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KDR Gene

protein-coding GIFtS: 75

GC04M055639

kinase insert domain receptor (a type III receptor tyrosine kinase)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CD309 ^¹, ²
EC 2.7.10.1 ^³
FLK1 ^¹, ², ³
VEGFR ^¹, ²
VEGFR-2 ^³
VEGFR2 ^¹, ²

Descriptions
CD309 antigen ^³
Kinase insert domain receptor ^², ³
Protein-tyrosine kinase receptor Flk-1 ^², ³
fetal liver kinase-1 ^²
kinase insert domain receptor (a type III receptor tyrosine kinase) ^²
soluble VEGFR2 ^²
tyrosine kinase growth factor receptor ^²
vascular endothelial growth factor receptor 2 ^²

External Ids
HGNC: 6307¹
Entrez Gene: 3791²
UniProtKB: P35968³
Ensembl: ENSG00000128052⁷

Search outside databases for aliases for KDR gene

Previous GC identifers: GC04M055748 GC04M055906 GC04M055860 GC04M055785

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KDR:

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene

encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain

receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of

VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting.

The signalling and trafficking of this receptor are regulated by multiple factors, including Rab

GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase,

etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by

RefSeq]

UniProtKB/Swiss-Prot: VGFR2_HUMAN, P35968

Function: Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase

ligand/receptor signaling system plays a key role in vascular development and regulation of

vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat

protein seems to enhance angiogenesis in Kaposi's sarcoma lesions

Gene Wiki entry for KDR (Kinase_insert_domain_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KDR gene

Entrez Gene cytogenetic band: 4q11-q12 Ensembl cytogenetic band: 4q12 HGNC cytogenetic band: 4q11-q12

KDR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M055639: (about GC identifiers)

Start:	55,639,406 bp from pter
End:	55,686,519 bp from pter
Size:	47,114 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000004.10 NT_022853.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: VGFR2_HUMAN, P35968 (See protein sequence)

Recommended Name: Vascular endothelial growth factor receptor 2 precursor

Size: 1356 amino acids; 151527 Da

Subunit: Interacts with MYOF (By similarity). Interacts with SHB; upon VEGF activation. Interacts

with HIV-1 Tat

Subcellular location: Membrane; Single-pass type I membrane protein

PDB structures from and Proteopedia :

1VR2 (3D)

1Y6A (3D)

1Y6B (3D)

1YWN (3D)

2OH4 (3D)

2P2H (3D)

2P2I (3D)

2QU5 (3D)

2QU6 (3D)

2RL5 (3D)

3B8Q (3D)

3B8R (3D)

3BE2 (3D)

3C7Q (3D)

3CJF (3D)

3CJG (3D)

3CP9 (3D)

3CPB (3D)

3CPC (3D)

3DTW (3D)

Secondary accessions: O60723 Q14178

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002244.1

ENSEMBL proteins:

ENSP00000263923

Human Recombinant Proteins

	Invitrogen human recombinant proteins for KDR
	Millipore Purified and/or Recombinant KDR Protein
	Sigma-Aldrich Proteins and CompoZr ZFN for KDR
	R&D Systems Recombinant & Natural Proteins for KDR (VEGF R2/KDR/Flk-1)
	Enzo Life Sciences proteins for KDR
	Recombinant Proteins from Abcam (VEGFR 1+VEGFR 2, VEGF Receptor 2)
	Human Recombinant Proteins from Abnova (KDR)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	TAS	1656371
GO:0016020	membrane	IEA	--

About this table

Antibodies for KDR:

	Invitrogen Antibodies for KDR
	Millipore Mono- and Polyclonal Antibodies for the study of KDR
	Sigma-Aldrich Antibodies for KDR
	R&D Systems Antibodies for KDR (VEGF R2/KDR/Flk-1)
	Cell Signaling Technology (CST) Antibodies for KDR (KDR, VEGF Receptor 2)
	Antibodies from Abcam (VEGFR 1+VEGFR 2, VEGF Receptor 2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (KDR)
	Novus Biologicals Antibodies for KDR

Assays for KDR:

	Invitrogen Assays for KDR
	Millipore Kits and Assays for the Analysis of KDR
	R&D Systems ELISAs for KDR (VEGF R2/KDR/Flk-1) (see all)
	Cell Signaling Technology (CST) Sandwich ELISA Kits for KDR (VEGF Receptor 2)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P35968

ProtoNet protein and cluster: P35968

5 Blocks protein families:

IPB001824 Receptor tyrosine kinase

IPB003598 Immunoglobulin C-2 type

IPB008266 Tyrosine protein kinase

IPB009134 Vascular endothelial growth factor receptor signature

IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: VGFR2_HUMAN, P35968

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF

receptor subfamily

Similarity: Contains 7 Ig-like C2-type (immunoglobulin-like) domains

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KDR)
		Millipore RNAi Products for the Analysis of KDR Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (KDR)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002253

Applied Biosystems Silencer® siRNAs for KDR

Sigma-Aldrich siRNA and siRNA Panels for KDR

Sigma-Aldrich shRNA Panels and shRNA for KDR

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002253
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002253
untagged cDNA clones in CMV expression vector (see all 2): NM_002253

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002253

UniProtKB/Swiss-Prot: VGFR2_HUMAN, P35968

Function: Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase

ligand/receptor signaling system plays a key role in vascular development and regulation of

vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat

protein seems to enhance angiogenesis in Kaposi's sarcoma lesions

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme Number (IUBMB): EC 2.7.10.1

Genatlas biochemistry entry for KDR:

vascular endothelial growth factor receptor,expressed on the surface of endothelial cells,activated

by VEGF in cooperation with integrin alpha V (ITGAV) beta 3 (ITGB3),involved in angiogenesis,also

regulating the migration of early mesodermally derived precursors into a microenvironnement that

is permissive for hematopoiesis (marker defining hematopoietic stem cells)

12 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Kdr):

	cellular	embryogenesis	growth/size	hematopoietic system
lethality-prenatal/perinatal	liver/biliary system	muscle	nervous system	no phenotypic analysis
normal	skin/coat/nails

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004872	receptor activity	IEA	--
GO:0005021	vascular endothelial growth factor receptor activity	TAS	1417831
GO:0005524	ATP binding	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for KDR (Your Favorite Gene powered by Ingenuity)

VEGF Signaling
Nitric Oxide Signaling in the Cardiovascular System
Hepatic Fibrosis / Hepatic Stellate Cell Activation
IL-8 Signaling

GeneDecks KDR for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for KDR

5/8 Interacting proteins for KDR (P35968^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 8 )
Interactant Interaction Details
GeneCard External ID(s)
NRP1 O14786¹^,² EBI-1005487, EBI-1187100 MINT-2834292 EBI-1005487, EBI-1187100 MINT-2834292
FLT4 P35916¹ EBI-1005487, EBI-1005467
NRP1 O14786¹^,² EBI-1005487, EBI-1187100 MINT-2834292 EBI-1005487, EBI-1187100 MINT-2834292
NCK1 P16333² MINT-3381258 MINT-3381278
CDH5 P33151² MINT-49634
About this table
5/20 Gene Ontology (GO) biological process terms (links to tree view) (see all 20 ):
GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001541 ovarian follicle development IEA --
GO:0001570 vasculogenesis IEA --
GO:0002053 positive regulation of mesenchymal cell proliferation IEA --
GO:0006468 protein amino acid phosphorylation IEA --
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for KDR

Sigma-Aldrich Small Molecules for KDR:

Inhibitor

Compounds for KDR available from Tocris Bioscience

Compound	Action	CAS number
SU 5416	VEGFR inhibitor. Also inhibits c-kit, Ret, MET and FLT3	[204005-46-9]
Ki 8751	Potent, selective VEGFR-2 inhibitor	[228559-41-9]
ZM 323881 hydrochloride	Potent, selective inhibitor of VEGFR-2	[324077-30-7]
SU 5402	Potent FGFR and VEGFR inhibitor	[215543-92-3]
ZM 306416 hydrochloride	Inhibitor of VEGF receptor tyrosine kinase	[690206-97-4]

