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KDR Gene

protein-coding   GIFtS: 78
GCID: GC04M055944

Kinase Insert Domain Receptor (A Type III Receptor Tyrosine...

  See KDR-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kinase Insert Domain Receptor (A Type III Receptor Tyrosine Kinase)1 2     Soluble VEGFR22
Fetal Liver Kinase 12 3     Tyrosine Kinase Growth Factor Receptor2
Protein-Tyrosine Kinase Receptor Flk-12 3     Vascular Endothelial Growth Factor Receptor 22
FLK12 3     FLK-13
VEGFR22 3     VEGFR-23
EC 2.7.10.13 8     CD309 Antigen3
CD3092     Kinase Insert Domain Receptor3
VEGFR2     EC 2.7.108
Fetal Liver Kinase-12     

External Ids:    HGNC: 63071   Entrez Gene: 37912   Ensembl: ENSG000001280527   OMIM: 1913065   UniProtKB: P359683   

Export aliases for KDR gene to outside databases

Previous GC identifers: GC04M055748 GC04M055906 GC04M055860 GC04M055785 GC04M055639 GC04M051893


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KDR Gene:
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of
the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor
tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival,
migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by
multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein
tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. (provided
by RefSeq, May 2009)

GeneCards Summary for KDR Gene:
KDR (kinase insert domain receptor (a type III receptor tyrosine kinase)) is a protein-coding gene. Diseases associated with KDR include bursitis, and hemangioma. GO annotations related to this gene include transmembrane receptor protein tyrosine kinase activity and protein tyrosine kinase activity. An important paralog of this gene is FLT4.

UniProtKB/Swiss-Prot: VGFR2_HUMAN, P35968
Function: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an
essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic
hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes
reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform
3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative
regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and
preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular
growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to
the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the
activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling
pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of
phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for
VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO)
by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and
SRC

Gene Wiki entry for KDR (Kinase insert domain receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_022853.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the KDR gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKDR promoter sequence
   Search Chromatin IP Primers for KDR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KDR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q11-q12   Ensembl cytogenetic band:  4q12   HGNC cytogenetic band: 4q11-q12

KDR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KDR gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M055944:  view genomic region     (about GC identifiers)

Start:
55,944,426 bp from pter      End:
55,991,762 bp from pter
Size:
47,337 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VGFR2_HUMAN, P35968 (See protein sequence)
Recommended Name: Vascular endothelial growth factor receptor 2 precursor  
Size: 1356 amino acids; 151527 Da
Subunit: Homodimer in the presence of bound dimeric VEGFA, VEGFC or VEGFD ligands; monomeric in the absence of
bound ligands. Can also form heterodimers with FLT1/VEGFR1 and FLT4/VEGFR2. Interacts (tyrosine phosphorylated)
with LFYN, NCK1, PLCG1. Interacts (tyrosine-phosphorylated active form preferentially) with DAB2IP (via C2 domain
and active form preferentially); the interaction occurs at the late phase of VEGFA response and inhibits
KDR/VEGFR2 activity. Interacts with SHBSH2D2A/TSAD, GRB2, MYOF, CBL and PDCD6. Interacts with HIV-1 Tat
Selected PDB 3D structures from and Proteopedia for KDR (see all 42):
1VR2 (3D)        1Y6A (3D)        1Y6B (3D)        1YWN (3D)        2OH4 (3D)        2P2H (3D)    
Secondary accessions: A2RRS0 B5A925 C5IFA0 O60723 Q14178
Alternative splicing: 3 isoforms:  P35968-1   P35968-2   P35968-3   

Explore the universe of human proteins at neXtProt for KDR: NX_P35968

Explore proteomics data for KDR at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Ubiquitinated. Tyrosine phosphorylation of the receptor promotes its poly-ubiquitination, leading to its
    degradation via the proteasome or lysosomal proteases1
  • Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit
    of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-951 is
    important for interaction with SH2D2A/TSAD and VEGFA-mediated reorganization of the actin cytoskeleton.
    Phosphorylation at Tyr-1175 is important for interaction with PLCG1 and SHB. Phosphorylation at Tyr-1214 is
    important for interaction with NCK1 and FYN. Dephosphorylated by PTPRB. Dephosphorylated by PTPRJ at Tyr-951,
    Tyr-996, Tyr-1054, Tyr-1059, Tyr-1175 and Tyr-12141
  • The inhibitory disulfide bond between Cys-1024 and Cys-1045 may serve as a specific molecular switch for
    H(2)S-induced modification that regulates VEGFR2 function1
  • Glycosylation2 at Asn46, Asn66, Asn96, Asn143, Asn158, Asn245, Asn318, Asn374, Asn395, Asn511,
                                 Asn523, Asn580, Asn613, Asn619, Asn631, Asn675, Asn704, Asn721
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for KDR (P35968) (see all 29)
     GTRMRAP  RDLAARN  ALMSELK  WEIFSLG 


