Aliases for KDM5A Gene
Aliases for KDM5A Gene
External Ids for KDM5A Gene
- HGNC: 9886
- Entrez Gene: 5927
- Ensembl: ENSG00000073614
- OMIM: 180202
- UniProtKB: P29375
Previous HGNC Symbols for KDM5A Gene
- RBBP2
- JARID1A
Previous GeneCards Identifiers for KDM5A Gene
- GC12M000259
- GC12M000389
Summaries for KDM5A Gene
-
This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013]
GeneCards Summary for KDM5A Gene
KDM5A (Lysine Demethylase 5A) is a Protein Coding gene. Diseases associated with KDM5A include Retinoblastoma and Alopecia Universalis Congenita. Among its related pathways are Circadian rythm related genes and Chromatin organization. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is KDM5B.
UniProtKB/Swiss-Prot for KDM5A Gene
-
Histone demethylase that specifically demethylates Lys-4 of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 Lys-9, H3 Lys-27, H3 Lys-36, H3 Lys-79 or H4 Lys-20. Demethylates trimethylated and dimethylated but not monomethylated H3 Lys-4. Regulates specific gene transcription through DNA-binding on 5-CCGCCC-3 motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228).
Additional gene information for KDM5A Gene
- Monarch Initiative
- Search for KDM5A at DataMed
- Search for KDM5A at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KDM5A Gene
Genomics for KDM5A Gene
GeneHancer (GH) Regulatory Elements for KDM5A Gene
Promoters and enhancers for KDM5A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around KDM5A on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for KDM5A Gene
Genomic Locations for KDM5A Gene
- chr12:280,057-389,455
- (GRCh38/hg38)
- Size:
- 109,399 bases
- Orientation:
- Minus strand
- chr12:389,223-498,620
- (GRCh37/hg19)
Genomic View for KDM5A Gene
Genes around KDM5A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p13.33 by Ensembl
- 12p13.33 by Entrez Gene
- 12p13.33 by HGNC
KDM5A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KDM5A Gene
Proteins for KDM5A Gene
-
Protein details for KDM5A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P29375-KDM5A_HUMAN
- Recommended name:
- Lysine-specific demethylase 5A
- Protein Accession:
- P29375
- A8MV76
- Q4LE72
- Q86XZ1
Protein attributes for KDM5A Gene
- Size:
- 1690 amino acids
- Molecular mass:
- 192095 Da
- Cofactor:
- Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
- Quaternary structure:
-
- Interacts with SUZ12; the interaction is direct (By similarity). Interacts with the viral protein-binding domain of RB1. Interacts with ESR1, MYC, MYCN and LMO2. Interacts with HDAC1 (By similarity). Interacts with ARNTL/BMAL1 and CLOCK. Interacts (via PHD-type 1 zinc finger) with histone H3 unmodified at Lys-4 and (via PHD-type 3 zinc finger) with histone H3 di- and trimethylated at Lys-4 (PubMed:19430464).
- SequenceCaution:
-
- Sequence=AAB28544.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=BAE06081.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for KDM5A Gene
Protein Expression for KDM5A Gene
Selected DME Specific Peptides for KDM5A Gene
- P29375:
-
- EAFGFEQA
- NFAEAVNF
- QRLNELEA
- DYFNMPVHMVPTE
- TFLKKNS
- RTNQCAGEFV
- CVFSHEELI
- EKEFWRLV
- RPRLETIL
- SQPDLLHQLVTIMNPN
- EQSVLAHI
- LLCDGCDDSYHTFCL
- HYRRLRR
- VERKILDL
- GEPKTWY
- ERWEEKA
- YSINYLH
- TTCFLSA
- PPPECPVFEPSW
- PWLYVGM
Post-translational modifications for KDM5A Gene
- Ubiquitination at posLast=347347, posLast=425425, posLast=733733, and isoforms=21275
Other Protein References for KDM5A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for KDM5A (JARID1A)
-
Custom Antibody ServicesOriGene Antibodies for KDM5A
- Novus Biologicals Antibodies for KDM5A
-
Abcam antibodies for KDM5A
- Invitrogen Antibodies for KDM5A
- antibodies-online: Search results for 74 available KDM5A Antibodies ranked by validation data
- Compare Top KDM5A Antibodies
-
Recommended
- 3 IHC (p) Antibodies (anti-mouse)
- 9 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 48 WB Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-rat)
- 5 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- Search GeneTex for Antibodies for KDM5A
-
Santa Cruz Biotechnology (SCBT) Antibodies for KDM5A
Protein Products
-
OriGene Purified Proteins for KDM5A
- Search Origene for MassSpec and Protein Over-expression Lysates for KDM5A
- Origene Custom Protein Services for KDM5A
- Novus Biologicals proteins for KDM5A
- Search GeneTex for Proteins for KDM5A
-
Abcam proteins for KDM5A
Assay Products
- antibodies-online: Search results for 1 available KDM5A Elisa Kits ranked by validation data
- Compare Top KDM5A Elisa Kits
-
Recommended
Domains & Families for KDM5A Gene
Gene Families for KDM5A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for KDM5A Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for KDM5A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P29375UniProtKB/Swiss-Prot:
KDM5A_HUMAN :- The GSGFP motif is required for the interaction with SUZ12 (By similarity). The ARID domain specifically binds to the CCGCCC motif and is required for the lysine-specific histone demethylase activity (PubMed:18270511). The PHD-type 3 zinc finger is required for the interaction with histone H3 di- and trimethylated at Lys-4 (PubMed:19430464).
