P35968
    Domain: The second and third Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFC binding
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily
    Similarity: Contains 7 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 protein kinase domain


    Function
    for KDR gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: VGFR2_HUMAN, P35968
    Function: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential
    role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis.
    Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the
    actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy
    receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and
    VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to
    FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads
    to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling
    molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation
    of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates
    phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin
    cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the
    production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes
    phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Present in an inactive conformation in the absence of bound ligand. Binding of VEGFA, VEGFC or VEGFD
    leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by the small molecule PTK
    inhibitor SU5614 ((3Z)-5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one)

         Genatlas biochemistry entry for KDR:
    vascular endothelial growth factor receptor,expressed on the surface of endothelial cells,activated by VEGF in
    cooperation with integrin alpha V (ITGAV) beta 3 (ITGB3),involved in angiogenesis,also regulating the migration of
    early mesodermally derived precursors into a microenvironnement that is permissive for hematopoiesis (marker defining
    hematopoietic stem cells)

    Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

    miRNA
    Products:            		 OriGene 3'-UTR Clone: KDR
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KDR
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate KDR (see all 41):
    hsa-miR-3146 hsa-miR-429 hsa-miR-15a hsa-miR-424 hsa-miR-889 hsa-miR-200b hsa-miR-15b hsa-miR-30c-2*
    SwitchGear 3'UTR luciferase reporter plasmid: KDR 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KDR (see all 7)
    OriGene shRNA RFP: KDR
    OriGene siRNA: KDR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KDR

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for KDR

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KDR (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KDR (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: KDR (NM_002253)
    Sino Biological Human cDNA Clone for KDR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KDR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KDR 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for KDR
    Search LifeMap BioReagents cell lines for KDR

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDR

    Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004713protein tyrosine kinase activity IDA10037737
    GO:0004714transmembrane receptor protein tyrosine kinase activity TAS1417831
    GO:0004716receptor signaling protein tyrosine kinase activity TAS10022831
    GO:0005021vascular endothelial growth factor-activated receptor activity IDA10022831
    GO:0005178integrin binding IPI10022831


    KDR for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for KDR:
     Decreased substrate adherent c  Increased G1 DNA content  Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Kdrtm1.2Jamb for KDR
         15/18 MGI mutant phenotypes (inferred from 14 alleles) (MGI details for Kdr) (see all 18):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  muscle  nervous system  no phenotypic analysis  normal 

    KDR for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KDR gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/40 super-pathways (see all 40) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/12 pathways (see all 12)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		Cellular Apoptosis Pathway0.65
    		p53 Mediated Apoptosis0.84
    		ERK5 Signaling0.61
    		Mitochondrial Apoptosis0.73
    		eIF2 Pathway0.60
    		Telomerase Components in Cell Signaling0.72
    		Rac1 Pathway0.58
    2GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    		P2Y Receptor Signaling0.38
    3Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    4VEGF Family Ligands and Receptor Interactions
    		VEGF Family Ligands and Receptor Interactions1.00
    		Development_VEGF-family signaling0.36
    		VEGF Pathway0.66
    		Development VEGF-family signaling0.36
    5Signaling by VEGF
    		Signaling by VEGF1.00
    		VEGF binds to VEGFR leading to receptor dimerization0.82
    		VEGF ligand-receptor interactions1.00
    		Neurophilin interactions with VEGF and VEGFR0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/6 EMD Millipore Pathways for KDR (see all 6)
        Development VEGF signaling and activation
    Development VEGF-family signaling
    Cytoskeleton remodeling FAK signaling
    Transcription P53 signaling pathway
    Development VEGF signaling via VEGFR2 - generic cascades

    5/59 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KDR (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for KDR
        Angiogenesis
    Tyrosine Kinases / Adaptors

