Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KDM5B Gene

protein-coding   GIFtS: 55
GCID: GC01M202696

Lysine (K)-Specific Demethylase 5B

(Previous names: Jumonji, AT rich interactive domain 1B (RBP2-like), jumonji,...)
(Previous symbol: JARID1B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Lysine (K)-Specific Demethylase 5B1 2     RBP2-H12 3
JARID1B1 2 3 5     PUT12 5
Cancer/Testis Antigen 311 2 3     RBBP2H1A2 5
PLU12 3 5     Jumonji, AT Rich Interactive Domain 1B (RBP2-Like)1
Jumonji, AT Rich Interactive Domain 1B1 2     Lysine-Specific Demethylase 5B2
Histone Demethylase JARID1B2 3     Putative DNA/Chromatin Binding Motif2
Jumonji/ARID Domain-Containing Protein 1B2 3     Retinoblastoma-Binding Protein 2, Homolog 1A2
Retinoblastoma-Binding Protein 2 Homolog 12 3     EC 1.14.11.-3
CT312 3     RBBP2H13
PLU-12 3     EC 1.14.118

External Ids:    HGNC: 180391   Entrez Gene: 107652   Ensembl: ENSG000001171397   OMIM: 6053935   UniProtKB: Q9UGL13   

Export aliases for KDM5B gene to outside databases

Previous GC identifers: GC01M200965 GC01M173862


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KDM5B Gene: 
KDM5B (lysine (K)-specific demethylase 5B) is a protein-coding gene. Diseases associated with KDM5B include retinoblastoma, and skin cancer. GO annotations related to this gene include oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is KDM5C.

UniProtKB/Swiss-Prot: KDM5B_HUMAN, Q9UGL1
Function: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone
code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and
monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of
breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor
suppressor for melanoma

Gene Wiki entry for KDM5B (JARID1B) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KDM5B gene promoter:
         NF-1   Elk-1   HSF1 (long)   NF-kappaB   LCR-F1   E2F-1   E2F   COMP1   HSF1short   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKDM5B promoter sequence
   Search SABiosciences Chromatin IP Primers for KDM5B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KDM5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

KDM5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KDM5B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M202696:  view genomic region     (about GC identifiers)

Start:
202,696,526 bp from pter      End:
202,778,598 bp from pter
Size:
82,073 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KDM5B_HUMAN, Q9UGL1 (See protein sequence)
Recommended Name: Lysine-specific demethylase 5B  
Size: 1544 amino acids; 175658 Da
Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)
Subunit: Interacts with FOXG1B, PAX9, MYC, MYCN and RB1. Interacts with HDAC1, HDAC4, HDAC5 and HDAC7 (By
similarity)
Subcellular location: Nucleus
Sequence caution: Sequence=CAB63108.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: O95811 Q15752 Q9Y3Q5
Alternative splicing: 2 isoforms:  Q9UGL1-1   Q9UGL1-2   

Explore the universe of human proteins at neXtProt for KDM5B: NX_Q9UGL1

Explore proteomics data for KDM5B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UGL1

  • 4/28 DME Specific Peptides for KDM5B (Q9UGL1) (see all 28)
     RYCVFSH  DKEYKPH  GEPKTWY  KCKTTCF 

    KDM5B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KDM5B Protein Expression
    REFSEQ proteins: NP_006609.3  
    ENSEMBL proteins: 
     ENSP00000356234   ENSP00000356233   ENSP00000235790   ENSP00000473481  

    Human Recombinant Protein Products for KDM5B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KDM5B
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for KDM5B
    GenScript Custom Purified and Recombinant Proteins Services for KDM5B
    Novus Biologicals KDM5B Protein
    Novus Biologicals KDM5B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KDM5B 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus TAS10336460
    GO:0005730nucleolus IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    KDM5B for ontologies           About GeneDecksing



    KDM5B Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of KDM5B
    R&D Systems Antibodies for KDM5B (Lysine (K)-specific Demethylase 5B/KDM5B)
    Cell Signaling Technology (CST) Antibodies for KDM5B  (JARID1B)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KDM5B
    GenScript Custom Superior Antibodies Services for KDM5B
    Novus Biologicals KDM5B Antibodies
    Abcam antibodies for KDM5B
    Cloud-Clone Corp. Antibodies for KDM5B 
    Search ThermoFisher Antibodies for KDM5B
    LSBio Antibodies in human, mouse, rat for KDM5B 

    Assay Products for KDM5B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KDM5B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KDM5B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KDM5B 
    Cloud-Clone Corp. CLIAs for KDM5B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KDM: Chromatin-modifying enzymes / K-demethylases
    PHF: Zinc fingers, PHD-type