- Belongs to the JARID1 histone demethylase family.
- Domain:
-
- The GSGFP motif is required for the interaction with SUZ12 (By similarity). The ARID domain specifically binds to the CCGCCC motif and is required for the lysine-specific histone demethylase activity (PubMed:18270511). The PHD-type 3 zinc finger is required for the interaction with histone H3 di- and trimethylated at Lys-4 (PubMed:19430464).
- Family:
-
- Belongs to the JARID1 histone demethylase family.
Function for KDM5A Gene
Molecular function for KDM5A Gene
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=9 uM for 2-oxoglutarate {ECO:0000269 PubMed:27427228}; KM=2.9 uM for histone H3K4me3 {ECO:0000269 PubMed:27427228}; Note=Kcat are 2.1 min(-1) and 1.9 min(-1) for 2-oxoglutarate and histone H3K4me3, respectively. {ECO:0000269 PubMed:27427228};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- The inhibitors KDOAM-25, CPI-455 and others inhibits its demethylase activity, resulting to cell growth arrest in cancer cells.
- UniProtKB/Swiss-Prot Function:
- Histone demethylase that specifically demethylates Lys-4 of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 Lys-9, H3 Lys-27, H3 Lys-36, H3 Lys-79 or H4 Lys-20. Demethylates trimethylated and dimethylated but not monomethylated H3 Lys-4. Regulates specific gene transcription through DNA-binding on 5-CCGCCC-3 motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228).
Enzyme Numbers (IUBMB) for KDM5A Gene
Phenotypes From GWAS Catalog for KDM5A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001046 | core promoter sequence-specific DNA binding | IMP | 18270511 |
| GO:0003677 | DNA binding | IEA,IDA | 15640446 |
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | IMP | 18270511 |
| GO:0003713 | transcription coactivator activity | IEA,ISS | -- |
Phenotypes for KDM5A Gene
- MGI mutant phenotypes for KDM5A:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for KDM5A:
Animal Models for KDM5A Gene
- MGI Knock Outs for KDM5A:
-
- Kdm5a tm1.1Kael
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for KDM5A
-
-
ViGene Biosciences lentiviral particle packaged cDNA for KDM5A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KDM5A gene
- Search ViGene Biosciences for KDM5A
CRISPR Products
-
OriGene CRISPR knockouts for KDM5A
- genomics-online: gRNA clones - Search results for 44 available KDM5A gene related products
- Overview of 44 available KDM5A gene related products
- Applied Biological Materials CRISPR for KDM5A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KDM5A
- GenScript: Design CRISPR guide RNA sequences for KDM5A
miRNA for KDM5A Gene
- miRTarBase miRNAs that target KDM5A
-
- hsa-mir-335-5p (MIRT017637)
- hsa-mir-130b-5p (MIRT134442)
- hsa-mir-517-5p (MIRT134449)
- hsa-mir-5684 (MIRT134487)
- hsa-mir-136-5p (MIRT440398)
- hsa-mir-526a (MIRT441623)
- hsa-mir-523-5p (MIRT441624)
- hsa-mir-522-5p (MIRT441625)
- hsa-mir-520c-5p (MIRT441626)
- hsa-mir-519c-5p (MIRT441627)
- hsa-mir-519b-5p (MIRT441628)
- hsa-mir-519a-5p (MIRT441629)
- hsa-mir-518f-5p (MIRT441630)
- hsa-mir-518e-5p (MIRT441631)
- hsa-mir-518d-5p (MIRT441632)
- hsa-mir-4662a-5p (MIRT441633)
- hsa-mir-539-5p (MIRT441634)
- hsa-mir-520g-5p (MIRT441635)
- hsa-mir-3123 (MIRT441636)
- hsa-mir-3925-5p (MIRT441637)
- hsa-mir-4797-5p (MIRT441638)
- hsa-mir-618 (MIRT441639)
- hsa-mir-4284 (MIRT623444)
- hsa-mir-4772-3p (MIRT623445)
- hsa-mir-4638-5p (MIRT623446)
- hsa-mir-1307-3p (MIRT623447)
- hsa-mir-1304-3p (MIRT623448)
- hsa-mir-6741-3p (MIRT623449)
- hsa-mir-4485-5p (MIRT623450)
- hsa-mir-6890-3p (MIRT623451)
- hsa-mir-4655-5p (MIRT623452)
- hsa-mir-559 (MIRT623453)
- hsa-mir-548y (MIRT623454)
- hsa-mir-548w (MIRT623455)
- hsa-mir-548o-5p (MIRT623456)
- hsa-mir-548j-5p (MIRT623457)
- hsa-mir-548i (MIRT623458)
- hsa-mir-548h-5p (MIRT623459)
- hsa-mir-548d-5p (MIRT623460)
- hsa-mir-548c-5p (MIRT623461)
- hsa-mir-548bb-5p (MIRT623462)
- hsa-mir-548b-5p (MIRT623463)
- hsa-mir-548ay-5p (MIRT623464)
- hsa-mir-548au-5p (MIRT623465)
- hsa-mir-548as-5p (MIRT623466)
- hsa-mir-548ar-5p (MIRT623467)
- hsa-mir-548aq-5p (MIRT623468)
- hsa-mir-548ap-5p (MIRT623469)
- hsa-mir-548am-5p (MIRT623470)