    4 Tocris Bioscience Pathways for KDR
        Akt Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    VEGF Pathway

    5/6 GeneGo (Thomson Reuters) Pathways for KDR (see all 6)
        Development VEGF-family signaling
    Development VEGF signaling via VEGFR2 - generic cascades
    Transcription P53 signaling pathway
    Cell adhesion Plasmin signaling
    Cytoskeleton remodeling FAK signaling

    5/9 BioSystems Pathways for KDR (see all 9) 
        Focal Adhesion
    Angiogenesis
    Id Signaling Pathway
    S1P1 pathway
    HIF-2-alpha transcription factor network

    5        Reactome Pathways for KDR
        Signaling by VEGF
    VEGF binds to VEGFR leading to receptor dimerization
    VEGF ligand-receptor interactions
    Signal Transduction
    Neurophilin interactions with VEGF and VEGFR

    3 PharmGKB Pathways for KDR
        Sorafenib Pharmacodynamics
    VEGF Signaling Pathway
    Vemurafenib Pathway, Pharmacodynamics

    4         Kegg Pathways  (Kegg details for KDR):
        Cytokine-cytokine receptor interaction
    Endocytosis
    VEGF signaling pathway
    Focal adhesion


    KDR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KDR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/113 Interacting proteins for KDR (P359681, 2, 3 ENSP000002639234) via UniProtKB, MINT, STRING, and/or I2D (see all 113)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FLT4P359161, 2, 3, ENSP000002619374EBI-1005487,EBI-1005467 MINT-7938244 MINT-7938235 I2D: score=4 STRING: ENSP00000261937
    SHC1P293532, 3, ENSP000004013034MINT-8036291 MINT-8036362 MINT-8036261 MINT-8036276 MINT-49637 I2D: score=3 STRING: ENSP00000401303
    PTPRJQ129132, 3, ENSP000004000104MINT-7027153 MINT-7027129 MINT-7027117 MINT-7027141 I2D: score=1 STRING: ENSP00000400010
    SHC2P980772, 3, ENSP000002645544MINT-8036302 MINT-8036317 I2D: score=4 STRING: ENSP00000264554
    PLCG1P191742, 3, ENSP000002440074MINT-8032571 I2D: score=5 STRING: ENSP00000244007
    About this table

    Gene Ontology (GO): 5/44 biological process terms (GO ID links to tree view) (see all 44):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis TAS10022831
    GO:0001541ovarian follicle development IEA--
    GO:0001570vasculogenesis ISS--
    GO:0001938positive regulation of endothelial cell proliferation IMP10022831
    GO:0001945lymph vessel development IEA--


    KDR for ontologies           About GeneDecksing



    Drugs & Compounds
    for KDR gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KDR for compounds           About GeneDecksing

    EMD Millipore small molecules for KDR:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for KDR

    Compounds for KDR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SU 5416 VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3 [204005-46-9]
    Ki 8751 Potent, selective VEGFR-2 inhibitor [228559-41-9]
    ZM 323881 hydrochloride Potent, selective inhibitor of VEGFR-2 [324077-30-7]
    Sunitinib malate Potent VEGFR, PDGFRbeta and KIT inhibitor [341031-54-7]
    SU 5402Potent FGFR and VEGFR inhibitor[215543-92-3]

    2 HMDB Compounds for KDR    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    10/14 DrugBank Compounds for KDR (see all 14)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    SunitinibSU11248 (see all 3)557795-19-4targetmultitarget16418310 12873999 11752352 12538485 16533791 14753710
    Sorafenib-- 284461-73-0targetantagonist16418310 16757355 16824050 16503817 16446323
    3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one-- --target--10592235
    3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one-- --target--10592235
    4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide-- --target--10592235
    6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide-- --target--10592235
    N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide-- --target--10592235
    N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide-- --target--10592235
    N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE-- --target--10592235
    N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE-- --target--10592235

