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Aliases for KDM8 Gene

Aliases for KDM8 Gene

  • Lysine (K)-Specific Demethylase 8 2 3
  • JMJD5 3 4 6
  • Jumonji Domain-Containing Protein 5 3 4
  • JmjC Domain-Containing Protein 5 3 4
  • Jumonji Domain Containing 5 2 3
  • Lysine-Specific Demethylase 8 3
  • EC 1.14.11.27 4

External Ids for KDM8 Gene

Previous Symbols for KDM8 Gene

  • JMJD5

Summaries for KDM8 Gene

Entrez Gene Summary for KDM8 Gene

  • This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]

GeneCards Summary for KDM8 Gene

KDM8 (Lysine (K)-Specific Demethylase 8) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and histone demethylase activity (H3-K36 specific). An important paralog of this gene is HSPBAP1.

UniProtKB/Swiss-Prot for KDM8 Gene

  • Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated Lys-36 (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KDM8 Gene

Genomics for KDM8 Gene

Genomic Location for KDM8 Gene

Start:
27,203,486 bp from pter
End:
27,221,768 bp from pter
Size:
18,283 bases
Orientation:
Plus strand

Genomic View for KDM8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KDM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KDM8 Gene

No data available for Regulatory Elements for KDM8 Gene

Proteins for KDM8 Gene

  • Protein details for KDM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N371-KDM8_HUMAN
    Recommended name:
    Lysine-specific demethylase 8
    Protein Accession:
    Q8N371
    Secondary Accessions:
    • B4DLU9
    • Q6VAK5
    • Q9H8B1

    Protein attributes for KDM8 Gene

    Size:
    416 amino acids
    Molecular mass:
    47270 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 1 Fe(2+) ion per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for KDM8 Gene

    Alternative splice isoforms for KDM8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KDM8 Gene

Proteomics data for KDM8 Gene at MOPED

Post-translational modifications for KDM8 Gene

No Post-translational modifications

Other Protein References for KDM8 Gene

No data available for DME Specific Peptides for KDM8 Gene

Domains for KDM8 Gene

Gene Families for KDM8 Gene

HGNC:
  • KDM :Chromatin-modifying enzymes / K-demethylases

Protein Domains for KDM8 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8N371

UniProtKB/Swiss-Prot:

KDM8_HUMAN
Domain:
  • Contains 1 JmjC domain.:
    • Q8N371
genes like me logo Genes that share domains with KDM8: view

No data available for Suggested Antigen Peptide Sequences for KDM8 Gene

Function for KDM8 Gene

Molecular function for KDM8 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Protein N(6),N(6)-dimethyl-L-lysine + 2-oxoglutarate + O(2) = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO(2)
UniProtKB/Swiss-Prot CatalyticActivity: Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O(2) = protein L-lysine + succinate + formaldehyde + CO(2)
UniProtKB/Swiss-Prot Function: Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated Lys-36 (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.

Enzyme Numbers (IUBMB) for KDM8 Gene

Gene Ontology (GO) - Molecular Function for KDM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 20457893
GO:0046872 metal ion binding IEA --
GO:0051864 histone demethylase activity (H3-K36 specific) IDA 20457893
genes like me logo Genes that share ontologies with KDM8: view
genes like me logo Genes that share phenotypes with KDM8: view

Animal Models for KDM8 Gene

MGI Knock Outs for KDM8:

miRNA for KDM8 Gene

miRTarBase miRNAs that target KDM8

No data available for Transcription Factor Targeting and HOMER Transcription for KDM8 Gene

Localization for KDM8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KDM8 Gene

Gene Ontology (GO) - Cellular Components for KDM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20457893
genes like me logo Genes that share ontologies with KDM8: view

No data available for Subcellular locations from COMPARTMENTS for KDM8 Gene

Pathways for KDM8 Gene

SuperPathways for KDM8 Gene

No Data Available

Interacting Proteins for KDM8 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000398410%0d%0a9606.ENSP00000442050%0d%0a9606.ENSP00000377801%0d%0a9606.ENSP00000272091%0d%0a
Selected Interacting proteins: ENSP00000398410 Q8N371-KDM8_HUMAN for KDM8 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for KDM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IMP 20457893
GO:0006351 transcription, DNA-templated IEA --
GO:0045893 positive regulation of transcription, DNA-templated IMP 20457893
GO:0055114 oxidation-reduction process IEA --
GO:0070544 histone H3-K36 demethylation IDA 20457893
genes like me logo Genes that share ontologies with KDM8: view

