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Aliases for KDM4C Gene

Aliases for KDM4C Gene

  • Lysine (K)-Specific Demethylase 4C 2 3
  • JMJD2C 3 4 6
  • GASC1 3 4 6
  • JmjC Domain-Containing Histone Demethylation Protein 3C 3 4
  • Gene Amplified In Squamous Cell Carcinoma 1 Protein 3 4
  • Jumonji Domain-Containing Protein 2C 3 4
  • Tudor Domain Containing 14C 2 3
  • KIAA0780 4 6
  • JHDM3C 3 4
  • Lysine-Specific Demethylase 4C 3
  • Jumonji Domain Containing 2C 2
  • GASC-1 Protein 4
  • EC 1.14.11.- 4
  • EC 1.14.11 63
  • TDRD14C 3

External Ids for KDM4C Gene

Previous HGNC Symbols for KDM4C Gene

  • JMJD2C

Previous GeneCards Identifiers for KDM4C Gene

  • GC09P006747
  • GC09P006676

Summaries for KDM4C Gene

Entrez Gene Summary for KDM4C Gene

  • This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for KDM4C Gene

KDM4C (Lysine (K)-Specific Demethylase 4C) is a Protein Coding gene. Among its related pathways are Coregulation of Androgen receptor activity. GO annotations related to this gene include enzyme binding and dioxygenase activity. An important paralog of this gene is KDM4D.

UniProtKB/Swiss-Prot for KDM4C Gene

  • Histone demethylase that specifically demethylates Lys-9 and Lys-36 residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 Lys-4, H3 Lys-27 nor H4 Lys-20. Demethylates trimethylated H3 Lys-9 and H3 Lys-36 residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.

Gene Wiki entry for KDM4C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KDM4C Gene

Genomics for KDM4C Gene

Regulatory Elements for KDM4C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KDM4C Gene

Start:
6,720,863 bp from pter
End:
7,175,648 bp from pter
Size:
454,786 bases
Orientation:
Plus strand

Genomic View for KDM4C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KDM4C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KDM4C Gene

Proteins for KDM4C Gene

  • Protein details for KDM4C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3R0-KDM4C_HUMAN
    Recommended name:
    Lysine-specific demethylase 4C
    Protein Accession:
    Q9H3R0
    Secondary Accessions:
    • B4E1Y4
    • B7ZL46
    • F5H347
    • F5H7P0
    • O94877
    • Q2M3M0
    • Q5JUC9
    • Q5VYJ2
    • Q5VYJ3

    Protein attributes for KDM4C Gene

    Size:
    1056 amino acids
    Molecular mass:
    119982 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 1 Fe(2+) ion per subunit.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA34500.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI39608.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KDM4C Gene

    Alternative splice isoforms for KDM4C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KDM4C Gene

Proteomics data for KDM4C Gene at MOPED

Post-translational modifications for KDM4C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for KDM4C Gene

Gene Families for KDM4C Gene

HGNC:
  • KDM :Chromatin-modifying enzymes / K-demethylases
  • TDRD :Tudor domain containing

Suggested Antigen Peptide Sequences for KDM4C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H3R0

UniProtKB/Swiss-Prot:

KDM4C_HUMAN :
  • Q9H3R0
Domain:
  • The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails (By similarity).
  • Contains 1 JmjC domain.
  • Contains 1 JmjN domain.
  • Contains 2 Tudor domains.
Family:
  • Belongs to the JHDM3 histone demethylase family.
Similarity:
  • Contains 2 PHD-type zinc fingers.
genes like me logo Genes that share domains with KDM4C: view

Function for KDM4C Gene

Molecular function for KDM4C Gene

UniProtKB/Swiss-Prot Function: Histone demethylase that specifically demethylates Lys-9 and Lys-36 residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 Lys-4, H3 Lys-27 nor H4 Lys-20. Demethylates trimethylated H3 Lys-9 and H3 Lys-36 residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.