    See KDR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002244.1  
    ENSEMBL proteins: 
     ENSP00000263923  
    Reactome Protein details: P35968

    KDR Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant KDR Protein
    R&D Systems Recombinant & Natural Proteins for KDR (VEGF R2/KDR/Flk-1)
    Enzo Life Sciences proteins for KDR
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KDR
    OriGene Custom MassSpec
    OriGene Custom Protein Services for KDR
    GenScript Custom Purified and Recombinant Proteins Services for KDR
    Novus Biologicals KDR Proteins
    Novus Biologicals KDR Lysate
    Sino Biological Recombinant Protein for KDR
    Sino Biological Cell Lysate for KDR
    ProSpec Recombinant Protein for KDR
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for KDR 

    KDR Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of KDR
    R&D Systems Antibodies for KDR (VEGF R2/KDR/Flk-1)
    Cell Signaling Technology (CST) Antibodies for KDR  (VEGFR2)
    OriGene Antibodies for KDR
    OriGene Custom Antibody Services for KDR
    Novus Biologicals KDR Antibodies
    Abcam antibodies for KDR
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for KDR
    LSBio Antibodies in human, mouse, rat for KDR

    KDR Assay Products:

    EMD Millipore Kits and Assays for the Analysis of KDR
    OriGene Custom Assay Services for KDR
    R&D Systems ELISAs for KDR (VEGF R2/KDR/Flk-1)         (see all)
    GenScript Custom Assay Services for KDR
    Cell Signaling Technology (CST) Sandwich ELISA Kits for KDR (VEGFR2)
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for KDR 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: kinase insert domain receptor (a type III receptor tyrosine kinase)
    VEGF (vascular endothelial growth factor) receptor family
    VEGF (vascular endothelial growth factor) receptor family

    Selected InterPro protein domains (see all 14):
     IPR003598 Ig_sub2
     IPR017441 Protein_kinase_ATP_BS
     IPR013098 Ig_I-set
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P35968

    ProtoNet protein and cluster: P35968

    5 Blocks protein domains:
    IPB001824 Receptor tyrosine kinase
    IPB003598 Immunoglobulin C-2 type
    IPB008266 Tyrosine protein kinase
    IPB009134 Vascular endothelial growth factor receptor signature
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: VGFR2_HUMAN, P35968
    Domain: The second and third Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFC binding
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily
    Similarity: Contains 7 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with KDR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VGFR2_HUMAN, P35968
    Function: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an
    essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic
    hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes
    reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform
    3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative
    regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and
    preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular
    growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to
    the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the
    activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling
    pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of
    phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for
    VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO)
    by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and
    SRC
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Present in an inactive conformation in the absence of bound ligand. Binding of VEGFA, VEGFC or
    VEGFD leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by the small
    molecule PTK inhibitor SU5614
    ((3Z)-5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one). May be regulated by
    hydrogen sulfide (H(2)S) levels via a H(2)S-sensitive intracellular disulfide bond

         Genatlas biochemistry entry for KDR:
    vascular endothelial growth factor receptor,expressed on the surface of endothelial cells,activated by VEGF in
    cooperation with integrin alpha V (ITGAV) beta 3 (ITGB3),involved in angiogenesis,also regulating the migration
    of early mesodermally derived precursors into a microenvironnement that is permissive for hematopoiesis (marker
    defining hematopoietic stem cells)

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity IDA10037737
    GO:0004714transmembrane receptor protein tyrosine kinase activity TAS1417831
    GO:0004716receptor signaling protein tyrosine kinase activity TAS10022831
    GO:0005021vascular endothelial growth factor-activated receptor activity IDA10022831
         
    Find genes that share ontologies with KDR           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for KDR:
     Decreased substrate adherent c  Increased G1 DNA content  Upregulation of Wnt/beta-caten 

