Aliases for KDM7A Gene
Aliases for KDM7A Gene
- Lysine Demethylase 7A 2 3 5
- JmjC Domain-Containing Histone Demethylation Protein 1D 3 4
- Lysine (K)-Specific Demethylase 7A 2 3
- Lysine-Specific Demethylase 7 3 4
- JHDM1D 3 4
- Jumonji C Domain Containing Histone Demethylase 1 Homolog D (S. Cerevisiae) 2
- Jumonji C Domain Containing Histone Demethylase 1 Homolog D 3
External Ids for KDM7A Gene
- HGNC: 22224
- Entrez Gene: 80853
- Ensembl: ENSG00000006459
- UniProtKB: Q6ZMT4
Previous HGNC Symbols for KDM7A Gene
- JHDM1D
Previous GeneCards Identifiers for KDM7A Gene
- GC07M139785
Summaries for KDM7A Gene
GeneCards Summary for KDM7A Gene
KDM7A (Lysine Demethylase 7A) is a Protein Coding gene. Diseases associated with KDM7A include Bone Benign Neoplasm and Connective Tissue Benign Neoplasm. Among its related pathways are Oncogenic MAPK signaling and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. An important paralog of this gene is PHF8.
UniProtKB/Swiss-Prot for KDM7A Gene
-
Histone demethylase required for brain development. Specifically demethylates dimethylated Lys-9 and Lys-27 (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 Lys-20 residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated Lys-4 of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KDM7A Gene
Genomics for KDM7A Gene
GeneHancer (GH) Regulatory Elements for KDM7A Gene
Regulatory Element Products
Genomic Locations for KDM7A Gene
- chr7:140,084,746-140,177,035
- (GRCh38/hg38)
- Size:
- 92,290 bases
- Orientation:
- Minus strand
- chr7:139,784,546-139,876,835
- (GRCh37/hg19)
Genomic View for KDM7A Gene
- Cytogenetic band:
-
- 7q34 by Ensembl
- 7q34 by Entrez Gene
- 7q34 by HGNC


RefSeq DNA sequence for KDM7A Gene
Proteins for KDM7A Gene
-
Protein details for KDM7A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6ZMT4-KDM7A_HUMAN
- Recommended name:
- Lysine-specific demethylase 7A
- Protein Accession:
- Q6ZMT4
- A4D1S9
- C9JJH9
- C9JQU2
- Q6MZL8
- Q9C0E5
Protein attributes for KDM7A Gene
- Size:
- 941 amino acids
- Molecular mass:
- 106557 Da
- Cofactor:
- Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAD18641.1; Type=Frameshift; Positions=902; Evidence={ECO:0000305}; Sequence=EAL24032.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for KDM7A Gene
Protein Expression for KDM7A Gene
Post-translational modifications for KDM7A Gene
Other Protein References for KDM7A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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Assay Products
No data available for DME Specific Peptides for KDM7A Gene
Domains & Families for KDM7A Gene
Gene Families for KDM7A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for KDM7A Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for KDM7A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6ZMT4UniProtKB/Swiss-Prot:
KDM7A_HUMAN :- The PHD-type zinc finger mediates the binding to H3K4me3. Binding to H3K4me3 prevents its access to H3K9me2.
- Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.
- Domain:
-
- The PHD-type zinc finger mediates the binding to H3K4me3. Binding to H3K4me3 prevents its access to H3K9me2.
- The linker region is a critical determinant of demethylase specificity. It prevents the active site of JmjC to reach the target H3K9me2 when the PHD-type zinc finger binds to H3K4me3, while it favors selectivity toward H3K27me2.
- Family:
-
- Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.
Function for KDM7A Gene
Molecular function for KDM7A Gene
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=1.2 uM for histone H3 H3K9Me2 {ECO:0000269 PubMed:20023638};
- UniProtKB/Swiss-Prot Function:
- Histone demethylase required for brain development. Specifically demethylates dimethylated Lys-9 and Lys-27 (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 Lys-20 residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated Lys-4 of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate.
Enzyme Numbers (IUBMB) for KDM7A Gene
Phenotypes From GWAS Catalog for KDM7A Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005506 | iron ion binding | TAS | 20194436 |
GO:0008270 | zinc ion binding | IDA | 20023638 |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | IDA | 20023638 |
GO:0032452 | histone demethylase activity | TAS | -- |
Phenotypes for KDM7A Gene
- MGI mutant phenotypes for KDM7A:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for KDM7A:
Animal Models for KDM7A Gene
- MGI Knock Outs for KDM7A:
-
- Kdm7a tm1a(EUCOMM)Wtsi
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miRNA for KDM7A Gene
- miRTarBase miRNAs that target KDM7A
-
- hsa-mir-335-5p (MIRT017172)
- hsa-mir-26b-5p (MIRT029121)
- hsa-mir-3692-3p (MIRT239629)
- hsa-mir-6875-3p (MIRT667794)
- hsa-mir-6826-3p (MIRT667795)
- hsa-mir-539-5p (MIRT667796)
- hsa-mir-3124-3p (MIRT667797)
- hsa-mir-6756-3p (MIRT667798)
- hsa-mir-3127-3p (MIRT667799)
- hsa-mir-5571-5p (MIRT667800)
- hsa-mir-137 (MIRT735350)
miRNA Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available JHDM1D gene related products
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No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KDM7A Gene
Localization for KDM7A Gene
Subcellular locations from UniProtKB/Swiss-Prot for KDM7A Gene
- Nucleus.
