Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KDM4E Gene

Aliases for KDM4E Gene

  • Lysine Demethylase 4E 2 3 5
  • Lysine (K)-Specific Demethylase 4E 2 3
  • KDM4D-Like Protein 3 4
  • KDM4DL 3 4
  • Lysine (K)-Specific Demethylase 4D-Like 2
  • Lysine-Specific Demethylase 4D-Like 4
  • Lysine-Specific Demethylase 4E 3
  • EC 1.14.11.- 4
  • JMJD2E 3
  • KDM5E 3

External Ids for KDM4E Gene

Previous HGNC Symbols for KDM4E Gene

  • KDM4DL

Previous GeneCards Identifiers for KDM4E Gene

  • GC11P094759

Summaries for KDM4E Gene

Entrez Gene Summary for KDM4E Gene

  • The protein encoded by this intronless gene is a member of a large family of histone lysine demethylases, which use oxygen and 2-oxoglutarate to demethylate di- and trimethylated lys9 of histone H3. Derepression of genes by demethylases is sometimes involved in viral infection or carcinogenesis, so inhibitors of these enzymes are desired. [provided by RefSeq, Dec 2016]

GeneCards Summary for KDM4E Gene

KDM4E (Lysine Demethylase 4E) is a Protein Coding gene. GO annotations related to this gene include dioxygenase activity. An important paralog of this gene is KDM4F.

UniProtKB/Swiss-Prot for KDM4E Gene

  • Histone demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KDM4E Gene

Genomics for KDM4E Gene

Regulatory Elements for KDM4E Gene

Enhancers for KDM4E Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G095091 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +67.5 67454 2.7 ELF3 HDGF ARID4B ZSCAN9 RAD21 SCRT2 ZNF143 FOS EGR2 SP5 LOC101929295 KDM4E ENDOD1 SRSF8 GC11P095093
GH11G094765 1.6 Ensembl ENCODE dbSUPER 9.5 -256.6 -256633 6.7 FOXA2 PKNOX1 CREB3L1 ARNT SIN3A FEZF1 ZNF2 ZNF766 ZNF143 KLF13 LOC105369438 ENSG00000256469 KDM4E MRE11 GC11M094750 GC11M094788
GH11G095066 1.4 ENCODE dbSUPER 10.7 +42.6 42640 3.2 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A FEZF1 ENDOD1 SRSF8 LOC101929295 KDM4E CWC15 KDM4D GC11P095067
GH11G094729 1.5 Ensembl ENCODE dbSUPER 8.9 -292.6 -292605 6.1 ATF1 TCF12 GATA2 FOS JUNB MAFF SMARCA4 ZNF585B GLIS1 STAT3 AMOTL1 KDM4E LOC105369438
GH11G095095 1.3 Ensembl ENCODE dbSUPER 9.5 +71.0 70987 1.7 PKNOX1 MXI1 TBL1XR1 ZBTB40 ARID3A CBX5 EED FOS RELB ETV6 LOC101929295 ENDOD1 KDM4D CWC15 KDM4E GC11P095093 GC11M095076
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KDM4E on UCSC Golden Path with GeneCards custom track

Genomic Location for KDM4E Gene

95,025,258 bp from pter
95,027,596 bp from pter
2,339 bases
Plus strand

Genomic View for KDM4E Gene

Genes around KDM4E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KDM4E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KDM4E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KDM4E Gene

Proteins for KDM4E Gene

  • Protein details for KDM4E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lysine-specific demethylase 4E
    Protein Accession:

    Protein attributes for KDM4E Gene

    506 amino acids
    Molecular mass:
    56804 Da
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for KDM4E Gene

neXtProt entry for KDM4E Gene

Post-translational modifications for KDM4E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KDM4E Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KDM4E Gene

Domains & Families for KDM4E Gene

Gene Families for KDM4E Gene

Protein Domains for KDM4E Gene


Suggested Antigen Peptide Sequences for KDM4E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the JHDM3 histone demethylase family.
  • Belongs to the JHDM3 histone demethylase family.
genes like me logo Genes that share domains with KDM4E: view

Function for KDM4E Gene

Molecular function for KDM4E Gene

UniProtKB/Swiss-Prot Function:
Histone demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code.