    5/10 InterPro protein domains (see all 10):
     IPR003347 JmjC_dom
     IPR013637 Lys_sp_deMease_like_dom
     IPR019786 Zinc_finger_PHD-type_CS
     IPR001965 Znf_PHD
     IPR003349 TF_JmjN

    Graphical View of Domain Structure for InterPro Entry Q9UGL1

    ProtoNet protein and cluster: Q9UGL1

    5 Blocks protein domains:
    IPB001606 ARID (AT-rich interaction domain) protein
    IPB003347 Transcription factor jumonji
    IPB003349 Transcription factor jumonji
    IPB004198 Zn-finger
    IPB013637 PLU-1-like


    UniProtKB/Swiss-Prot: KDM5B_HUMAN, Q9UGL1
    Domain: Both the JmjC domain and the JmjN domain are required for enzymatic activity
    Domain: The 2 first PHD-type zinc finger domains are required for transcription repression activity
    Similarity: Belongs to the JARID1 histone demethylase family
    Similarity: Contains 1 ARID domain
    Similarity: Contains 1 JmjC domain
    Similarity: Contains 1 JmjN domain
    Similarity: Contains 3 PHD-type zinc fingers


    KDM5B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KDM5B_HUMAN, Q9UGL1
    Function: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone
    code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and
    monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of
    breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor
    suppressor for melanoma

         Enzyme Numbers (IUBMB): EC 1.14.11.-1 EC 1.14.112

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS10336460
    GO:0003714transcription corepressor activity IDA12657635
    GO:0005515protein binding IPI12657635
    GO:0008270zinc ion binding IEA--
         
    KDM5B for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for KDM5B:
     Increased cell death HMECs cel  Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Kdm5b):
     no phenotypic analysis 

    KDM5B for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KDM5B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KDM5B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KDM5B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KDM5B 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KDM5B
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate KDM5B (see all 49):
    hsa-miR-607 hsa-miR-300 hsa-miR-605 hsa-miR-29a hsa-miR-183* hsa-miR-4330 hsa-miR-155 hsa-miR-532-5p
    SwitchGear 3'UTR luciferase reporter plasmidKDM5B 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KDM5B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KDM5B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KDM5B
    Sirion Biotech Customized adenovirus for overexpression of KDM5B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for KDM5B (see all 7)
    OriGene ORF clones in mouse, rat for KDM5B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KDM5B (NM_006618)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KDM5B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KDM5B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KDM5B
    Search LifeMap BioReagents cell lines for KDM5B
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM5B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KDM5B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for KDM5B
        Chromatin Regulation / Acetylation



    KDM5B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KDM5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/66 Interacting proteins for KDM5B (Q9UGL13 ENSP000003562344) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAX9P557713, ENSP000003552454I2D: score=3 STRING: ENSP00000355245
    FOXG1P553163, ENSP000003390044I2D: score=2 STRING: ENSP00000339004
    PRPF4O431723, ENSP000003633134I2D: score=2 STRING: ENSP00000363313
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    AXIN2Q9Y2T13, ENSP000003026254I2D: score=1 STRING: ENSP00000302625
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0034720histone H3-K4 demethylation IDA--
    GO:0034721histone H3-K4 demethylation, trimethyl-H3-K4-specific IDA--
    GO:0045892negative regulation of transcription, DNA-dependent IDA12657635
    GO:0055114oxidation-reduction process ----

    KDM5B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KDM5B

    Search CenterWatch for drugs/clinical trials and news about KDM5B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KDM5B gene: 
    NM_006618.3  

    Unigene Cluster for KDM5B:

    Lysine (K)-specific demethylase 5B
    Hs.443650  [show with all ESTs]
    Unigene Representative Sequence: AJ243706
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367265(uc001gyf.3) ENST00000367264(uc009xag.3) ENST00000472822
    ENST00000491153 ENST00000235790(uc001gyg.1) ENST00000498276 ENST00000456180
    ENST00000602511 ENST00000470573 ENST00000467487
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KDM5B
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate KDM5B (see all 49):
    hsa-miR-607 hsa-miR-300 hsa-miR-605 hsa-miR-29a hsa-miR-183* hsa-miR-4330 hsa-miR-155 hsa-miR-532-5p
    SwitchGear 3'UTR luciferase reporter plasmidKDM5B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KDM5B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KDM5B
    Clone
    Products:
         
    OriGene clones in human, mouse for KDM5B (see all 7)
    OriGene ORF clones in mouse, rat for KDM5B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KDM5B (NM_006618)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KDM5B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KDM5B
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KDM5B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KDM5B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KDM5B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KDM5B

    Additional mRNA sequence: 

    AB015348.1 AF087481.1 AJ132440.1 AJ243706.1 AK001400.1 AK022521.1 AK022553.1 AK074250.1 
    AK122752.1 AK125746.1 AL133040.1 AL133048.1 AL133072.1 AL137622.1 AL833515.1 

