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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KDM4B Gene

protein-coding   GIFtS: 61
GCID: GC19P004969

Lysine (K)-Specific Demethylase 4B

(Previous name: jumonji domain containing 2B)
(Previous symbol: JMJD2B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Lysine (K)-Specific Demethylase 4B1 2     KIAA08763 5
JMJD2B1 2 3 5     TDRD14B2
Jumonji Domain Containing 2B1 2     Lysine-Specific Demethylase 4B2
Tudor Domain Containing 14B1 2     EC 1.14.11.-3
JmjC Domain-Containing Histone Demethylation Protein 3B2 3     JHDM3B3
Jumonji Domain-Containing Protein 2B2 3     EC 1.14.118

External Ids:    HGNC: 291361   Entrez Gene: 230302   Ensembl: ENSG000001276637   OMIM: 6097655   UniProtKB: O949533   

Export aliases for KDM4B gene to outside databases

Previous GC identifers: GC19P004921 GC19P004730


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KDM4B Gene: 
KDM4B (lysine (K)-specific demethylase 4B) is a protein-coding gene. Diseases associated with KDM4B include malignant spindle cell melanoma, and retinoblastoma. GO annotations related to this gene include oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen and zinc ion binding. An important paralog of this gene is KDM4D.

UniProtKB/Swiss-Prot: KDM4B_HUMAN, O94953
Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in
histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to
demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys
residue generates formaldehyde and succinate

Gene Wiki entry for KDM4B (JMJD2B) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011255.14  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KDM4B gene promoter:
         MAZR   AML1a   Lmo2   Nkx5-1   LCR-F1   NF-E2 p45   C/EBPalpha   Egr-2   USF-1   NF-E2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KDM4B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KDM4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

KDM4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KDM4B gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P004969:  view genomic region     (about GC identifiers)

Start:
4,969,124 bp from pter      End:
5,153,609 bp from pter
Size:
184,486 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KDM4B_HUMAN, O94953 (See protein sequence)
Recommended Name: Lysine-specific demethylase 4B  
Size: 1096 amino acids; 121897 Da
Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)
Subcellular location: Nucleus
Sequence caution: Sequence=AAC33799.1; Type=Erroneous gene model prediction; Sequence=BAA74899.2; Type=Erroneous
initiation;
Secondary accessions: B9EGN8 D6W631 O75274 Q6P3R5 Q9P1V1 Q9UF40
Alternative splicing: 2 isoforms:  O94953-1   O94953-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KDM4B: NX_O94953

Explore proteomics data for KDM4B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O94953

  • 4/11 DME Specific Peptides for KDM4B (O94953) (see all 11)
     YSINYLH  VHASCYG  AESTNFA  DMVKISM 

    KDM4B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KDM4B Protein Expression
    REFSEQ proteins: NP_055830.1  
    ENSEMBL proteins: 
     ENSP00000468514   ENSP00000159111   ENSP00000371178   ENSP00000440495   ENSP00000467678  

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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KDM4B 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    KDM4B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TDRD: Tudor domain containing
    KDM: Chromatin-modifying enzymes / K-demethylases

    5/6 InterPro protein domains (see all 6):
     IPR003347 JmjC_dom
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR003349 TF_JmjN
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry O94953

    ProtoNet protein and cluster: O94953

    3 Blocks protein domains:
    IPB001965 Zn-finger-like
    IPB003347 Transcription factor jumonji
    IPB003349 Transcription factor jumonji


    UniProtKB/Swiss-Prot: KDM4B_HUMAN, O94953
    Domain: The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated
    structure and the unusual fold is required for its ability to bind methylated histone tails (By similarity)
    Similarity: Belongs to the JHDM3 histone demethylase family
    Similarity: Contains 1 JmjC domain
    Similarity: Contains 1 JmjN domain
    Similarity: Contains 2 PHD-type zinc fingers
    Similarity: Contains 2 Tudor domains


    KDM4B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KDM4B_HUMAN, O94953
    Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in
    histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to
    demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys
    residue generates formaldehyde and succinate

         Enzyme Numbers (IUBMB): EC 1.14.11.-1 EC 1.14.112

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ----
    GO:0051213dioxygenase activity IEA--
         
