Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



KDM4B Gene

protein-coding   GIFtS: 61
GCID: GC19P004969

Lysine (K)-Specific Demethylase 4B

(Previous name: jumonji domain containing 2B)
(Previous symbol: JMJD2B)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Lysine (K)-Specific Demethylase 4B1 2     KIAA08763 5
JMJD2B1 2 3 5     TDRD14B2
Jumonji Domain Containing 2B1 2     Lysine-Specific Demethylase 4B2
Tudor Domain Containing 14B1 2     EC 1.14.11.-3
JmjC Domain-Containing Histone Demethylation Protein 3B2 3     JHDM3B3
Jumonji Domain-Containing Protein 2B2 3     EC 1.14.118

External Ids:    HGNC: 291361   Entrez Gene: 230302   Ensembl: ENSG000001276637   OMIM: 6097655   UniProtKB: O949533   

Export aliases for KDM4B gene to outside databases

Previous GC identifers: GC19P004921 GC19P004730


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for KDM4B Gene:
KDM4B (lysine (K)-specific demethylase 4B) is a protein-coding gene. GO annotations related to this gene include dioxygenase activity. An important paralog of this gene is KDM4D.

UniProtKB/Swiss-Prot: KDM4B_HUMAN, O94953
Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in
histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to
demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys
residue generates formaldehyde and succinate

Gene Wiki entry for KDM4B (JMJD2B) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KDM4B gene promoter:
         MAZR   AML1a   Lmo2   Nkx5-1   LCR-F1   NF-E2 p45   C/EBPalpha   Egr-2   USF-1   NF-E2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for KDM4B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KDM4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

KDM4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KDM4B gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P004969:  view genomic region     (about GC identifiers)

Start:
4,969,124 bp from pter      End:
5,153,609 bp from pter
Size:
184,486 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KDM4B_HUMAN, O94953 (See protein sequence)
Recommended Name: Lysine-specific demethylase 4B  
Size: 1096 amino acids; 121897 Da
Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)
Sequence caution: Sequence=AAC33799.1; Type=Erroneous gene model prediction; Sequence=BAA74899.2; Type=Erroneous
initiation;
Secondary accessions: B9EGN8 D6W631 O75274 Q6P3R5 Q9P1V1 Q9UF40
Alternative splicing: 2 isoforms:  O94953-1   O94953-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KDM4B: NX_O94953

Explore proteomics data for KDM4B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys106, Lys1032
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for KDM4B (O94953) (see all 11)
     YSINYLH  VHASCYG  AESTNFA  DMVKISM 


    See KDM4B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055830.1  
    ENSEMBL proteins: 
     ENSP00000468514   ENSP00000159111   ENSP00000371178   ENSP00000440495   ENSP00000467678  

    KDM4B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KDM4B
    OriGene Custom MassSpec
    OriGene Custom Protein Services for KDM4B
    GenScript Custom Purified and Recombinant Proteins Services for KDM4B
    Novus Biologicals KDM4B Protein
    Novus Biologicals KDM4B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KDM4B

     
    Search eBioscience for Proteins for KDM4B 

    KDM4B Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of KDM4B
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for KDM4B  (JMJD2B)
    OriGene Antibodies for KDM4B
    OriGene Custom Antibody Services for KDM4B
    Novus Biologicals KDM4B Antibodies
    Search for Antibodies for KDM4B at Abcam
    Cloud-Clone Corp. Antibodies for KDM4B
    ThermoFisher Antibodies for KDM4B
    LSBio Antibodies in human, mouse, rat for KDM4B

    KDM4B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KDM4B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KDM4B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KDM4B
    Cloud-Clone Corp. CLIAs for KDM4B
    Search eBioscience for ELISAs for KDM4B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    TDRD: Tudor domain containing
    KDM: Chromatin-modifying enzymes / K-demethylases

    Selected InterPro protein domains (see all 6):
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR003347 JmjC_dom
     IPR003349 TF_JmjN
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry O94953

    ProtoNet protein and cluster: O94953

    3 Blocks protein domains:
    IPB001965 Zn-finger-like
    IPB003347 Transcription factor jumonji
    IPB003349 Transcription factor jumonji


    UniProtKB/Swiss-Prot: KDM4B_HUMAN, O94953
    Domain: The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated
    structure and the unusual fold is required for its ability to bind methylated histone tails (By similarity)
    Similarity: Belongs to the JHDM3 histone demethylase family
    Similarity: Contains 1 JmjC domain
    Similarity: Contains 1 JmjN domain
    Similarity: Contains 2 PHD-type zinc fingers
    Similarity: Contains 2 Tudor domains


