Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



KDM6B Gene

protein-coding   GIFtS: 56
GCID: GC17P007686

Lysine (K)-Specific Demethylase 6B

(Previous names: jumonji domain containing 3, jumonji domain containing 3,...)
(Previous symbol: JMJD3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Lysine (K)-Specific Demethylase 6B1 2     KIAA03463 5
JMJD31 2 3 5     Jumonji Domain Containing 31
Jumonji Domain Containing 3, Histone Lysine Demethylase1 2     Lysine-Specific Demethylase 6B2
JmjC Domain-Containing Protein 32 3     EC 1.14.11.-3
Jumonji Domain-Containing Protein 32 3     EC 1.14.118
Lysine Demethylase 6B2 3     

External Ids:    HGNC: 290121   Entrez Gene: 231352   Ensembl: ENSG000001325107   OMIM: 6115775   UniProtKB: O150543   

Export aliases for KDM6B gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for KDM6B Gene:
KDM6B (lysine (K)-specific demethylase 6B) is a protein-coding gene. Diseases associated with KDM6B include wiskott-aldrich syndrome, and hodgkin's lymphoma. GO annotations related to this gene include sequence-specific DNA binding and dioxygenase activity. An important paralog of this gene is UTY.

UniProtKB/Swiss-Prot: KDM6B_HUMAN, O15054
Function: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central
role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation
of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating
in macrophage differentiation in case of inflammation by regulating gene expression and macrophage
differentiation

summary for KDM6B Gene:
Histone demethylases are a family of enzymes that catalyze the removal of methyl groups from lysine and
arginine residues on histone tails. They reverse the methylation of lysine and arginine residues that is
catalyzed by histone methyltransferases.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000017.11  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KDM6B gene promoter:
         Pax-6   Olf-1   XBP-1   HNF-4alpha2   Nkx2-5   NF-kappaB   LCR-F1   HNF-4alpha1   c-Ets-1   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for KDM6B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KDM6B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

KDM6B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KDM6B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007686:  view genomic region     (about GC identifiers)

Start:
7,743,222 bp from pter      End:
7,758,118 bp from pter
Size:
14,897 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KDM6B_HUMAN, O15054 (See protein sequence)
Recommended Name: Lysine-specific demethylase 6B  
Size: 1643 amino acids; 176632 Da
Cofactor: Ascorbate (By similarity)
Cofactor: Fe(2+)
Subunit: Interacts with TLE1 (By similarity). Component of the MLL4 complex, at least composed of KMT2B/MLL4,
ASH2L, RBBP5, WDR5, and KDM6B
Sequence caution: Sequence=BAA21572.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for KDM6B:
2XUE (3D)        2XXZ (3D)        4ASK (3D)    
Secondary accessions: C9IZ40 Q96G33
Alternative splicing: 2 isoforms:  O15054-2   O15054-1   (Gene prediction based on similarity to mouse ortholog)

Explore the universe of human proteins at neXtProt for KDM6B: NX_O15054

Explore proteomics data for KDM6B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for KDM6B (O15054) (see all 5)
     IKFGTNIDLSD  KLNPPTPSIYLE  SHTTIAKYAQYQA  GWCNNIAWNVGPLTA 


    See KDM6B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073893.1  
    ENSEMBL proteins: 
     ENSP00000254846   ENSP00000412513   ENSP00000458445  
    Reactome Protein details: O15054

    KDM6B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KDM6B
    OriGene Custom MassSpec
    OriGene Custom Protein Services for KDM6B
    GenScript Custom Purified and Recombinant Proteins Services for KDM6B
    Novus Biologicals KDM6B Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KDM6B

    KDM6B Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of KDM6B
    R&D Systems Antibodies for KDM6B (Lysine (K)-specific Demethylase 6B/KDM6B)
    Cell Signaling Technology (CST) Antibodies for KDM6B  (JMJD3)
    OriGene Antibodies for KDM6B
    OriGene Custom Antibody Services for KDM6B
    Novus Biologicals KDM6B Antibodies
    Abcam antibodies for KDM6B
    Cloud-Clone Corp. Antibodies for KDM6B
    ThermoFisher Antibodies for KDM6B
    LSBio Antibodies in human, mouse, rat for KDM6B

    KDM6B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KDM6B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KDM6B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KDM6B
    Cloud-Clone Corp. CLIAs for KDM6B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    KDM: Chromatin-modifying enzymes / K-demethylases

