Aliases for KDM4B Gene
External Ids for KDM4B Gene
Previous HGNC Symbols for KDM4B Gene
Previous GeneCards Identifiers for KDM4B Gene
GeneCards Summary for KDM4B Gene
KDM4B (Lysine Demethylase 4B) is a Protein Coding gene. Among its related pathways are DNA Double Strand Break Response and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include dioxygenase activity. An important paralog of this gene is KDM4C.
UniProtKB/Swiss-Prot for KDM4B Gene
Histone demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 Lys-4, H3 Lys-27, H3 Lys-36 nor H4 Lys-20. Only able to demethylate trimethylated H3 Lys-9, with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.