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10/24 Novoseek chemical compound relationships for KDR gene (see all 24 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
zd6474	91.59	94	16688779 (3), 17889445 (3), 18698025 (3), 16783964 (3) (see all 39)
azd 2171	84.82	22	17671138 (4), 17699717 (4), 18320010 (2), 15899831 (1) (see all 8)
tyrosine	84.52	613	18377662 (5), 10816419 (4), 14744794 (4), 10753929 (4) (see all 99)
su6668	78.92	15	15701856 (3), 16144927 (1), 14611919 (1), 15958585 (1) (see all 10)
matrigel	74.64	15	16447633 (2), 15915456 (1), 16308314 (1), 11549592 (1) (see all 10)
angiozyme	70.23	1	16387667 (1)
rebimastat	64.43	1	14611919 (1)
axitinib	63.61	4	18541897 (2), 19010843 (2)
beta-tyrosine	60.16	1	19002179 (1)
prinomastat	48.51	1	14611919 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KDR)
		Millipore RNAi Products for the Analysis of KDR Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (KDR)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002253

Sigma-Aldrich siRNA and siRNA Panels for KDR

Sigma-Aldrich shRNA Panels and shRNA for KDR

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002253

REFSEQ mRNAs for KDR gene:

NM_002253.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002253

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002253
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002253
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002253

Additional cDNA sequence:

AB209901.1 AF035121.1 AF063658.1 AK293668.1 BC131822.1 CR606055.1 EU826563.1 L04947.1

X61656.1

3 DOTS entries:

DT.417781 DT.40108156 DT.99946559

24/148 AceView cDNA sequences (see all 148 ):

BM667447 F09283 CD107886 AI422100 T28612 CR606055 R97663 BU677947

AL712924 AI679509 BM978033 AF063658 CD671986 BQ029568 F10490 BM698530

CD671985 AI347902 BQ695075 AA768258 W86413 N77001 F09266 CA449800

highest scoring ESTs for KDR:

AF035121 L04947 AF063658 AL589555 CD653033 X61656 AA020766 AA021227 AA026831 AA027012

Unigene Cluster for KDR:

Kinase insert domain receptor (a type III receptor tyrosine kinase)

Hs.479756 [show with all ESTs]

Unigene Representative Sequence: NM_002253

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for KDR

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19a	·	19b	^	20	^	21a	·	21b	^	22	^	23	^	24	^
SP1:																																					-
SP2:
SP3:

ExUns:	25	^	26	^	27	^	28	^	29	^	30	^	31a	·	31b
SP1:
SP2:
SP3:

About this scheme

ECgene alternative splicing isoforms for KDR

1 Ensembl transcript including schematic representation:

ENST00000263923

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KDR expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KDR

¹ / ² / ³

4 probe-sets matching KDR gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1954_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.27	AF035121	1.00	1.00	1.00	1
690_s_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.73	L04947	1.00	1.00	1.00	1
203934_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002253	0.60	1.00	0.82	1
203934_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks KDR for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTATGGCACA

SOURCE GeneReport for Unigene cluster: Hs.479756
Expression variation in blood from EXPOLDB for KDR

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KDR gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KDR¹	--	kinase insert domain receptor (a type III receptor more	91.39(n) 93.06(a)	482154 XM_539273.2 XP_539273.2
chimpanzee (Pan troglodytes)	KDR¹	--	kinase insert domain receptor (a type III receptor more	99.75(n) 99.78(a)	461315 XM_517284.2 XP_517284.2
cow (Bos taurus)	KDR¹	--	kinase insert domain receptor (a type III receptor more	89.72(n) 91.08(a)	407170 XM_611785.3 XP_611785.3
mouse (Mus musculus)	Kdr^{1, 5}	5 (42.00 cM)⁵	kinase insert domain protein receptor^{1, 5}	85.46(n)¹ 86.75(a)¹	16542¹ NM_010612.2¹ NP_034742.2¹ AF061804⁵ AF153058⁵ (see all 13)
chicken (Gallus gallus)	KDR¹	--	kinase insert domain receptor (a type III receptor more	72.24(n) 73.73(a)	395323 NM_001004368.1 NP_001004368.1