    1 InterPro protein domain:
     IPR003347 JmjC_dom

    Graphical View of Domain Structure for InterPro Entry O15054

    ProtoNet protein and cluster: O15054

    1 Blocks protein domain: IPB003347 Transcription factor jumonji

    UniProtKB/Swiss-Prot: KDM6B_HUMAN, O15054
    Similarity: Belongs to the UTX family
    Similarity: Contains 1 JmjC domain


    KDM6B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KDM6B_HUMAN, O15054
    Function: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central
    role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation
    of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating
    in macrophage differentiation in case of inflammation by regulating gene expression and macrophage
    differentiation
    Induction: By 12-O-tetradecanoylphorbol-13-acetate (TPA) in myeloid leukemia cells

         Enzyme Numbers (IUBMB): EC 1.14.11.-1 EC 1.14.112

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046872metal ion binding IEA--
    GO:0051213dioxygenase activity IEA--
    GO:0071558histone demethylase activity (H3-K27 specific) EXP--
         
    KDM6B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KDM6B:
     Small cells 

         10 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Kdm6b):
     cardiovascular system  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  nervous system  no phenotypic analysis  reproductive system  respiratory system 

    KDM6B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Kdm6btm1Aki for KDM6B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KDM6B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KDM6B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KDM6B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KDM6B

    miRNA
    Products:
        
    miRTarBase miRNAs that target KDM6B:
    hsa-mir-18a-3p (MIRT040965), hsa-mir-335-5p (MIRT017568), hsa-mir-101-3p (MIRT027296), hsa-let-7a-5p (MIRT052574), hsa-mir-92a-3p (MIRT049017), hsa-mir-186-5p (MIRT021179)

    Block miRNA regulation of human, mouse, rat KDM6B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KDM6B (see all 101):
    hsa-miR-3607-3p hsa-miR-3194-5p hsa-miR-106a hsa-miR-146a hsa-miR-1260b hsa-miR-30d hsa-miR-342-3p hsa-miR-519a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KDM6B
    Predesigned siRNA for gene silencing in human, mouse, rat KDM6B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KDM6B

    Clone
    Products:
         
    OriGene clones in human, mouse for KDM6B (see all 5)
    OriGene ORF clones in mouse, rat for KDM6B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KDM6B (NM_001080424)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KDM6B
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KDM6B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KDM6B
    Browse ESI BIO Cell Lines and PureStem Progenitors for KDM6B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM6B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    KDM6B_HUMAN, O15054: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    extracellular2
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--

    KDM6B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for KDM6B About    
    See pathways by source

    SuperPathContained pathways About
    1Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    2Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for KDM6B
        Chromatin Regulation / Acetylation

    1 Reactome Pathway for KDM6B
        Oxidative Stress Induced Senescence



    KDM6B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including KDM6B: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for KDM6B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KDM6B (O150541, 2, 3 ENSP000002548464) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313, ENSP000003502754I2D: score=1 STRING: ENSP00000350275
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0016577histone demethylation ----
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--
    GO:0071557histone H3-K27 demethylation EXP--

    KDM6B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for KDM6B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    IOX 1Histone demethylase inhibitor; cell permeable[5852-78-8]
    GSK J4Histone demethylase JMJD3/UTX inhibitor; cell permeable[1373423-53-0]
    DaminozideSelective histone demethylase KDM2/7 subfamily inhibitor[1596-84-5]
    GSK J1Potent histone demethylase JMJD3/UTX inhibitor[1373422-53-7]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for KDM6B gene: 
    NM_001080424.1  

    Unigene Cluster for KDM6B:

    Lysine (K)-specific demethylase 6B
    Hs.223678  [show with all ESTs]
    Unigene Representative Sequence: NM_001080424
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000571047 ENST00000254846(uc002giw.1 uc002gix.3) ENST00000448097
    ENST00000572030 ENST00000575521 ENST00000570632
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KDM6B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KDM6B (see all 101):
    hsa-miR-3607-3p hsa-miR-3194-5p hsa-miR-106a hsa-miR-146a hsa-miR-1260b hsa-miR-30d hsa-miR-342-3p hsa-miR-519a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KDM6B
    Predesigned siRNA for gene silencing in human, mouse, rat KDM6B
    Clone
    Products:
         
