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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KDM4B Gene

protein-coding GIFtS: 57
GCID: GC19P004969

lysine (K)-specific demethylase 4B

(Previous name: jumonji domain containing 2B )
(Previous symbol: JMJD2B)

Explore 6 diseases affiliated with
KDM4B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Lysine (K)-Specific Demethylase 4B¹ ²		Jumonji Domain-Containing Protein 2B² ³
JMJD2B¹ ² ³ ⁵		Lysine-Specific Demethylase 4B²
KIAA0876¹ ³ ⁵		Tudor Domain Containing 14B²
TDRD14B¹ ²		EC 1.14.11.-³
Jumonji Domain Containing 2B¹ ²		JHDM3B³
JmjC Domain-Containing Histone Demethylation Protein 3B² ³		EC 1.14.11⁸

External Ids:	HGNC: 29136¹	Entrez Gene: 23030²	Ensembl: ENSG00000127663⁷	OMIM: 609765⁵	UniProtKB: O94953³

Export aliases for KDM4B gene to outside databases

Previous GC identifers: GC19P004921 GC19P004730

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: KDM4B_HUMAN, O94953

Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone

code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate

trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates

formaldehyde and succinate

Gene Wiki entry for KDM4B (JMJD2B)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011255.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KDM4B gene promoter:
MAZR AML1a Lmo2 Nkx5-1 LCR-F1 NF-E2 p45 C/EBPalpha Egr-2 USF-1 NF-E2
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for KDM4B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KDM4B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3

KDM4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KDM4B gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P004969: view genomic region (about GC identifiers)

Start:	4,969,124 bp from pter	End:	5,153,609 bp from pter
Size:	184,486 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KDM4B_HUMAN, O94953 (See protein sequence)

Recommended Name: Lysine-specific demethylase 4B

Size: 1096 amino acids; 121897 Da

Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)

Subcellular location: Nucleus

Sequence caution: Sequence=AAC33799.1; Type=Erroneous gene model prediction; Sequence=BAA74899.2; Type=Erroneous

initiation;

Secondary accessions: B9EGN8 D6W631 O75274 Q6P3R5 Q9P1V1 Q9UF40

Alternative splicing: 2 isoforms: O94953-1 O94953-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KDM4B: NX_O94953

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O94953

4/11 DME Specific Peptides for KDM4B (O94953) (see all 11)

YSINYLH

VHASCYG

AESTNFA

DMVKISM

KDM4B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055830.1

ENSEMBL proteins:

ENSP00000468514 ENSP00000159111 ENSP00000371178 ENSP00000440495 ENSP00000467678

Human Recombinant Protein Products:

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	Novus Biologicals KDM4B Protein Novus Biologicals KDM4B Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KDM4B

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

KDM4B for ontologies About GeneDecksing

KDM4B Antibody Products:

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	Uscn ELISAs and CLIAs for KDM4B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KDM4B for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR001965 Znf_PHD

IPR013083 Znf_RING/FYVE/PHD

IPR003347 JmjC_dom

IPR003349 TF_JmjN

IPR011011 Znf_FYVE_PHD

Graphical View of Domain Structure for InterPro Entry O94953

ProtoNet protein and cluster: O94953

3 Blocks protein families:

IPB001965 Zn-finger-like

IPB003347 Transcription factor jumonji

IPB003349 Transcription factor jumonji

UniProtKB/Swiss-Prot: KDM4B_HUMAN, O94953

Domain: The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure

and the unusual fold is required for its ability to bind methylated histone tails (By similarity)

Similarity: Belongs to the JHDM3 histone demethylase family

Similarity: Contains 1 JmjC domain

Similarity: Contains 1 JmjN domain

Similarity: Contains 2 PHD-type zinc fingers

Similarity: Contains 2 Tudor domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KDM4B_HUMAN, O94953

Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone

code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate

trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates

formaldehyde and succinate

Enzyme Numbers (IUBMB): EC 1.14.11.-¹ EC 1.14.11²

miRNA Products:		OriGene 3'-UTR Clone: KDM4B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KDM4B
		8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate KDM4B (see all 30):
		hsa-miR-3678-3p hsa-miR-125a-5p hsa-miR-4251 hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-513a-5p hsa-miR-3129-5p hsa-miR-29c

		SwitchGear 3'UTR luciferase reporter plasmid: KDM4B 3' UTR sequence

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KDM4B (see all 4) OriGene shRNA RFP: KDM4B Browse OriGene siRNA
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for KDM4B

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM4B

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008270	zinc ion binding	IEA	--
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	--

KDM4B for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for KDM4B:

Decreased NANOG protein expres

Decreased OCT4 protein express

Decreased POU5F1-GFP protein e

Animal Models:
8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Kdm4b):

cellular	craniofacial	endocrine/exocrine gland	integument	mortality/aging
normal	skeleton	vision/eye

KDM4B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Chromatin Regulation / Acetylation

Chromatin Regulation / Acetylation

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for KDM4B

Chromatin Regulation / Acetylation

KDM4B for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KDM4B

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/28 Interacting proteins for KDM4B (O94953^{2, 3} ENSP00000159111⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 28)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MED10	Q9BTT4²^,³, ENSP00000255764⁴	MINT-65334 I2D: score=4 STRING: ENSP00000255764
ESR1	P03372³, ENSP00000206249⁴	I2D: score=1 STRING: ENSP00000206249
EMX1	Q04741³	I2D: score=1
NFE2	Q16621³	I2D: score=1
SMARCA4	P51532³	I2D: score=1

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0016568	chromatin modification	IEA	--

KDM4B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KDM4B
Search CenterWatch for drugs/clinical trials and news about KDM4B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KDM4B gene:

NM_015015.2

Unigene Cluster for KDM4B:

Lysine (K)-specific demethylase 4B

Hs.654816 [show with all ESTs]

Unigene Representative Sequence: NM_015015

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000588337 ENST00000159111(uc002mbq.4 uc010xim.2 uc002mbr.4)

ENST00000381759(uc010xil.1) ENST00000536461 ENST00000592175 ENST00000589104

ENST00000593227 ENST00000588961 ENST00000588361 ENST00000592159 ENST00000588166

miRNA Products:		OriGene 3'-UTR Clone: KDM4B Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KDM4B
		8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate KDM4B (see all 30):
		hsa-miR-3678-3p hsa-miR-125a-5p hsa-miR-4251 hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-513a-5p hsa-miR-3129-5p hsa-miR-29c

		SwitchGear 3'UTR luciferase reporter plasmid: KDM4B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KDM4B

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		GenScript: all cDNA clones in your preferred vector: KDM4B (NM_015015)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KDM4B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KDM4B

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KDM4B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KDM4B

Additional cDNA sequence:

AB020683.2 AF052144.1 AK026040.1 AK090405.1 AK126854.1 AL133622.1 AL831872.1 BC015378.1

BC040014.1 BC046167.1 BC063889.1 BC136611.1 BC144292.1

14 DOTS entries:

DT.95268131 DT.100673094 DT.91736535 DT.100782044 DT.97842572 DT.75166336 DT.99929060 DT.91894949

DT.91736528 DT.100025963 DT.92010446 DT.101967033 DT.121459830 DT.97798143

24/63 AceView cDNA sequences (see all 63):

BM992894 AW450344 BC063889 BF868628 BQ219578 AA884638 AL831872 CB158429

AL560679 BU844833 BE672463 AA326284 BM801857 BE261870 BF313933 BU552683

AI939571 AI658783 AI362737 BQ225977 BI020470 BM703553 BM703561 AI684636

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for KDM4B (see all 13) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11a	·	11b	^	12	^	13a	·	13b	^	14a	·	14b	^	15	^	16	^	17	^	18	^	19	^	20	^	21a	·	21b	·
SP1:			-		-										-				-								-
SP2:
SP3:
SP4:																											-										-		-		-
SP5:

ExUns:	21c	^	22	^	23a	·	23b	^	24a	·	24b	^	25	^	26	^	27	^	28a	·	28b	^	29	^	30	^	31a	·	31b	^	32
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for KDM4B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KDM4B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACGCTGCGA

About this image

KDM4B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Spinal Neural Tube Cells

Neural Ectoderm

Eye

Retina

Eye

Spinal Cord

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KDM4B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KDM4B

SOURCE GeneReport for Unigene cluster: Hs.654816

SABiosciences Custom PCR Arrays for KDM4B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KDM4B Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KDM4B