About this table Species with no ortholog for KDR

ENSEMBL Gene Tree for KDR

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KDR gene

FLT4² FLT1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/360 NCBI SNPs in KDR are shown (see all 360 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 141)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2071559^1,2	A,C,F,H	55687123(-)	`GAATGT/CTGGCG`	1	--	ng3¹		14	EA EU WA NA	2716
	rs2305948^1,2	C,F,H,O	55674315(+)	`GGTTAC/TACCAT`	1	V/I	mis¹		15	EA NA EU WA	2649
	rs1870377^1,2	C,F,H,O	55667731(+)	`ACAGCT/ATGGCT`	1	H/Q	mis¹		16	MN EU EA WA NA	2816
	rs7667298^1,2	A,C,F,H	55686488(+)	`ACACAC/TTGACC`	1	--	ut5¹ ese³		5	EU EA WA NA	430
	rs2239702^1,2	C,F,H	55686896(-)	`AAGAGG/AGTCCT`	1	--	ng3¹		5	EU EA WA NA	460
--	rs9994560^1,2	A,C,F	55686584(+)	`GCCGGA/GGCGGA`	1	--	ng3¹		1	NA	46
	rs1139776^1,2	C,F,H	55658657(-)	`CCAAGT/AGATTG`	1	E/V	mis¹		9	MN EU EA WA	1024
--	rs33978472^1,2	C,F	55640580(+)	`GTTCTA/-AACCC`	1	--	ut3¹		1	NA	46
	rs34231037^1,2	C,F	55667703(+)	`TTCACA/GAGGGT`	1	C/R	mis¹		1	NA	76
	rs35636987^1,2	C,F	55676288(+)	`GTACAC/TGACTC`	1	V/M	mis¹		4	EU EA WA	420

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HapMap Linkage Disequilibrium images for KDR (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 191306 disorders: 602089 602089

10/93 Novoseek disease relationships for KDR gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
neovascularization	83.10	45	12766257 (2), 9705358 (1), 15951738 (1), 16835467 (1) (see all 37)
tumors	72.74	684	17479290 (7), 11169947 (7), 11801954 (6), 8644848 (5) (see all 99)
solid tumor	66.26	15	11779082 (1), 16015035 (1), 19357226 (1), 12526219 (1) (see all 14)
metastasis	62.00	87	11218896 (3), 17230507 (3), 14517445 (3), 7535799 (2) (see all 59)
blood vessel tumors	61.62	5	14657001 (4), 19248046 (1)
cancer	60.10	107	15756022 (2), 16688779 (2), 18320010 (2), 15310417 (2) (see all 77)
glioblastoma	55.57	25	16021678 (5), 16000592 (3), 15015778 (2), 15657358 (1) (see all 12)
carcinoma renal cell	51.51	16	17332933 (2), 17465216 (2), 9063473 (1), 17229632 (1) (see all 12)
lymphatic metastasis	50.49	3	18687659 (2), 17018613 (1)
glioma	49.79	45	17189383 (6), 10616207 (3), 15072443 (3), 19020728 (3) (see all 23)

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Human Gene Mutation Database: KDR
Genetic Association Database: KDR
Human Genome Epidemiology Navigator: KDR (17 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1262 PubMed articles for KDR gene (see all 1262 ):