    10/86 Novoseek chemical compound relationships for KDR gene (see all 86)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 96.8 3315 14691147 (9), 19633424 (8), 11943724 (8), 18645275 (8) (see all 99)
    zd6474 91.8 110 16688779 (3), 17889445 (3), 18698025 (3), 16783964 (3) (see all 47)
    su5416 87.2 49 15958585 (2), 19733172 (2), 15519795 (2), 11779082 (1) (see all 36)
    tyrosine 85.2 688 18377662 (5), 10816419 (4), 14744794 (4), 10753929 (4) (see all 99)
    azd 2171 85 22 17671138 (4), 17699717 (4), 18320010 (2), 15899831 (1) (see all 8)
    ptk787 84.5 36 20090952 (3), 15958586 (2), 16369175 (2), 15958638 (2) (see all 21)
    sunitinib 82.8 38 17327610 (2), 19754358 (2), 20103629 (2), 16240452 (1) (see all 33)
    su6668 79.9 16 15701856 (3), 16144927 (1), 14611919 (1), 15958585 (1) (see all 11)
    matrigel 75.7 15 16447633 (2), 15915456 (1), 16308314 (1), 11549592 (1) (see all 10)
    sorafenib 75.6 57 17178882 (2), 16757355 (2), 16503817 (1), 17619763 (1) (see all 41)

    Search CenterWatch for drugs/clinical trials and news about KDR / VGFR2 

    Transcripts
    for KDR gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KDR gene: 
    NM_002253.2  

    Unigene Cluster for KDR:

    Kinase insert domain receptor (a type III receptor tyrosine kinase)
    Hs.479756  [show with all ESTs]
    Unigene Representative Sequence: NM_002253
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263923(uc003has.3 uc003hat.1 uc011bzx.2) ENST00000509309
    ENST00000512566

    miRNA
    Products:             		 OriGene 3'-UTR Clone: KDR
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KDR
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate KDR (see all 41):
    hsa-miR-3146 hsa-miR-429 hsa-miR-15a hsa-miR-424 hsa-miR-889 hsa-miR-200b hsa-miR-15b hsa-miR-30c-2*
    SwitchGear 3'UTR luciferase reporter plasmid: KDR 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KDR (see all 7)
    OriGene shRNA RFP: KDR
    OriGene siRNA: KDR
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    Clone
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    Additional cDNA sequence: 

    AB209901.1 AF035121.1 AF063658.1 AK293668.1 BC131822.1 EU826563.1 FJ899739.1 L04947.1 
    X61656.1 

    3 DOTS entries:

    DT.417781  DT.40108156  DT.99946559 

    24/148 AceView cDNA sequences (see all 148):

    BM978033 AI422100 AL712924 F10490 F09283 BM667447 AI679509 AA768258 
    N77001 CD671986 CR606055 CD671985 R97663 T28612 AI347902 W86413 
    CA449800 AF063658 BQ695075 F09266 BU677947 BM698530 BQ029568 CD107886 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KDR    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^
    SP1:                                                                                                              -                                             
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b
    SP1:                                                
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for KDR

    Expression
    for KDR gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KDR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTATGGCACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KDR expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/28 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 28) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EndotheliumArteriesEndothelial tip cellsEndothelium
    Extraembryonic MesodermExtraembryonic Blood IslandsPrimitive Hematopoietic Stem CellsBlood
    HeartEndocardiumEndocardial CellsEndocardium
    Lateral Plate MesodermAorta-Gonad-MesonephrosHematopoietic Stem CellsBlood
    Lateral Plate MesodermEmbryonic Blood IslandsAngioblastsEndothelium
    Lateral Plate MesodermEmbryonic Capillary PlexusAngioblastsEndothelium
    Lateral Plate MesodermPaired Dorsal AortaArterial endothelial cellsEndothelium
    MesodermMesodermCardiac progenitor CellsEndocardium, Myocardium
    Neural TubePerineural capillary PlexusAngioblastsBlood Brain Barrier, Endothelium
    Primitive StreakPosterior Primitive StreakHemangioblastsBlood, Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/39 LifeMap Cells (see all 39) 
    NameCategory
    Bone marrow-derived adherent progenitor cells (MultiStem) (Adult Stem / Progenitor Cell)Bone
    Bone marrow-derived CD34+ stem cells (ACT34) (Adult Stem / Progenitor Cell)Bone
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    Endothelial progenitor cells (Adult Stem / Progenitor Cell)Endothelium
    Human umbilical vein endothelial cells (HUVEC) (Primary Cell)Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    Human multipotent adipose-derived (hMAD) stem cells (Adult Stem / Progenitor Cell)Adipose