         Selected MGI mutant phenotypes (inferred from 15 alleles(MGI details for Kdr) (see all 19):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  muscle  nervous system  no phenotypic analysis  normal 

    Find genes that share phenotypes with KDR           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Kdrtm1.2Jamb for KDR

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KDR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KDR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KDR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KDR

    miRNA
    Products:
        
    miRTarBase miRNAs that target KDR:
    hsa-mir-335-5p (MIRT016978), hsa-mir-19b-1-5p (MIRT006277), hsa-mir-200b-3p (MIRT006442)

    Block miRNA regulation of human, mouse, rat KDR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KDR (see all 41):
    hsa-miR-3146 hsa-miR-429 hsa-miR-15a hsa-miR-424 hsa-miR-889 hsa-miR-200b hsa-miR-15b hsa-miR-30c-2*
    SwitchGear 3'UTR luciferase reporter plasmidKDR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KDR
    Predesigned siRNA for gene silencing in human, mouse, rat KDR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KDR

    Clone
    Products:
         
    OriGene clones in human, mouse for KDR (see all 9)
    OriGene ORF clones in mouse, rat for KDR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KDR (NM_002253)
    Sino Biological Human cDNA Clone for KDR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KDR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KDR
    Addgene plasmids for KDR 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KDR
    Browse ESI BIO Cell Lines and PureStem Progenitors for KDR 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDR

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12264) for KDR 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VGFR2_HUMAN, P35968: Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus.
    Cytoplasmic vesicle. Early endosome. Note=Detected on caveolae-enriched lipid rafts at the cell surface. Is
    recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding
    promotes internalization and subsequent degradation. VEGFA binding triggers internalization and translocation to
    the nucleus
    VGFR2_HUMAN, P35968: Cell junction (By similarity). Note=Localized with RAP1A at cell-cell junctions (By
    similarity)
    VGFR2_HUMAN, P35968: Isoform 2: Secreted (Probable)
    VGFR2_HUMAN, P35968: Isoform 3: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    extracellular5
    golgi apparatus5
    nucleus5
    plasma membrane5
    cytoskeleton2
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005634nucleus IEA--
    GO:0005768endosome IDA--
    GO:0005769early endosome ISS--
    GO:0005794Golgi apparatus IDA--

    Find genes that share ontologies with KDR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KDR About   (see all 47)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1VEGF Pathway
    VEGF Family Ligands and Receptor Interactions0.66
    Development VEGF family signaling0.36
    VEGF Pathway0.66
    2Sorafenib Pharmacodynamics
    Sorafenib Pharmacodynamics0.37
    VEGF Pathway0.36
    Vemurafenib Pathway, Pharmacodynamics0.37
    3Focal adhesion
    Focal adhesion0.65
    Focal Adhesion0.65
    4PEDF Induced Signaling
    Endothelin-1 Signaling Pathway0.46
    Cytokine-cytokine receptor interaction0.43
    5Immune response Fc epsilon RI pathway
    VEGF signaling pathway0.39
    VEGF - VEGF R2 Signaling Pathways0.35


    Find genes that share SuperPaths with KDR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for KDR
        Akt Signaling Pathway
    VEGF - VEGF R2 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KDR (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for KDR
        Angiogenesis
    Tyrosine Kinases / Adaptors

    4 Tocris Bioscience Pathways for KDR
        Akt Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    VEGF Pathway

    Selected GeneGo (Thomson Reuters) Pathways for KDR (see all 6)
        Development VEGF-family signaling
    Development VEGF signaling via VEGFR2 - generic cascades
    Transcription P53 signaling pathway
    Cell adhesion Plasmin signaling
    Cytoskeleton remodeling FAK signaling

    Selected BioSystems Pathways for KDR (see all 10)
        Angiogenesis
    Focal Adhesion
    Cardiac Progenitor Differentiation
    Id Signaling Pathway
    S1P1 pathway

    1 Sino Biological Pathway for KDR
        VEGF Signaling

    3 Reactome Pathways for KDR
        VEGF binds to VEGFR leading to receptor dimerization
    Integrin cell surface interactions
    Neurophilin interactions with VEGF and VEGFR

