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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KDM4E Gene

protein-coding GIFtS: 29
GCID: GC11P094759

lysine (K)-specific demethylase 4E

(Previous name: lysine (K)-specific demethylase 4D-like )
(Previous symbol: KDM4DL)

Explore 2 diseases affiliated with
KDM4E via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Lysine (K)-Specific Demethylase 4E¹ ²		Lysine (K)-Specific Demethylase 4D-Like¹
KDM4DL¹ ² ³		Lysine-Specific Demethylase 4E²
JMJD2E¹ ²		EC 1.14.11.-³
KDM4D-Like Protein² ³		Lysine-Specific Demethylase 4D-Like³

External Ids:	HGNC: 37098¹	Entrez Gene: 390245²	Ensembl: ENSG00000235268⁷	UniProtKB: B2RXH2³

Export aliases for KDM4E gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: KDM4E_HUMAN, B2RXH2

Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in

histone code

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for KDM4E
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KDM4E

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q21 Ensembl cytogenetic band: 11q21 HGNC cytogenetic band: 11q21

KDM4E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KDM4E gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P094759: view genomic region (about GC identifiers)

Start:	94,758,422 bp from pter	End:	94,760,760 bp from pter
Size:	2,339 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
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About This Section

UniProtKB/Swiss-Prot: KDM4E_HUMAN, B2RXH2 (See protein sequence)

Recommended Name: Lysine-specific demethylase 4E

Size: 506 amino acids; 56804 Da

Cofactor: Binds 1 Fe(2+) ion per subunit

Subcellular location: Nucleus (By similarity)

1 PDB 3D structure from and Proteopedia for KDM4E:

2W2I (3D)

Explore the universe of human proteins at neXtProt for KDM4E: NX_B2RXH2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_B2RXH2

KDM4E Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001155102.1

ENSEMBL proteins:

ENSP00000397239

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

KDM4E for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KDM4E for domains About GeneDecksing

2 InterPro domains/families:

IPR003347 JmjC_dom

IPR003349 TF_JmjN

Graphical View of Domain Structure for InterPro Entry B2RXH2

ProtoNet protein and cluster: B2RXH2

UniProtKB/Swiss-Prot: KDM4E_HUMAN, B2RXH2

Similarity: Belongs to the JHDM3 histone demethylase family

Similarity: Contains 1 JmjC domain

Similarity: Contains 1 JmjN domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KDM4E_HUMAN, B2RXH2

Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in

histone code

Enzyme Number (IUBMB): EC 1.14.11.-¹

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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	--
GO:0046872	metal ion binding	IEA	--

KDM4E for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KDM4E

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0016568	chromatin modification	IEA	--

KDM4E for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KDM4E
Search CenterWatch for drugs/clinical trials and news about KDM4E

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for KDM4E gene:

NM_001161630.1

Unigene Cluster for KDM4E:

Lysine (K)-specific demethylase 4E

Hs.714692

Unigene Representative Sequence: BC157851

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000450979(uc010ruf.1)

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Additional cDNA sequence:

BC157851.1 BC157889.1 BC171916.1

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

See KDM4E Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.714692

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for KDM4E gene from 6/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	Q5ZMG6_CHICK⁶	Uncharacterized protein	23(a)	1 → many	28(4307621-4376554)
lizard (Anolis carolinensis)	Reptilia	KDM4C⁶ KDM4B⁶	--	5(a) 22(a)	possible ortholog 1 ↔ many	2(52946472-53065355) GL343661.1(3007-199112)
zebrafish (Danio rerio)	Actinopterygii	kdm4b⁶	lysine (K)-specific demethylase 4B	21(a)	1 → many	22(3888478-3981093)
fruit fly (Drosophila melanogaster)	Insecta	Kdm4A⁶ Kdm4B⁶	Histone demethylase 4B	37(a) 28(a)	many ↔ many many ↔ many	2R(3810280-3812488) 2R(9063599-9085869)
worm (Caenorhabditis elegans)	Secernentea	jmjd-2⁶	Lysine-specific demethylase 4	17(a)	1 → many	II(14234898-14243515)
rice (Oryza sativa)	Liliopsida	-- --	ZOS3-03 - C2H2 zinc finger protein, expressed	6(a)	possible ortholog possible ortholog	3(2712309-2714914) 3(2837768-2840687)

ENSEMBL Gene Tree for KDM4E (if available)
TreeFam Gene Tree for KDM4E (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KDM4E gene

KDM4D² KDM4A² KDM4C² KDM4B²

5 SIMAP similar genes for KDM4E using alignment to 1 protein entry: KDM4E_HUMAN:

KDM4C JMJD2B KDM4A KDM4B KDM4D

KDM4E for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for KDM4E
PGOHUM00000242868 PGOHUM00000262572

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189765376^1,2		--	94756457(+)	`AAGGGA/GTGCAT`	1	--	us2k¹		0	--	--	--	--
rs183132267^1,2		--	94756462(+)	`GTGCAA/TGATCG`	1	--	us2k¹		0	--	--	--	--
rs149636554^1,2		--	94756536(+)	`GGATGC/TGAAGG`	1	--	us2k¹		0	--	--	--	--
rs114402099^1,2	F,	--	94756600(+)	`TAGTGA/CAGGAA`	1	--	us2k¹		1		WA	118
rs189161156^1,2		--	94756609(+)	`AAGCAA/GATAAT`	1	--	us2k¹		0	--	--	--	--
rs192868384^1,2		--	94756630(+)	`TGTCTC/TGACCT`	1	--	us2k¹		0	--	--	--	--
rs11021010^1,2	C,	--	94756972(+)	`TTTTTC/TGACAA`	1	--	us2k¹		4		WA NA EA	360
rs35117736^1,2	C,F,	--	94756994(+)	`GTCTCG/ATAGGA`	1	--	us2k¹		4		NA CSA	8
rs139241996^1,2		--	94757021(+)	`GCCATC/TTTCTG`	1	--	us2k¹		0	--	--	--	--
rs183829191^1,2		--	94757028(+)	`TCTGGC/GCATTT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KDM4E (94758422 - 94760760 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KDM4E: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KDM4E for disorders About GeneDecksing

2 diseases for KDM4E: About MalaCards

retinoblastoma malaria

Export disorders for KDM4E gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KDM4E gene integrated from 9 sources:
(articles sorted by number of sources associating them with KDM4E)

Utopia: connect your pdf to the dynamic
world of online information

Inhibition of the histone demethylase JMJD2E by 3-subs tituted pyridine 2,4-dicarboxylates. (PubMed id 21076780)^{1, 3} Thalhammer A....Schofield C.J. (2011)
Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family. (PubMed id 21914792)² Hillringhaus L.... Oppermann U. (2011)
Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)² Taylor T.D....Sakaki Y. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 390245	HGNC: 37098	Ensembl:ENSG00000235268	euGenes: HUgn390245	ECgene: KDM4E
H-InvDB: KDM4E

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KDM4E	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KDM4E gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for KDM4E gene:
Search GeneIP for patents involving KDM4E

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes KDM4E gene at Home site.

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KDM4E Gene

lysine (K)-specific demethylase 4E

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KDM4E Gene

lysine (K)-specific demethylase 4E

Aliasesfor KDM4E gene

Summariesfor KDM4E gene

Genomic Viewsfor KDM4E gene

Proteinsfor KDM4E gene

Protein Domains /Familiesfor KDM4E gene

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for KDM4E gene

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for KDM4E gene

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for KDM4E gene

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