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KDM8 Gene

protein-coding   GIFtS: 43
GCID: GC16P027214

Lysine (K)-Specific Demethylase 8

(Previous name: jumonji domain containing 5)
(Previous symbol: JMJD5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lysine (K)-Specific Demethylase 81 2     Jumonji Domain-Containing Protein 52 3
JMJD51 2 3 5     Lysine-Specific Demethylase 82
Jumonji Domain Containing 51 2     EC 1.14.11.273
JmjC Domain-Containing Protein 52 3     

External Ids:    HGNC: 258401   Entrez Gene: 798312   Ensembl: ENSG000001556667   OMIM: 6119175   UniProtKB: Q8N3713   

Export aliases for KDM8 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KDM8 Gene:
This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential
role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been
described.(provided by RefSeq, Feb 2009)

GeneCards Summary for KDM8 Gene:
KDM8 (lysine (K)-specific demethylase 8) is a protein-coding gene. Diseases associated with KDM8 include pandas, and obesity. GO annotations related to this gene include chromatin binding and histone demethylase activity (H3-K36 specific). An important paralog of this gene is TYW5.

UniProtKB/Swiss-Prot: KDM8_HUMAN, Q8N371
Function: Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates
dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription
activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_187260.1  NC_018927.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for KDM8
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKDM8 promoter sequence
   Search Chromatin IP Primers for KDM8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KDM8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.1   Ensembl cytogenetic band:  16p12.1   HGNC cytogenetic band: 16p12.1

KDM8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KDM8 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P027214:  view genomic region     (about GC identifiers)

Start:
27,214,807 bp from pter      End:
27,233,089 bp from pter
Size:
18,283 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KDM8_HUMAN, Q8N371 (See protein sequence)
Recommended Name: Lysine-specific demethylase 8  
Size: 416 amino acids; 47270 Da
Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)
5 PDB 3D structures from and Proteopedia for KDM8:
3UYJ (3D)        4AAP (3D)        4GAZ (3D)        4GJY (3D)        4GJZ (3D)    
Secondary accessions: B4DLU9 Q6VAK5 Q9H8B1
Alternative splicing: 3 isoforms:  Q8N371-1   Q8N371-2   Q8N371-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KDM8: NX_Q8N371

Explore proteomics data for KDM8 at MOPED


See KDM8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001138820.1  NP_079049.2  

ENSEMBL proteins: 
 ENSP00000286096   ENSP00000456107   ENSP00000398410   ENSP00000454215   ENSP00000456901  
 ENSP00000455463   ENSP00000370335  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
KDM: Chromatin-modifying enzymes / K-demethylases

1 InterPro protein domain:
 IPR003347 JmjC_dom

Graphical View of Domain Structure for InterPro Entry Q8N371

ProtoNet protein and cluster: Q8N371

UniProtKB/Swiss-Prot: KDM8_HUMAN, Q8N371
Similarity: Contains 1 JmjC domain


KDM8 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: KDM8_HUMAN, Q8N371
Function: Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates
dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription
activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation
Catalytic activity: Protein N(6),N(6)-dimethyl-L-lysine + 2-oxoglutarate + O(2) = protein N(6)-methyl-L-lysine +
succinate + formaldehyde + CO(2)
Catalytic activity: Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O(2) = protein L-lysine + succinate +
formaldehyde + CO(2)

     Enzyme Number (IUBMB): EC 1.14.11.271

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003682chromatin binding IDA--
GO:0005515protein binding ----
GO:0046872metal ion binding IEA--
GO:0051864histone demethylase activity (H3-K36 specific) IDA--
     
KDM8 for ontologies           About GeneDecksing


Phenotypes:
     14 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Kdm8):
 behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size/body 
 hematopoietic system  homeostasis/metabolism  immune system  integument  mortality/aging 
 nervous system  normal  pigmentation  vision/eye 

KDM8 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Kdm8tm1.2Tasu for KDM8

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KDM8
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KDM8

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KDM8
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KDM8

miRNA
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miRTarBase miRNAs that target KDM8:
hsa-mir-378c (MIRT052832), hsa-mir-149-5p (MIRT045429)