Enzyme Numbers (IUBMB) for KDM4C Gene

Gene Ontology (GO) - Molecular Function for KDM4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0019899 enzyme binding IPI 17277772
GO:0032452 histone demethylase activity EXP --
GO:0032454 histone demethylase activity (H3-K9 specific) IMP 17277772
genes like me logo Genes that share ontologies with KDM4C: view
genes like me logo Genes that share phenotypes with KDM4C: view

Animal Model Products

CRISPR Products

miRNA for KDM4C Gene

miRTarBase miRNAs that target KDM4C

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KDM4C

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for KDM4C Gene

Localization for KDM4C Gene

Subcellular locations from UniProtKB/Swiss-Prot for KDM4C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KDM4C Gene COMPARTMENTS Subcellular localization image for KDM4C gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for KDM4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 17277772
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with KDM4C: view

Pathways for KDM4C Gene

genes like me logo Genes that share pathways with KDM4C: view

Pathways by source for KDM4C Gene

1 BioSystems pathway for KDM4C Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Epigenetic Chromatin Modification Enzymes in human,mouse,rat

Gene Ontology (GO) - Biological Process for KDM4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA 17277772
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0008284 positive regulation of cell proliferation IMP 17277772
genes like me logo Genes that share ontologies with KDM4C: view

Transcripts for KDM4C Gene

Unigene Clusters for KDM4C Gene

Lysine (K)-specific demethylase 4C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KDM4C

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KDM4C Gene

No ASD Table

Relevant External Links for KDM4C Gene

GeneLoc Exon Structure for
KDM4C
ECgene alternative splicing isoforms for
KDM4C

Expression for KDM4C Gene

mRNA expression in normal human tissues for KDM4C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KDM4C Gene

SOURCE GeneReport for Unigene cluster for KDM4C Gene Hs.709425

mRNA Expression by UniProt/SwissProt for KDM4C Gene

Q9H3R0-KDM4C_HUMAN
Tissue specificity: Overexpressed in several esophageal squamous cell carcinomas (ESCs).
genes like me logo Genes that share expressions with KDM4C: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for KDM4C Gene

Orthologs for KDM4C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KDM4C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KDM4C 35
  • 99.08 (n)
  • 99.34 (a)
KDM4C 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KDM4C 35
  • 86.6 (n)
  • 86.1 (a)
KDM4C 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KDM4C 35
  • 89.65 (n)
  • 90.12 (a)
KDM4C 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kdm4c 35
  • 83.97 (n)
  • 84.63 (a)
Kdm4c 16
Kdm4c 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KDM4C 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 22 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Kdm4c 35
  • 84.59 (n)
  • 85.16 (a)
chicken
(Gallus gallus)
Aves KDM4C 35
  • 74.52 (n)
  • 76.35 (a)
KDM4C 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KDM4C 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kdm4c 35
  • 68.21 (n)
  • 65.41 (a)
Str.16473 35
zebrafish
(Danio rerio)
Actinopterygii KDM4C 36
  • 42 (a)
OneToOne
zgc:153957 35
  • 64.9 (n)
  • 67.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta Kdm4A 36
  • 47 (a)
ManyToMany
Kdm4B 36
  • 40 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea jmjd-2 36
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GIS1 36
  • 18 (a)
ManyToMany
RPH1 36
  • 26 (a)
ManyToMany
RPH1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8892 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10508 36
  • 40 (a)
OneToMany
Species with no ortholog for KDM4C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KDM4C Gene

ENSEMBL:
Gene Tree for KDM4C (if available)
TreeFam:
Gene Tree for KDM4C (if available)

Paralogs for KDM4C Gene

Paralogs for KDM4C Gene

Selected SIMAP similar genes for KDM4C Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with KDM4C: view

Variants for KDM4C Gene

Sequence variations from dbSNP and Humsavar for KDM4C Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs594253 -- 6,736,523(-) acagc(C/T)tgagc intron-variant
rs594610 -- 6,736,459(-) agtcc(C/T)tagac intron-variant
rs632343 -- 6,724,599(-) gagcc(A/G)agatc intron-variant
rs702279 -- 6,969,634(+) ACTAT(A/C)AAATC intron-variant
rs702280 -- 6,743,963(-) tgaga(A/C)cagcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KDM4C Gene

