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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KDM8 Gene

protein-coding GIFtS: 44
GCID: GC16P027214

lysine (K)-specific demethylase 8

(Previous name: jumonji domain containing 5 )
(Previous symbol: JMJD5)

Explore 2 diseases affiliated with
KDM8 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Lysine (K)-Specific Demethylase 8¹ ²		Jumonji Domain-Containing Protein 5² ³
JMJD5¹ ² ³ ⁵		FLJ13798¹
Jumonji Domain Containing 5¹ ²		Lysine-Specific Demethylase 8²
JmjC Domain-Containing Protein 5² ³		EC 1.14.11.27³

External Ids:	HGNC: 25840¹	Entrez Gene: 79831²	Ensembl: ENSG00000155666⁷	OMIM: 611917⁵	UniProtKB: Q8N371³

Export aliases for KDM8 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KDM8:

This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role

for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.(provided by

RefSeq, Feb 2009)

UniProtKB/Swiss-Prot: KDM8_HUMAN, Q8N371

Function: Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated

'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator.

Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for KDM8
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KDM8 promoter sequence

Search SABiosciences Chromatin IP Primers for KDM8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KDM8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.1 Ensembl cytogenetic band: 16p12.1 HGNC cytogenetic band: 16p12.1

KDM8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KDM8 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P027214: view genomic region (about GC identifiers)

Start:	27,214,807 bp from pter	End:	27,233,089 bp from pter
Size:	18,283 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KDM8_HUMAN, Q8N371 (See protein sequence)

Recommended Name: Lysine-specific demethylase 8

Size: 416 amino acids; 47270 Da

Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)

Subcellular location: Nucleus

4 PDB 3D structures from and Proteopedia for KDM8:

3UYJ (3D)

4AAP (3D)

4GJY (3D)

4GJZ (3D)

Secondary accessions: B4DLU9 Q6VAK5 Q9H8B1

Alternative splicing: 3 isoforms: Q8N371-1 Q8N371-2 Q8N371-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KDM8: NX_Q8N371

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N371

KDM8 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001138820.1 NP_079049.2

ENSEMBL proteins:

ENSP00000286096 ENSP00000456107 ENSP00000398410 ENSP00000454215 ENSP00000456901

ENSP00000455463 ENSP00000370335

Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KDM8

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--

KDM8 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for KDM8

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KDM8 for domains About GeneDecksing

1 InterPro domain/family:

IPR003347 JmjC_dom

Graphical View of Domain Structure for InterPro Entry Q8N371

ProtoNet protein and cluster: Q8N371

UniProtKB/Swiss-Prot: KDM8_HUMAN, Q8N371

Similarity: Contains 1 JmjC domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KDM8_HUMAN, Q8N371

Function: Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated

'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator.

Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation

Catalytic activity: Protein N(6),N(6)-dimethyl-L-lysine + 2-oxoglutarate + O(2) = protein N(6)-methyl-L-lysine +

succinate + formaldehyde + CO(2)

Catalytic activity: Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O(2) = protein L-lysine + succinate + formaldehyde

+ CO(2)

Enzyme Number (IUBMB): EC 1.14.11.27¹

miRNA Products:		OriGene 3'-UTR Clone (see all 2): KDM8 Browse MicroRNA Expression Plasmids
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM8

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003682	chromatin binding	IDA	--
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	--
GO:0046872	metal ion binding	IEA	--
GO:0051864	histone demethylase activity (H3-K36 specific)	IDA	--

KDM8 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Kdm8^tm1.2Tasu for KDM8
     14 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Kdm8):

behavior/neurological	cardiovascular system	cellular	embryogenesis	growth/size
hematopoietic system	homeostasis/metabolism	immune system	integument	mortality/aging
nervous system	normal	pigmentation	vision/eye

KDM8 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KDM8

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for KDM8 (Q8N371³ ENSP00000398410⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PCYT2	Q99447³, ENSP00000331719⁴	I2D: score=4 STRING: ENSP00000331719

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000086	G2/M transition of mitotic cell cycle	IMP	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0045893	positive regulation of transcription, DNA-dependent	IMP	--
GO:0070544	histone H3-K36 demethylation	IDA	--

KDM8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KDM8
Search CenterWatch for drugs/clinical trials and news about KDM8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KDM8 gene (2 alternative transcripts):

NM_001145348.1 NM_024773.2

Unigene Cluster for KDM8:

Lysine (K)-specific demethylase 8

Hs.145717 [show with all ESTs]

Unigene Representative Sequence: NM_001145348

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000286096(uc002doh.2 uc010vcn.1 uc010bxx.2) ENST00000564961(uc010bxv.2)

ENST00000562269 ENST00000569329 ENST00000441782 ENST00000562733 ENST00000563881

ENST00000568965 ENST00000563571 ENST00000567785 ENST00000567366 ENST00000568792

ENST00000567735 ENST00000569592 ENST00000380948(uc010bxw.2)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): KDM8 Browse OriGene MicroRNA Expression Plasmids
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KDM8

Additional cDNA sequence:

AK023860.1 AK055679.1 AK225066.1 AK297166.1 AK298410.1 AK308499.1 AK310885.1 AY345239.1

BC027911.1

11 DOTS entries:

DT.40305942 DT.102823164 DT.70104071 DT.100736450 DT.101978080 DT.75128004 DT.100664964 DT.100736452

DT.120661097 DT.95153259 DT.100725007

24/52 AceView cDNA sequences (see all 52):