    3 PharmGKB Pathways for KDR
        Sorafenib Pharmacodynamics
    VEGF Signaling Pathway
    Vemurafenib Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for KDR) (see all 8):
        Ras signaling pathway
    Rap1 signaling pathway
    Cytokine-cytokine receptor interaction
    Endocytosis
    PI3K-Akt signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including KDR (see all 11): 
              Terminal Differentiation Markers in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Cancer PathwayFinder in human mouse rat
              VEGF Signaling in human mouse rat
              Liver Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KDR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KDR (P359681, 2, 3 ENSP000002639234) via UniProtKB, MINT, STRING, and/or I2D (see all 153)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPRJQ129131, 2, 3, ENSP000004000104EBI-1005487,EBI-2264500 MINT-7027153 MINT-7027129 MINT-7027117 MINT-7027141 I2D: score=1 STRING: ENSP00000400010
    FLT4P359161, 2, 3, ENSP000002619374EBI-1005487,EBI-1005467 MINT-7938244 MINT-7938235 I2D: score=4 STRING: ENSP00000261937
    SHC1P293532, 3, ENSP000004013034MINT-8036291 MINT-8036362 MINT-8036261 MINT-8036276 MINT-49637 I2D: score=3 STRING: ENSP00000401303
    SHC2P980772, 3, ENSP000002645544MINT-8036302 MINT-8036317 I2D: score=4 STRING: ENSP00000264554
    PLCG1P191742, 3, ENSP000002440074MINT-8032571 I2D: score=5 STRING: ENSP00000244007
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 48):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis TAS10022831
    GO:0001541ovarian follicle development IEA--
    GO:0001570vasculogenesis ISS--
    GO:0001934positive regulation of protein phosphorylation IDA19033661
    GO:0001938positive regulation of endothelial cell proliferation IMP10022831

    Find genes that share ontologies with KDR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for KDR
      Browse compounds at ApexBio 

    Browse Tocris compounds for KDR (VGFR2)

    2 HMDB Compounds for KDR    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Selected DrugBank Compounds for KDR (see all 19)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    SunitinibSU011248 (see all 2)557795-19-4targetmultitarget16418310 12873999 11752352 12538485 16533791 14753710
    Sorafenib-- 284461-73-0targetantagonist16418310 16757355 16824050 16503817 16446323
    Cabozantinibcabozantinib s-malate (see all 2)849217-68-1targetantagonist21606412 21926191
    3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one-- --target--10592235
    3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one-- --target--10592235
    4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide-- --target--10592235
    6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide-- --target--10592235
    Axitinib-- 319460-85-0targetinhibitor18541897
    N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide-- --target--10592235
    N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide-- --target--10592235

    3 IUPHAR Ligands for KDR (kinase insert domain receptor (a type III receptor tyrosine kinase))    About this table
    LigandTypeActionAffinityPubmed IDs
    VEGFC
    NoneNone--
    VEGFA
    NoneNone--
    VEGFE
    NoneNone--

    Selected Novoseek inferred chemical compound relationships for KDR gene (see all 86)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 96.8 3315 14691147 (9), 19633424 (8), 11943724 (8), 18645275 (8) (see all 99)
    zd6474 91.8 110 16688779 (3), 17889445 (3), 18698025 (3), 16783964 (3) (see all 47)
    su5416 87.2 49 15958585 (2), 19733172 (2), 15519795 (2), 11779082 (1) (see all 36)
    tyrosine 85.2 688 18377662 (5), 10816419 (4), 14744794 (4), 10753929 (4) (see all 99)
    azd 2171 85 22 17671138 (4), 17699717 (4), 18320010 (2), 15899831 (1) (see all 8)
    ptk787 84.5 36 20090952 (3), 15958586 (2), 16369175 (2), 15958638 (2) (see all 21)
    sunitinib 82.8 38 17327610 (2), 19754358 (2), 20103629 (2), 16240452 (1) (see all 33)
    su6668 79.9 16 15701856 (3), 16144927 (1), 14611919 (1), 15958585 (1) (see all 11)
    matrigel 75.7 15 16447633 (2), 15915456 (1), 16308314 (1), 11549592 (1) (see all 10)
    sorafenib 75.6 57 17178882 (2), 16757355 (2), 16503817 (1), 17619763 (1) (see all 41)

    3 PharmGKB related drug/compound annotations for KDR gene    About this table
    Drug/compound PharmGKB Annotation
    pazopanib
    regorafenib
    vandetanib