    16 DOTS entries:

    DT.97857065  DT.449384  DT.97770938  DT.101963351  DT.121434552  DT.101967997  DT.97810559  DT.91804138 
    DT.121434559  DT.121434585  DT.121434525  DT.121434554  DT.121434582  DT.92384997  DT.95200889  DT.92008652 

    24/359 AceView cDNA sequences (see all 359):

    AI262935 AW613260 AL133048 BX422693 Z40215 AL597692 AI308132 AI026894 
    BX104183 AI824976 AI208717 AI005463 CF593335 BM665545 AU124063 AW137683 
    AL044801 CF541414 F03403 T30187 AI681251 BM702957 BF000575 BM998212 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for KDM5B (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a ·
    SP1:              -     -           -                                         -                             -                                               -   
    SP2:                                -                                         -                             -                                               -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31
    SP1:                                                              -                                 
    SP2:                                                              -                                 
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for KDM5B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KDM5B expression in normal human tissues (normalized intensities)      KDM5B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAGCATTA
    KDM5B Expression
    About this image


    KDM5B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/38 selected tissues (see all 38) fully expand
     
     Testis (Reproductive System)    fully expand to see all 6 entries
             XY Germ Cells Testis Cord
             seminal vesicle ; glandular cells   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See KDM5B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KDM5B

    SOURCE GeneReport for Unigene cluster: Hs.443650

    UniProtKB/Swiss-Prot: KDM5B_HUMAN, Q9UGL1
    Tissue specificity: Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and
    glioblastoma. Up-regulated in breast cancer (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Array including KDM5B: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KDM5B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KDM5B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KDM5B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KDM5B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM5B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KDM5B gene from 9/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kdm5b1 , 5 lysine (K)-specific demethylase 5B1, 5 88.97(n)1
    94.24(a)1
      1 (58.24 cM)5
    756051  NM_152895.21  NP_690855.21 
     1345601715 
    chicken
    (Gallus gallus)
    Aves KDM5B1 lysine (K)-specific demethylase 5B 76.1(n)
    84(a)
      421168  NM_001031029.1  NP_001026200.1 
    lizard
    (Anolis carolinensis)
    Reptilia KDM5B6
    Uncharacterized protein
    81(a)
    1 ↔ 1
    4(133781884-133846309)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ070037.12   -- 74.8(n)    BJ070037.1 
    zebrafish
    (Danio rerio)
    Actinopterygii idibd50502 Danio rerio cDNA clone IMAGE5603807, partial cds 74.2(n)    BC061452.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta lid6
    little imaginal discs
    34(a)
    1 → many
    2L(5989463-5999501)
    worm
    (Caenorhabditis elegans)
    Secernentea rbr-21 Protein RBR-2 45.79(n)
    33.47(a)
      177985  NM_069631.5  NP_502032.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes JHD26
    JmjC domain family histone demethylase specific fo...
    28(a)
    1 → many
    X(644304-646490)
    rice
    (Oryza sativa)
    Liliopsida Os.108682 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 76(n)    AK121381.1 


    ENSEMBL Gene Tree for KDM5B (if available)
    TreeFam Gene Tree for KDM5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KDM5B gene
    KDM5C2  JARID22  KDM5A2  KDM5D2  
    18/55 SIMAP similar genes for KDM5B using alignment to 2 protein entries:     KDM5B_HUMAN (see all proteins) (see all similar genes):
    DKFZp434D0815    DKFZp434I0617    DKFZp434I2412    DKFZp434N0335    JARID1B    HRIHFB2060
    CRCP    AURA2    TNFRSF17    ZNF20    HKR1    LYRM4
    APOD    SHANK2    ZNF547    ZNF585B    ZNF738    EIF3L

    KDM5B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1713 SNPs in KDM5B are shown (see all 1713)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1889353101,2
    --202696033(+) GGCAAC/GTGACA 1 -- ds50010--------
    rs1908853511,2
    --202696136(+) TAACTC/TACTCA 1 -- ds50010--------
    rs1827663381,2
    --202696164(+) CTTCCC/TCAAAG 1 -- ds50010--------
    rs720474591,2
    C--202696192(+) TGTGT-/ACCACCAC 1 -- ds50010--------
    rs1503657541,2
    --202696236(+) GGGGGC/TAGGGG 1 -- ds50010--------
    rs43487781,2
    C,F,A,H--202696247(+) TTGTGC/TTTACT 1 -- ds500122Minor allele frequency- T:0.50NS EA NA CSA WA 2347
    rs1450958421,2
    --202696266(+) AAAAGC/GTCTCT 1 -- ds50010--------
    rs1147668571,2
    C,F--202696276(+) TAAAGG/ACAGTG 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1421435581,2
    --202696349(+) GACAGG/TTGGCA 1 -- ds50010--------
    rs1871639571,2
    --202696421(+) AACCAC/TGATGA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for KDM5B (202696526 - 202778598 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for KDM5B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1740431CNV Deletion17803354
    nsv4110CNV Insertion18451855
    esv2490406CNV Insertion19546169
    nsv832359CNV Loss17160897
    nsv832348CNV Loss17160897
    dgv173e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KDM5B
    DNA2.0 Custom Variant and Variant Library Synthesis for KDM5B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605393    OMIM disorders: --

