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Aliases for KDM4E Gene

Aliases for KDM4E Gene

  • Lysine Demethylase 4E 2 3
  • Lysine (K)-Specific Demethylase 4E 2 3 5
  • KDM4D-Like Protein 3 4
  • KDM4DL 3 4
  • Lysine (K)-Specific Demethylase 4D-Like 2
  • Lysine-Specific Demethylase 4D-Like 4
  • EC 1.14.11.- 4
  • JMJD2E 3

External Ids for KDM4E Gene

Previous HGNC Symbols for KDM4E Gene

  • KDM4DL

Previous GeneCards Identifiers for KDM4E Gene

  • GC11P094759

Summaries for KDM4E Gene

GeneCards Summary for KDM4E Gene

KDM4E (Lysine Demethylase 4E) is a Protein Coding gene. GO annotations related to this gene include dioxygenase activity. An important paralog of this gene is KDM4D.

UniProtKB/Swiss-Prot for KDM4E Gene

  • Histone demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KDM4E Gene

Genomics for KDM4E Gene

Genomic Location for KDM4E Gene

Chromosome:
11
Start:
95,025,258 bp from pter
End:
95,027,596 bp from pter
Size:
2,339 bases
Orientation:
Plus strand

Genomic View for KDM4E Gene

Genes around KDM4E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KDM4E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KDM4E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KDM4E Gene

No data available for Regulatory Elements for KDM4E Gene

Proteins for KDM4E Gene

  • Protein details for KDM4E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B2RXH2-KDM4E_HUMAN
    Recommended name:
    Lysine-specific demethylase 4E
    Protein Accession:
    B2RXH2

    Protein attributes for KDM4E Gene

    Size:
    506 amino acids
    Molecular mass:
    56804 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for KDM4E Gene

neXtProt entry for KDM4E Gene

Proteomics data for KDM4E Gene at MOPED

Post-translational modifications for KDM4E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KDM4E Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KDM4E Gene

Domains & Families for KDM4E Gene

Gene Families for KDM4E Gene

Protein Domains for KDM4E Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KDM4E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

B2RXH2

UniProtKB/Swiss-Prot:

KDM4E_HUMAN :
  • Contains 1 JmjC domain.
  • Belongs to the JHDM3 histone demethylase family.
Domain:
  • Contains 1 JmjC domain.
  • Contains 1 JmjN domain.
Family:
  • Belongs to the JHDM3 histone demethylase family.
genes like me logo Genes that share domains with KDM4E: view

Function for KDM4E Gene

Molecular function for KDM4E Gene

UniProtKB/Swiss-Prot Function:
Histone demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code.

Enzyme Numbers (IUBMB) for KDM4E Gene

genes like me logo Genes that share phenotypes with KDM4E: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KDM4E Gene

Localization for KDM4E Gene

Subcellular locations from UniProtKB/Swiss-Prot for KDM4E Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KDM4E Gene COMPARTMENTS Subcellular localization image for KDM4E gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for KDM4E Gene

Pathways & Interactions for KDM4E Gene

SuperPathways for KDM4E Gene

No Data Available

Gene Ontology (GO) - Biological Process for KDM4E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with KDM4E: view

No data available for Pathways by source and SIGNOR curated interactions for KDM4E Gene

Drugs & Compounds for KDM4E Gene

(1) Drugs for KDM4E Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
JIB-04 Pharma Jumonji histone demethylase inihibitor 0

(1) ApexBio Compounds for KDM4E Gene

Compound Action Cas Number
JIB-04 Jumonji histone demethylase inihibitor 199596-05-9
genes like me logo Genes that share compounds with KDM4E: view

Transcripts for KDM4E Gene

mRNA/cDNA for KDM4E Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KDM4E Gene

No ASD Table

Relevant External Links for KDM4E Gene

GeneLoc Exon Structure for
KDM4E
ECgene alternative splicing isoforms for
KDM4E

Expression for KDM4E Gene

mRNA expression in normal human tissues for KDM4E Gene

mRNA differential expression in normal tissues according to GTEx for KDM4E Gene

This gene is overexpressed in Testis (x5.8).

SOURCE GeneReport for Unigene cluster for KDM4E Gene Hs.714692

genes like me logo Genes that share expression patterns with KDM4E: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KDM4E Gene

Orthologs for KDM4E Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KDM4E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KDM4DL 35
  • 98.22 (n)
  • 97.63 (a)
KDM4E 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 61 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 63 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Kdm4A 36
  • 37 (a)
ManyToMany
Kdm4B 36
  • 26 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPH1 36
  • 18 (a)
ManyToMany
GIS1 36
  • 13 (a)
ManyToMany
Species with no ortholog for KDM4E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KDM4E Gene

ENSEMBL:
Gene Tree for KDM4E (if available)
TreeFam:
Gene Tree for KDM4E (if available)

Paralogs for KDM4E Gene

(5) SIMAP similar genes for KDM4E Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for KDM4E Gene

genes like me logo Genes that share paralogs with KDM4E: view

Variants for KDM4E Gene

Sequence variations from dbSNP and Humsavar for KDM4E Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs12798990 - 95,025,633(+) AATTT(A/G)CAGAT reference, missense
rs2257265 - 95,025,682(+) ACATC(A/G/T)AGCTG reference, missense
rs10752685 - 95,025,895(+) ACACC(A/G)GAATT reference, missense
rs16921260 - 95,026,330(+) TCCCT(C/T)CAATT reference, missense
rs1810061 -- 95,025,680(-) GCTTG(A/G)TGTGC reference, synonymous-codon

Variation tolerance for KDM4E Gene

Gene Damage Index Score: 4.72; 66.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KDM4E Gene

HapMap Linkage Disequilibrium report
KDM4E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KDM4E Gene

Disorders for KDM4E Gene

Relevant External Links for KDM4E

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KDM4E

No disorders were found for KDM4E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KDM4E Gene

Publications for KDM4E Gene

  1. Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates. (PMID: 21076780) Thalhammer A. … Schofield C.J. (Org. Biomol. Chem. 2011) 2 3 67
  2. Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase. (PMID: 23092293) SA!nchez-FernA!ndez E.M. … Flashman E. (Biochem. J. 2013) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for KDM4E Gene

Sources for KDM4E Gene

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