    Find genes that share compounds with KDR           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for KDR gene: 
    NM_002253.2  

    Unigene Cluster for KDR:

    Kinase insert domain receptor (a type III receptor tyrosine kinase)
    Hs.479756  [show with all ESTs]
    Unigene Representative Sequence: NM_002253
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263923(uc003has.3 uc003hat.1 uc011bzx.2) ENST00000509309
    ENST00000512566
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate KDR (see all 41):
    hsa-miR-3146 hsa-miR-429 hsa-miR-15a hsa-miR-424 hsa-miR-889 hsa-miR-200b hsa-miR-15b hsa-miR-30c-2*
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12264) for KDR 

    Additional mRNA sequence: 

    AB209901.1 AF035121.1 AF063658.1 AK293668.1 BC131822.1 EU826563.1 FJ899739.1 L04947.1 
    X61656.1 

    3 DOTS entries:

    DT.417781  DT.40108156  DT.99946559 

    Selected AceView cDNA sequences (see all 148):

    F09283 CR606055 AL712924 CD671985 BM667447 F10490 F09266 BU677947 
    AA768258 CD671986 AI679509 CD107886 BM698530 T28612 W86413 AI422100 
    BQ029568 AI347902 BM978033 R97663 AF063658 BQ695075 CA449800 N77001 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KDR    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^
    SP1:                                                                                                              -                                             
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b
    SP1:                                                
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for KDR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    KDR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTATGGCACA
    KDR Expression
    About this image


    KDR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 28) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 41 entries
             Endothelial Tip Cells Arteries
             eNOS-transfected endothelial progenitor cells
             CD34+ cells
             Human Cardiac Microvascular Endothelial Cells (HCMEC)   
     
     Heart (Cardiovascular System)    fully expand to see all 19 entries
             Endocardial Cells Endocardium
             Coronary Vessels
             Human cardiac stem cells
             Cardiomyocyte-like progenitor cells
             Human Cardiac Microvascular Endothelial Cells (HCMEC)   
     
     Blood (Cardiovascular System)    fully expand to see all 10 entries
             Hemangioblasts Posterior Primitive Streak
             Angiogenic cell precursor
             Hematopoietic progenitor cells
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 10 entries
             Extraembryonic Hemangioblast Cells Chorionic Villus
             Allantois
             Placenta-derived adherent stromal cell (PLX)
    KDR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KDR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.479756

    UniProtKB/Swiss-Prot: VGFR2_HUMAN, P35968
    Tissue specificity: Detected in cornea (at protein level). Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Arrays including KDR (see all 11): 
              Terminal Differentiation Markers in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Cancer PathwayFinder in human mouse rat
              VEGF Signaling in human mouse rat
              Liver Cancer in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for KDR gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kdr1 , 5 kinase insert domain protein receptor1, 5 85.46(n)1
    86.75(a)1
      5 (40.23 cM)5
    165421  NM_010612.21  NP_034742.21 
     759328275 
    chicken
    (Gallus gallus)
    Aves KDR1 kinase insert domain receptor (a type III receptor more 72.17(n)
    73.73(a)
      395323  NM_001004368.1  NP_001004368.1 
    lizard
    (Anolis carolinensis)
    Reptilia KDR6
    kinase insert domain receptor (a type III receptor...
    70(a)
    1 ↔ 1
    5(104592599-104655768)
    African clawed frog
    (Xenopus laevis)
    Amphibia kdr-A-prov2 receptor tyrosine kinase 77.48(n)    AF007760.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kdr1 kinase insert domain receptor (a type III receptor more 58.06(n)
    53.32(a)
      554230  NM_001024653.2  NP_001019824.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta tor3 eggshell pattern formation
    transmembrane receptor more
    45(a)   43E12   --


    ENSEMBL Gene Tree for KDR (if available)
    TreeFam Gene Tree for KDR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KDR gene
    FLT42  FGFR42  PDGFRB2  CSF1R2  KIT2  FGFR32  PDGFRA2  RET2  
    FGFR12  FGFR22  FLT32  FLT12  
    4 SIMAP similar genes for KDR using alignment to 1 protein entry:     VGFR2_HUMAN:
    EPHA2    FLT1    FLT4    FGFR1