    Find genes that share domains with KDM4B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KDM4B_HUMAN, O94953
    Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in
    histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to
    demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys
    residue generates formaldehyde and succinate

         Enzyme Numbers (IUBMB): EC 1.14.11.-1 EC 1.14.112

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0051213dioxygenase activity IEA--
         
    Find genes that share ontologies with KDM4B           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for KDM4B:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Kdm4b):
     cellular  craniofacial  endocrine/exocrine gland  integument  mortality/aging 
     normal  skeleton  vision/eye 

    Find genes that share phenotypes with KDM4B           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KDM4B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KDM4B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KDM4B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KDM4B

    miRNA
    Products:
        
    miRTarBase miRNAs that target KDM4B:
    hsa-mir-615-3p (MIRT040426), hsa-mir-505-5p (MIRT037961), hsa-mir-106b-3p (MIRT038564), hsa-mir-335-5p (MIRT018784)

    Block miRNA regulation of human, mouse, rat KDM4B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KDM4B (see all 30):
    hsa-miR-3678-3p hsa-miR-125a-5p hsa-miR-4251 hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-513a-5p hsa-miR-3129-5p hsa-miR-29c
    SwitchGear 3'UTR luciferase reporter plasmidKDM4B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KDM4B
    Predesigned siRNA for gene silencing in human, mouse, rat KDM4B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KDM4B

    Clone
    Products:
         
    OriGene clones in human, mouse for KDM4B (see all 6)
    OriGene ORF clones in mouse, rat for KDM4B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KDM4B (NM_015015)
    Sino Biological Human cDNA Clone for KDM4B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KDM4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KDM4B
    Addgene plasmids for KDM4B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KDM4B
    Browse ESI BIO Cell Lines and PureStem Progenitors for KDM4B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM4B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    KDM4B_HUMAN, O94953: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005925focal adhesion IDA--
    GO:0030054cell junction IDA--

    Find genes that share ontologies with KDM4B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for KDM4B About    
    See pathways by source

    SuperPathContained pathways About
    1Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation


    Find genes that share SuperPaths with KDM4B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for KDM4B
        Chromatin Regulation / Acetylation



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KDM4B
    Interactions:

        Search GeneGlobe Interaction Network for KDM4B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KDM4B (O949532, 3 ENSP000001591114) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED10Q9BTT42, 3, ENSP000002557644MINT-65334 I2D: score=4 STRING: ENSP00000255764
    SMARCA4P515323, ENSP000003507204I2D: score=1 STRING: ENSP00000350720
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    HIST1H4FP628052, ENSP000003669744MINT-8387764 STRING: ENSP00000366974
    HIST1H4HP628052, ENSP000002893524MINT-8387764 STRING: ENSP00000289352
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0016568chromatin modification IEA--

    Find genes that share ontologies with KDM4B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KDM4B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for KDM4B gene: 
    NM_015015.2  

    Unigene Cluster for KDM4B:

    Lysine (K)-specific demethylase 4B
    Hs.654816  [show with all ESTs]
    Unigene Representative Sequence: NM_015015
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000588337 ENST00000159111(uc002mbq.4 uc010xim.2 uc002mbr.4)
    ENST00000381759(uc010xil.1) ENST00000536461 ENST00000592175 ENST00000589104
    ENST00000588961 ENST00000588361 ENST00000592159 ENST00000588166
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KDM4B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KDM4B (see all 30):
    hsa-miR-3678-3p hsa-miR-125a-5p hsa-miR-4251 hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-513a-5p hsa-miR-3129-5p hsa-miR-29c
    SwitchGear 3'UTR luciferase reporter plasmidKDM4B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KDM4B
    Predesigned siRNA for gene silencing in human, mouse, rat KDM4B
    Clone
    Products:
         
    OriGene clones in human, mouse for KDM4B (see all 6)
    OriGene ORF clones in mouse, rat for KDM4B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KDM4B (NM_015015)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KDM4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KDM4B
    Addgene plasmids for KDM4B 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KDM4B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KDM4B
      QuantiTect SYBR Green Assays in human, mouse, rat KDM4B
      QuantiFast Probe-based Assays in human, mouse, rat KDM4B

    Additional mRNA sequence: 

