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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KDM4A Gene

protein-coding   GIFtS: 57
GCID: GC01P044115

lysine (K)-specific demethylase 4A

(Previous names: jumonji domain containing 2, jumonji domain containing...)
(Previous symbols: JMJD2, JMJD2A)
 Explore 5 diseases affiliated with
KDM4A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KDM4A    

Aliases
for KDM4A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Lysine (K)-Specific Demethylase 4A1 2     JmjC Domain-Containing Histone Demethylation Protein 3A2 3
JHDM3A1 2 3 5     Jumonji Domain-Containing Protein 2A2 3
JMJD2A1 2 3 5     Jumonji C Domain-Containing Histone Demethylase 3A2
JMJD21 2 3     Lysine-Specific Demethylase 4A2
KIAA06771 3 5     Tudor Domain Containing 14A2
TDRD14A1 2     EC 1.14.11.-3
Jumonji Domain Containing 21 2     EC 1.14.118
Jumonji Domain Containing 2A1 2     

External Ids:    HGNC: 229781   Entrez Gene: 96822   Ensembl: ENSG000000661357   OMIM: 6097645   UniProtKB: O751643   

Export aliases for KDM4A gene to outside databases

Previous GC identifers: GC01P043889 GC01P042237


Summaries
for KDM4A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KDM4A:
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC
domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a
trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and
as a transcriptional repressor. (provided by RefSeq, Apr 2009)

UniProtKB/Swiss-Prot: KDM4A_HUMAN, O75164
Function: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby
playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'.
Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated
residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional
repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively
Function: Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by
directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain

Gene Wiki entry for KDM4A (JMJD2A)


Genomic Views
for KDM4A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KDM4A gene promoter:
         STAT1   Spz1   MAZR   STAT1beta   AP-4   LCR-F1   STAT1alpha   C/EBPalpha   IRF-7A   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KDM4A promoter sequence
   Search SABiosciences Chromatin IP Primers for KDM4A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KDM4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p34.1

KDM4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KDM4A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P044115:  view genomic region     (about GC identifiers)

Start:
 44,115,797 bp from pter      End:
 44,171,189 bp from pter
Size:
 55,393 bases      Orientation:
 plus strand

Proteins
for KDM4A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KDM4A_HUMAN, O75164 (See protein sequence)
Recommended Name: Lysine-specific demethylase 4A  
Size: 1064 amino acids; 120662 Da
Cofactor: Binds 1 Fe(2+) ion per subunit
Subunit: Interacts with histone deacetylase proteins HDAC1, HDAC2 and HDAC3. Interacts with RB and NCOR1. Interacts
with HTLV-1 Tax protein
Subcellular location: Nucleus
Sequence caution: Sequence=BAA31652.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
6/27 PDB 3D structures from and Proteopedia for KDM4A (see all 27):
2GF7 (3D)        2GFA (3D)        2GP3 (3D)        2GP5 (3D)        2OQ6 (3D)        2OQ7 (3D)    
Secondary accessions: Q5VVB1
Alternative splicing: 2 isoforms:  O75164-1   O75164-2   

Explore the universe of human proteins at neXtProt for KDM4A: NX_O75164

Post-translational modifications:

  • Ubiquitinated by RNF8 and RNF168 following DNA damage, leading to its degradation. Degradation promotes accessibility
    • of H4K20me2 mark for DNA repair protein TP53BP1, which is then recruited1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75164

    • 4/13 DME Specific Peptides for KDM4A (O75164) (see all 13)
     YSINYLH  VHASCYG  RWIEYGK  AESTNFA 

    KDM4A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055478.2  
    ENSEMBL proteins: 
     ENSP00000361473  

    Human Recombinant Protein Products: 
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    Uscn Proteins for KDM4A

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16024779
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--


    KDM4A for ontologies           About GeneDecksing



    KDM4A Antibody Products: 
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    R&D Systems Antibodies for KDM4A (Lysine (K)-specific Demethylase 4A/KDM4A)
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    Uscn ELISAs and CLIAs for KDM4A

    Protein Domains /
    Families
    for KDM4A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KDM4A for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR003347 JmjC_dom
     IPR003349 TF_JmjN
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry O75164

    ProtoNet protein and cluster: O75164

    2 Blocks protein families:
    IPB003347 Transcription factor jumonji
    IPB003349 Transcription factor jumonji


    UniProtKB/Swiss-Prot: KDM4A_HUMAN, O75164
    Domain: The 2 Tudor domains recognize and bind methylated histone H3 'Lys-4' residue (H3K4me). Double Tudor domain has
    an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails.
    Trimethylated H3 'Lys-4' (H3K4me3) is bound in a cage of 3 aromatic residues, 2 of which are from the Tudor domain 2,
    while the binding specificity is determined by side-chain interactions involving residues from the Tudor domain 1. The
    Tudor domains are also able to bind trimethylated histone H3 'Lys-9' (H3K9me3), di- and trimethylated H4 'Lys-20'
    (H4K20me2 and H4K20me3). Has high affinity for H4K20me2, blocking recruitment of proteins such as TP53BP1
    Similarity: Belongs to the JHDM3 histone demethylase family
    Similarity: Contains 1 JmjC domain
    Similarity: Contains 1 JmjN domain
    Similarity: Contains 2 PHD-type zinc fingers
    Similarity: Contains 2 Tudor domains


    Function
    for KDM4A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KDM4A_HUMAN, O75164
    Function: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby
    playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'.
    Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated
    residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional
    repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively
    Function: Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by
    directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain

    Enzyme Numbers (IUBMB): EC 1.14.11.-1 EC 1.14.112

    miRNA
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    hsa-miR-607 hsa-miR-4328 hsa-miR-429 hsa-miR-1260b hsa-miR-624 hsa-miR-578 hsa-miR-346 hsa-miR-632
    SwitchGear 3'UTR luciferase reporter plasmid: KDM4A 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KDM4A (see all 4)
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17567753
    GO:0008270zinc ion binding IEA--
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA--
    GO:0031625ubiquitin protein ligase binding IPI--
    GO:0035064methylated histone residue binding IDA--


    KDM4A for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for KDM4A:
     Decreased Hepatitis C virus re 

    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Kdm4a):
     cardiovascular system  homeostasis/metabolism  muscle 

    KDM4A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KDM4A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Chromatin Regulation / Acetylation
    		Chromatin Regulation / Acetylation1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for KDM4A
        Chromatin Regulation / Acetylation



    KDM4A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KDM4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/41 Interacting proteins for KDM4A (O751641, 2, 3 ENSP000003614734) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4BP628052, 3MINT-8387660 MINT-8387734 MINT-2830405 MINT-8387643 MINT-2829542 MINT-2829504 MINT-2829876 I2D: score=2 
    HIST1H4CP628052, 3MINT-8387660 MINT-8387734 MINT-2830405 MINT-8387643 MINT-2829542 MINT-2829504 MINT-2829876 I2D: score=2 
    HIST1H4DP628052, 3MINT-8387660 MINT-8387734 MINT-2830405 MINT-8387643 MINT-2829542 MINT-2829504 MINT-2829876 I2D: score=2 
    HIST1H4EP628052, 3MINT-8387660 MINT-8387734 MINT-2830405 MINT-8387643 MINT-2829542 MINT-2829504 MINT-2829876 I2D: score=2 
    HIST1H4FP628052, 3MINT-8387660 MINT-8387734 MINT-2830405 MINT-8387643 MINT-2829542 MINT-2829504 MINT-2829876 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0016577histone demethylation IDA16024779
    GO:0019048virus-host interaction IEA--
    GO:0044419interspecies interaction between organisms ----
    GO:0045892negative regulation of transcription, DNA-dependent IDA16024779