    OriGene clones in human, mouse for KDM6B (see all 5)
    OriGene ORF clones in mouse, rat for KDM6B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KDM6B (NM_001080424)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KDM6B
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KDM6B
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KDM6B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KDM6B
      QuantiTect SYBR Green Assays in human, mouse, rat KDM6B
      QuantiFast Probe-based Assays in human, mouse, rat KDM6B

    Additional mRNA sequence: 

    AB002344.2 BC009994.1 BC035897.1 BC067879.1 

    8 DOTS entries:

    DT.85105311  DT.95162298  DT.120930861  DT.410301  DT.100689210  DT.100673297  DT.100696592  DT.95114142 

    Selected AceView cDNA sequences (see all 255):

    CR597798 BQ013674 BC035897 BQ013215 AI671664 BQ015649 AI359849 NM_203411 
    AA991279 BI092918 BQ012561 AA355717 CD365458 AA736517 BM849688 AA594247 
    BG222892 CB154770 W56526 BQ721168 BQ649062 BC057812 BQ438795 CF529968 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KDM6B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b
    SP1:                                                                                      -                                                         
    SP2:                                                                                                                                                
    SP3:                                                                                                                                                
    SP4:                                                                                                                                                
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for KDM6B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    KDM6B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCTCAAAC
    KDM6B Expression
    About this image

    KDM6B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KDM6B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.223678
        Pathway & Disease-focused RT2 Profiler PCR Array including KDM6B: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KDM6B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KDM6B
    QuantiTect SYBR Green Assays in human, mouse, rat KDM6B
    QuantiFast Probe-based Assays in human, mouse, rat KDM6B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM6B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for KDM6B gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kdm6b1 , 5 KDM1 lysine (K)-specific demethylase 6B1, 5 88.36(n)1
    92.44(a)1
      11 (42.60 cM)5
    2168501  NM_001017426.11  NP_001017426.11 
     693985085 
    lizard
    (Anolis carolinensis)
    Reptilia KDM6B6
    lysine (K)-specific demethylase 6B
    57(a)
    1 ↔ 1
    GL343784.1(158025-188486)
    zebrafish
    (Danio rerio)
    Actinopterygii KDM6B (2 of 2)6
    kdm6bb6
    lysine (K)-specific demethylase 6B, b
    32(a)
    30(a)
    1 ↔ many
    1 ↔ many
    7(22933203-22946812) ENSDARG00000088087
    10(22924269-22963924) ENSDARG00000056929
    worm
    (Caenorhabditis elegans)
    Secernentea jmjd-3.36
    jmjd-3.16
    (see all 3)
    Protein JMJD-3.1, isoform b
    (see all 3)
    20(a)
    18(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    X(13436454-13441883) WBGene00007813
    X(8571049-8575442) WBGene00017571
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CYC86
    General transcriptional co-repressor, acts togethe...
    10(a)
    1 → many
    II(462870-465770) YBR112C


    ENSEMBL Gene Tree for KDM6B (if available)
    TreeFam Gene Tree for KDM6B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for KDM6B gene
    UTY2  KDM6A2  
    5 SIMAP similar genes for KDM6B using alignment to 2 protein entries:     KDM6B_HUMAN (see all proteins):
    DKFZp686A03225    UTY    KDM6A    UTX    DKFZp451J023

    KDM6B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for KDM6B (see all 509)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1113368201,2
    C,F--7741404(+) TGATTC/TTGAAG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs126011291,2
    H--7741763(+) CCCCCA/CCCCAC 1 -- us2k1 tfbs3 trp30--------
    rs126011301,2
    C,H--7741765(+) CCCCCA/CCACAC 1 -- us2k1 tfbs3 trp30--------
    rs1919075071,2
    --7741914(+) CACCCC/GTCACA 1 -- us2k10--------
    rs1436512221,2
    C--7741993(+) CTCTCG/TACTAG 1 -- us2k10--------
    rs1510225831,2
    C--7742070(+) TCTCTA/GCTCCC 1 -- us2k10--------
    rs1829319671,2
    --7742260(+) CTTGCA/GGAACA 1 -- us2k10--------
    rs2018095451,2
    C--7742276(+) CATGG-/AGAC  
            
    AGACT
    1 -- us2k10--------
    rs1408749381,2
    --7742287(+) GGGGGC/TTAGAG 1 -- us2k10--------
    rs1448470331,2
    --7742445(+) GAGGTA/GAGGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KDM6B (7743222 - 7758118 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for KDM6B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715606CNV Deletion23290073
    esv2715604CNV Deletion23290073
    esv2715605CNV Deletion23290073
    esv989512CNV Deletion20482838
    nsv907653CNV Loss21882294
    nsv833351CNV Loss17160897
    dgv510n67CNV Gain20364138

