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Aliases for KDM4E Gene

Aliases for KDM4E Gene

  • Lysine (K)-Specific Demethylase 4E 2 3
  • KDM4D-Like Protein 3 4
  • KDM4DL 3 4
  • Lysine (K)-Specific Demethylase 4D-Like 2
  • Lysine-Specific Demethylase 4D-Like 4
  • Lysine-Specific Demethylase 4E 3
  • EC 1.14.11.- 4
  • JMJD2E 3

External Ids for KDM4E Gene

Previous HGNC Symbols for KDM4E Gene

  • KDM4DL

Previous GeneCards Identifiers for KDM4E Gene

  • GC11P094759

Summaries for KDM4E Gene

GeneCards Summary for KDM4E Gene

KDM4E (Lysine (K)-Specific Demethylase 4E) is a Protein Coding gene. GO annotations related to this gene include dioxygenase activity. An important paralog of this gene is KDM4D.

UniProtKB/Swiss-Prot for KDM4E Gene

  • Histone demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KDM4E Gene

Genomics for KDM4E Gene

Genomic Location for KDM4E Gene

Start:
95,025,258 bp from pter
End:
95,027,596 bp from pter
Size:
2,339 bases
Orientation:
Plus strand

Genomic View for KDM4E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KDM4E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KDM4E Gene

No data available for Regulatory Elements for KDM4E Gene

Proteins for KDM4E Gene

  • Protein details for KDM4E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B2RXH2-KDM4E_HUMAN
    Recommended name:
    Lysine-specific demethylase 4E
    Protein Accession:
    B2RXH2
    Secondary Accessions:

    Protein attributes for KDM4E Gene

    Size:
    506 amino acids
    Molecular mass:
    56804 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 1 Fe(2+) ion per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for KDM4E Gene

neXtProt entry for KDM4E Gene

Proteomics data for KDM4E Gene at MOPED

Post-translational modifications for KDM4E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KDM4E Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KDM4E Gene

Domains for KDM4E Gene

Gene Families for KDM4E Gene

HGNC:
  • KDM :Chromatin-modifying enzymes / K-demethylases

Protein Domains for KDM4E Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

B2RXH2

UniProtKB/Swiss-Prot:

KDM4E_HUMAN :
  • B2RXH2
Domain:
  • Contains 1 JmjC domain.
  • Contains 1 JmjN domain.
Family:
  • Belongs to the JHDM3 histone demethylase family.
genes like me logo Genes that share domains with KDM4E: view

No data available for Suggested Antigen Peptide Sequences for KDM4E Gene

Function for KDM4E Gene

Molecular function for KDM4E Gene

UniProtKB/Swiss-Prot Function: Histone demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code.

Enzyme Numbers (IUBMB) for KDM4E Gene

Gene Ontology (GO) - Molecular Function for KDM4E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
GO:0051213 dioxygenase activity IEA --
genes like me logo Genes that share ontologies with KDM4E: view

Animal Model Products

CRISPR Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KDM4E Gene

Localization for KDM4E Gene

Subcellular locations from UniProtKB/Swiss-Prot for KDM4E Gene

Gene Ontology (GO) - Cellular Components for KDM4E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with KDM4E: view

No data available for Subcellular locations from COMPARTMENTS for KDM4E Gene

Pathways for KDM4E Gene

SuperPathways for KDM4E Gene

No Data Available

Gene Ontology (GO) - Biological Process for KDM4E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016568 chromatin modification IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with KDM4E: view

No data available for Pathways by source for KDM4E Gene

Transcripts for KDM4E Gene

mRNA/cDNA for KDM4E Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KDM4E

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KDM4E Gene

No ASD Table

Relevant External Links for KDM4E Gene

GeneLoc Exon Structure for
KDM4E
ECgene alternative splicing isoforms for
KDM4E

Expression for KDM4E Gene

mRNA expression in normal human tissues for KDM4E Gene

mRNA differential expression in normal tissues according to GTEx for KDM4E Gene

This gene is overexpressed in Testis (5.8).

SOURCE GeneReport for Unigene cluster for KDM4E Gene Hs.714692

genes like me logo Genes that share expressions with KDM4E: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for KDM4E Gene

Orthologs for KDM4E Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KDM4E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KDM4DL 35
  • 98.22 (n)
  • 97.63 (a)
KDM4E 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 61 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 63 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Kdm4A 36
  • 37 (a)
ManyToMany
Kdm4B 36
  • 26 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GIS1 36
  • 13 (a)
ManyToMany
RPH1 36
  • 18 (a)
ManyToMany
Species with no ortholog for KDM4E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KDM4E Gene

ENSEMBL:
Gene Tree for KDM4E (if available)
TreeFam:
Gene Tree for KDM4E (if available)

Paralogs for KDM4E Gene

Paralogs for KDM4E Gene

Selected SIMAP similar genes for KDM4E Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for KDM4E Gene

genes like me logo Genes that share paralogs with KDM4E: view

Variants for KDM4E Gene

Sequence variations from dbSNP and Humsavar for KDM4E Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1810061 -- 95,025,680(-) GCTTG(A/G)TGTGC synonymous-codon, reference
rs1960159 -- 95,025,746(-) TCTTC(A/G)ATATC reference, synonymous-codon
rs2020207 -- 95,025,692(-) TTGGC(A/G)AGGCC synonymous-codon, reference
rs2020210 -- 95,025,856(-) CCAAG(C/T)GGCGA missense, reference
rs2257265 - 95,025,682(+) ACATC(A/G)AGCTG reference, missense

Relevant External Links for KDM4E Gene

HapMap Linkage Disequilibrium report
KDM4E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KDM4E Gene

Disorders for KDM4E Gene

No disorders were found for KDM4E Gene.

No data available for UniProtKB/Swiss-Prot for KDM4E Gene

Publications for KDM4E Gene

  1. Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates. (PMID: 21076780) Thalhammer A. … Schofield C.J. (Org. Biomol. Chem. 2011) 2 3
  2. Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase. (PMID: 23092293) SA!nchez-FernA!ndez E.M. … Flashman E. (Biochem. J. 2013) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4
  5. Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family. (PMID: 21914792) Hillringhaus L. … Oppermann U. (J. Biol. Chem. 2011) 4

Products for KDM4E Gene

Sources for KDM4E Gene

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