    KDM4B for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for KDM4B:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Kdm4b):
     cellular  craniofacial  endocrine/exocrine gland  integument  mortality/aging 
     normal  skeleton  vision/eye 

    KDM4B for phenotypes           About GeneDecksing

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidKDM4B 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KDM4B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for KDM4B
        Chromatin Regulation / Acetylation




    KDM4B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KDM4B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/28 Interacting proteins for KDM4B (O949532, 3 ENSP000001591114) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED10Q9BTT42, 3, ENSP000002557644MINT-65334 I2D: score=4 STRING: ENSP00000255764
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    EMX1Q047413I2D: score=1 
    NFE2Q166213I2D: score=1 
    SMARCA4P515323I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0016568chromatin modification IEA--

    KDM4B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KDM4B

    Search CenterWatch for drugs/clinical trials and news about KDM4B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KDM4B gene: 
    NM_015015.2  

    Unigene Cluster for KDM4B:

    Lysine (K)-specific demethylase 4B
    Hs.654816  [show with all ESTs]
    Unigene Representative Sequence: NM_015015
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000588337 ENST00000159111(uc002mbq.4 uc010xim.2 uc002mbr.4)
    ENST00000381759(uc010xil.1) ENST00000536461 ENST00000592175 ENST00000589104
    ENST00000588961 ENST00000588361 ENST00000592159 ENST00000588166
    miRNA
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    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate KDM4B (see all 30):
    hsa-miR-3678-3p hsa-miR-125a-5p hsa-miR-4251 hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-513a-5p hsa-miR-3129-5p hsa-miR-29c
    SwitchGear 3'UTR luciferase reporter plasmidKDM4B 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB020683.2 AF052144.1 AK026040.1 AK090405.1 AK126854.1 AL133622.1 AL831872.1 BC015378.1 
    BC040014.1 BC046167.1 BC063889.1 BC136611.1 BC144292.1 

    14 DOTS entries:

    DT.95268131  DT.100673094  DT.91736535  DT.100782044  DT.97842572  DT.75166336  DT.99929060  DT.91894949 
    DT.91736528  DT.100025963  DT.92010446  DT.101967033  DT.121459830  DT.97798143 

    24/63 AceView cDNA sequences (see all 63):

    AW450344 BM992894 CB158429 AL831872 AA884638 BQ219578 BC063889 BF868628 
    BE672463 BU844833 AL560679 BG236071 AI684636 CA307451 BM703561 BI020470 
    BM703553 BQ225977 BU552683 AI362737 AI939571 AI658783 BF313933 BE261870 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for KDM4B (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ·
    SP1:        -     -                             -           -                       -                                                                           
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                -                             -     -     -                                 
    SP5:                                                                                                                                                            

    ExUns: 21c ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31a · 31b ^ 32
    SP1:                                                                                                
    SP2:                                                                                                
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for KDM4B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KDM4B expression in normal human tissues (normalized intensities)      KDM4B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACGCTGCGA
    KDM4B Expression
    About this image


    KDM4B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             superior temporal gyrus   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 3 entries
             autonomic/sympathetic/ganglion   
     
     Breast (Uncategorized)    fully expand to see all 2 entries
             breast ductal cells   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See KDM4B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KDM4B

    SOURCE GeneReport for Unigene cluster: Hs.654816
        SABiosciences Custom PCR Arrays for KDM4B
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM4B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for KDM4B gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kdm4b1 , 5 lysine (K)-specific demethylase 4B1, 5 80.9(n)1
    83.71(a)1
      17 (29.27 cM)5
    1937961  NM_172132.21  NP_742144.11 
     563260625 
    chicken
    (Gallus gallus)
    Aves KDM4B1 lysine (K)-specific demethylase 4B 69.86(n)
    76.09(a)
      428354  XM_001233691.2  XP_001233692.2 
    lizard
    (Anolis carolinensis)
    Reptilia KDM4B6
    lysine (K)-specific demethylase 4B
    70(a)
    1 ↔ 1
    GL343661.1(164-219742)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BC061307.12   -- 74.88(n)    BC061307.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kdm4b1 lysine (K)-specific demethylase 4B 65.12(n)
    62.24(a)
      556504  NM_001082805.1  NP_001076274.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Kdm4A1 Histone demethylase 4A 62.15(n)
    59.62(a)
      35744  NM_136487.3  NP_610331.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPH1(YER169W)4 JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway less   --   5(523369-525759) 856916  NP_011096.1 