    Human Gene Mutation Database (HGMD): KDM6B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KDM6B
    DNA2.0 Custom Variant and Variant Library Synthesis for KDM6B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611577    OMIM disorders: --

    4 diseases for KDM6B:    
    About MalaCards
    wiskott-aldrich syndrome    hodgkin's lymphoma    myeloid leukemia    leukemia


    KDM6B for disorders           About GeneDecksing


    Export disorders for KDM6B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for KDM6B gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with KDM6B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1997)
    2. The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. (PubMed id 17825402)1, 2 De Santa F....Natoli G. (Cell 2007)
    3. Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases. (PubMed id 18003914)1, 2 Hong S.... Ge K. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    4. Physical map of 17p13 and the genes adjacent to p53. (PubMed id 10662545)1, 3 Cousin P....Shaw P. (Genomics 2000)
    5. Global H3K4me3 genome mapping reveals alterations of innate immunity signaling and overexpression of JMJD3 in human myelodysplastic syndrome CD34+ cells. (PubMed id 23538751)1 Wei Y....Garcia-Manero G. (Leukemia 2013)
    6. Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway. (PubMed id 22907667)1 Jiang W....Zhang Y. (Cell Res. 2013)
    7. Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis. (PubMed id 22915621)1 KrAomer M....Distler J.H. (Ann. Rheum. Dis. 2013)
    8. Proteomic changes induced by histone demethylase JMJD3 in TNF alpha-treated human monocytic (THP-1) cells. (PubMed id 23711388)1 Das A....Chai Y.G. (Mol. Immunol. 2013)
    9. Histone demethylase KDM6B promotes epithelial-mesenchymal transition. (PubMed id 23152497)1 Ramadoss S....Wang C.Y. (J. Biol. Chem. 2012)
    10. Gene networking and inflammatory pathway analysis in a JMJD3 knockdown human monocytic cell line. (PubMed id 22252741)1 Das N.D....Chai Y.G. (Cell Biochem. Funct. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23135 HGNC: 29012 AceView: FLJ32499andLOC92162andJMJD3 Ensembl:ENSG00000132510 euGenes: HUgn23135
    ECgene: KDM6B H-InvDB: KDM6B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0346

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for KDM6B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KDM6B gene:
    Search GeneIP for patents involving KDM6B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of KDM6B
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for KDM6B (Lysine (K)-specific Demethylase 6B/KDM6B)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for KDM6B   OriGene RNAi products in human, mouse, rat for KDM6B  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for KDM6B  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KDM6B  
     OriGene qSTAR qPCR primer pairs in human, mouse for KDM6B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KDM6B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KDM6B   OriGene Custom Protein Services for KDM6B  

     
     
     Block miRNA regulation of human, mouse, rat KDM6B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KDM6B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KDM6B Predesigned siRNA for gene silencing in human, mouse, rat KDM6B
     QuantiFast Probe-based Assays in human, mouse, rat KDM6B QuantiTect SYBR Green Assays in human, mouse, rat KDM6B
     PCR Arrays including human, mouse, rat KDM6B Search Chromatin IP Primers for KDM6B
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KDM6B  Search GeneGlobe Interaction Network for KDM6B
     Regulatory tfbs in KDM6B promoter
     GenScript Custom Purified and Recombinant Proteins Services for KDM6B GenScript cDNA clones with any tag delivered in your preferred vector for KDM6B
     GenScript Custom Assay Services for KDM6B GenScript Custom overexpressing Cell Line Services for KDM6B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for KDM6B  (JMJD3)

     Tocris compounds for KDM6B
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     KDM6B antibodies
     KDM6B proteins
     Antibodies for KDM6B
     See all of Abcam's Antibodies, Kits and Proteins for KDM6B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for KDM6B
     Antibodies for KDM6B
     ELISAs for KDM6B
     CLIAs for KDM6B



     Browse ESI BIO Cell Lines and PureStem Progenitors for KDM6B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM6B
     Browse SwitchGear 3'UTR luciferase reporter plasmids for KDM6B
     Browse SwitchGear Promoter luciferase reporter plasmids for KDM6B
     ThermoFisher Antibodies for KDM6B
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KDM6B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KDM6B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KDM6B
     LSBio Antibodies in human, mouse, rat for KDM6B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KDM6B gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4