No data available for Pathways by source for KDM8 Gene

Transcripts for KDM8 Gene

Unigene Clusters for KDM8 Gene

Lysine (K)-specific demethylase 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KDM8 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b · 13c ·
SP1: -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - - - - -
SP6:
SP7: - -
SP8: -
SP9: - - - - - - -
SP10: - - - - - - - - - - - -

ExUns: 13d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for KDM8 Gene

GeneLoc Exon Structure for
KDM8
ECgene alternative splicing isoforms for
KDM8

Expression for KDM8 Gene

mRNA expression in normal human tissues for KDM8 Gene

mRNA differential expression in normal tissues according to GTEx for KDM8 Gene

This gene is overexpressed in Liver (15.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KDM8 Gene

SOURCE GeneReport for Unigene cluster for KDM8 Gene Hs.145717

mRNA Expression by UniProt/SwissProt for KDM8 Gene

Q8N371-KDM8_HUMAN
Tissue specificity: Weakly expressed in most cells. Highly expressed in breast cancer cells.
genes like me logo Genes that share expressions with KDM8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KDM8 Gene

Orthologs for KDM8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KDM8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia JMJD5 35
  • 99.34 (n)
  • 99.12 (a)
KDM8 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KDM8 35
  • 83.37 (n)
  • 82.72 (a)
KDM8 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KDM8 35
  • 83.45 (n)
  • 81.11 (a)
KDM8 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kdm8 35
  • 79.18 (n)
  • 78.45 (a)
Kdm8 16
Kdm8 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KDM8 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KDM8 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kdm8 35
  • 79.42 (n)
  • 79.18 (a)
chicken
(Gallus gallus)
Aves KDM8 35
  • 66.33 (n)
  • 63.27 (a)
KDM8 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KDM8 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kdm8 35
  • 61.68 (n)
  • 58.12 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.16868 35
kdm8 35
  • 59.93 (n)
  • 57.11 (a)
kdm8 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13902 35
  • 52.35 (n)
  • 42.64 (a)
CG13902 36
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea jmjd-5 35
  • 46.34 (n)
  • 37.36 (a)
jmjd-5 36
  • 24 (a)
OneToOne
soybean
(Glycine max)
eudicotyledons Gma.17248 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G20810 35
  • 49.47 (n)
  • 44.93 (a)
rice
(Oryza sativa)
Liliopsida Os09g0489200 35
  • 52.22 (n)
  • 45.76 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.15579 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.718 36
  • 17 (a)
ManyToMany
Species with no ortholog for KDM8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for KDM8 Gene

ENSEMBL:
Gene Tree for KDM8 (if available)
TreeFam:
Gene Tree for KDM8 (if available)

Paralogs for KDM8 Gene

Paralogs for KDM8 Gene

genes like me logo Genes that share paralogs with KDM8: view

Variants for KDM8 Gene

Sequence variations from dbSNP and Humsavar for KDM8 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs877584 -- 27,203,941(+) GCGCT(G/T)TAGCG upstream-variant-2KB, intron-variant
rs877585 -- 27,203,946(+) TTAGC(A/G)GTTCT upstream-variant-2KB, intron-variant
rs908382 -- 27,204,059(-) CAGCC(G/T)GCCTT utr-variant-5-prime, intron-variant
rs1108029 -- 27,204,445(-) CCAGG(A/G)AAGTT intron-variant, upstream-variant-2KB
rs1134366 -- 27,221,420(+) GTCAT(A/C)CCCAT utr-variant-3-prime

Relevant External Links for KDM8 Gene

HapMap Linkage Disequilibrium report
KDM8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KDM8 Gene

Disorders for KDM8 Gene

No disorders were found for KDM8 Gene.

No data available for UniProtKB/Swiss-Prot for KDM8 Gene

Publications for KDM8 Gene

  1. KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation. (PMID: 20457893) Hsia D.A. … Izumiya Y. (Proc. Natl. Acad. Sci. U.S.A. 2010) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice. (PMID: 16858412) Suzuki T. … Copeland N.G. (EMBO J. 2006) 3

Products for KDM8 Gene

Sources for KDM8 Gene

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