Enzyme Numbers (IUBMB) for KDM4E Gene

Gene Ontology (GO) - Molecular Function for KDM4E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
GO:0032454 histone demethylase activity (H3-K9 specific) IDA 21914792
GO:0046872 metal ion binding IEA --
GO:0051213 dioxygenase activity IEA --
genes like me logo Genes that share ontologies with KDM4E: view
genes like me logo Genes that share phenotypes with KDM4E: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KDM4E Gene

Localization for KDM4E Gene

Subcellular locations from UniProtKB/Swiss-Prot for KDM4E Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KDM4E gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for KDM4E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21914792
genes like me logo Genes that share ontologies with KDM4E: view

Pathways & Interactions for KDM4E Gene

SuperPathways for KDM4E Gene

No Data Available

Interacting Proteins for KDM4E Gene

Gene Ontology (GO) - Biological Process for KDM4E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016569 covalent chromatin modification IEA --
GO:0033169 histone H3-K9 demethylation IDA 21914792
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with KDM4E: view

No data available for Pathways by source and SIGNOR curated interactions for KDM4E Gene

Drugs & Compounds for KDM4E Gene

(2) Drugs for KDM4E Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
IOX 1 Pharma 0
JIB-04 Pharma Jumonji histone demethylase inihibitor, Pan Jumonji inhibitor; active in vivo 0

(2) ApexBio Compounds for KDM4E Gene

Compound Action Cas Number
IOX 1 5852-78-8
JIB-04 Jumonji histone demethylase inihibitor 199596-05-9
genes like me logo Genes that share compounds with KDM4E: view

Drug Products

Transcripts for KDM4E Gene

mRNA/cDNA for KDM4E Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KDM4E Gene

No ASD Table

Relevant External Links for KDM4E Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KDM4E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KDM4E Gene

mRNA differential expression in normal tissues according to GTEx for KDM4E Gene

This gene is overexpressed in Testis (x5.8).

NURSA nuclear receptor signaling pathways regulating expression of KDM4E Gene:


SOURCE GeneReport for Unigene cluster for KDM4E Gene:

genes like me logo Genes that share expression patterns with KDM4E: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KDM4E Gene

Orthologs for KDM4E Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KDM4E Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KDM4DL 34
  • 98.22 (n)
KDM4E 35
  • 98 (a)
(Canis familiaris)
Mammalia -- 35
  • 63 (a)
(Bos Taurus)
Mammalia -- 35
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 56 (a)
-- 35
  • 39 (a)
fruit fly
(Drosophila melanogaster)
Insecta Kdm4A 35
  • 37 (a)
Kdm4B 35
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPH1 35
  • 18 (a)
GIS1 35
  • 13 (a)
Species where no ortholog for KDM4E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KDM4E Gene

Gene Tree for KDM4E (if available)
Gene Tree for KDM4E (if available)

Paralogs for KDM4E Gene

Paralogs for KDM4E Gene

(5) SIMAP similar genes for KDM4E Gene using alignment to 1 proteins: Pseudogenes for KDM4E Gene

genes like me logo Genes that share paralogs with KDM4E: view

Variants for KDM4E Gene

Sequence variations from dbSNP and Humsavar for KDM4E Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs869025228 Uncertain significance 95,027,050(+) TGCCA(A/G)TGATT reference, missense
rs1002177445 -- 95,027,398(+) CTAAG(C/T)TTTCC utr-variant-3-prime
rs1002838076 -- 95,025,203(+) GTTTC(A/G/T)ACTTC upstream-variant-2KB
rs1005765574 -- 95,026,597(+) AGAGC(C/T)CAGGG reference, missense
rs1006178330 -- 95,023,324(+) GTAGA(A/G)GTATC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KDM4E Gene

Variant ID Type Subtype PubMed ID
esv2446980 CNV deletion 19546169
esv3892074 CNV loss 25118596
esv7852 CNV loss 19470904
nsv826045 CNV gain 20364138
nsv972063 CNV duplication 23825009

Variation tolerance for KDM4E Gene

Gene Damage Index Score: 4.72; 66.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KDM4E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KDM4E Gene

Disorders for KDM4E Gene

Relevant External Links for KDM4E

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KDM4E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KDM4E Gene

Publications for KDM4E Gene

  1. Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family. (PMID: 21914792) Hillringhaus L. … Oppermann U. (J. Biol. Chem. 2011) 3 4 64
  2. Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates. (PMID: 21076780) Thalhammer A. … Schofield C.J. (Org. Biomol. Chem. 2011) 2 3 64
  3. Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase. (PMID: 23092293) SA!nchez-FernA!ndez E.M. … Flashman E. (Biochem. J. 2013) 3 64
  4. Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activity (PMID: 24260783) Rai G. … Maloney D.J. ( 2010) 3 64
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64

Products for KDM4E Gene

Sources for KDM4E Gene

Loading form....