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. (PubMed id 1417831)^{1, 2, 3, 4} Terman B.I.... Boehlen P. (1992)
The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF- dependent cellular migration. (PubMed id 15026417)^{1, 3, 4} Holmqvist K.... Welsh M. (2004)
Association of vascular endothelial growth factor (VEGF) and VEGF receptor gene polymorphisms with coronary artery lesions of Kawasaki disease. (PubMed id 15470196)^{3, 6} Kariyazono H....Hara T. (2004)
Identification of specific molecular structures of human immunodeficiency virus type 1 Tat relevant for its biological effects on vascular endothelial cells. (PubMed id 10590123)^{3, 4} Mitola S.... Bussolino F. (2000)
Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis. (PubMed id 10368301)^{3, 4} McTigue M.A....Appelt K. (1999)
Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor. (PubMed id 7559454)^{3, 4} Patterson C....Harber E. (1995)
Identification of a new endothelial cell growth factor receptor tyrosine kinase. (PubMed id 1656371)^{3, 4} Terman B.I....Shows T.B. (1991)
Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation. (PubMed id 15060076)^{1, 3} Murdaca J....Giorgetti-Peraldi S. (2004)
The carboxyl terminus of VEGFR-2 is required for PKC-mediated down-regulation. (PubMed id 15673613)^{1, 3} Singh A.J....Rahimi N. (2005)
Heterotrimeric G alpha q/G alpha 11 proteins function upstream of vascular endothelial growth factor (VEGF) receptor-2 (KDR) phosphorylation in vascular permeability factor/VEGF signaling. (PubMed id 12670961)^{1, 3} Zeng H....Mukhopadhyay D. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3791	HGNC: 6307	AceView: KDR	Ensembl:ENSG00000128052	euGenes: HUgn3791
ECgene: KDR	H-InvDB: KDR

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for KDR	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for KDR
(Available from WIS Yeda, Salk, Tufts)

About This Section

Licensable Technologies for KDR gene:

Weizmann Institute:

Porphyrin and Corrole -like analogs as potent inhibitors of Growth Factor Receptor Binding and Activation

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KDR:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KDR-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KDR		Antibodies for KDR
	Explore super-pooled esiRNAs		Proteins for KDR
	Lentivirus-delivered shRNAs for KDR		Small molecules for KDR
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (KDR)
	Antibodies (KDR)
	Chimera RNAi (KDR)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for KDR (KDR, VEGF Receptor 2)

	Recombinant Proteins (VEGFR 1+VEGFR 2, VEGF Receptor 2)
	Antibodies (VEGFR 1+VEGFR 2, VEGF Receptor 2)

Search OriGene for KDR

Tocris compounds for KDR

	Drugs/Proteins for KDR
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for KDR

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
KDR Gene at Home site.
Version 2.41.1
server5.xennexinc.com

KDR Gene

protein-coding GIFtS: 75

Aliases &
Descriptions
for KDR

Summaries
for KDR

Genomic Location
for KDR

Proteins
for KDR

Protein Domains/
Families
for KDR

Gene Function
for KDR

Pathways & Interactions
for KDR

Drugs & Compounds
for KDR

Transcripts
for KDR

Expression
for KDR

Orthologs
for KDR

Paralogs
for KDR

SNPs/Variants
for KDR

Disorders & Mutations
for KDR

Medical News
for KDR

Publications
for KDR

Search for KDR

Genome Databases showing KDR

Other Databases showing KDR

Specialized Databases showing KDR

Licensable Technologies
for KDR

Services
for KDR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KDR Gene

protein-coding GIFtS: 75

Aliases & Descriptionsfor KDR

Summariesfor KDR

Genomic Locationfor KDR

Proteinsfor KDR

Protein Domains/Familiesfor KDR

Gene Functionfor KDR

Pathways & Interactionsfor KDR

Drugs & Compoundsfor KDR

Transcriptsfor KDR

Expression for KDR

Orthologsfor KDR

Paralogsfor KDR

SNPs/Variantsfor KDR

Disorders & Mutationsfor KDR

Medical Newsfor KDR

Publicationsfor KDR

Search for KDR

Genome Databases showing KDR

Other Databases showing KDR

Specialized Databases showing KDR

Licensable Technologiesfor KDR

Servicesfor KDR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KDR

Summaries
for KDR

Genomic Location
for KDR

Proteins
for KDR

Protein Domains/
Families
for KDR

Gene Function
for KDR

Pathways & Interactions
for KDR

Drugs & Compounds
for KDR

Transcripts
for KDR

Expression
for KDR

Orthologs
for KDR

Paralogs
for KDR

SNPs/Variants
for KDR

Disorders & Mutations
for KDR

Medical News
for KDR

Publications
for KDR

Licensable Technologies
for KDR

Services
for KDR