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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KDM6A Gene

protein-coding GIFtS: 56
GCID: GC0XP044732

lysine (K)-specific demethylase 6A

(Previous names: ubiquitously transcribed tetratricopeptide repeat, X chromosome...)
(Previous symbol: UTX)

Explore 9 diseases affiliated with
KDM6A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Lysine (K)-Specific Demethylase 6A¹ ²		BA386N14.2 (Ubiquitously Transcribed X Chromosome Tetratricopeptide Repeat Protein (UTX))²
UTX¹ ² ³ ⁵		Lysine-Specific Demethylase 6A²
Histone Demethylase UTX² ³		Ubiquitously Transcribed Tetratricopeptide Repeat Protein X-Linked²
Ubiquitously-Transcribed TPR Protein On The X Chromosome² ³		Ubiquitously Transcribed TPR Protein On The X Chromosome²
Ubiquitously-Transcribed X Chromosome Tetratricopeptide Repeat Protein² ³		Ubiquitously Transcribed X Chromosome Tetratricopeptide Repeat Protein²
Ubiquitously Transcribed Tetratricopeptide Repeat, X Chromosome¹		Ubiquitously-Transcribed TPR Gene On The X Chromosome²
KABUK2²		EC 1.14.11.-³
BA386N14.2¹		EC 1.14.11⁸

External Ids:	HGNC: 12637¹	Entrez Gene: 7403²	Ensembl: ENSG00000147050⁷	OMIM: 300128⁵	UniProtKB: O15550³

Export aliases for KDM6A gene to outside databases

Previous GC identifers: GC0XP044619 GC0XP042453

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KDM6A:

This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a

tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the

demethylation of tri/dimethylated histone H3. (provided by RefSeq, Nov 2009)

UniProtKB/Swiss-Prot: KDM6A_HUMAN, O15550

Function: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in

histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in

regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is

concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and

monoubiquitination of histone H2A

Gene Wiki entry for KDM6A (UTX)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_079573.4

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KDM6A gene promoter:
E2F-3a E2F-4 E2F-5 Spz1 AP-1 E2F-2 E4BP4 YY1 E2F-1 E2F
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KDM6A promoter sequence

Search SABiosciences Chromatin IP Primers for KDM6A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KDM6A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.2 Ensembl cytogenetic band: Xp11.3 HGNC cytogenetic band: Xp11.2

KDM6A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KDM6A gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP044732: view genomic region (about GC identifiers)

Start:	44,732,423 bp from pter	End:	44,971,847 bp from pter
Size:	239,425 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KDM6A_HUMAN, O15550 (See protein sequence)

Recommended Name: Lysine-specific demethylase 6A

Size: 1401 amino acids; 154177 Da

Cofactor: Ascorbate

Cofactor: Fe(2+)

Subunit: Interacts with TLE1 (By similarity). Component of the MLL2/3 complex (also named ASCOM complex), at least

composed of MLL2/ALR or MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A (or KDM6B), PAXIP1/PTIP, PAGR1 and alpha- and

beta-tubulin

Subcellular location: Nucleus (Probable)

Miscellaneous: Escapes X chromosome inactivation

2 PDB 3D structures from and Proteopedia for KDM6A:

3AVR (3D)

3AVS (3D)

Secondary accessions: Q52LL9 Q5JVQ7

Explore the universe of human proteins at neXtProt for KDM6A: NX_O15550

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O15550

4/16 DME Specific Peptides for KDM6A (O15550) (see all 16)

YQRYYSLQ

IGKVQDAF

ASSPSSAIST

GTCDKVNNIHP

KDM6A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_066963.2

ENSEMBL proteins:

ENSP00000367203 ENSP00000399980 ENSP00000405910 ENSP00000398929 ENSP00000408230

ENSP00000437405 ENSP00000372355 ENSP00000443078

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	Uscn Proteins for KDM6A

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	17500065
GO:0035097	histone methyltransferase complex	IDA	17500065

KDM6A for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for KDM6A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KDM6A for domains About GeneDecksing

5 InterPro domains/families:

IPR011990 TPR-like_helical

IPR003347 JmjC_dom

IPR001440 TPR-1

IPR013026 TPR-contain_dom

IPR019734 TPR_repeat

Graphical View of Domain Structure for InterPro Entry O15550

ProtoNet protein and cluster: O15550

1 Blocks protein family: IPB003347 Transcription factor jumonji

UniProtKB/Swiss-Prot: KDM6A_HUMAN, O15550

Similarity: Belongs to the UTX family

Similarity: Contains 1 JmjC domain

Similarity: Contains 8 TPR repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KDM6A_HUMAN, O15550

Function: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in

histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in

regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is

concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and

monoubiquitination of histone H2A

Enzyme Numbers (IUBMB): EC 1.14.11.-¹ EC 1.14.11²

miRNA Products:		OriGene 3'-UTR Clone: KDM6A Browse MicroRNA Expression Plasmids
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		8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate KDM6A (see all 88):
		hsa-miR-576-3p hsa-miR-300 hsa-miR-411 hsa-miR-199a-3p hsa-miR-134 hsa-miR-371-5p hsa-miR-890 hsa-miR-3148

		SwitchGear 3'UTR luciferase reporter plasmid: KDM6A 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM6A

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	--
GO:0046872	metal ion binding	IEA	--

KDM6A for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for KDM6A:

Decreased Hepatitis C virus re

Animal Models:
Mouse knock-out Kdm6a^tm1.2Itl for KDM6A
8 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Kdm6a):

cardiovascular system	embryogenesis	growth/size	hematopoietic system	mortality/aging
nervous system	no phenotypic analysis	respiratory system

KDM6A for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KDM6A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/40 Interacting proteins for KDM6A (O15550^{2, 3} ENSP00000367203⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 40)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H3A	P68431³, ENSP00000350275⁴	I2D: score=1 STRING: ENSP00000350275
HIST1H3B	P68431³	I2D: score=1
HIST1H3C	P68431³	I2D: score=1
HIST1H3D	P68431³	I2D: score=1
HIST1H3E	P68431³	I2D: score=1

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0051568	histone H3-K4 methylation	ISS	17178841

KDM6A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KDM6A
Search CenterWatch for drugs/clinical trials and news about KDM6A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KDM6A gene:

NM_021140.2

Unigene Cluster for KDM6A:

Lysine (K)-specific demethylase 6A

Hs.522616 [show with all ESTs]

Unigene Representative Sequence: CR749602

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000377967(uc022bvi.1 uc010nhk.2 uc004dge.4 uc011mkz.2 uc011mla.2 uc011mlb.2 uc011mlc.2 uc022bvj.1 uc022bvk.1 uc011mld.2)

ENST00000475233 ENST00000451692 ENST00000414389 ENST00000433797 ENST00000485072

ENST00000484732 ENST00000431196 ENST00000479423 ENST00000536777 ENST00000382899

ENST00000543216

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KDM6A
		8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate KDM6A (see all 88):
		hsa-miR-576-3p hsa-miR-300 hsa-miR-411 hsa-miR-199a-3p hsa-miR-134 hsa-miR-371-5p hsa-miR-890 hsa-miR-3148

		SwitchGear 3'UTR luciferase reporter plasmid: KDM6A 3' UTR sequence

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Additional cDNA sequence:

AB208795.1 AF000992.1 AF000993.1 AK294456.1 AK303430.1 AK304114.1 AK307691.1 AL831996.2

BC093868.1 BC113381.1 BC143272.1 BC143275.1 BC143277.1 BC143278.1 BX640694.1 CR749602.1

DQ062676.1 DQ062677.1 DQ062678.1 EF491815.1 EU026283.1 EU026291.1

9 DOTS entries:

DT.100780960 DT.447189 DT.70105225 DT.121298244 DT.217278 DT.92014693 DT.91974254 DT.100724996

DT.95232890

24/151 AceView cDNA sequences (see all 151):

AA693874 AA345227 Z40981 AI079569 BF223605 AI872450 BM713871 BF061443

AI523735 AW152421 CB990705 AA576031 AI919522 Z39029 BU689838 BQ951340

AW467475 BU507564 W96301 CR749602 BX096433 BE674197 BP361021 BM803755

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for KDM6A About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15	^	16	^	17	^	18a	·	18b	^	19a	·	19b	^	20	^	21	^	22	^	23a	·
SP1:																													-
SP2:
SP3:
SP4:
SP5:

ExUns:	23b	^	24	^	25	^	26a	·	26b	^	27	^	28	^	29	^	30	^	31a	·	31b	^	32	^	33
SP1:									-
SP2:									-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for KDM6A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KDM6A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGGTTACAC

About this image

KDM6A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Endocardium

Endocardial Tube Cells

Endocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KDM6A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KDM6A

SOURCE GeneReport for Unigene cluster: Hs.522616

SABiosciences Custom PCR Arrays for KDM6A

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for KDM6A gene from 7/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Kdm6a^{1 , 5}	lysine (K)-specific demethylase 6A^{1, 5}	95.49(n)¹ 97.48(a)¹		X (13.45 cM)⁵ 22289¹ NM_009483.1¹ NP_033509.1¹ 18162575⁵
chicken (Gallus gallus)	Aves	KDM6A¹	lysine (K)-specific demethylase 6A	90.47(n) 93.77(a)		418556 XM_416762.3 XP_416762.3
lizard (Anolis carolinensis)	Reptilia	--	--	88(a)	1 → many	3(135665327-135777229)
African clawed frog (Xenopus laevis)	Amphibia	Xl.34704²	Xenopus laevis transcribed sequence with moderate similarity more	85.27(n)		CA790840.1
zebrafish (Danio rerio)	Actinopterygii	Dr.7106²	Transcribed sequences	84.82(n)		57064909
fruit fly (Drosophila melanogaster)	Insecta	Utx¹	CG5640-PA	58.9(n) 61.83(a)		34377 NM_001201844.1 NP_001188773.1
worm (Caenorhabditis elegans)	Secernentea	utx-1¹	Protein UTX-1	49.89(n) 40.35(a)		181110 NM_077049.3 NP_509450.1

ENSEMBL Gene Tree for KDM6A (if available)
TreeFam Gene Tree for KDM6A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KDM6A gene

KDM6B² UTY²

6 SIMAP similar genes for KDM6A using alignment to 8 protein entries: KDM6A_HUMAN (see all proteins):

DKFZp686A03225 DKFZp451J023 UTX UTY DKFZp686N1481 KDM6B

KDM6A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs5952268^1,2	C,	--	44730493(+)	`ctgctC/Ttccaa`	1	--	us2k¹		0	--	--	--	--
rs5952269^1,2	C,F,H,	--	44730599(+)	`GACCTG/AAGTCA`	1	--	us2k¹		12		NS EA NA	1512
rs201069971^1,2		--	44730668(+)	`GCAAG-/TGTG TGTGTATGTGT`	1	--	us2k¹		0	--	--	--	--
rs201745300^1,2		--	44730670(+)	`AAGTG-/TGT GTGTATGTGT`	1	--	us2k¹		0	--	--	--	--
rs199786189^1,2		--	44730672(+)	`GTGTG-/TGTGTA TGTGT`	1	--	us2k¹		0	--	--	--	--
rs200779667^1,2		--	44730674(+)	`GTGTG-/TGTA TGTGT`	1	--	us2k¹		0	--	--	--	--
rs201092469^1,2		--	44730676(+)	`GTGTG-/TATGTGT`	1	--	us2k¹		0	--	--	--	--
rs113519676^1,2	C,	--	44730677(+)	`TGTGTA/GTGTGT`	1	--	us2k¹		0	--	--	--	--
rs200040853^1,2		--	44730703(+)	`TGTAT-/GAGAGAG`	1	--	us2k¹		0	--	--	--	--
rs145530978^1,2		--	44730990(+)	`TCCCGC/TTGAAT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KDM6A (44732423 - 44971847 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for KDM6A
2 CNVs: 96629 83483
2 Indels: 83484 96630
Human Gene Mutation Database (HGMD): KDM6A

Locus Specific Mutation Databases (LSDB): KDM6A

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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KDM6A for disorders About GeneDecksing

OMIM gene information: 300128 OMIM disorders: --

UniProtKB/Swiss-Prot: KDM6A_HUMAN, O15550

Defects in KDM6A are the cause of Kabuki syndrome type 2 (KABUK2) [MIM:300867]. KABUK2 is a congenital mental

retardation syndrome with additional features, including postnatal dwarfism, a peculiar facies characterized by long

palpebral fissures with eversion of the lateral third of the lower eyelids, a broad and depressed nasal tip, large

prominent earlobes, a cleft or high-arched palate, scoliosis, short fifth finger, persistence of fingerpads,

radiographic abnormalities of the vertebrae, hands, and hip joints, and recurrent otitis media in infancy

9 diseases for KDM6A: About MalaCards

x inactivation male infertility graves' disease keratitis

infertility renal carcinoma carcinoma leukemia

kabuki syndrome

1 disease from the University of Copenhagen DISEASES database for KDM6A:

Infertility

Human Genome Epidemiology (HuGE) Navigator: KDM6A (1 document)

Export disorders for KDM6A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KDM6A gene, integrated from 9 sources (see all 45):
(articles sorted by number of sources associating them with KDM6A)

Utopia: connect your pdf to the dynamic
world of online information

Functional coherence of the human Y chromosome. (PubMed id 9381176)^{1, 2, 3} Lahn B.T. and Page D.C. (1997)
Deletion of KDM6A, a histone demethylase interacting with MLL2, in three patients with Kabuki syndrome. (PubMed id 22197486)^{1, 2} Lederer D.... Verellen-Dumoulin C. (2012)
Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A. (PubMed id 22002947)^{1, 2} Sengoku T. and Yokoyama S. (2011)
Mutational spectrum analysis of chronic myelomonocyti c leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. (PubMed id 21828135)^{1, 2} Jankowska A.M....Maciejewski J.P. (2011)
PTIP Associates with MLL3- and MLL4-containing Histone H3 Lysine 4 Methyltransferase Complex. (PubMed id 17500065)^{1, 2} Cho Y.W.... Ge K. (2007)
A histone H3 lysine 27 demethylase regulates animal posterior development. (PubMed id 17851529)^{1, 2} Lan F....Shi Y. (2007)
Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases. (PubMed id 18003914)^{1, 2} Hong S....Ge K. (2007)
Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. (PubMed id 17761849)^{1, 2} Lee M.G.... Shiekhattar R. (2007)
The UTX gene escapes X inactivation in mice and humans. (PubMed id 9499428)^{1, 3} Greenfield A....Koopman P. (1998)
UTX, a histone H3-lysine 27 demethylase, acts as a cri tical switch to activate the cardiac developmental program. (PubMed id 22192413)¹ Lee S....Lee S.K. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7403	HGNC: 12637	AceView: UTX	Ensembl:ENSG00000147050	euGenes: HUgn7403
ECgene: KDM6A	H-InvDB: KDM6A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KDM6A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KDM6A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KDM6A gene:
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GeneCards and IP:
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lysine (K)-specific demethylase 6A

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lysine (K)-specific demethylase 6A

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