    KDM4A for ontologies           About GeneDecksing



    Drugs & Compounds
    for KDM4A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KDM4A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for KDM4A

    Browse Tocris compounds for KDM4A
    1 Novoseek chemical compound relationship for KDM4A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 35.7 1 16603238 (1)

    Search CenterWatch for drugs/clinical trials and news about KDM4A 

    Transcripts
    for KDM4A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KDM4A gene: 
    NM_014663.2  

    Unigene Cluster for KDM4A:

    Lysine (K)-specific demethylase 4A
    Hs.155983  [show with all ESTs]
    Unigene Representative Sequence: NM_014663
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372396(uc001cjx.3 uc010oki.2) ENST00000463151 ENST00000485249
    ENST00000472265 ENST00000481296

    miRNA
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    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate KDM4A (see all 48):
    hsa-miR-607 hsa-miR-4328 hsa-miR-429 hsa-miR-1260b hsa-miR-624 hsa-miR-578 hsa-miR-346 hsa-miR-632
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    Inhib. RNA
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    Primer
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    Additional cDNA sequence: 

    AB014577.1 AK294596.1 AK300039.1 AK310295.1 BC002558.2 Z70219.1 

    10 DOTS entries:

    DT.415303  DT.91975395  DT.86854217  DT.97811185  DT.100000158  DT.92024385  DT.95329546  DT.95338656 
    DT.97815843  DT.97843731 

    24/147 AceView cDNA sequences (see all 147):

    AA234726 BM904299 BC002558 BM459303 BQ777634 BQ440865 AA505761 BQ216769 
    BP357225 CD244838 BQ052710 AI473334 AI623088 BQ229739 BE249964 BU507829 
    T60254 AB014577 AA481160 BQ669502 BX471167 AI554888 Z70219 AI417107 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for KDM4A (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^
    SP1:        -     -     -     -           -                                                                       -                                             
    SP2:                                      -                                                                                                                     
    SP3:                                                                                                                                                            
    SP4:                          -           -                                                                                                                     
    SP5:                          -                                                                                                                                 

    ExUns: 22a · 22b ^ 23a · 23b · 23c ^ 24a · 24b
    SP1:  -           -           -               
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for KDM4A

    Expression
    for KDM4A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KDM4A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGGGGCTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See KDM4A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KDM4A

    SOURCE GeneReport for Unigene cluster: Hs.155983

    UniProtKB/Swiss-Prot: KDM4A_HUMAN, O75164
    Tissue specificity: Ubiquitous

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              Epigenetic Chromatin Modification Enzymes in human mouse rat

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    Orthologs
    for KDM4A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KDM4A gene from 7/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KDM4A1 lysine (K)-specific demethylase 4A 74.04(n)
    79.41(a)    		   424571  XM_422410.3  XP_422410.2 
    lizard
    (Anolis carolinensis)    		 Reptilia KDM4A6
    KDM4C6
    		 --
    		 77(a)
    36(a)
    		 1 ↔ 1
    possible ortholog
    		 4(108384093-108415470)
    2(52946472-53065355)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BJ071720.12   -- 77.82(n)    BJ071720.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC047193.12   -- 77.06(n)    BC047193.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Kdm4A6
    Kdm4B6
    		 Histone demethylase 4B
    		 46(a)
    34(a)
    		 many ↔ many
    many ↔ many
    		 2R(3810280-3812488)
    2R(9063599-9085869)
    worm
    (Caenorhabditis elegans)    		 Secernentea jmjd-21 Protein JMJD-2 49.26(n)
    41.9(a)    		   175080  NM_064568.2  NP_496969.2 
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 ZOS3-01 - C2H2 zinc finger protein, expressed
    		 9(a)
    1(a)
    		 possible ortholog
    possible ortholog
    		 3(2837768-2840687)
    3(2712309-2714914)


    ENSEMBL Gene Tree for KDM4A (if available)
    TreeFam Gene Tree for KDM4A (if available) 

