Aliases for KDM4C Gene
External Ids for KDM4C Gene
Previous HGNC Symbols for KDM4C Gene
Previous GeneCards Identifiers for KDM4C Gene
This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
GeneCards Summary for KDM4C Gene
KDM4C (Lysine Demethylase 4C) is a Protein Coding gene. Diseases associated with KDM4C include Squamous Cell Carcinoma. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include enzyme binding and dioxygenase activity. An important paralog of this gene is KDM4B.
UniProtKB/Swiss-Prot for KDM4C Gene
Histone demethylase that specifically demethylates Lys-9 and Lys-36 residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 Lys-4, H3 Lys-27 nor H4 Lys-20. Demethylates trimethylated H3 Lys-9 and H3 Lys-36 residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.