Aliases for KDM5A Gene
Aliases for KDM5A Gene
External Ids for KDM5A Gene
- HGNC: 9886
- Entrez Gene: 5927
- Ensembl: ENSG00000073614
- OMIM: 180202
- UniProtKB: P29375
Previous HGNC Symbols for KDM5A Gene
- RBBP2
- JARID1A
Previous GeneCards Identifiers for KDM5A Gene
- GC12M000259
- GC12M000389
Summaries for KDM5A Gene
-
This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013]
GeneCards Summary for KDM5A Gene
KDM5A (Lysine Demethylase 5A) is a Protein Coding gene. Diseases associated with KDM5A include Retinoblastoma. Among its related pathways are Chromatin organization and Visual Cycle in Retinal Rods. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription coactivator activity. An important paralog of this gene is KDM5D.
UniProtKB/Swiss-Prot for KDM5A Gene
-
Histone demethylase that specifically demethylates Lys-4 of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 Lys-9, H3 Lys-27, H3 Lys-36, H3 Lys-79 or H4 Lys-20. Demethylates trimethylated and dimethylated but not monomethylated H3 Lys-4. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity).
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KDM5A Gene
Genomics for KDM5A Gene
Regulatory Elements for KDM5A Gene
Enhancers for KDM5A Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around KDM5A on UCSC Golden Path with GeneCards custom track
Promoters for KDM5A Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around KDM5A on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the KDM5A gene promoter:
Regulatory Element Products
Genomic Location for KDM5A Gene
- Chromosome:
- 12
- Start:
- 280,057 bp from pter
- End:
- 389,455 bp from pter
- Size:
- 109,399 bases
- Orientation:
- Minus strand
Genomic View for KDM5A Gene
Genes around KDM5A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p13.33 by Ensembl
- 12p11 by Entrez Gene
- 12p13.33 by HGNC
KDM5A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KDM5A Gene
Proteins for KDM5A Gene
-
Protein details for KDM5A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P29375-KDM5A_HUMAN
- Recommended name:
- Lysine-specific demethylase 5A
- Protein Accession:
- P29375
- A8MV76
- Q4LE72
- Q86XZ1
Protein attributes for KDM5A Gene
- Size:
- 1690 amino acids
- Molecular mass:
- 192095 Da
- Cofactor:
- Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
- Quaternary structure:
-
- Interacts with SUZ12; the interaction is direct (By similarity). Interacts with the viral protein-binding domain of RB1. Interacts with ESR1, MYC, MYCN and LMO2. Interacts with HDAC1 (By similarity). Interacts with ARNTL/BMAL1 and CLOCK.
- SequenceCaution:
-
- Sequence=AAB28544.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=BAE06081.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for KDM5A Gene
Protein Expression for KDM5A Gene
Selected DME Specific Peptides for KDM5A Gene
Post-translational modifications for KDM5A Gene
Other Protein References for KDM5A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for KDM5A (JARID1A)
-
Custom Antibody ServicesOriGene Antibodies for KDM5A
- Novus Biologicals Antibodies for KDM5A
- antibodies-online Antibodies for KDM5A: See all 63
- Search GeneTex for Antibodies for KDM5A
-
Santa Cruz Biotechnology (SCBT) Antibodies for KDM5A
Protein Products
-
OriGene Purified Proteins for KDM5A
- Search Origene for MassSpec and Protein Over-expression Lysates for KDM5A
- Origene Custom Protein Services for KDM5A
- Novus Biologicals proteins for KDM5A
- antibodies-online Proteins for KDM5A: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for KDM5A
Assay Products
- antibodies-online Kits for KDM5A: See all 1
Domains & Families for KDM5A Gene
Gene Families for KDM5A Gene
Protein Domains for KDM5A Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for KDM5A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P29375UniProtKB/Swiss-Prot:
KDM5A_HUMAN :- The GSGFP motif is required for the interaction with SUZ12.
- Belongs to the JARID1 histone demethylase family.
- Contains 3 PHD-type zinc fingers.
- Domain:
-
- The GSGFP motif is required for the interaction with SUZ12.
- Contains 1 ARID domain.
- Contains 1 JmjC domain.
- Contains 1 JmjN domain.
- Family:
-
- Belongs to the JARID1 histone demethylase family.
- Similarity:
-
- Contains 3 PHD-type zinc fingers.
Function for KDM5A Gene
Molecular function for KDM5A Gene
- UniProtKB/Swiss-Prot Function:
- Histone demethylase that specifically demethylates Lys-4 of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 Lys-9, H3 Lys-27, H3 Lys-36, H3 Lys-79 or H4 Lys-20. Demethylates trimethylated and dimethylated but not monomethylated H3 Lys-4. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity).