    Find genes that share paralogs with KDR           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KDR (see all 1337)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361274
    A colorectal cancer sample4--see VAR_0361272 G R mis40--------
    VAR_0420554
    A renal clear cell carcinoma sample4--see VAR_0420552 A G mis40--------
    VAR_0631474
    Hemangioma, capillary infantile (HCI)4--see VAR_0631472 P S mis40--------
    VAR_0420534
    A lung adenocarcinoma sample4--see VAR_0420532 Q R mis40--------
    VAR_0361264
    A colorectal cancer sample4--see VAR_0361262 R L mis40--------
    rs342310371,2,,4
    C,Fother151921531(+) TTCACA/GAGGGT 2 R C mis15Minor allele frequency- G:0.02NA EU 5998
    rs598857911,2
    C,F--51892545(+) GTGGGG/AGGTGG 1 -- ds50013Minor allele frequency- A:0.22WA NA 240
    rs1815244901,2
    --51892853(+) AGACAC/TACTTA 1 -- ds50010--------
    rs1501589381,2
    --51892870(+) AAATAC/GTTGTG 1 -- ds50010--------
    rs1859094161,2
    C--51893075(+) CTGACC/GATGTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KDR (55944426 - 55991762 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KDR:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829939CNV Gain17160897
    nsv526344CNV Gain19592680

    Human Gene Mutation Database (HGMD): KDR
    Locus Specific Mutation Databases (LSDB): KDR

    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing KDR:
    Glioma
    Oncogenes & Tumor Suppressor Genes 384HC
    SeqTarget long-range PCR primers for resequencing KDR
    DNA2.0 Custom Variant and Variant Library Synthesis for KDR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 191306   
    OMIM disorders: 602089  
    UniProtKB/Swiss-Prot: VGFR2_HUMAN, P35968
  • Hemangioma, capillary infantile (HCI) [MIM:602089]: A condition characterized by dull red, firm,
    dome-shaped hemangiomas, sharply demarcated from surrounding skin, usually presenting at birth or occurring
    within the first two or three months of life. They result from highly proliferative, localized growth of
    capillary endothelium and generally undergo regression and involution without scarring. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry
  • Note=Plays a major role in tumor angiogenesis. In case of HIV-1 infection, the interaction with
    extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions

  • 20 diseases for KDR:    
    About MalaCards
    bursitis    hemangioma    olecranon bursitis    fibrosarcoma of bone
    hemangioma, capillary infantile, somatic    angiosarcoma    hemangioma, capillary infantile    cervical adenosquamous carcinoma
    adenosquamous carcinoma    oligodendroglioma    capillary hemangioma    thoracic cancer
    epithelioid hemangioendothelioma    leukostasis    exudative vitreoretinopathy    thyroid cancer
    renal cell carcinoma    gastrointestinal stromal tumor    kaposi's sarcoma    colorectal cancer

    3 diseases from the University of Copenhagen DISEASES database for KDR:
    Cancer     Malaria     Vascular disease

    Find genes that share disorders with KDR           About GenesLikeMe

    Selected Novoseek inferred disease relationships for KDR gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 83.2 51 12766257 (2), 9705358 (1), 15951738 (1), 16835467 (1) (see all 43)
    tumors 74 772 17479290 (7), 11169947 (7), 11801954 (6), 8644848 (5) (see all 99)
    solid tumor 68 19 11779082 (1), 16015035 (1), 19357226 (1), 12526219 (1) (see all 18)
    blood vessel tumors 64.5 5 14657001 (4), 19248046 (1)
    metastasis 63.9 103 11218896 (3), 17230507 (3), 19776290 (3), 14517445 (3) (see all 67)
    cancer 62.2 137 19633424 (6), 15756022 (2), 16688779 (2), 18320010 (2) (see all 96)
    carcinoma renal cell 59.1 18 17332933 (2), 17465216 (2), 9063473 (1), 17229632 (1) (see all 14)
    glioblastoma 57.4 29 16021678 (5), 16000592 (3), 15015778 (2), 15657358 (1) (see all 16)
    nsclc 52.3 45 19357226 (4), 19324448 (3), 16849585 (2), 11820558 (2) (see all 24)
    metastatic renal cell carcinoma 52.1 4 17825982 (1), 17962201 (1), 19258226 (1), 20418203 (1)

    Genetic Association Database (GAD): KDR
    Human Genome Epidemiology (HuGE) Navigator: KDR (52 documents)