CR608978 AK055679 BQ022832 BM478152 BQ066794 BQ689669 BQ057705 AW665036

AY345239 CB160363 BP338003 AL529811 BU689901 CB216288 AU141170 BM919718

CB158529 BI768810 AI122764 AK023860 AI401500 BM724364 AA383674 BM922658

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for KDM8 (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	^	10	^	11a	·	11b	·	11c	^	12a	·	12b	^	13a	·	13b	·	13c	·
SP1:																																											-
SP2:							-		-								-
SP3:																																									-		-		-
SP4:							-		-		-
SP5:							-		-		-												-		-

ExUns:	13d
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for KDM8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KDM8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTCAAGGAT

About this image

KDM8 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Limb Bud

Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KDM8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KDM8

SOURCE GeneReport for Unigene cluster: Hs.145717

UniProtKB/Swiss-Prot: KDM8_HUMAN, Q8N371

Tissue specificity: Weakly expressed in most cells. Highly expressed in breast cancer cells

SABiosciences Custom PCR Arrays for KDM8

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM8

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for KDM8 gene from 7/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	JMJD5¹	jumonji domain containing 5	66.33(n) 63.27(a)		416583 XM_414883.3 XP_414883.3
lizard (Anolis carolinensis)	Reptilia	JMJD5⁶	--	54(a)	1 ↔ 1	GL343612.1(162675-168042)
zebrafish (Danio rerio)	Actinopterygii	Dr.16868²	Transcribed sequence with weak similarity to protein more	77.99(n)		BI984262.1
fruit fly (Drosophila melanogaster)	Insecta	CG13902¹	CG13902	52.35(n) 42.64(a)		38097 NM_138219.2 NP_612063.2
worm (Caenorhabditis elegans)	Secernentea	jmjd-5¹	Protein JMJD-5	46.25(n) 37.36(a)		179543 NM_073430.2 NP_505831.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G20810¹	transcription factor jumonji (jmjC) domain-containing more	49.32(n) 43.6(a)		821629 NM_180286.1 NP_850617.1
rice (Oryza sativa)	Liliopsida	Os09g0489200¹	hypothetical protein	52.34(n) 45.73(a)		4347435 NM_001070068.2 NP_001063533.2

ENSEMBL Gene Tree for KDM8 (if available)
TreeFam Gene Tree for KDM8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KDM8 gene

TYW5² JMJD7² HSPBAP1² HIF1AN²

KDM8 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189144049^1,2		--	27212871(+)	`ACGGAC/GTCTCG`	1	--	us2k¹		0	--	--	--	--
rs181552808^1,2		--	27212924(+)	`AGCTCC/TGCCTC`	1	--	us2k¹		0	--	--	--	--
rs184281416^1,2		--	27213055(+)	`GGATGA/GTCTCA`	1	--	us2k¹		0	--	--	--	--
rs8049204^1,2	C,F,A,H,	--	27213081(+)	`GATCCG/ACCCGC`	1	--	us2k¹		6		NA	14
rs189839943^1,2		--	27213084(+)	`CCGCCC/TGCCTC`	1	--	us2k¹		0	--	--	--	--
rs147276624^1,2		--	27213129(+)	`CACCAC/TGCCTG`	1	--	us2k¹		0	--	--	--	--
rs148706330^1,2		--	27213222(+)	`CTTTTC/GTTTCA`	1	--	us2k¹		0	--	--	--	--
rs7190453^1,2	C,F,	--	27213359(+)	`ccaggC/Gccagg`	2	--	us2k¹		1		WA	118
rs56062326^1,2	C,F,	--	27213581(+)	`GGGGTG/AGGGGG`	2	--	us2k¹		1		NA	120
rs181120880^1,2		--	27213654(+)	`TTTTCC/TGGGGA`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KDM8 (27214807 - 27233089 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KDM8: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KDM8

DNA2.0 Custom Variant and Variant Library Synthesis for KDM8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KDM8 for disorders           About GeneDecksing

OMIM gene information: 611917    OMIM disorders: --

2 diseases for KDM8:    About MalaCards

pandas breast cancer

Export disorders for KDM8 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KDM8 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with KDM8)

Utopia: connect your pdf to the dynamic
world of online information

KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation. (PubMed id 20457893)^{1, 2, 3} Hsia D.A....Izumiya Y. (2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Crystal structure and functional analysis of JMJD5 ind icate an alternate specificity and function. (PubMed id 22851697)¹ Del Rizzo P.A....Trievel R.C. (2012)
JMJD5, a Jumonji C (JmjC) domain-containing protein, n egatively regulates osteoclastogenesis by facilitating NFATc1 protein degradatio n. (PubMed id 22375008)¹ Youn M.Y....Imai Y. (2012)
Jumonji domain protein JMJD5 functions in both the pl ant and human circadian systems. (PubMed id 21115819)¹ Jones M.A....Harmer S.L. (2010)
Histone lysine demethylases: emerging roles in development, physiology and disease. (PubMed id 17909537)¹ Shi Y. (2007)
Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice. (PubMed id 16858412)¹ Suzuki T....Copeland N.G. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)² Martin J.... Pennacchio L.A. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 79831	HGNC: 25840	AceView: FLJ13798	Ensembl:ENSG00000155666	euGenes: HUgn79831
ECgene: KDM8	H-InvDB: KDM8

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KDM8	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KDM8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for KDM8 gene:
Search GeneIP for patents involving KDM8

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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KDM8 Gene

lysine (K)-specific demethylase 8

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KDM8 Gene

lysine (K)-specific demethylase 8

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