Enzyme Numbers (IUBMB) for KDM5A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IEA,IPI | 21960634 |
| GO:0031490 | chromatin DNA binding | IEA | -- |
Phenotypes for KDM5A Gene
- MGI mutant phenotypes for KDM5A:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for KDM5A:
Animal Models for KDM5A Gene
- MGI Knock Outs for KDM5A:
-
- Kdm5a tm1.1Kael
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for KDM5A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KDM5A gene
- Search ViGene Biosciences for KDM5A
CRISPR Products
-
OriGene CRISPR knockouts for KDM5A
-
Santa Cruz Biotechnology (SCBT) CRISPR for KDM5A
- GenScript: Design CRISPR guide RNA sequences for KDM5A
miRNA for KDM5A Gene
- miRTarBase miRNAs that target KDM5A
-
- hsa-mir-335-5p (MIRT017637)
- hsa-mir-130b-5p (MIRT134442)
- hsa-mir-517-5p (MIRT134449)
- hsa-mir-5684 (MIRT134487)
- hsa-mir-136-5p (MIRT440398)
- hsa-mir-526a (MIRT441623)
- hsa-mir-523-5p (MIRT441624)
- hsa-mir-522-5p (MIRT441625)
- hsa-mir-520c-5p (MIRT441626)
- hsa-mir-519c-5p (MIRT441627)
- hsa-mir-519b-5p (MIRT441628)
- hsa-mir-519a-5p (MIRT441629)
- hsa-mir-518f-5p (MIRT441630)
- hsa-mir-518e-5p (MIRT441631)
- hsa-mir-518d-5p (MIRT441632)
- hsa-mir-4662a-5p (MIRT441633)
- hsa-mir-539-5p (MIRT441634)
- hsa-mir-520g-5p (MIRT441635)
- hsa-mir-3123 (MIRT441636)
- hsa-mir-3925-5p (MIRT441637)
- hsa-mir-4797-5p (MIRT441638)
- hsa-mir-618 (MIRT441639)
- hsa-mir-4284 (MIRT623444)
- hsa-mir-4772-3p (MIRT623445)
- hsa-mir-4638-5p (MIRT623446)
- hsa-mir-1307-3p (MIRT623447)
- hsa-mir-1304-3p (MIRT623448)
- hsa-mir-6741-3p (MIRT623449)
- hsa-mir-4485-5p (MIRT623450)
- hsa-mir-6890-3p (MIRT623451)
- hsa-mir-4655-5p (MIRT623452)
- hsa-mir-559 (MIRT623453)
- hsa-mir-548y (MIRT623454)
- hsa-mir-548w (MIRT623455)
- hsa-mir-548o-5p (MIRT623456)
- hsa-mir-548j-5p (MIRT623457)
- hsa-mir-548i (MIRT623458)
- hsa-mir-548h-5p (MIRT623459)
- hsa-mir-548d-5p (MIRT623460)
- hsa-mir-548c-5p (MIRT623461)
- hsa-mir-548bb-5p (MIRT623462)
- hsa-mir-548b-5p (MIRT623463)
- hsa-mir-548ay-5p (MIRT623464)
- hsa-mir-548au-5p (MIRT623465)
- hsa-mir-548as-5p (MIRT623466)
- hsa-mir-548ar-5p (MIRT623467)
- hsa-mir-548aq-5p (MIRT623468)
- hsa-mir-548ap-5p (MIRT623469)
- hsa-mir-548am-5p (MIRT623470)
- hsa-mir-548ak (MIRT623471)
- hsa-mir-548ae-5p (MIRT623472)
- hsa-mir-548ad-5p (MIRT623473)
- hsa-mir-548ab (MIRT623474)
- hsa-mir-548a-5p (MIRT623475)
- hsa-mir-548n (MIRT623476)
- hsa-mir-548x-3p (MIRT623477)
- hsa-mir-548j-3p (MIRT623478)
- hsa-mir-548aq-3p (MIRT623479)
- hsa-mir-548am-3p (MIRT623480)
- hsa-mir-548aj-3p (MIRT623481)
- hsa-mir-548ah-3p (MIRT623482)
- hsa-mir-548ae-3p (MIRT623483)
- hsa-mir-4634 (MIRT628060)
- hsa-mir-548z (MIRT656977)
- hsa-mir-548h-3p (MIRT656978)
- hsa-mir-548d-3p (MIRT656979)
- hsa-mir-548bb-3p (MIRT656980)
- hsa-mir-548ac (MIRT656981)
- hsa-mir-96-5p (MIRT656982)
- hsa-mir-1271-5p (MIRT656983)
- hsa-mir-182-5p (MIRT656984)
- hsa-mir-6809-3p (MIRT656985)
- hsa-mir-7150 (MIRT656986)
- hsa-mir-4753-3p (MIRT656987)
- hsa-mir-4778-3p (MIRT656988)
- hsa-mir-136-3p (MIRT656989)
- hsa-mir-181c-5p (MIRT727401)
- hsa-mir-181d-5p (MIRT727402)
- hsa-mir-181b-5p (MIRT727403)
- hsa-mir-181a-5p (MIRT727404)
miRNA Products
- Search ViGene Biosciences for KDM5A
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for KDM5A
- Browse OriGene Inhibitory RNA Products For KDM5A
-
ViGene Biosciences ready-to-package AAV shRNAs for KDM5A gene
Clone Products
- OriGene clones in human for KDM5A
- OriGene ORF clones in human,rat for KDM5A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for KDM5A
Cell Line Products
-
Horizon Cell Lines for KDM5A
-
ViGene Biosciences adenoviral particle packaged cDNA for KDM5A gene
-
ViGene Biosciences lentiviral particle packaged cDNA for KDM5A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KDM5A gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KDM5A Gene
Localization for KDM5A Gene
Subcellular locations from UniProtKB/Swiss-Prot for KDM5A Gene