    Export disorders for KDR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KDR gene, integrated from 10 sources (see all 1889):
    (articles sorted by number of sources associating them with KDR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. (PubMed id 1417831)1, 2, 3, 9 Terman B.I.... Boehlen P. (Biochem. Biophys. Res. Commun. 1992)
    2. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. (PubMed id 7929439)1, 2, 9 Waltenberger J....Heldin C.H. (J. Biol. Chem. 1994)
    3. Clinical relevance of vascular endothelial growth factor (VEGFA) and VEGF receptor (VEGFR2) gene polymorphism on the treatment outcome following imatinib therapy. (PubMed id 19875757)1, 4, 9 Kim D.H....Lipton J.H. (Ann. Oncol. 2010)
    4. VEGF-dependent tumor angiogenesis requires inverse and reciprocal regulation of VEGFR1 and VEGFR2. (PubMed id 19834490)1, 2, 9 Zhang Z.... Nor J.E. (Cell Death Differ. 2010)
    5. The -271 G&gt;A polymorphism of kinase insert domain-containing receptor gene regulates its transcription level in patients with non-small cell lung cancer. (PubMed id 19435508)1, 4, 9 An S.J....Wu Y.L. (BMC Cancer 2009)
    6. Polymorphisms in the VEGFA and VEGFR-2 genes and neovascular age-related macular degeneration. (PubMed id 20019880)1, 4, 9 Fang A.M....Brantley M.A. (Mol. Vis. 2009)
    7. Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF. (PubMed id 16966330)1, 2, 9 Lamalice L.... Huot J. (J. Biol. Chem. 2006)
    8. Structural determinants of growth factor binding and specificity by VEGF receptor 2. (PubMed id 20145116)1, 2, 9 Leppanen V.M.... Alitalo K. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    9. Angiogenesis in systemic sclerosis: impaired expression of vascular endothelial growth factor receptor 1 in endothelial progenitor-derived cells under hypoxic conditions. (PubMed id 18975312)1, 4, 9 Avouac J....Allanore Y. (Arthritis Rheum. 2008)
    10. Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma. (PubMed id 18931684)1, 2, 9 Jinnin M.... Olsen B.R. (Nat. Med. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3791 HGNC: 6307 AceView: KDR Ensembl:ENSG00000128052 euGenes: HUgn3791
    ECgene: KDR Kegg: 3791 H-InvDB: KDR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KDR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KDR Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KDR gene:
    Search GeneIP for patents involving KDR

    Licensable Technologies for KDR gene:
    Weizmann Institute:Porphyrin and Corrole -like analogs as potent inhibitors of Growth Factor Receptor Binding and Activation
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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     OriGene ORF clones in mouse, rat for KDR   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KDR   OriGene Custom Protein Services for KDR  

     
     
     Block miRNA regulation of human, mouse, rat KDR using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KDR
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KDR Predesigned siRNA for gene silencing in human, mouse, rat KDR
     QuantiFast Probe-based Assays in human, mouse, rat KDR QuantiTect SYBR Green Assays in human, mouse, rat KDR
     PCR Arrays including human, mouse, rat KDR Search Chromatin IP Primers for KDR
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KDR  GeneGlobe Interaction Network for KDR
     Regulatory tfbs in KDR promoter
     GenScript Custom Purified and Recombinant Proteins Services for KDR GenScript cDNA clones with any tag delivered in your preferred vector for KDR
     GenScript Custom Assay Services for KDR GenScript Custom overexpressing Cell Line Services for KDR
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for KDR  (VEGFR2)

     Search Tocris compounds for KDR (VGFR2)
     Proteins for KDR
     Cell Lysates for KDR
     cDNA Clones for KDR
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
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     Protein A/G/L resins
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     Drugs/Proteins for KDR
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     See all of Abcam's Antibodies, Kits and Proteins for KDR
     Custom Antibody / Protein Production Service
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     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for KDR
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for KDR
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDR
     SwitchGear 3'UTR luciferase reporter plasmids for KDR
     SwitchGear Promoter luciferase reporter plasmids for KDR
     ThermoFisher Antibody for KDR
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KDR
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KDR
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KDR
     LSBio Antibodies in human, mouse, rat for KDR
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     Humanization
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     Browse compounds at ApexBio
     Addgene plasmids for KDR
      Search eBioscience for proteins for KDR
      Search eBioscience for elisas for KDR
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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