Aliases for KDM4D Gene
External Ids for KDM4D Gene
Previous HGNC Symbols for KDM4D Gene
Previous GeneCards Identifiers for KDM4D Gene
GeneCards Summary for KDM4D Gene
KDM4D (Lysine Demethylase 4D) is a Protein Coding gene. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include dioxygenase activity and histone demethylase activity (H3-K9 specific). An important paralog of this gene is KDM4B.
UniProtKB/Swiss-Prot for KDM4D Gene
Histone demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 Lys-4, H3 Lys-27, H3 Lys-36 nor H4 Lys-20. Demethylates both di- and trimethylated H3 Lys-9 residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.