    AB020683.2 AF052144.1 AK026040.1 AK090405.1 AK126854.1 AL133622.1 AL831872.1 BC015378.1 
    BC040014.1 BC046167.1 BC063889.1 BC136611.1 BC144292.1 

    14 DOTS entries:

    DT.95268131  DT.100673094  DT.91736535  DT.100782044  DT.97842572  DT.75166336  DT.99929060  DT.91894949 
    DT.91736528  DT.100025963  DT.92010446  DT.101967033  DT.121459830  DT.97798143 

    Selected AceView cDNA sequences (see all 63):

    CB158429 AL831872 AA884638 BQ219578 BC063889 BF868628 AW450344 BM992894 
    BG236071 AI684636 CA307451 BM703561 BI020470 BM703553 BQ225977 BU552683 
    AI362737 AI939571 AI658783 BF313933 BE261870 BM801857 AA326284 BE672463 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KDM4B (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ·
    SP1:        -     -                             -           -                       -                                                                           
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                -                             -     -     -                                 
    SP5:                                                                                                                                                            

    ExUns: 21c ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31a · 31b ^ 32
    SP1:                                                                                                
    SP2:                                                                                                
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for KDM4B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    KDM4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACGCTGCGA
    KDM4B Expression
    About this image


    KDM4B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    KDM4B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KDM4B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654816
        Custom PCR Arrays for KDM4B
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KDM4B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KDM4B
    QuantiTect SYBR Green Assays in human, mouse, rat KDM4B
    QuantiFast Probe-based Assays in human, mouse, rat KDM4B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM4B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for KDM4B gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kdm4b1 , 5 lysine (K)-specific demethylase 4B1, 5 80.81(n)1
    83.52(a)1
      17 (29.27 cM)5
    1937961  NM_172132.21  NP_742144.11 
     563260625 
    chicken
    (Gallus gallus)
    Aves KDM4B1 lysine (K)-specific demethylase 4B 69.52(n)
    74.79(a)
      428354  XM_004948952.1  XP_004949009.1 
    lizard
    (Anolis carolinensis)
    Reptilia KDM4B6
    lysine (K)-specific demethylase 4B
    70(a)
    1 ↔ 1
    GL343661.1(164-219742)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BC061307.12   -- 74.88(n)    BC061307.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kdm4b1 lysine (K)-specific demethylase 4B 68.39(n)
    66.9(a)
      556504  NM_001082805.1  NP_001076274.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Kdm4A1 Histone demethylase 4A 65.86(n)
    64.05(a)
      35744  NM_001259265.1  NP_001246194.1 
    worm
    (Caenorhabditis elegans)
    Secernentea jmjd-26
    Protein JMJD-2 (jmjd-2) mRNA, complete cds
    32(a)
    1 → many
    II(14234973-14243590) WBGene00012982
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPH1(YER169W)4 JmjC domain-containing histone demethylase; specifically more   --   5(523369-525759) 856916  NP_011096.1 


    ENSEMBL Gene Tree for KDM4B (if available)
    TreeFam Gene Tree for KDM4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for KDM4B gene
    KDM4D2  KDM4A2  KDM4C2  KDM4E2  
    6 SIMAP similar genes for KDM4B using alignment to 4 protein entries:     KDM4B_HUMAN (see all proteins):
    JMJD2B    KDM4E    KDM4C    KDM4D    KDM4A    AF10

    Find genes that share paralogs with KDM4B           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for KDM4B
    PGOHUM00000242867


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for KDM4B (see all 4542)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2019171191,2
    Cuntested15151384(+) TTCTCA/C/GGGGGA 2 S syn10--------
    rs1420340221,2
    --4967302(+) TACCAA/GTGTGC 1 -- us2k10--------
    rs1971471,2
    C,F,H--4967407(-) AAACCG/AGTATC 1 -- us2k112Minor allele frequency- A:0.05MN NS EA NA CSA WA 1396
    rs1442185231,2
    C--4967467(+) TGTCCC/GTAGCT 1 -- us2k10--------
    rs1847676521,2
    --4967476(+) CTCAGC/TGGTTG 1 -- us2k10--------
    rs1880328121,2
    --4967500(+) GTTTGC/TAAACA 1 -- us2k10--------
    rs48076721,2
    C,F--4967525(+) TTTTTC/GTTTTC 1 -- us2k1 tfbs3 trp35Minor allele frequency- G:0.07NA WA CSA 244
    rs1926558521,2
    --4967642(+) CATGCA/GCCACC 1 -- us2k10--------
    rs121855181,2
    C,F--4967701(+) TTGGCC/GAGGCT 1 -- us2k14Minor allele frequency- G:0.27NA 126
    rs121855191,2
    C,F--4967739(+) CCACCC/TGACTC 1 -- us2k14Minor allele frequency- T:0.26NA 126