- hsa-mir-548ak (MIRT623471)
- hsa-mir-548ae-5p (MIRT623472)
- hsa-mir-548ad-5p (MIRT623473)
- hsa-mir-548ab (MIRT623474)
- hsa-mir-548a-5p (MIRT623475)
- hsa-mir-548n (MIRT623476)
- hsa-mir-548x-3p (MIRT623477)
- hsa-mir-548j-3p (MIRT623478)
- hsa-mir-548aq-3p (MIRT623479)
- hsa-mir-548am-3p (MIRT623480)
- hsa-mir-548aj-3p (MIRT623481)
- hsa-mir-548ah-3p (MIRT623482)
- hsa-mir-548ae-3p (MIRT623483)
- hsa-mir-4634 (MIRT628060)
- hsa-mir-548z (MIRT656977)
- hsa-mir-548h-3p (MIRT656978)
- hsa-mir-548d-3p (MIRT656979)
- hsa-mir-548bb-3p (MIRT656980)
- hsa-mir-548ac (MIRT656981)
- hsa-mir-96-5p (MIRT656982)
- hsa-mir-1271-5p (MIRT656983)
- hsa-mir-182-5p (MIRT656984)
- hsa-mir-6809-3p (MIRT656985)
- hsa-mir-7150 (MIRT656986)
- hsa-mir-4753-3p (MIRT656987)
- hsa-mir-4778-3p (MIRT656988)
- hsa-mir-136-3p (MIRT656989)
- hsa-mir-181c-5p (MIRT727401)
- hsa-mir-181d-5p (MIRT727402)
- hsa-mir-181b-5p (MIRT727403)
- hsa-mir-181a-5p (MIRT727404)
miRNA Products
- Search ViGene Biosciences for KDM5A
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for KDM5A
- Browse OriGene Inhibitory RNA Products For KDM5A
- genomics-online: shRNA clones - Search results for 44 available KDM5A gene related products
- Overview of 44 available KDM5A gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for KDM5A gene
Clone Products
-
OriGene ORF clones in human for KDM5A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for KDM5A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KDM5A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for KDM5A
- Applied Biological Materials Clones for KDM5A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for KDM5A
-
ViGene Biosciences adenoviral particle packaged cDNA for KDM5A gene
-
ViGene Biosciences lentiviral particle packaged cDNA for KDM5A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KDM5A gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KDM5A Gene
Localization for KDM5A Gene
Subcellular locations from UniProtKB/Swiss-Prot for KDM5A Gene
- Nucleus, nucleolus. Nucleus. Note=Occupies promoters of genes involved in RNA metabolism and mitochondrial function. {ECO:0000250 UniProtKB:Q3UXZ9}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
- Nuclear bodies (3)
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 18270511 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005730 | nucleolus | IEA | -- |
| GO:0019907 | colocalizes_with cyclin-dependent protein kinase activating kinase holoenzyme complex | IDA | 11445587 |
| GO:0032993 | protein-DNA complex | IEA | -- |
Pathways & Interactions for KDM5A Gene
Pathways by source for KDM5A Gene
1 GeneTex pathway for KDM5A Gene
1 Cell Signaling Technology pathway for KDM5A Gene
1 BioSystems pathway for KDM5A Gene
3 Reactome pathways for KDM5A Gene
1 Qiagen pathway for KDM5A Gene
Interacting Proteins for KDM5A Gene
Selected Interacting proteins:
ENSP00000382688
P29375-KDM5A_HUMAN
for KDM5A Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006366 | transcription by RNA polymerase II | TAS | 8414517 |
| GO:0007275 | multicellular organism development | IEA | -- |
Drugs & Compounds for KDM5A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| IOX 1 | Pharma | 0 | ||||
| JIB-04 | Pharma | Jumonji histone demethylase inihibitor | 0 | |||
| ML324 | Pharma | JMJD2 demethylase inhibitor, potent and cell-permeable | 0 | |||
| SP2509 | Pharma | Demethylase 1 (LSD1) antagonist, novel Lysine-specific | 0 | |||
| Tranylcypromine hydrochloride | Pharma | 0 |
(5) ApexBio Compounds for KDM5A Gene
| Compound | Action | Cas Number |
|---|---|---|
| IOX 1 | 5852-78-8 | |
| JIB-04 | Jumonji histone demethylase inihibitor | 199596-05-9 |
| ML324 | JMJD2 demethylase inhibitor, potent and cell-permeable | 1222800-79-4 |
| SP2509 | Demethylase 1 (LSD1) antagonist, novel Lysine-specific | 1423715-09-6 |
| Tranylcypromine hydrochloride | 1986-47-6 |
Transcripts for KDM5A Gene
mRNA/cDNA for KDM5A Gene
- (2) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (416) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for KDM5A Gene
- Lysine (K)-specific demethylase 5A:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for KDM5A
