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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KDM5B Gene

protein-coding GIFtS: 55
GCID: GC01M202696

lysine (K)-specific demethylase 5B

(Previous names: Jumonji, AT rich interactive domain 1B (RBP2-like), jumonji,...)
(Previous symbol: JARID1B)

Explore 10 diseases affiliated with
KDM5B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Lysine (K)-Specific Demethylase 5B¹ ²		Retinoblastoma-Binding Protein 2 Homolog 1² ³
JARID1B¹ ² ³ ⁵		RBP2-H1² ³
CT31¹ ² ³		PUT1² ⁵
PLU-1¹ ² ³		Jumonji, AT Rich Interactive Domain 1B (RBP2-Like)¹
RBBP2H1A¹ ² ⁵		Lysine-Specific Demethylase 5B²
PLU1² ³ ⁵		Putative DNA/Chromatin Binding Motif²
Jumonji, AT Rich Interactive Domain 1B¹ ²		Retinoblastoma-Binding Protein 2, Homolog 1A²
Cancer/Testis Antigen 31² ³		EC 1.14.11.-³
Histone Demethylase JARID1B² ³		RBBP2H1³
Jumonji/ARID Domain-Containing Protein 1B² ³		EC 1.14.11⁸

External Ids:	HGNC: 18039¹	Entrez Gene: 10765²	Ensembl: ENSG00000117139⁷	OMIM: 605393⁵	UniProtKB: Q9UGL1³

Export aliases for KDM5B gene to outside databases

Previous GC identifers: GC01M200965 GC01M173862

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: KDM5B_HUMAN, Q9UGL1

Function: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code.

Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3

'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by

repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma

Gene Wiki entry for KDM5B (JARID1B)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KDM5B gene promoter:
NF-1 Elk-1 HSF1 (long) NF-kappaB LCR-F1 E2F-1 E2F COMP1 HSF1short NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KDM5B promoter sequence

Search SABiosciences Chromatin IP Primers for KDM5B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KDM5B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.1

KDM5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KDM5B gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M202696: view genomic region (about GC identifiers)

Start:	202,696,526 bp from pter	End:	202,778,598 bp from pter
Size:	82,073 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KDM5B_HUMAN, Q9UGL1 (See protein sequence)

Recommended Name: Lysine-specific demethylase 5B

Size: 1544 amino acids; 175658 Da

Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)

Subunit: Interacts with FOXG1B, PAX9, MYC, MYCN and RB1. Interacts with HDAC1, HDAC4, HDAC5 and HDAC7 (By similarity)

Subcellular location: Nucleus

Sequence caution: Sequence=CAB63108.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: O95811 Q15752 Q9Y3Q5

Alternative splicing: 2 isoforms: Q9UGL1-1 Q9UGL1-2

Explore the universe of human proteins at neXtProt for KDM5B: NX_Q9UGL1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UGL1

4/28 DME Specific Peptides for KDM5B (Q9UGL1) (see all 28)

RYCVFSH

DKEYKPH

GEPKTWY

KCKTTCF

KDM5B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006609.3

ENSEMBL proteins:

ENSP00000356234 ENSP00000356233 ENSP00000235790

Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KDM5B

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	12657635
GO:0005730	nucleolus	IDA	--
GO:0043231	intracellular membrane-bounded organelle	IDA	--

KDM5B for ontologies About GeneDecksing

KDM5B Antibody Products:

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Assay Products for KDM5B:

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	GenScript Custom Assay Services for KDM5B
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for KDM5B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KDM5B for domains About GeneDecksing

5/10 InterPro domains/families (see all 10):

IPR001965 Znf_PHD

IPR013083 Znf_RING/FYVE/PHD

IPR003347 JmjC_dom

IPR013637 Lys_sp_deMease_like_dom

IPR019786 Zinc_finger_PHD-type_CS

Graphical View of Domain Structure for InterPro Entry Q9UGL1

ProtoNet protein and cluster: Q9UGL1

5 Blocks protein families:

IPB001606 ARID (AT-rich interaction domain) protein

IPB003347 Transcription factor jumonji

IPB003349 Transcription factor jumonji

IPB004198 Zn-finger

IPB013637 PLU-1-like

UniProtKB/Swiss-Prot: KDM5B_HUMAN, Q9UGL1

Domain: Both the JmjC domain and the JmjN domain are required for enzymatic activity

Domain: The 2 first PHD-type zinc finger domains are required for transcription repression activity

Similarity: Belongs to the JARID1 histone demethylase family

Similarity: Contains 1 ARID domain

Similarity: Contains 1 JmjC domain

Similarity: Contains 1 JmjN domain

Similarity: Contains 3 PHD-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KDM5B_HUMAN, Q9UGL1

Function: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code.

Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3

'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by

repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma

Enzyme Numbers (IUBMB): EC 1.14.11.-¹ EC 1.14.11²

miRNA Products:		OriGene 3'-UTR Clone: KDM5B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KDM5B
		8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate KDM5B (see all 49):
		hsa-miR-607 hsa-miR-300 hsa-miR-605 hsa-miR-29a hsa-miR-183* hsa-miR-4330 hsa-miR-155 hsa-miR-532-5p

		SwitchGear 3'UTR luciferase reporter plasmid: KDM5B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KDM5B (see all 4) OriGene shRNA RFP: KDM5B OriGene siRNA: KDM5B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KDM5B

Gene Editing
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DNA2.0 Custom Protein Engineering Service for KDM5B

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KDM5B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KDM5B OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KDM5B
		Search LifeMap BioReagents cell lines for KDM5B

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM5B

Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	TAS	10336460
GO:0003714	transcription corepressor activity	IDA	12657635
GO:0005515	protein binding	IPI	12657635
GO:0008270	zinc ion binding	IEA	--

KDM5B for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for KDM5B:

Increased cell death HMECs cel

Synthetic lethal with Ras

Animal Models:
1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Kdm5b):

no phenotypic analysis

KDM5B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Chromatin Regulation / Acetylation

Chromatin Regulation / Acetylation

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for KDM5B

Chromatin Regulation / Acetylation

KDM5B for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KDM5B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/65 Interacting proteins for KDM5B (Q9UGL1³ ENSP00000356234⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 65)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PAX9	P55771³, ENSP00000355245⁴	I2D: score=3 STRING: ENSP00000355245
FOXG1	P55316³, ENSP00000339004⁴	I2D: score=2 STRING: ENSP00000339004
PRPF4	O43172³, ENSP00000363313⁴	I2D: score=2 STRING: ENSP00000363313
AR	P10275³, ENSP00000363822⁴	I2D: score=1 STRING: ENSP00000363822
AXIN2	Q9Y2T1³, ENSP00000302625⁴	I2D: score=1 STRING: ENSP00000302625

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0034720	histone H3-K4 demethylation	IDA	--
GO:0034721	histone H3-K4 demethylation, trimethyl-H3-K4-specific	IDA	--
GO:0045892	negative regulation of transcription, DNA-dependent	IDA	12657635

KDM5B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KDM5B
Search CenterWatch for drugs/clinical trials and news about KDM5B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KDM5B gene:

NM_006618.3

Unigene Cluster for KDM5B:

Lysine (K)-specific demethylase 5B

Hs.443650 [show with all ESTs]

Unigene Representative Sequence: AJ243706

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367265(uc001gyf.3) ENST00000367264(uc009xag.3) ENST00000472822

ENST00000491153 ENST00000235790(uc001gyg.1) ENST00000498276 ENST00000456180

ENST00000467487 ENST00000470573

miRNA Products:		OriGene 3'-UTR Clone: KDM5B Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KDM5B
		8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate KDM5B (see all 49):
		hsa-miR-607 hsa-miR-300 hsa-miR-605 hsa-miR-29a hsa-miR-183* hsa-miR-4330 hsa-miR-155 hsa-miR-532-5p

		SwitchGear 3'UTR luciferase reporter plasmid: KDM5B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KDM5B (see all 4) OriGene shRNA RFP: KDM5B OriGene siRNA: KDM5B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KDM5B

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		GenScript: all cDNA clones in your preferred vector: KDM5B (NM_006618)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KDM5B
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KDM5B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KDM5B

Additional cDNA sequence:

AB015348.1 AF087481.1 AJ132440.1 AJ243706.1 AK001400.1 AK022521.1 AK022553.1 AK074250.1

AK122752.1 AK125746.1 AL133040.1 AL133048.1 AL133072.1 AL137622.1 AL833515.1

16 DOTS entries:

DT.97857065 DT.449384 DT.101963351 DT.97770938 DT.121434552 DT.101967997 DT.97810559 DT.91804138

DT.121434559 DT.121434585 DT.121434525 DT.121434554 DT.121434582 DT.92384997 DT.95200889 DT.92008652

24/359 AceView cDNA sequences (see all 359):

AW151255 BQ637269 CD557093 AI352104 BP369386 AI522066 BM556312 AU132575

AI392929 AA937740 Z39493 BF791642 AI139571 BQ222747 BM799464 AI244904

BF430951 W94357 AI374844 AI334589 AA513428 W70250 AJ132440 BF739897

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for KDM5B (see all 8) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18	^	19a	·
SP1:					-		-				-														-										-																-
SP2:											-														-										-																-
SP3:
SP4:
SP5:

ExUns:	19b	^	20a	·	20b	^	21	^	22	^	23	^	24	^	25	^	26	^	27	^	28a	·	28b	^	29	^	30a	·	30b	^	31
SP1:																					-
SP2:																					-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for KDM5B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KDM5B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACAGCATTA

About this image

KDM5B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Reproductive System

Early Gonad

Testis Somatic Cells

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KDM5B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KDM5B

SOURCE GeneReport for Unigene cluster: Hs.443650

UniProtKB/Swiss-Prot: KDM5B_HUMAN, Q9UGL1

Tissue specificity: Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma.

Up-regulated in breast cancer (at protein level)

SABiosciences Expression via Pathway-Focused PCR Array including KDM5B:

Epigenetic Chromatin Modification Enzymes in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KDM5B Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KDM5B

In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for KDM5B gene from 8/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KDM5B¹	lysine (K)-specific demethylase 5B	76.1(n) 84(a)		421168 NM_001031029.1 NP_001026200.1
lizard (Anolis carolinensis)	Reptilia	KDM5B⁶	--	81(a)	1 ↔ 1	4(133781884-133841686)
African clawed frog (Xenopus laevis)	Amphibia	BJ070037.1²	--	74.8(n)		BJ070037.1
zebrafish (Danio rerio)	Actinopterygii	idibd5050²	Danio rerio cDNA clone IMAGE5603807, partial cds	74.2(n)		BC061452.1
fruit fly (Drosophila melanogaster)	Insecta	lid⁶	little imaginal discs	34(a)	1 → many	2L(5989463-5999501)
worm (Caenorhabditis elegans)	Secernentea	rbr-2¹	Protein RBR-2	45.79(n) 33.47(a)		177985 NM_069631.5 NP_502032.2
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G30810⁶ MEE27⁶ (see all 6)	transcription factor jumonji and C5HC2 type zinc f... transcription factor jumonji and C5HC2 type zinc f... (see all 6)	27(a) 26(a) (see all 6)	many ↔ many many ↔ many (see all 6)	1(10936765-10942292) 2(14711880-14716634)
rice (Oryza sativa)	Liliopsida	Os.10868²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	76(n)		AK121381.1

ENSEMBL Gene Tree for KDM5B (if available)
TreeFam Gene Tree for KDM5B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KDM5B gene