    HapMap Linkage Disequilibrium report for KDM4B (4969124 - 5153609 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KDM4B (see all 26):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2013056CNV Deletion18987734
    dgv616e199CNV Deletion23128226
    esv1001351CNV Deletion20482838
    esv2718039CNV Deletion23290073
    esv2105827CNV Deletion18987734
    esv2718038CNV Deletion23290073
    esv2718037CNV Deletion23290073
    esv1690767CNV Insertion17803354
    esv1201127CNV Insertion17803354
    dgv3684n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KDM4B
    DNA2.0 Custom Variant and Variant Library Synthesis for KDM4B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609765    OMIM disorders: --


    Find genes that share disorders with KDM4B           About GenesLikeMe

    Genetic Association Database (GAD): KDM4B
    Human Genome Epidemiology (HuGE) Navigator: KDM4B (1 document)

    Export disorders for KDM4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for KDM4B gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with KDM4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    2. Identification and characterization of JMJD2 family genes in silico. (PubMed id 15138608)1, 3, 9 Katoh M. and Katoh M. (Int. J. Oncol. 2004)
    3. Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. (PubMed id 15927959)1, 2, 9 Gray S.G.... Dangond F. (J. Biol. Chem. 2005)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. (PubMed id 16603238)1, 2 Whetstine J.R.... Shi Y. (Cell 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    8. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    9. Comparative integromics on JMJD2A, JMJD2B and JMJD2C: preferential expression of JMJD2C in undifferentiated ES cells. (PubMed id 17611647)1, 9 Katoh Y. and Katoh M. (Int. J. Mol. Med. 2007)
    10. Heat shock protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase. (PubMed id 23589305)1 Ipenberg I....Ayoub N. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23030 HGNC: 29136 AceView: JMJD2B Ensembl:ENSG00000127663 euGenes: HUgn23030
    ECgene: KDM4B H-InvDB: KDM4B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0876

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for KDM4B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KDM4B gene:
    Search GeneIP for patents involving KDM4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of KDM4B
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for KDM4B   OriGene RNAi products in human, mouse, rat for KDM4B  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for KDM4B  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KDM4B  
     OriGene qSTAR qPCR primer pairs in human, mouse for KDM4B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KDM4B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KDM4B   OriGene Custom Protein Services for KDM4B  

     
     
     Block miRNA regulation of human, mouse, rat KDM4B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KDM4B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KDM4B Predesigned siRNA for gene silencing in human, mouse, rat KDM4B
     QuantiFast Probe-based Assays in human, mouse, rat KDM4B QuantiTect SYBR Green Assays in human, mouse, rat KDM4B
     Custom PCR Arrays for KDM4B Search Chromatin IP Primers for KDM4B
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KDM4B  Search GeneGlobe Interaction Network for KDM4B
     Regulatory tfbs in KDM4B promoter
     GenScript Custom Purified and Recombinant Proteins Services for KDM4B GenScript cDNA clones with any tag delivered in your preferred vector for KDM4B
     GenScript Custom Assay Services for KDM4B GenScript Custom overexpressing Cell Line Services for KDM4B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for KDM4B  (JMJD2B)

     Search Tocris compounds for KDM4B
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for KDM4B
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     KDM4B antibodies
     KDM4B proteins
     KDM4B lysates
     Search for Antibodies for KDM4B at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for KDM4B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for KDM4B
     Antibodies for KDM4B
     ELISAs for KDM4B
     CLIAs for KDM4B



     Browse ESI BIO Cell Lines and PureStem Progenitors for KDM4B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM4B
     SwitchGear 3'UTR luciferase reporter plasmids for KDM4B
     Browse SwitchGear Promoter luciferase reporter plasmids for KDM4B
     ThermoFisher Antibodies for KDM4B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KDM4B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KDM4B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KDM4B
     LSBio Antibodies in human, mouse, rat for KDM4B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for KDM4B
      Search eBioscience for proteins for KDM4B
      Search eBioscience for elisas for KDM4B
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KDM4B gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4