- Nucleus, nucleolus. Nucleus. Note=Occupies promoters of genes involved in RNA metabolism and mitochondrial function. {ECO:0000250 UniProtKB:Q3UXZ9}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
No data available for Gene Ontology (GO) - Cellular Components for KDM5A Gene
Pathways & Interactions for KDM5A Gene
More details on SuperPathways for KDM5APathways by source for KDM5A Gene
1 GeneTex pathway for KDM5A Gene
1 Cell Signaling Technology pathway for KDM5A Gene
3 Reactome pathways for KDM5A Gene
1 Qiagen pathway for KDM5A Gene
Interacting Proteins for KDM5A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007283 | spermatogenesis | IEA | -- |
| GO:0045893 | positive regulation of transcription, DNA-templated | IDA | 11358960 |
| GO:0055114 | oxidation-reduction process | IEA | -- |
| GO:1901726 | negative regulation of histone deacetylase activity | IEA,ISS | -- |
Drugs & Compounds for KDM5A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| IOX 1 | Pharma | Histone demethylase inhibitor; cell permeable | 0 | |||
| JIB-04 | Pharma | Jumonji histone demethylase inihibitor | 0 | |||
| ML324 | Pharma | JMJD2 demethylase inhibitor, potent and cell-permeable | 0 | |||
| SP2509 | Pharma | Demethylase 1 (LSD1) antagonist, novel Lysine-specific | 0 | |||
| Tranylcypromine hydrochloride | Pharma | Irreversible inhibitor of LSD1; also inhibits MAO | 0 |
(5) ApexBio Compounds for KDM5A Gene
| Compound | Action | Cas Number |
|---|---|---|
| IOX 1 | 5852-78-8 | |
| JIB-04 | Jumonji histone demethylase inihibitor | 199596-05-9 |
| ML324 | JMJD2 demethylase inhibitor, potent and cell-permeable | 1222800-79-4 |
| SP2509 | Demethylase 1 (LSD1) antagonist, novel Lysine-specific | 1423715-09-6 |
| Tranylcypromine hydrochloride | 1986-47-6 |
Drug Products
- ApexBio compounds for KDM5A
Transcripts for KDM5A Gene
mRNA/cDNA for KDM5A Gene
- (2) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (416) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for KDM5A Gene
- Lysine (K)-specific demethylase 5A:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for KDM5A
-
Santa Cruz Biotechnology (SCBT) CRISPR for KDM5A
- GenScript: Design CRISPR guide RNA sequences for KDM5A
miRNA Products
- Search ViGene Biosciences for KDM5A
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for KDM5A
- Browse OriGene Inhibitory RNA Products For KDM5A
-
ViGene Biosciences ready-to-package AAV shRNAs for KDM5A gene
Clone Products
- OriGene clones in human for KDM5A
- OriGene ORF clones in human,rat for KDM5A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for KDM5A
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
| ExUns: | 24b | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | · | 27c | ^ | 28 | ^ | 29 | ^ | 30 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||
| SP2: | |||||||||||||||||
| SP3: | |||||||||||||||||
| SP4: | |||||||||||||||||
| SP5: | |||||||||||||||||
| SP6: | |||||||||||||||||
| SP7: |
Expression for KDM5A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- pre Conventional Dendritic Cells Peripheral Blood
-
Gonad (Reproductive System)
- Testis Somatic Cells Primitive Gonad
-
Testis (Reproductive System)
- Testis Somatic Cells Primitive Gonad
- Limb (Muscoskeletal System)
- Eye (Sensory Organs)
-
Thyroid (Endocrine System)
This gene is overexpressed in Peripheral blood mononuclear cells (16.5), Blymphocyte (13.9), Liver (10.6), and Bone marrow mesenchymal stem cell (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KDM5A Gene
SOURCE GeneReport for Unigene cluster for KDM5A Gene Hs.76272
Primer Products
-
OriGene qPCR primer pairs for KDM5A
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KDM5A Gene
Orthologs for KDM5A Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | KDM5A 35 |
|
||
| KDM5A 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | KDM5A 35 |
|
||
| KDM5A 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Kdm5a 35 |