    Paralogs
    for KDM4A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KDM4A gene
    KDM4D2  KDM4C2  KDM4B2  KDM4E2  
    5 SIMAP similar genes for KDM4A using alignment to 2 protein entries:     KDM4A_HUMAN (see all proteins):
    KDM4D    KDM4E    KDM4C    KDM4B    JMJD2B

    KDM4A for paralogs           About GeneDecksing



    Genomic Variants
    for KDM4A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/960 NCBI SNPs in KDM4A are shown (see all 960)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1436953221,2
    		--44113817(+) ATCGTA/GCCTGG 1 -- us2k10--------
    rs1837283601,2
    		--44113832(+) CAAGAA/GCGAAA 1 -- us2k10--------
    rs1467963331,2
    		--44113898(+) AAGGGA/TAAGGT 1 -- us2k10--------
    rs1894131421,2
    		--44113977(+) TCCACC/TTATCA 1 -- us2k10--------
    rs1123951861,2
    		--44114042(+) ATCTGA/GCAGCA 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs1140398411,2
    		F,--44114075(+) GTTTAT/CGGAAC 1 -- us2k11Minor allele frequency- C:0.08WA 118
    rs1164099701,2
    		C,F,--44114106(+) CTGTAT/GCCATG 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs6175211,2
    		C,F,A,H,--44114199(+) CCGCAT/GGATTT 1 -- us2k140Minor allele frequency- G:0.21NS MN EA NA WA CSA 3526
    rs740706441,2
    		C,F,--44114368(+) CTTTTT/CGAAAC 1 -- us2k14Minor allele frequency- C:0.07WA CSA 124
    rs5138621,2
    		C,F,A,H,--44114405(-) ATCTTA/TAAAAA 1 -- us2k1 tfbs316Minor allele frequency- T:0.24NS EA NA WA CSA 794

    HapMap Linkage Disequilibrium report for KDM4A (44115797 - 44171189 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KDM4A: --

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    Disorders / Diseases
    for KDM4A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KDM4A for disorders           About GeneDecksing

    OMIM gene information: 609764    OMIM disorders: --

    5 diseases for KDM4A:    About MalaCards
    wiskott-aldrich syndrome    kaposi's sarcoma    sarcoma    retinoblastoma
    malaria


    Export disorders for KDM4A gene to outside databases

    Publications
    for KDM4A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KDM4A gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with KDM4A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (1998)
    2. JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2). (PubMed id 16024779)1, 2, 9 Zhang D.... Wong J. (2005)
    3. Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. (PubMed id 15927959)1, 2, 9 Gray S.G.... Dangond F. (2005)
    4. Identification and characterization of JMJD2 family genes in silico. (PubMed id 15138608)1, 3, 9 Katoh M. and Katoh M. (2004)
    5. Structural insights into histone demethylation by JMJD2 family members. (PubMed id 16677698)1, 2, 9 Chen Z.... Zhang G. (2006)
    6. Recognition of histone H3 lysine-4 methylation by the double Tudor domain of JMJD2A. (PubMed id 16601153)1, 2, 9 Huang Y.... Xu R.-M. (2006)
    7. Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. (PubMed id 16603238)1, 2, 9 Whetstine J.R.... Shi Y. (2006)
    8. RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites. (PubMed id 22373579)1, 2 Mallette F.A....Richard S. (2012)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    10. Tudor, MBT and chromo domains gauge the degree of lysine methylation. (PubMed id 16415788)1, 2 Kim J....Bedford M.T. (2006)

    External Searches for KDM4A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KDM4A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9682 HGNC: 22978 AceView: JMJD2A Ensembl:ENSG00000066135 euGenes: HUgn9682
    ECgene: KDM4A H-InvDB: KDM4A

    Other Databases showing KDM4A gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0677

    Specialized Databases showing KDM4A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KDM4A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KDM4A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KDM4A gene:
    Search GeneIP for patents involving KDM4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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