- Nucleoli (2)
- Nucleoplasm (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IC | 20023638 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005730 | nucleolus | IDA | -- |
Pathways & Interactions for KDM7A Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Chromatin organization | ||
2 | HIV Life Cycle |
.45
|
|
3 | Oncogenic MAPK signaling | ||
4 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
Pathways by source for KDM7A Gene
7 Reactome pathways for KDM7A Gene
Interacting Proteins for KDM7A Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006351 | transcription, DNA-templated | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0007399 | nervous system development | IEA | -- |
GO:0016569 | covalent chromatin modification | IEA | -- |
GO:0030901 | midbrain development | ISS | -- |
No data available for SIGNOR curated interactions for KDM7A Gene
Drugs & Compounds for KDM7A Gene
(1) ApexBio Compounds for KDM7A Gene
Compound | Action | Cas Number |
---|---|---|
TC-E 5002 | 1453071-47-0 |
Transcripts for KDM7A Gene
mRNA/cDNA for KDM7A Gene
- (2) REFSEQ mRNAs :
- (10) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for KDM7A
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Vectors and viruses for KO, Activation, Repression, and more
-
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available JHDM1D gene related products
- orf clones - Search results for available JHDM1D gene related products
- Applied Biological Materials Clones for KDM7A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||
SP2: |
Expression for KDM7A Gene
mRNA differential expression in normal tissues according to GTEx for KDM7A Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KDM7A Gene
NURSA nuclear receptor signaling pathways regulating expression of KDM7A Gene:
KDM7APrimer Products
-
OriGene qPCR primer pairs for KDM7A
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KDM7A Gene
Orthologs for KDM7A Gene
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | KDM7A 34 |
|
OneToOne | |
JHDM1D 33 |
|
||||
dog (Canis familiaris) |
Mammalia | KDM7A 34 |
|
OneToOne | |
JHDM1D 33 |
|
||||
cow (Bos Taurus) |
Mammalia | JHDM1D 33 |
|
||
KDM7A 34 |
|
OneToOne | |||
mouse (Mus musculus) |
Mammalia | Kdm7a 33 16 |
|
||
Jhdm1d 34 |
|
OneToOne | |||
rat (Rattus norvegicus) |
Mammalia | Jhdm1d 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | KDM7A 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | KDM7A 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | KDM7A 34 |
|
OneToOne | |
JHDM1D 33 |
|
||||
lizard (Anolis carolinensis) |
Reptilia | KDM7A 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | kdm7a 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | kdm7ab 33 34 |
|
||
kdm7aa 34 |
|
OneToMany | |||
worm (Caenorhabditis elegans) |
Secernentea | jmjd-1.1 34 |
|
ManyToMany | |
jmjd-1.2 34 |
|
ManyToMany | |||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | JHD1 34 |
|
OneToMany |
- Species where no ortholog for KDM7A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for KDM7A Gene
Variants for KDM7A Gene
SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000094529 | -- | 140,097,799(-) | C/T | intron_variant | |
rs1000119989 | -- | 140,152,854(-) | G/A | genic_upstream_transcript_variant, intron_variant | |
rs1000135774 | -- | 140,093,179(-) | G/C | intron_variant | |
rs1000170033 | -- | 140,171,475(-) | TATATTTATATTTATATTTATAT/TATATTTATATTTATATTTATATTTATAT | genic_upstream_transcript_variant, intron_variant | |
rs1000174506 | -- | 140,135,932(-) | G/A | genic_upstream_transcript_variant, intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv11623n54 | CNV | loss | 21841781 |
dgv11624n54 | CNV | gain | 21841781 |
dgv11625n54 | CNV | gain | 21841781 |
dgv11626n54 | CNV | loss | 21841781 |
dgv3678n106 | CNV | deletion | 24896259 |
esv2622729 | CNV | deletion | 19546169 |
esv2735212 | CNV | deletion | 23290073 |
esv29440 | CNV | loss | 19812545 |
nsv477579 | CNV | novel sequence insertion | 20440878 |
nsv608478 | CNV | loss | 21841781 |
nsv608479 | CNV | loss | 21841781 |
nsv608480 | CNV | gain+loss | 21841781 |
nsv608481 | CNV | gain | 21841781 |
nsv608482 | CNV | loss | 21841781 |
nsv608486 | CNV | loss | 21841781 |
nsv608487 | CNV | gain+loss | 21841781 |
nsv608496 | CNV | loss | 21841781 |
nsv966894 | CNV | duplication | 23825009 |
Additional Variant Information for KDM7A Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KDM7A Gene
Disorders for KDM7A Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
bone benign neoplasm |
|
|
connective tissue benign neoplasm |
|
|
Additional Disease Information for KDM7A
No data available for UniProtKB/Swiss-Prot and Genatlas for KDM7A Gene
Publications for KDM7A Gene
- Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases. (PMID: 20023638) Horton JR … Cheng X (Nature structural & molecular biology 2010) 2 3 4 58
- Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4. (PMID: 20084082) Huang C … Chen CD (Cell research 2010) 2 3 58
- KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development. (PMID: 20194436) Tsukada Y … Nakayama KI (Genes & development 2010) 3 4 58
- Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development. (PMID: 20622853) Qi HH … Shi Y (Nature 2010) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 33 available JHDM1D Antibodies ranked by validation data
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Sources for KDM7A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
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