|
||
| Kdm5a 16 |
|
||||
| Kdm5a 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | KDM5A 35 |
|
||
| KDM5A 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Kdm5a 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | KDM5A 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 36 |
|
OneToMany | |
| -- 36 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | KDM5A 35 |
|
||
| KDM5A 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | KDM5A 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | kdm5a 35 |
|
||
| Str.17676 35 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | kdm5a 35 |
|
||
| KDM5A 36 |
|
OneToOne | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004854 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | lid 35 |
|
||
| lid 36 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | rbr-2 36 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | JHD2 36 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToMany |
- Species with no ortholog for KDM5A:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for KDM5A Gene
(11) SIMAP similar genes for KDM5A Gene using alignment to 6 proteins:
Variants for KDM5A Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs11062385 | - | 318,409(-) | CATGA(C/G/T)GGATG | reference, missense | |
| rs2229353 | - | 307,816(-) | GTGTT(C/G)CTCTT | reference, missense | |
| rs2015554 | -- | 385,108(+) | aaccc(A/G)ggagg | intron-variant | |
| rs2041299 | -- | 358,853(+) | tataa(C/T)cccag | intron-variant | |
| rs2052279 | -- | 325,412(+) | gtgcc(A/G)tggct | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv898563 | CNV | Gain | 21882294 |
| dgv451e1 | CNV | Complex | 17122850 |
| dgv452e1 | CNV | Complex | 17122850 |
| nsv570 | CNV | Loss | 18451855 |
| nsv898564 | CNV | Loss | 21882294 |
| esv34939 | CNV | Loss | 17911159 |
| nsv819688 | CNV | Loss | 19587683 |
| esv33025 | CNV | Gain | 17666407 |
| nsv898565 | CNV | Gain | 21882294 |
| nsv8883 | CNV | Gain+Loss | 18304495 |
| esv33918 | CNV | Gain | 17666407 |
| nsv442250 | CNV | CNV | 18776908 |
| essv9499 | CNV | CNV | 17122850 |
Residual Variation Intolerance Score:
1.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
11.31;
92.60% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for KDM5A Gene
- Human Gene Mutation Database (HGMD)
- KDM5A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KDM5A Gene
Disorders for KDM5A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinoblastoma |
|
Search KDM5A in MalaCards
View complete list of genes associated with diseases
Relevant External Links for KDM5A
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- KDM5A
No data available for UniProtKB/Swiss-Prot and Genatlas for KDM5A Gene
Publications for KDM5A Gene
- Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product. (PMID: 1857421) Defeo-Jones D. … Oliff A. (Nature 1991) 2 3 4 23 67
- RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation. (PMID: 17573780) Hayakawa T. … Nakayama J. (Genes Cells 2007) 3 23
- Retinoblastoma-binding protein 2 (Rbp2) potentiates nuclear hormone receptor-mediated transcription. (PMID: 11358960) Chan S.W. … Hong W. (J. Biol. Chem. 2001) 3 23
- T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2. (PMID: 9129143) Mao S. … Goorha R.M. (Oncogene 1997) 3 23
- Isolation and regional assignment of human chromosome 12p cDNAs. (PMID: 8530100) Baens M. … Marynen P. (Genomics 1995) 3 23
Products for KDM5A Gene
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- Custom Antibody ServicesOriGene Antibodies for KDM5A
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- antibodies-online Antibodies for KDM5A: See all 63
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- ViGene Biosciences adenoviral particle packaged cDNA for KDM5A gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for KDM5A
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Sources for KDM5A Gene
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