- genomics-online: gRNA clones - Search results for 44 available KDM5A gene related products
- Overview of 44 available KDM5A gene related products
- Applied Biological Materials CRISPR for KDM5A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KDM5A
- GenScript: Design CRISPR guide RNA sequences for KDM5A
miRNA Products
- Search ViGene Biosciences for KDM5A
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for KDM5A
- Browse OriGene Inhibitory RNA Products For KDM5A
- genomics-online: shRNA clones - Search results for 44 available KDM5A gene related products
- Overview of 44 available KDM5A gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for KDM5A gene
Clone Products
-
OriGene ORF clones in human for KDM5A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for KDM5A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KDM5A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for KDM5A
- Applied Biological Materials Clones for KDM5A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
| ExUns: | 24b | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | · | 27c | ^ | 28 | ^ | 29 | ^ | 30 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||
| SP2: | |||||||||||||||||
| SP3: | |||||||||||||||||
| SP4: | |||||||||||||||||
| SP5: | |||||||||||||||||
| SP6: | |||||||||||||||||
| SP7: |
Expression for KDM5A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- pre Conventional Dendritic Cells Peripheral Blood
-
Gonad (Reproductive System)
- Testis Somatic Cells Primitive Gonad
-
Testis (Reproductive System)
- Testis Somatic Cells Primitive Gonad
- Limb (Muscoskeletal System)
- Eye (Sensory Organs)
-
Thyroid (Endocrine System)
This gene is overexpressed in Peripheral blood mononuclear cells (16.5), Blymphocyte (13.9), Liver (10.6), and Bone marrow mesenchymal stem cell (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KDM5A Gene
NURSA nuclear receptor signaling pathways regulating expression of KDM5A Gene:
KDM5ASOURCE GeneReport for Unigene cluster for KDM5A Gene:
Hs.76272Evidence on tissue expression from TISSUES for KDM5A Gene
- Liver(4.3)
- Eye(4.1)
- Nervous system(3.1)
- Lung(2.7)
Primer Products
-
OriGene qPCR primer pairs for KDM5A
- genomics-online: primer clones - Search results for 44 available KDM5A gene related products
- Overview of 44 available KDM5A gene related products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KDM5A Gene
Orthologs for KDM5A Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KDM5A 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | KDM5A 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | KDM5A 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Kdm5a 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Kdm5a 33 |
|
||
| cow (Bos Taurus) |
Mammalia | KDM5A 33 34 |
|
||
| chicken (Gallus gallus) |
Aves | KDM5A 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | KDM5A 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | kdm5a 33 |
|
||
| Str.17676 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | KDM5A 34 |
|
OneToOne | |
| kdm5a 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004854 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | lid 33 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | rbr-2 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | JHD2 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for KDM5A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for KDM5A Gene
(11) SIMAP similar genes for KDM5A Gene using alignment to 6 proteins:
Variants for KDM5A Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs367537993 | not-provided, not provided | 293,103(-) | G/A | coding_sequence_variant, missense_variant | |
| rs1000017947 | -- | 280,239(-) | G/C | 3_prime_UTR_variant | |
| rs1000039021 | -- | 360,725(-) | T/G | intron_variant | |
| rs1000049651 | -- | 365,475(-) | C/G | intron_variant | |
| rs1000067097 | -- | 388,903(-) | C/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759875 | CNV | gain+loss | 17122850 |
| esv33025 | CNV | gain | 17666407 |
| esv33918 | CNV | gain | 17666407 |
| esv34939 | CNV | loss | 17911159 |
| esv3580008 | CNV | loss | 25503493 |