    10 diseases for KDM5B:    About MalaCards
    retinoblastoma    skin cancer    essential hypertension    hypertension
    mental retardation    glioblastoma    melanoma    breast cancer
    prostate cancer    prostatitis


    KDM5B for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: KDM5B (1 document)

    Export disorders for KDM5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KDM5B gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with KDM5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. (PubMed id 17363312)1, 2 Yamane K.... Zhang Y. (2007)
    2. Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases. (PubMed id 17373667)1, 2 Barrett A.... Taylor-Papadimitriou J. (2007)
    3. Re-expression of the retinoblastoma-binding protein 2-homolog 1 reveals tumor-suppressive functions in highly metastatic melanoma cells. (PubMed id 16645588)1, 2 Roesch A....Vogt T. (2006)
    4. Retinoblastoma-binding protein 2-homolog 1: a retinoblastoma-binding protein downregulated in malignant melanomas. (PubMed id 15803180)1, 2 Roesch A....Vogt T. (2005)
    5. Human PLU-1 has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9. (PubMed id 12657635)1, 2 Tan K....Freemont P.S. (2003)
    6. PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: a new cancer/testis antigen? (PubMed id 12237901)1, 2 Barrett A.... Taylor-Papadimitriou J. (2002)
    7. Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs. (PubMed id 11483573)1, 3 Lahoud M.H....Kola I. (2001)
    8. Dynamics of the Mrf-2 DNA-binding domain free and in complex with DNA. (PubMed id 11478881)1, 3 Zhu L....Chen Y. (2001)
    9. Isolation and chromosomal localization of a new human retinoblastoma binding protein 2 homologue 1a (RBBP2H1A). (PubMed id 10878660)1, 2 Kashuba V.... Zabarovsky E. (2000)
    10. A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer. (PubMed id 10336460)1, 2 Lu P.J....Taylor-Papadimitriou J. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10765 HGNC: 18039 AceView: JARID1B Ensembl:ENSG00000117139 euGenes: HUgn10765
    ECgene: KDM5B H-InvDB: KDM5B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KDM5B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KDM5B gene:
    Search GeneIP for patents involving KDM5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of KDM5B
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for KDM5B (Lysine (K)-specific Demethylase 5B/KDM5B)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KDM5B  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for KDM5B  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KDM5B  
     OriGene qSTAR qPCR primer pairs in human, mouse for KDM5B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KDM5B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KDM5B   OriGene Custom Protein Services for KDM5B  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KDM5B
     QIAGEN SeqTarget long-range PCR primers for resequencing KDM5B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KDM5B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KDM5B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KDM5B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KDM5B
     GenScript Custom Purified and Recombinant Proteins Services for KDM5B GenScript cDNA clones with any tag delivered in your preferred vector for KDM5B
     GenScript Custom Assay Services for KDM5B GenScript Custom Superior Antibodies Services for KDM5B
     GenScript Custom overexpressing Cell Line Services for KDM5B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for KDM5B  (JARID1B)

     Regulatory tfbs in KDM5B promoter
     Search Chromatin IP Primers for KDM5B
     RT2 qPCR Primer Assay in human, mouse, rat KDM5B
     GNC Network for KDM5B
     SABiosciences PCR Arrays including human, mouse, rat KDM5B
     Search Tocris compounds for KDM5B
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KDM5B antibodies
     KDM5B proteins
     KDM5B lysates
     Antibodies for KDM5B
     See all of Abcam's Antibodies, Kits and Proteins for KDM5B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for KDM5B
     Antibodies for KDM5B
     ELISAs for KDM5B
     CLIAs for KDM5B
     Search LifeMap BioReagents cell lines for KDM5B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM5B
     SwitchGear 3'UTR luciferase reporter plasmids for KDM5B
     SwitchGear Promoter luciferase reporter plasmids for KDM5B
     Search ThermoFisher Antibodies for KDM5B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KDM5B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for KDM5B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KDM5B
    Customized:
     lentivirus for stable overexpression
     lentivirus expression plasmids for stable overexpression
     adenovirus for overexpression of KDM5B
     LSBio Antibodies in human, mouse, rat for KDM5B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KDM5B gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4