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM4B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for KDM4B gene from 8/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Kdm4b^{1 , 5}	lysine (K)-specific demethylase 4B^{1, 5}	80.9(n)¹ 83.71(a)¹		17 (29.27 cM)⁵ 193796¹ NM_172132.2¹ NP_742144.1¹ 56326062⁵
chicken (Gallus gallus)	Aves	KDM4B¹	lysine (K)-specific demethylase 4B	69.86(n) 76.09(a)		428354 XM_001233691.2 XP_001233692.2
lizard (Anolis carolinensis)	Reptilia	KDM4B⁶ KDM4C⁶	--	67(a) 38(a)	many → 1 possible ortholog	GL343661.1(3007-199112) 2(52946472-53065355)
tropical clawed frog (Xenopus tropicalis)	Amphibia	BC061307.1²	--	74.88(n)		BC061307.1
zebrafish (Danio rerio)	Actinopterygii	kdm4b¹	lysine (K)-specific demethylase 4B	65.12(n) 62.24(a)		556504 NM_001082805.1 NP_001076274.1
fruit fly (Drosophila melanogaster)	Insecta	Kdm4A¹	Histone demethylase 4A	62.15(n) 59.62(a)		35744 NM_136487.3 NP_610331.1
worm (Caenorhabditis elegans)	Secernentea	jmjd-2⁶	Lysine-specific demethylase 4	26(a)	1 → many	II(14234898-14243515)
rice (Oryza sativa)	Liliopsida	-- --	ZOS3-01 - C2H2 zinc finger protein, expressed	8(a) 1(a)	possible ortholog possible ortholog	3(2837768-2840687) 3(2712309-2714914)

ENSEMBL Gene Tree for KDM4B (if available)
TreeFam Gene Tree for KDM4B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KDM4B gene

KDM4D² KDM4A² KDM4C² KDM4E²

6 SIMAP similar genes for KDM4B using alignment to 4 protein entries: KDM4B_HUMAN (see all proteins):

JMJD2B KDM4E KDM4C KDM4D KDM4A AF10

KDM4B for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for KDM4B
PGOHUM00000242867

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201917119^1,2	C,	other	5151384(+)	`TTCTCA/C/GGGGGA`	3	S	syn¹		0	--	--	--	--
rs111359012^1,2	C,	--	4805245(+)	`TATCCC/TGTGCT`	1	--	int¹		1		WA	2
rs142034022^1,2		--	4967302(+)	`TACCAA/GTGTGC`	1	--	us2k¹		0	--	--	--	--
rs197147^1,2	C,F,H,	--	4967407(-)	`AAACCG/AGTATC`	1	--	us2k¹		12		MN NS EA NA CSA WA	1396
rs144218523^1,2		--	4967467(+)	`TGTCCC/GTAGCT`	1	--	us2k¹		0	--	--	--	--
rs184767652^1,2		--	4967476(+)	`CTCAGC/TGGTTG`	1	--	us2k¹		0	--	--	--	--
rs188032812^1,2		--	4967500(+)	`GTTTGC/TAAACA`	1	--	us2k¹		0	--	--	--	--
rs4807672^1,2	C,F,	--	4967525(+)	`TTTTTC/GTTTTC`	1	--	us2k¹ tfbs³ trp³		5		NA WA CSA	244
rs192655852^1,2		--	4967642(+)	`CATGCA/GCCACC`	1	--	us2k¹		0	--	--	--	--
rs12185518^1,2	C,F,	--	4967701(+)	`TTGGCC/GAGGCT`	1	--	us2k¹		4		NA	126

HapMap Linkage Disequilibrium report for KDM4B (4969124 - 5153609 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for KDM4B
1 CNV: 67446
3 Indels: 73299 45779 45778

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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KDM4B for disorders           About GeneDecksing

OMIM gene information: 609765    OMIM disorders: --

6 diseases for KDM4B:    About MalaCards

malignant spindle cell melanoma retinoblastoma melanoma breast cancer

hypoxia malaria

Human Genome Epidemiology (HuGE) Navigator: KDM4B (1 document)

Export disorders for KDM4B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for KDM4B gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with KDM4B)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)^{1, 2, 3} Nagase T....Ohara O. (1998)
Identification and characterization of JMJD2 family genes in silico. (PubMed id 15138608)^{1, 3, 9} Katoh M. and Katoh M. (2004)
Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. (PubMed id 15927959)^{1, 2, 9} Gray S.G.... Dangond F. (2005)
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. (PubMed id 16603238)^{1, 2} Whetstine J.R.... Shi Y. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (2004)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (2002)
Comparative integromics on JMJD2A, JMJD2B and JMJD2C: preferential expression of JMJD2C in undifferentiated ES cells. (PubMed id 17611647)^{1, 9} Katoh Y. and Katoh M. (2007)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Histone demethylases KDM4B and KDM6B promotes osteogen ic differentiation of human MSCs. (PubMed id 22770241)¹ Ye L....Wang C.Y. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23030	HGNC: 29136	AceView: JMJD2B	Ensembl:ENSG00000127663	euGenes: HUgn23030
ECgene: KDM4B	H-InvDB: KDM4B

(According to HUGE)
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HUGE: KIAA0876

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KDM4B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KDM4B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KDM4B gene:
Search GeneIP for patents involving KDM4B

GeneCards and IP:
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lysine (K)-specific demethylase 4B

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lysine (K)-specific demethylase 4B

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