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Predesigned siRNA for gene silencing in human, mouse, rat KDM8

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM8


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
KDM8_HUMAN, Q8N371: Nucleus

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA--

KDM8 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KDM8
Interactions:

    Search GeneGlobe Interaction Network for KDM8

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for KDM8 (Q8N3713 ENSP000003984104) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
PCYT2Q994473, ENSP000003317194I2D: score=4 STRING: ENSP00000331719
--ENSP000003002334STRING: ENSP00000300233
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Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000086G2/M transition of mitotic cell cycle IMP--
GO:0006351transcription, DNA-templated IEA--
GO:0045893positive regulation of transcription, DNA-templated IMP--
GO:0070544histone H3-K36 demethylation IDA--

KDM8 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for KDM8



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for KDM8 gene (2 alternative transcripts): 
NM_001145348.1  NM_024773.2  

Unigene Cluster for KDM8:

Lysine (K)-specific demethylase 8
Hs.145717  [show with all ESTs]
Unigene Representative Sequence: NM_001145348
15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000286096(uc002doh.2 uc010vcn.1 uc010bxx.2) ENST00000564961(uc010bxv.2)
ENST00000562269 ENST00000569329 ENST00000441782 ENST00000562733 ENST00000563881
ENST00000568965 ENST00000563571 ENST00000567785 ENST00000567366 ENST00000568792
ENST00000567735 ENST00000569592 ENST00000380948(uc010bxw.2)
miRNA
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Inhib. RNA
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Primer
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OriGene qPCR primer pairs and template standards for KDM8
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  QuantiTect SYBR Green Assays in human, mouse, rat KDM8
  QuantiFast Probe-based Assays in human, mouse, rat KDM8

Additional mRNA sequence: 

AK023860.1 AK055679.1 AK225066.1 AK297166.1 AK298410.1 AK308499.1 AK310885.1 AY345239.1 
BC027911.1 

11 DOTS entries:

DT.40305942  DT.102823164  DT.70104071  DT.100736450  DT.101978080  DT.75128004  DT.100664964  DT.100736452 
DT.120661097  DT.95153259  DT.100725007 

Selected AceView cDNA sequences (see all 52):

BQ689669 BQ066794 CR608978 BP338003 CB160363 AY345239 AW665036 BQ057705 
AK055679 BM478152 BQ022832 AA491024 NM_024773 BI768810 CB158529 CB216288 
AU141170 BM919718 BX329005 BC027911 AI288219 AL529811 BX283857 AI122764 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for KDM8 (see all 10)    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b · 13c ·
SP1:                                                                                                                                -                           
SP2:                    -     -                       -                                                                                                         
SP3:                                                                                                                          -     -     -                     
SP4:                    -     -     -                                                                                                                           
SP5:                    -     -     -                                   -     -                                                                                 

ExUns: 13d
SP1:      
SP2:      
SP3:      
SP4:      
SP5:      


ECgene alternative splicing isoforms for KDM8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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KDM8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCTCAAGGAT
KDM8 Expression
About this image

KDM8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

KDM8 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.145717

UniProtKB/Swiss-Prot: KDM8_HUMAN, Q8N371
Tissue specificity: Weakly expressed in most cells. Highly expressed in breast cancer cells

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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM8

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for KDM8 gene from Selected species (see all 18)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Kdm81 , 5 jumonji domain containing 55
lysine (K)-specific demethylase 81
79.18(n)1
78.45(a)1
  7 (68.85 cM)5
770351  NM_029842.51  NP_084118.11 
 1254446765 
chicken
(Gallus gallus)
Aves KDM81 lysine (K)-specific demethylase 8 66.33(n)
63.27(a)
  416583  XM_414883.4  XP_414883.3 
lizard
(Anolis carolinensis)
Reptilia KDM86
lysine (K)-specific demethylase 8
54(a)
1 ↔ 1
GL343612.1(162675-168042)
tropical clawed frog
(Xenopus tropicalis)
Amphibia kdm81 lysine (K)-specific demethylase 8 61.68(n)
58.12(a)
  100158649  NM_001128053.1  NP_001121525.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.168682 Transcribed sequence with weak similarity to protein more 77.99(n)    BI984262.1 
fruit fly
(Drosophila melanogaster)
Insecta CG139021 CG13902 52.35(n)
42.64(a)
  38097  NM_138219.3  NP_612063.2 
worm
(Caenorhabditis elegans)
Secernentea jmjd-51 jmjd-5 46.34(n)
37.36(a)
  179543  NM_073430.3  NP_505831.1 
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G208101 AT3G20810 49.47(n)
44.93(a)
  821629  NM_180286.1  NP_850617.1 
rice
(Oryza sativa)
Liliopsida Os09g04892001 Os09g0489200 52.22(n)
45.76(a)
  4347435  NM_001070068.2  NP_001063533.2 


ENSEMBL Gene Tree for KDM8 (if available)
TreeFam Gene Tree for KDM8 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for KDM8 gene
TYW52  HSPBAP12  HIF1AN2  

KDM8 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for KDM8 (see all 458)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1891440491,2
--27212871(+) ACGGAC/GTCTCG 1 -- us2k10--------
rs1815528081,2
--27212924(+) AGCTCC/TGCCTC 1 -- us2k10--------
rs1842814161,2
C--27213055(+) GGATGA/GTCTCA 1 -- us2k10--------
rs80492041,2
C,F,A,H--27213081(+) gatccG/Acccgc 1 -- us2k16Minor allele frequency- A:0.43NA 14
rs1898399431,2
--27213084(+) CCGCCC/TGCCTC 1 -- us2k10--------
rs1472766241,2
--27213129(+) CACCAC/TGCCTG 1 -- us2k10--------
rs1487063301,2
--27213222(+) CTTTTC/GTTTCA 1 -- us2k10--------
rs71904531,2
C,F--27213359(+) ccaggC/Gccagg 2 -- us2k11Minor allele frequency- G:0.05WA 118
rs560623261,2
C,F--27213581(+) GGGGTG/AGGGGG 2 -- us2k11Minor allele frequency- A:0.08NA 120
rs1811208801,2
--27213654(+) TTTTCC/TGGGGA 2 -- us2k10--------

HapMap Linkage Disequilibrium report for KDM8 (27214807 - 27233089 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for KDM8: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing KDM8
DNA2.0 Custom Variant and Variant Library Synthesis for KDM8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611917    OMIM disorders: --

3 diseases for KDM8:    
About MalaCards
pandas    obesity    breast cancer


KDM8 for disorders           About GeneDecksing


Export disorders for KDM8 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for KDM8 gene, integrated from 10 sources (see all 16):
(articles sorted by number of sources associating them with KDM8)
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  1. KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation. (PubMed id 20457893)1, 2, 3 Hsia D.A.... Izumiya Y. (Proc. Natl. Acad. Sci. U.S.A. 2010)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1I+-mediated glucose metabolism. (PubMed id 24344305)1 Wang H.J....Wang W.C. (Proc. Natl. Acad. Sci. U.S.A. 2014)
  4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
  5. Crystal structure and functional analysis of JMJD5 indicate an alternate specificity and function. (PubMed id 22851697)1 Del Rizzo P.A....Trievel R.C. (Mol. Cell. Biol. 2012)
  6. JMJD5, a Jumonji C (JmjC) domain-containing protein, negatively regulates osteoclastogenesis by facilitating NFATc1 protein degradation. (PubMed id 22375008)1 Youn M.Y....Imai Y. (J. Biol. Chem. 2012)
  7. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
  8. Jumonji domain protein JMJD5 functions in both the plant and human circadian systems. (PubMed id 21115819)1 Jones M.A....Harmer S.L. (Proc. Natl. Acad. Sci. U.S.A. 2010)
  9. Histone lysine demethylases: emerging roles in development, physiology and disease. (PubMed id 17909537)1 Shi Y. (Nat. Rev. Genet. 2007)
  10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 79831 HGNC: 25840 AceView: FLJ13798 Ensembl:ENSG00000155666 euGenes: HUgn79831
ECgene: KDM8 H-InvDB: KDM8

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for KDM8 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for KDM8 gene:
Search GeneIP for patents involving KDM8

GeneCards and IP:
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