Aliases for KDM4A Gene
- Lysine Demethylase 4A 2 3 5
- JmjC Domain-Containing Histone Demethylation Protein 3A 3 4
- Jumonji C Domain-Containing Histone Demethylase 3A 2 3
- Jumonji Domain-Containing Protein 2A 3 4
- Lysine (K)-Specific Demethylase 4A 2 3
- Jumonji Domain Containing 2A 2 3
- Tudor Domain Containing 14A 2 3
- Jumonji Domain Containing 2 2 3
- JMJD2A 3 4
External Ids for KDM4A Gene
Previous HGNC Symbols for KDM4A Gene
Previous GeneCards Identifiers for KDM4A Gene
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009]
GeneCards Summary for KDM4A Gene
KDM4A (Lysine Demethylase 4A) is a Protein Coding gene. Among its related pathways are DNA Double Strand Break Response and Chromatin organization. GO annotations related to this gene include ubiquitin protein ligase binding and histone demethylase activity (H3-K36 specific). An important paralog of this gene is KDM4C.
UniProtKB/Swiss-Prot for KDM4A Gene
Histone demethylase that specifically demethylates Lys-9 and Lys-36 residues of histone H3, thereby playing a central role in histone code (PubMed:26741168). Does not demethylate histone H3 Lys-4, H3 Lys-27 nor H4 Lys-20. Demethylates trimethylated H3 Lys-9 and H3 Lys-36 residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.
Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.