    See KDR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KDR

    SOURCE GeneReport for Unigene cluster: Hs.479756

    UniProtKB/Swiss-Prot: VGFR2_HUMAN, P35968
    Tissue specificity: Detected in cornea (at protein level). Widely expressed

        SABiosciences Expression via Pathway-Focused PCR Arrays including KDR (see all 11): 
              Terminal Differentiation Markers in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Cancer PathwayFinder in human mouse rat
              VEGF Signaling in human mouse rat
              Liver Cancer in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for KDR gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KDR gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KDR1 kinase insert domain receptor (a type III receptor more 72.24(n)
    73.73(a)    		   395323  NM_001004368.1  NP_001004368.1 
    lizard
    (Anolis carolinensis)    		 Reptilia KDR6
    		 --
    		 71(a)
    		 1 ↔ 1
    		 5(104594617-104644326)
    African clawed frog
    (Xenopus laevis)    		 Amphibia kdr-A-prov2 receptor tyrosine kinase 77.48(n)    AF007760.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii kdr1 kinase insert domain receptor (a type III receptor more 58.41(n)
    54.02(a)    		   554230  NM_001024653.2  NP_001019824.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta tor3 eggshell pattern formation transmembrane
    receptor more    		 45(a)   43E12   --


    ENSEMBL Gene Tree for KDR (if available)
    TreeFam Gene Tree for KDR (if available) 

    Paralogs
    for KDR gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KDR gene
    FLT42  FGFR42  PDGFRB2  CSF1R2  FGFR32  KIT2  PDGFRA2  RET2  
    FGFR12  FGFR22  FLT32  FLT12  
    5 SIMAP similar genes for KDR using alignment to 1 protein entry:     VGFR2_HUMAN:
    EPHA2    FLT1    FLT4    FGFR1    FGFR3

    KDR for paralogs           About GeneDecksing



    Genomic Variants
    for KDR gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): KDR

    Locus Specific Mutation Databases (LSDB): KDR
    SABiosciences Cancer Mutation PCR Assays
    2 SABiosciences qBiomarker Copy Number PCR Arrays containing KDR:
    Glioma
    Oncogenes & Tumor Suppressor Genes 384HC
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KDR
    DNA2.0 Custom Variant and Variant Library Synthesis for KDR

    Disorders / Diseases
    for KDR gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KDR for disorders           About GeneDecksing

    OMIM gene information: 191306   
    OMIM disorders: 602089  
    UniProtKB/Swiss-Prot: VGFR2_HUMAN, P35968
  • Defects in KDR are associated with susceptibility to hemangioma capillary infantile (HCI) [MIM:602089]. HCI
    • are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the
    most common tumor of infancy, occurring in up to 10% of all births. Hemangiomas tend to appear shortly after birth and
    show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of
    mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty
    stroma
  • Note=Plays a major role in tumor angiogenesis. In case of HIV-1 infection, the interaction with extracellular
    • viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions

    20/203 diseases for KDR (see all 203):    About MalaCards
    capillary hemangioma    hemangioma, capillary infantile    hemangioma    hemangioma, capillary infantile, somatic
    olecranon bursitis    congenital nephrotic syndrome finnish type    cerebral cavernous malformations    cavernous malformation
    diffuse large b-cell lymphoma    age related macular degeneration    arteriovenous malformation    corneal neovascularization
    renal clear cell carcinoma    non-small cell lung carcinoma    congenital diaphragmatic hernia    ovarian hyperstimulation syndrome
    b-cell lymphomas    renal cell carcinoma    anaplastic oligodendroglioma    bursitis