    ENSEMBL Gene Tree for KDM4B (if available)
    TreeFam Gene Tree for KDM4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KDM4B gene
    KDM4D2  KDM4A2  KDM4C2  KDM4E2  
    6 SIMAP similar genes for KDM4B using alignment to 4 protein entries:     KDM4B_HUMAN (see all proteins):
    JMJD2B    KDM4E    KDM4C    KDM4D    KDM4A    AF10

    KDM4B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KDM4B
    PGOHUM00000242867


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4542 SNPs in KDM4B are shown (see all 4542)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2019171191,2
    Cuntested15151384(+) TTCTCA/C/GGGGGA 2 S syn10--------
    VAR_0262244
    ----see VAR_0262242 K E mis40--------
    rs1420340221,2
    --4967302(+) TACCAA/GTGTGC 1 -- us2k10--------
    rs1971471,2
    C,F,H--4967407(-) AAACCG/AGTATC 1 -- us2k112Minor allele frequency- A:0.05MN NS EA NA CSA WA 1396
    rs1442185231,2
    C--4967467(+) TGTCCC/GTAGCT 1 -- us2k10--------
    rs1847676521,2
    --4967476(+) CTCAGC/TGGTTG 1 -- us2k10--------
    rs1880328121,2
    --4967500(+) GTTTGC/TAAACA 1 -- us2k10--------
    rs48076721,2
    C,F--4967525(+) TTTTTC/GTTTTC 1 -- us2k1 tfbs3 trp35Minor allele frequency- G:0.07NA WA CSA 244
    rs1926558521,2
    --4967642(+) CATGCA/GCCACC 1 -- us2k10--------
    rs121855181,2
    C,F--4967701(+) TTGGCC/GAGGCT 1 -- us2k14Minor allele frequency- G:0.27NA 126

    HapMap Linkage Disequilibrium report for KDM4B (4969124 - 5153609 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/26 variations for KDM4B (see all 26):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2013056CNV Deletion18987734
    dgv616e199CNV Deletion23128226
    esv1001351CNV Deletion20482838
    esv2718039CNV Deletion23290073
    esv2105827CNV Deletion18987734
    esv2718038CNV Deletion23290073
    esv2718037CNV Deletion23290073
    esv1690767CNV Insertion17803354
    esv1201127CNV Insertion17803354
    dgv3684n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609765    OMIM disorders: --

    7 diseases for KDM4B:    About MalaCards
    malignant spindle cell melanoma    retinoblastoma    hypoxia    melanoma
    gastric cancer    colorectal cancer    breast cancer


    KDM4B for disorders           About GeneDecksing

    Genetic Association Database (GAD): KDM4B
    Human Genome Epidemiology (HuGE) Navigator: KDM4B (1 document)

    Export disorders for KDM4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KDM4B gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with KDM4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T....Ohara O. (1998)
    2. Identification and characterization of JMJD2 family genes in silico. (PubMed id 15138608)1, 3, 9 Katoh M. and Katoh M. (2004)
    3. Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. (PubMed id 15927959)1, 2, 9 Gray S.G.... Dangond F. (2005)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. (PubMed id 16603238)1, 2 Whetstine J.R.... Shi Y. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    8. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    9. Comparative integromics on JMJD2A, JMJD2B and JMJD2C: preferential expression of JMJD2C in undifferentiated ES cells. (PubMed id 17611647)1, 9 Katoh Y. and Katoh M. (2007)
    10. Heat shock protein 90 (Hsp90) selectively regulates th e stability of KDM4B/JMJD2B histone demethylase. (PubMed id 23589305)1 Ipenberg I....Ayoub N. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23030 HGNC: 29136 AceView: JMJD2B Ensembl:ENSG00000127663 euGenes: HUgn23030
    ECgene: KDM4B H-InvDB: KDM4B

    (According to HUGE)
    About This Section
    HUGE: KIAA0876

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KDM4B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KDM4B gene:
    Search GeneIP for patents involving KDM4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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