Variant ID Type Subtype PubMed ID
nsv892162 CNV Gain 21882294
esv2752308 CNV Gain 17911159
nsv466111 CNV Gain 19166990
dgv2278e1 CNV Complex 17122850
nsv892166 CNV Loss 21882294
nsv519777 CNV Gain 19592680
dgv8023n71 CNV Loss 21882294
nsv892173 CNV Gain 21882294
nsv466112 CNV Gain 19166990
esv2752309 CNV Gain 17911159
nsv466113 CNV Loss 19166990
dgv8024n71 CNV Loss 21882294
nsv471273 CNV Loss 18288195
nsv892179 CNV Loss 21882294
nsv892181 CNV Gain 21882294
esv32977 CNV Loss 17666407
nsv466114 CNV Loss 19166990
nsv831499 CNV Loss 17160897
esv1268323 CNV Insertion 17803354
esv991061 CNV Insertion 20482838
esv2575633 CNV Deletion 19546169
nsv512087 CNV Loss 21212237
esv2738170 CNV Deletion 23290073
esv8547 CNV Loss 19470904
esv2662375 CNV Deletion 23128226
esv27835 CNV Loss 19812545
nsv820480 CNV Deletion 20802225
nsv892182 CNV Gain 21882294
essv2425 CNV CNV 17122850
nsv466115 CNV Gain 19166990
nsv824840 CNV Loss 20364138
nsv818679 CNV Loss 17921354
esv35116 CNV Loss 17911159
esv268119 CNV Insertion 20981092
esv274166 CNV Insertion 20981092
nsv824841 CNV Loss 20364138
nsv892183 CNV Gain 21882294
nsv524069 CNV Gain 19592680
nsv831500 CNV Loss 17160897
nsv831501 CNV Gain 17160897
esv2426665 CNV Deletion 19546169
esv2205276 CNV Deletion 18987734
esv2738171 CNV Deletion 23290073
esv4186 CNV Deletion 18987735
esv1403882 CNV Deletion 17803354
esv2537839 CNV Deletion 19546169
nsv416139 CNV Loss 16902084
esv9139 CNV Loss 19470904
nsv892184 CNV Gain 21882294
esv268487 CNV Insertion 20981092
dgv8025n71 CNV Gain 21882294
nsv892187 CNV Gain 21882294
esv259805 OTHER Complex 20981092
esv2502836 CNV Deletion 19546169
nsv522977 CNV Loss 19592680
esv2365258 CNV Deletion 18987734
esv4579 CNV Deletion 18987735
esv2738172 CNV Deletion 23290073
esv1002679 CNV Deletion 20482838
esv1599076 CNV Deletion 17803354
nsv892188 CNV Gain 21882294
nsv466117 CNV Gain 19166990
esv26908 CNV Loss 19812545
nsv523788 CNV Loss 19592680
nsv892189 CNV Gain 21882294
nsv892190 CNV Gain 21882294
nsv524896 CNV Gain 19592680
nsv892191 CNV Gain 21882294
nsv892192 CNV Gain 21882294
nsv519762 CNV Loss 19592680
nsv528873 CNV Loss 19592680
dgv2279e1 CNV Complex 17122850

Relevant External Links for KDM4C Gene

HapMap Linkage Disequilibrium report
KDM4C
Human Gene Mutation Database (HGMD)
KDM4C

PCR Panel Products

  • Copy Number PCR Panels: for KDM4C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KDM4C Gene

Disorders for KDM4C Gene

(2) Novoseek inferred disease relationships for KDM4C Gene

Disease -log(P) Hits PubMed IDs
carcinoma squamous cell 41 4
cancer 0 1

Relevant External Links for KDM4C

Genetic Association Database (GAD)
KDM4C
Human Genome Epidemiology (HuGE) Navigator
KDM4C
genes like me logo Genes that share disorders with KDM4C: view

No data available for UniProtKB/Swiss-Prot for KDM4C Gene

Publications for KDM4C Gene

  1. Identification and characterization of JMJD2 family genes in silico. (PMID: 15138608) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 2 3 23
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  3. Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines. (PMID: 10987278) Yang Z.Q. … Inazawa J. (Cancer Res. 2000) 3 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for KDM4C Gene

  • Addgene plasmids for KDM4C

Sources for KDM4C Gene

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