    3 diseases from the University of Copenhagen DISEASES database for KDR:
    Cancer     Malaria     Vascular disease

    10/93 Novoseek disease relationships for KDR gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 83.2 51 12766257 (2), 9705358 (1), 15951738 (1), 16835467 (1) (see all 43)
    tumors 74 772 17479290 (7), 11169947 (7), 11801954 (6), 8644848 (5) (see all 99)
    solid tumor 68 19 11779082 (1), 16015035 (1), 19357226 (1), 12526219 (1) (see all 18)
    blood vessel tumors 64.5 5 14657001 (4), 19248046 (1)
    metastasis 63.9 103 11218896 (3), 17230507 (3), 19776290 (3), 14517445 (3) (see all 67)
    cancer 62.2 137 19633424 (6), 15756022 (2), 16688779 (2), 18320010 (2) (see all 96)
    carcinoma renal cell 59.1 18 17332933 (2), 17465216 (2), 9063473 (1), 17229632 (1) (see all 14)
    glioblastoma 57.4 29 16021678 (5), 16000592 (3), 15015778 (2), 15657358 (1) (see all 16)
    nsclc 52.3 45 19357226 (4), 19324448 (3), 16849585 (2), 11820558 (2) (see all 24)
    metastatic renal cell carcinoma 52.1 4 17825982 (1), 17962201 (1), 19258226 (1), 20418203 (1)

    Genetic Association Database (GAD): KDR
    Human Genome Epidemiology (HuGE) Navigator: KDR (52 documents)

    Export disorders for KDR gene to outside databases

    Publications
    for KDR gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KDR gene, integrated from 9 sources (see all 1804):
    (articles sorted by number of sources associating them with KDR)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. (PubMed id 1417831)1, 2, 3, 9 Terman B.I.... Boehlen P. (1992)
    2. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. (PubMed id 7929439)1, 2, 9 Waltenberger J....Heldin C.H. (1994)
    3. VEGF-dependent tumor angiogenesis requires inverse an d reciprocal regulation of VEGFR1 and VEGFR2. (PubMed id 19834490)1, 2, 9 Zhang Z....NAPr J.E. (2010)
    4. Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF. (PubMed id 16966330)1, 2, 9 Lamalice L....Huot J. (2006)
    5. Structural determinants of growth factor binding and specificity by VEGF receptor 2. (PubMed id 20145116)1, 2, 9 LeppAonen V.M....Alitalo K. (2010)
    6. Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma. (PubMed id 18931684)1, 2, 9 Jinnin M....Olsen B.R. (2008)
    7. A novel function of VEGF receptor-2 (KDR): rapid release of nitric oxide in response to VEGF-A stimulation in endothelial cells. (PubMed id 10600473)1, 2, 9 Kroll J. and Waltenberger J. (1999)
    8. Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues. (PubMed id 10037737)1, 2, 9 Kendall R.L....Thomas K.A. (1999)
    9. The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF- dependent cellular migration. (PubMed id 15026417)1, 2, 9 Holmqvist K.... Welsh M. (2004)
    10. Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma. (PubMed id 11807987)1, 2, 9 Walter J.W.... Marchuk D.A. (2002)

    External Searches for KDR gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KDR gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3791 HGNC: 6307 AceView: KDR Ensembl:ENSG00000128052 euGenes: HUgn3791
    ECgene: KDR Kegg: 3791 H-InvDB: KDR

    Other Databases showing KDR gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KDR gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KDR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KDR Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for KDR gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KDR gene:
    Search GeneIP for patents involving KDR

    Licensable Technologies for KDR gene:
    Weizmann Institute:Porphyrin and Corrole -like analogs as potent inhibitors of Growth Factor Receptor Binding and Activation
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for KDR gene

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    Advanced Cell Diagnostics
    About This Section

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     KDR Proteins, Antibodies, CLIAs, and ELISAs
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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