KDM5C² JARID2² KDM5A² KDM5D²

10 SIMAP similar genes for KDM5B using alignment to 1 protein entry: KDM5B_HUMAN:

DKFZp434D0815 DKFZp434I0617 DKFZp434I2412 DKFZp434N0335 JARID1B HRIHFB2060

KDM5A KDM5D JARID1C KDM5C

KDM5B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35598184^1,2	C	--	173908354(+)	`GCTTCT/-TTTTT`	1	--	int¹		1		CSA	2
rs34784079^1,2	C	--	173911961(+)	`CCTGT-/AAAAAAAA`	1	--	int¹		1		NA	2
rs188935310^1,2		--	202696033(+)	`GGCAAC/GTGACA`	1	--	ds500¹		0	--	--	--	--
rs190885351^1,2		--	202696136(+)	`TAACTC/TACTCA`	1	--	ds500¹		0	--	--	--	--
rs182766338^1,2		--	202696164(+)	`CTTCCC/TCAAAG`	1	--	ds500¹		0	--	--	--	--
rs72047459^1,2	C,	--	202696192(+)	`TGTGT-/ACCACCAC`	1	--	ds500¹		0	--	--	--	--
rs150365754^1,2		--	202696236(+)	`GGGGGC/TAGGGG`	1	--	ds500¹		0	--	--	--	--
rs4348778^1,2	C,F,A,H,	--	202696247(+)	`TTGTGC/TTTACT`	1	--	ds500¹		22		NS EA NA CSA WA	2347
rs145095842^1,2		--	202696266(+)	`AAAAGC/GTCTCT`	1	--	ds500¹		0	--	--	--	--
rs114766857^1,2	F,	--	202696276(+)	`TAAAGG/ACAGTG`	1	--	ds500¹		1		WA	118

HapMap Linkage Disequilibrium report for KDM5B (202696526 - 202778598 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for KDM5B
1 CNV: 3327
2 Indels: 97613 24044

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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KDM5B for disorders           About GeneDecksing

OMIM gene information: 605393    OMIM disorders: --

10 diseases for KDM5B:    About MalaCards

retinoblastoma essential hypertension skin cancer hypertension

melanoma breast cancer prostate cancer glioblastoma

prostatitis malaria

Human Genome Epidemiology (HuGE) Navigator: KDM5B (1 document)

Export disorders for KDM5B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for KDM5B gene, integrated from 9 sources (see all 54):
(articles sorted by number of sources associating them with KDM5B)

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PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. (PubMed id 17363312)^{1, 2} Yamane K.... Zhang Y. (2007)
Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases. (PubMed id 17373667)^{1, 2} Barrett A.... Taylor-Papadimitriou J. (2007)
Re-expression of the retinoblastoma-binding protein 2-homolog 1 reveals tumor-suppressive functions in highly metastatic melanoma cells. (PubMed id 16645588)^{1, 2} Roesch A....Vogt T. (2006)
Retinoblastoma-binding protein 2-homolog 1: a retinoblastoma-binding protein downregulated in malignant melanomas. (PubMed id 15803180)^{1, 2} Roesch A....Vogt T. (2005)
Human PLU-1 has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9. (PubMed id 12657635)^{1, 2} Tan K....Freemont P.S. (2003)
PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: a new cancer/testis antigen? (PubMed id 12237901)^{1, 2} Barrett A.... Taylor-Papadimitriou J. (2002)
Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs. (PubMed id 11483573)^{1, 3} Lahoud M.H....Kola I. (2001)
Dynamics of the Mrf-2 DNA-binding domain free and in complex with DNA. (PubMed id 11478881)^{1, 3} Zhu L....Chen Y. (2001)
Isolation and chromosomal localization of a new human retinoblastoma binding protein 2 homologue 1a (RBBP2H1A). (PubMed id 10878660)^{1, 2} Kashuba V.... Zabarovsky E. (2000)
A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer. (PubMed id 10336460)^{1, 2} Lu P.J....Taylor-Papadimitriou J. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10765	HGNC: 18039	AceView: JARID1B	Ensembl:ENSG00000117139	euGenes: HUgn10765
ECgene: KDM5B	H-InvDB: KDM5B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for KDM5B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KDM5B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KDM5B gene:
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KDM5B Gene

lysine (K)-specific demethylase 5B

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KDM5B (Gene Symbol)
Lysine (K)-Specific Demethylase 5B
JARID1B
CT31
PLU-1
RBBP2H1A
PLU1
Jumonji, AT Rich Interactive Domain 1B
Cancer/Testis Antigen 31
Histone Demethylase JARID1B
Jumonji/ARID Domain-Containing Protein 1B
Retinoblastoma-Binding Protein 2 Homolog 1
RBP2-H1
PUT1
Jumonji, AT Rich Interactive Domain 1B (RBP2-Like)
Lysine-Specific Demethylase 5B
Putative DNA/Chromatin Binding Motif
Retinoblastoma-Binding Protein 2, Homolog 1A
EC 1.14.11.-
RBBP2H1
EC 1.14.11

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KDM5B Gene

lysine (K)-specific demethylase 5B

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