| esv3628231 | CNV | gain | 21293372 |
| esv3628232 | CNV | gain | 21293372 |
| esv3892121 | CNV | gain | 25118596 |
| nsv1050781 | CNV | loss | 25217958 |
| nsv1050912 | CNV | gain | 25217958 |
| nsv1069629 | CNV | deletion | 25765185 |
| nsv1138089 | CNV | deletion | 24896259 |
| nsv1143399 | CNV | deletion | 24896259 |
| nsv1146752 | CNV | deletion | 26484159 |
| nsv442250 | CNV | gain | 18776908 |
| nsv570 | CNV | deletion | 18451855 |
| nsv819688 | CNV | loss | 19587683 |
| nsv8883 | CNV | gain+loss | 18304495 |
Residual Variation Intolerance Score:
1.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
11.31;
92.60% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KDM5A Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KDM5A Gene
Disorders for KDM5A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinoblastoma |
|
|
| alopecia universalis congenita |
|
|
Search KDM5A in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for KDM5A
No data available for UniProtKB/Swiss-Prot and Genatlas for KDM5A Gene
Publications for KDM5A Gene
- Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product. (PMID: 1857421) Defeo-Jones D … Oliff A (Nature 1991) 2 3 4 22 58
- Retinoblastoma-binding protein 2 (Rbp2) potentiates nuclear hormone receptor-mediated transcription. (PMID: 11358960) Chan SW … Hong W (The Journal of biological chemistry 2001) 3 4 22 58
- T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2. (PMID: 9129143) Mao S … Goorha RM (Oncogene 1997) 3 4 22 58
- Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein. (PMID: 7935440) Kim YW … Kaye FJ (Molecular and cellular biology 1994) 3 4 22 58
- Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases. (PMID: 26645689) Horton JR … Cheng X (The Journal of biological chemistry 2016) 3 4 58
Products for KDM5A Gene
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- Custom Antibody ServicesOriGene Antibodies for KDM5A
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- Find your target
- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
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- Browse Antibodies at Cloud-Clone Corp.
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for KDM5A
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for KDM5A
- Cyagen custom Knockout/knockin (KOKI) mouse models for KDM5A
- VectorBuilder custom plasmid, inducible vectors for KDM5A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KDM5A
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for KDM5A
- antibodies-online: Search results for 74 available KDM5A Antibodies ranked by validation data
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- 4 IHC (p) Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 12 IF (p) Antibodies (anti-mouse)
- 9 WB Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- antibodies-online: Search results for 1 available KDM5A Elisa Kits ranked by validation data
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- Search GeneTex for Antibodies for KDM5A
- Search GeneTex for Proteins for KDM5A
- ViGene Biosciences adenoviral particle packaged cDNA for KDM5A gene
- ViGene Biosciences lentiviral particle packaged cDNA for KDM5A gene
- ViGene Biosciences ready-to-package AAV shRNAs for KDM5A gene
- Search ViGene Biosciences for KDM5A
- Santa Cruz Biotechnology (SCBT) Antibodies for KDM5A
- Search Santa Cruz Biotechnology (SCBT) for KDM5A siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for KDM5A
- Horizon Cell Lines for KDM5A
- genomics-online: cdna clones - Search results for 44 available KDM5A gene related products
- Overview of 44 available KDM5A gene related products
- orf clones - Search results for 44 available KDM5A gene related products
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- genomics-online: primer clones - Search results for 44 available KDM5A gene related products
- Overview of 44 available KDM5A gene related products
- genomics-online: shRNA clones - Search results for 44 available KDM5A gene related products
- Overview of 44 available KDM5A gene related products
Sources for KDM5A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew