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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KDM5D Gene

protein-coding GIFtS: 54
GCID: GC0YM021865

lysine (K)-specific demethylase 5D

(Previous names: Jumonji, AT rich interactive domain 1D (RBP2-like), Smcy...)
(Previous symbols: HYA, HY, SMCY, JARID1D)

Explore 9 diseases affiliated with
KDM5D via

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Lysine (K)-Specific Demethylase 5D¹ ²		Protein SmcY² ³
HYA¹ ² ³ ⁵		H-Y² ³
JARID1D¹ ² ³ ⁵		Jumonji, AT Rich Interactive Domain 1D¹
SMCY¹ ² ³ ⁵		Smcy Homolog, Y-Linked (Mouse)¹
HY¹ ² ³		Lysine-Specific Demethylase 5D²
Jumonji, AT Rich Interactive Domain 1D (RBP2-Like)¹ ²		Selected Mouse CDNA On Y, Human Homolog Of²
KIAA0234¹ ³		SMC Homolog, Y Chromosome²
Histocompatibility Y Antigen² ³		Smcy Homolog, Y-Linked²
Histone Demethylase JARID1D² ³		EC 1.14.11.-³
Jumonji/ARID Domain-Containing Protein 1D² ³		EC 1.14.11⁸

External Ids:	HGNC: 11115¹	Entrez Gene: 8284²	Ensembl: ENSG00000012817⁷	OMIM: 426000⁵	UniProtKB: Q9BY66³

Export aliases for KDM5D gene to outside databases

Previous GC identifers: GC0YM020326 GC0YM015577

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KDM5D:

This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor

histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient. Alternative

splicing results in multiple transcript variants. (provided by RefSeq, Apr 2009)

UniProtKB/Swiss-Prot: KDM5D_HUMAN, Q9BY66

Function: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in

histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'.

Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis

Gene Wiki entry for KDM5D (JARID1D)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000024.9 NT_011875.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KDM5D gene promoter:
Egr-3 GR AML1a GR-beta AP-2gamma SRY AP-2beta STAT3 SEF-1 (1) GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KDM5D promoter sequence

Search SABiosciences Chromatin IP Primers for KDM5D

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KDM5D

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Yq11 Ensembl cytogenetic band: Yq11.222 HGNC cytogenetic band: Yq11

KDM5D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KDM5D gene location

GeneLoc information about chromosome Y GeneLoc Exon Structure

GeneLoc location for GC0YM021865: view genomic region (about GC identifiers)

Start:	21,865,751 bp from pter	End:	21,906,825 bp from pter
Size:	41,075 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KDM5D_HUMAN, Q9BY66 (See protein sequence)

Recommended Name: Lysine-specific demethylase 5D

Size: 1539 amino acids; 174073 Da

Cofactor: Ascorbate

Cofactor: Binds 1 Fe(2+) ion per subunit

Subunit: Interacts with PCGF6 and MSH5

Subcellular location: Nucleus (Probable)

Sequence caution: Sequence=BAA13241.2; Type=Erroneous initiation;

2 PDB 3D structures from and Proteopedia for KDM5D:

2E6R (3D)

2YQE (3D)

Secondary accessions: A2RU19 A6H8V7 B7ZLX1 Q92509 Q92809 Q9HCU1

Alternative splicing: 3 isoforms: Q9BY66-1 Q9BY66-2 Q9BY66-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KDM5D: NX_Q9BY66

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BY66

4/54 DME Specific Peptides for KDM5D (Q9BY66) (see all 54)

DKEYKPH

STKRSRW

LLEVLCP

TFLKKNS

KDM5D Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001140177.1 NP_001140178.1 NP_004644.2

ENSEMBL proteins:

ENSP00000322408 ENSP00000372256 ENSP00000398543 ENSP00000389433 ENSP00000416377

ENSP00000444293 ENSP00000445530

Human Recombinant Protein Products:

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	Uscn Proteins for KDM5D

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

KDM5D for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for KDM5D

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KDM5D for domains About GeneDecksing

5/10 InterPro domains/families (see all 10):

IPR001965 Znf_PHD

IPR013083 Znf_RING/FYVE/PHD

IPR003347 JmjC_dom

IPR013637 Lys_sp_deMease_like_dom

IPR019786 Zinc_finger_PHD-type_CS

Graphical View of Domain Structure for InterPro Entry Q9BY66

ProtoNet protein and cluster: Q9BY66

5/6 Blocks protein families (see all 6):

IPB001606 ARID (AT-rich interaction domain) protein

IPB001965 Zn-finger-like

IPB003347 Transcription factor jumonji

IPB003349 Transcription factor jumonji

IPB004198 Zn-finger

UniProtKB/Swiss-Prot: KDM5D_HUMAN, Q9BY66

Domain: The JmjC domain is required for enzymatic activity

Similarity: Belongs to the JARID1 histone demethylase family

Similarity: Contains 1 ARID domain

Similarity: Contains 1 JmjC domain

Similarity: Contains 1 JmjN domain

Similarity: Contains 2 PHD-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KDM5D_HUMAN, Q9BY66

Function: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in

histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'.

Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis

Enzyme Numbers (IUBMB): EC 1.14.11.-¹ EC 1.14.11²

miRNA Products:		OriGene 3'-UTR Clone (see all 3): KDM5D Browse MicroRNA Expression Plasmids
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM5D

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	--
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	IEA	--

KDM5D for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for KDM5D:

Decreased viability of wild-ty

Synthetic lethal with c-Myc af

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KDM5D

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for KDM5D (Q9BY66³ ENSP00000322408⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PCGF6	Q9BYE7³, ENSP00000358862⁴	I2D: score=1 STRING: ENSP00000358862
HIST3H3	ENSP00000355657⁴	STRING: ENSP00000355657

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007283	spermatogenesis	NAS	--
GO:0034720	histone H3-K4 demethylation	IDA	17320160

KDM5D for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KDM5D

1 DrugBank Compound for KDM5D About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Vitamin C	Ascorbate (see all 6)	50-81-7	target	--	17139284 17016423

Search CenterWatch for drugs/clinical trials and news about KDM5D

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KDM5D gene (3 alternative transcripts):

NM_001146705.1 NM_001146706.1 NM_004653.4

Unigene Cluster for KDM5D:

Lysine (K)-specific demethylase 5D

Hs.80358 [show with all ESTs]

Unigene Representative Sequence: NM_001146705

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000469599 ENST00000317961(uc004fuf.3) ENST00000382806 ENST00000492117

ENST00000440077 ENST00000415360 ENST00000485154 ENST00000478891 ENST00000447300

ENST00000541639(uc011naz.2 uc004fug.3 uc010nwy.3 uc011nba.1 uc004fuh.2)

ENST00000535647

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Additional cDNA sequence:

AK095923.1 AK304027.1 BC011053.1 BC132721.1 BC144101.1 BC144102.1 BC146767.1 BX648643.1

D87072.1 U52191.1 U52365.1

12 DOTS entries:

DT.95159961 DT.40233810 DT.92046785 DT.100691331 DT.40131582 DT.120654025 DT.101957266 DT.120654022

DT.120654028 DT.120654029 DT.91978680 DT.95322478

24/87 AceView cDNA sequences (see all 87):

AL043711 AA465521 AA113921 AA262767 AA846126 BQ053814 BI025365 BX648643

AA377435 U52365 D87072 AA215375 AI341366 CF552345 AI660371 CD652272

BQ651915 BM052719 BP367589 AA864889 NM_004653 AV763928 AL039020 CB269359

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for KDM5D (see all 10) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	·	12c	^	13	^	14a	·	14b	^	15	^	16	^	17a	·	17b	^	18a	·	18b	·	18c	^	19a	·
SP1:																									-																-								-
SP2:											-														-																-								-
SP3:																																																	-
SP4:																																									-										-
SP5:																																																	-

ExUns:	19b	^	20a	·	20b	^	21	^	22	^	23a	·	23b	^	24a	·	24b	^	25	^	26a	·	26b	·	26c	^	27	^	28a	·	28b	^	29a	·	29b
SP1:			-				-
SP2:			-				-
SP3:			-				-
SP4:	-		-
SP5:			-

ECgene alternative splicing isoforms for KDM5D

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KDM5D expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTCTACCTG

About this image

KDM5D expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Reproductive System

Early Gonad

Testis Somatic Cells

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KDM5D Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KDM5D

SOURCE GeneReport for Unigene cluster: Hs.80358

SABiosciences Expression via Pathway-Focused PCR Array including KDM5D:

Polycomb & Trithorax Complexes in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for KDM5D gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	--	--	75(a)	1 → many	1(204860450-204880349)
zebrafish (Danio rerio)	Actinopterygii	kdm5c⁶	lysine (K)-specific demethylase 5C	58(a)	1 → many	8(38095710-38138758)
fruit fly (Drosophila melanogaster)	Insecta	lid⁶	little imaginal discs	33(a)	1 → many	2L(5989463-5999501)
worm (Caenorhabditis elegans)	Secernentea	rbr-2⁶	Lysine-specific demethylase rbr-2	25(a)	1 → many	IV(10920086-10926776)
thale cress (Arabidopsis thaliana)	eudicotyledons	MEE27⁶ AT1G30810⁶ (see all 6)	transcription factor jumonji and C5HC2 type zinc f... transcription factor jumonji and C5HC2 type zinc f... (see all 6)	26(a) 26(a) (see all 6)	many ↔ many many ↔ many (see all 6)	2(14711880-14716634) 1(10936765-10942292)
rice (Oryza sativa)	Liliopsida	-- --	transcription factor jumonji, putative, expressed	24(a) 20(a)	many ↔ many many ↔ many	5(13516404-13522202) 5(5940076-5946805)

ENSEMBL Gene Tree for KDM5D (if available)
TreeFam Gene Tree for KDM5D (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KDM5D gene

KDM5C² JARID2² KDM5B² KDM5A²

12 SIMAP similar genes for KDM5D using alignment to 5 protein entries: KDM5D_HUMAN (see all proteins):

JARID1C KDM5C PLU-1 KDM5A PHF8 KDM5B

JARID1B DKFZp434N0335 DKFZp434D0815 DKFZp434I0617 AIRE DKFZp434I2412

KDM5D for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for KDM5D
PGOHUM00000233789

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr Y pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2032630^1,2	F,H	--	21866840(+)	`AAAGCT/AACTAC`	3	--	ds500¹		2		NS	114
rs2032631^1,2	C,F,H	--	21867787(+)	`AGATAG/AGCAAA`	3	--	ut3¹ ese³		12		MN NA NS WA CSA	432
rs35681523^1,2	C	--	21868068(-)	`GGGCCG/AAGAAG`	6	/Q /R	mis¹		2		MN NA	48
rs2032632^1,2	C,H	--	21868672(+)	`ACACCT/CGTCTT`	3	--	int¹		6		NS EA NA	264
rs2032633^1,2	C,F	--	21868726(+)	`CTGTCT/CCCATT`	6	/G	syn¹		5		MN NA CSA	286
rs34078768^1,2	C,F	--	21868863(-)	`GAAGCC/TTGTGT`	3	--	int¹		3		MN NA CSA	48
rs2032620^1,2	C,H	--	21869264(+)	`CGCACG/AGGCAG`	6	/P	syn¹ ese³		7		MN NS EA NA	446
rs2032625^1,2	C,F,H	--	21870638(+)	`CTCAAG/AGAATC`	3	--	int¹		9		NA EA NS	516
rs112794051^1,2	C	--	21872499(-)	`TTTTCA/GAATCT`	3	--	int¹		0	--	--	--	--
rs2032621^1,2	C,F,H	--	21872738(+)	`AGTTAT/CATTTT`	3	--	int¹		5		NS EA NA	195

HapMap Linkage Disequilibrium report for KDM5D (21865751 - 21906825 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KDM5D
1 CNV: 31588

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KDM5D for disorders           About GeneDecksing

OMIM gene information: 426000    OMIM disorders: --

9 diseases for KDM5D:    About MalaCards

graft versus host disease azoospermia retinoblastoma prostate cancer

prostatitis malaria chronic graft versus host disease y chromosome infertility

infertility

Export disorders for KDM5D gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KDM5D gene, integrated from 9 sources (see all 43):
(articles sorted by number of sources associating them with KDM5D)

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world of online information

Gene sequence and evolutionary conservation of human SMCY. (PubMed id 8841177)^{1, 2, 3} Kent-First M.G.... Vandeberg J. (1996)
Spermatogenesis-specific association of SMCY and MSH5. (PubMed id 18459961)^{1, 2} Akimoto C....Kato S. (2008)
Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein. (PubMed id 17320162)^{1, 2} Lee M.G.... Shiekhattar R. (2007)
The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. (PubMed id 17320160)^{1, 2} Iwase S.... Shi Y. (2007)
The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)^{1, 2} Skaletsky H.... Page D.C. (2003)
Population genetic implications from sequence variation in four Y chromosome genes. (PubMed id 10861003)^{1, 2} Shen P.... Oefner P.J. (2000)
Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven. (PubMed id 9060413)^{1, 2} Agulnik A.I.... Solovyev V.V. (1997)
Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)^{1, 2} Nagase T....Nomura N. (1996)
Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein. (PubMed id 7667640)^{1, 9} Wang W....Bishop C.E. (1995)
Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission. (PubMed id 15613541)^{1, 9} Miklos D.B....Ritz J. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8284	HGNC: 11115	AceView: JARID1D	Ensembl:ENSG00000012817	euGenes: HUgn8284
ECgene: KDM5D	H-InvDB: KDM5D

(According to HUGE)
About This Section

HUGE: KIAA0234

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KDM5D	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KDM5D gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KDM5D gene:
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GeneCards and IP:
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KDM5D Gene

lysine (K)-specific demethylase 5D

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KDM5D (Gene Symbol)
Lysine (K)-Specific Demethylase 5D
HYA
JARID1D
SMCY
HY
Jumonji, AT Rich Interactive Domain 1D (RBP2-Like)
KIAA0234
Histocompatibility Y Antigen
Histone Demethylase JARID1D
Jumonji/ARID Domain-Containing Protein 1D
Protein SmcY
H-Y
Jumonji, AT Rich Interactive Domain 1D
Smcy Homolog, Y-Linked (Mouse)
Lysine-Specific Demethylase 5D
Selected Mouse CDNA On Y, Human Homolog Of
SMC Homolog, Y Chromosome
Smcy Homolog, Y-Linked
EC 1.14.11.-
EC 1.14.11

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KDM5D Gene

lysine (K)-specific demethylase 5D

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